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Universities have more intenseive stem cell research then this company will ever have..
Look at all the other stocks they covered before. See where they are now.
Oracle Dispatch is fake. A paid promoter
Universities have more progress in stem cell research
https://www.bing.com/news/search?q=Leading+Universities+In+Stem+Cell+Research&qpvt=leading+universities+in+stem+cell+research&FORM=EWRE
China a more difficult place for foreign firms to do business. Without what U.S. and European firms consider adequate safeguards of intellectual property, some foreign business leaders are worried that Chinese companies will copy their technology and use it to compete against the foreign firms in the global marketplace.
In need of scrutiny: Misleading stem cell claims by academic medical centers
https://www.healthnewsreview.org/2017/11/need-scrutiny-misleading-stem-cell-claims-academic-medical-centers/
Stem Cell Information
General Information
Clinical Trials
Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology at the University of Colorado Anschutz Medical Campus Using adult stem cells, researchers here are working on developing therapies to help patients suffering from diseases ranging from inherited skin blistering, to Parkinson’s, to victims of central nervous system degeneration.
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Scientists here are carrying out studies aimed at understanding and developing treatment strategies for such conditions as heart disease, diabetes, epilepsy, multiple sclerosis, Parkinson’s disease, Lou Gehrig’s disease, spinal cord injury and cancer.
Georgetown University Medical Center’s Center for Cell Reprogramming Focuses on research in conditional reprogramming and its application to cancer biology and regenerative medicine.
Harvard Stem Cell Institute Supports research into all aspects of stem cell biology, with special emphasis on those areas with the greatest potential for improving human health.
Johns Hopkins Institute for Cell Engineering (ICE) Represents the stem cell research effort at the Johns Hopkins University School of Medicine, where faculty, fellows, postdocs and students and staff study some of the most exciting problems in stem cell science today.
McGowan Institute for Regenerative Medicine Established for University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center scientists and clinical faculty working to develop tissue engineering, cellular therapies, biosurgery, and artificial and biohybrid organ devices.
National Human Neural Stem Cell Resource Provides neural stem cells harvested from the post-natal, post-mortem, human brain to the research community for stem cell research.
New York Stem Cell Science (NYSTEM) Supports basic, applied, translational or other research and development activities that will advance scientific discoveries in fields related to stem cell biology.
Pittsburgh Development Center of Magee-Womens Research Institute Explores the molecular biology of cell function, including the potential of stem cells for treating human disease.
Sloan-Kettering Institute Part of the Memorial Sloan-Kettering Cancer Center, the world’s oldest and largest private institution devoted to patient care, education, and research into cancer.
Stanford University School of Medicine/Institute for Cancer/Stem Cell Biology and Medicine Explains Stanford’s involvement and perspective on stem cell issues, with links to related sites.
Texas A&M University Mesenchymal Stem Cell Distribution Prepares and distributes well-characterized marrow stromal cells (MSCs) derived from adult human and rodent bone marrow using standardized protocols.
Texas Heart Institute Stem Cell Center Dedicated to the study of adult stem cells and their role in treating cardiovascular disease, including clinical trials (in human patients), as well as many preclinical studies (in the laboratory) using stem cells.
Tulane Center for Stem Cell Research and Regenerative Medicine Developing new therapies for a series of common diseases including osteoporosis, osteoarthritis, Parkinsonism, spinal cord injury, stroke, diabetes and Alzheimer’s disease. The Center also provides educational programs for career development, job training and life-long learning of citizens.
University of Miami, Miller School of Medicine’s Interdisciplinary Stem Cell Institute ISCI’s goal is to spearhead cell based therapies for a host of untreatable diseases. Its focus includes research in basic cell biology, hematology, oncology, cardiology, dermatology, diabetes and endocrinology, neurology, orthopaedics, pediatrics, and ethics and science policy.
University of Michigan/A. Alfred Taubman Medical Research Institute Consortium for Stem Cell Therapies The University of Michigan has been a long-time leader in the study of adult stem cells, has bolstered its human embryonic stem cell program, and added a complementary iPS cell research effort. m Cell Institute Works to enhance understanding of stem cells' potential to improve human and animal health.
University of Minnesota: Stem Cell Institute Works to enhance understanding of stem cells' potential to improve human and animal health.
University of Notre Dame Center for Stem Cells and Regenerative Medicine Focused on the study, application, and ethical understanding of adult and induced pluripotent stem cells and their potential to treat and cure many diseases.
University of Pennsylvania: Institute for Regenerative Medicine IRM was created to promote basic discoveries in stem cell biology and regeneration, and to translate those discoveries into new therapies that may alleviate suffering and disease. Additionally, education and outreach at the IRM aims to ensure students from kindergarten through graduate school are exposed to exciting and accurate education about regenerative biology and stem cell research.
The UW–Madison Stem Cell and Regenerative Medicine Center The Center provides a central point of contact, information and facilitation for all stem cell research activities on campus. The center's mission is to advance the science of stem cell biology and foster breakthroughs in regenerative medicine through faculty interactions, research support and education.
Yale Stem Cell Center The mission of the Yale Stem Cell Center is to advance our understanding of stem cell biology and to harness its potential to improve human health.
https://stemcells.nih.gov/research/education-research.htm
Most orders fall after the close. Can't really go with those #'s. When the market gets ready to open all open orders return..
Apr 02, 2018 NT 10-K Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405
http://www.guidedinc.com/regulatory-filings/
Incredible Penny Stocks: What is a Form T-Trade?
There is much confusion and rumor regarding “T Trades” in the penny stock market. Nasdaq Pink Sheet stocks often close at a certain price and, within 3-10 minutes after the closing bell, will show a large final trade that gets labeled as an “after hours” trade. Simply put, this is an inaccurate description of that trade.
To understand how this trade works, one must understand the role of the market maker. The most frustrating aspect of investing in the pennies, is market maker manipulation of the stock price. Anyone that claims this manipulation doesn’t happen truly does not understand the OTC Market. Market makers are in place to “control” the price of a stock and, theoretically, to ensure that the market reacts properly to supply and demand for a certain stock. Unfortunately, when large sums of money and a lack of regulation are involved, more often than not, there is manipulation that suits the needs of certain investors or the market makers themselves. After all, they are in business to make money as well. If the average investor is purchasing stocks in the OTC Market, that investor is truly at the mercy of the market makers involved in the purchase and sale of that security.
When researching this article, The response from the SEC defined a “Form T Trade” a “trade reporting form used by broker-dealer members of the Financial Industry Regulatory Authority, Inc. (FINRA) to report equity trades executed either in the OTC market or during extended hours trading. Recent amendments to FINRA rules will expand the types of situations in which Form T is to be used, but they are not yet in effect.” The response also recommended contacting FINRA. Notice the first portion of the response. “either in the OTC Market or…” Once again, it is confirmed by the SEC that ”after hours” trades do not exist in the Pinks.
FINRA was much less transparent in their response and essentially spewed the same limited information regarding T Trades that is available on their website. None of which, accurately reflects why these trades occur in the OTC Markets. (http://www.finra.org/web/groups/industry/@ip/@reg/@notice/documents/notices/p123750.pdf)
Trying to decipher the meaning of these trades with the limited information that is available on the subject led down several dark paths. Clearly, the average investor is not meant to understand the concept or its rules. Even more disconcerting is the second part of the SEC message “Recent amendments to FINRA rules will expand the types of situations in which Form T is to be used, but they are not yet in effect.” That means there is even less transparency about this mysterious T Trade.
After months of due diligence, there are a few poorly publicized uses for a T Trade. The most important factor here is that the only requirement of market makers by FINRA is that they must report all trades in a day. They are not required to do so when the actual trade occurs.
To avoid creating “an unbalanced market”, market makers often do not report certain trades during the day to the public and then use a T Trade not to “scare” investors into thinking a market for that stock is going in one direction or the other at the spurring of one large investor.
If a market maker wants to accumulate a large amount of a stock in one trading day, that market maker may actually not report any of the trades that occurred until the trading day has ended so as not to alert the market to the collection. This practice is completely legal under the FINRA rules of the OTC Markets so long as the trade is reported at the end of the day.
To execute a Market on Close” order, a market maker may have an order to purchase the stock at a certain price at the end of the trading day. This is the most unlikely scenario because it needs to be assured that someone selling the stock and someone buying that stock are agreeing upon a price. Simply put, this is more likely with insider buying and selling.
The T Trade that the public sees is nothing more than one or all of the above scenarios. The T Trade reported at the end of the day can be from one market maker or many involved market makers. It can be a single purchase price but is usually an average of all of the previously unreported purchases from that business day.
Penny stocks are an exciting and lucrative business. As most everyone will tell you, it is not for the weak of heart. There is definite money to be made in the OTC Markets and more penny stock millionaires are made every day. But the best way to win the game is to know the rules!
One additional fact surfaced about market makers while researching T Trades. Did you know that market makers are not required to honor their offer price? That is correct, because the OTC market is essentially a “best offer” market. If a buyer meets the asking price for a security, the market maker can, and often does, decide to rescind the offer, not sell the security and adjust the selling price.
Happy Trading.
https://incrediblepennystocks.wordpress.com/2013/06/25/incredible-penny-stocks-what-is-a-form-t-trade/
I'll be back when the 50 day crosses back under the 200 day. GLTA
Most orders fall after the close. Can't really go with those #'s. When the market gets ready to open tomorrow all open orders return..
GTHP. Volume 13 Million today. Doubled the 10 day avg. Up 39%
13 Million.. Good volume today. Doubled the 10 day avg.
Bought a nice position Friday. Will be looking to add more.
In @ .011 GTHP Friday.. Just sold USRM for a nice profit. I'll be on board to see what's happening here, I'm also a short term trader. GLTA
Good news today, stock up 39%..
*NEWS* They compete license agreement with Turkish Distribution Partner. Can't copy link to paste..
#Take my shares. Sold 70% for a 50% profit. I'll let 30% ride.. GLTA
Read an article this morning, had to rethink my position..
Beware of the Cheerleaders. Might be time to reevaluate your position. All penny stocks face major hurdles..
Late Financials – Time to Sell?
by Olga Usvyatsky
Thousands of NT (“non-timely”) filings are disclosed every year, but only a small percentage seems to trigger a significant market reaction. A non-timely filing is a notice that a company needs additional time to file periodic financial statements. (See here and here for more information about NT filings.) Reasons for a delay range from requiring a few additional days to complete an audit, to dealing with an unexpected material government investigation.
In our recent post about Hertz (NYSE: HTZ), we provided an analysis of red flags that could have provided investors with advanced warning of impending accounting problems. Among those red flags, we identified a non-timely filing that indicated potential accounting issues as one of the most powerful warning signals. This flag was largely overlooked by the market, and only a subsequent 8-K Item 4.02 filing (Non-Reliance disclosure) triggered a massive sell-off. In that post, we also noted that in most cases, by the time news of a restatement hits the market, it is already too late for most investors.
http://www.auditanalytics.com/blog/late-financials-time-to-sell/
Why do companies postpone earnings announcements?
By Matt Lee
During the course of a fiscal year, a company will report earnings on a total of four separate occasions: three quarterly statements filed as 10-Qs, and one annual report with Quarter 4 data within, filed as a 10-K. The SEC requires companies to file 10-Qs no later than 45 days after the end of a quarter, and 10-Ks must be being submitted no later than 90 days following a company's fiscal year-end. Occasionally, companies will postpone an earnings release for some unforeseen reason. However, most often, the delay will be a result of the company not completing the report on time due to audits taking longer than expected, inexperienced officers completing their first report and the firm losing some or all of its financial data due to a technical error, fire or theft. Although a company may file a report later than expected, this will sometimes have an impact on its stock price.
If a company announces that it is filing later than expected, investors may take this as a sign of a negative earnings surprise, and a sell-off may follow. Price reductions can be further enhanced by noise traders and technical analysts who may follow those who are selling their stock. The smart investor should keep in mind that the best thing for them to do during a time like this is to consider why the company is delaying its release, and/or wait for information to be released concerning whether management's reasons are valid, and see how the new data corresponds to the original investment thesis.
One possible winner in this scenario is the contrarian investor because the contrarian may pick up the now relatively cheaper stock, which will enhance any gains going forward.
Read more: Why do companies postpone earnings announcements? https://www.investopedia.com/ask/answers/06/postponeearnings.asp#ixzz5B2wSZws0
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Late filings will result in a company’s receipt of a notice of failure to meet the exchange’s continued listing requirements
http://100fstreet.com/index.php/2011/03/the-consequences-of-a-late-filing/
Newfound 'organ' had been missed by standard method for visualizing anatomy
Date:March 27, 2018
Source:NYU Langone Health/NYU School of Medicine
Summary:Researchers have identified a previously unknown feature of human anatomy with implications for the function of all organs, most tissues and the mechanisms of most major diseases.
Researchers have identified a previously unknown feature of human anatomy with implications for the function of all organs, most tissues and the mechanisms of most major diseases.
Published March 27 in Scientific Reports, a new study co-led by an NYU School of Medicine pathologist reveals that layers of the body long thought to be dense, connective tissues -- below the skin's surface, lining the digestive tract, lungs and urinary systems, and surrounding arteries, veins, and the fascia between muscles -- are instead interconnected, fluid-filled compartments.
This series of spaces, supported by a meshwork of strong (collagen) and flexible (elastin) connective tissue proteins, may act like shock absorbers that keep tissues from tearing as organs, muscles, and vessels squeeze, pump, and pulse as part of daily function.
Importantly, the finding that this layer is a highway of moving fluid may explain why cancer that invades it becomes much more likely to spread. Draining into the lymphatic system, the newfound network is the source of lymph, the fluid vital to the functioning of immune cells that generate inflammation. Furthermore, the cells that reside in the space, and collagen bundles they line, change with age, and may contribute to the wrinkling of skin, the stiffening of limbs, and the progression of fibrotic, sclerotic and inflammatory diseases.
The field has long known that more than half the fluid in the body resides within cells, and about a seventh inside the heart, blood vessels, lymph nodes, and lymph vessels. The remaining fluid is "interstitial," and the current study is the first to define the interstitium as an organ in its own right, and as one of the largest of the body, say the authors.
The researchers say that no one saw these spaces before because of the medical field's dependence on the examination of fixed tissue on microscope slides, believed to offer the most accurate view of biological reality. Scientists prepare tissue this examination by treating it with chemicals, slicing it thinly, and dying it to highlight key features. The "fixing" process makes vivid details of cells and structures, but drains away any fluid. The current research team found that the removal of fluid as slides are made causes the connective protein meshwork surrounding once fluid-filled compartments to pancake, like the floors of a collapsed building.
"This fixation artifact of collapse has made a fluid-filled tissue type throughout the body appear solid in biopsy slides for decades, and our results correct for this to expand the anatomy of most tissues," says co-senior author Neil Theise, MD, professor in the Department of Pathology at NYU Langone Health. "This finding has potential to drive dramatic advances in medicine, including the possibility that the direct sampling of interstitial fluid may become a powerful diagnostic tool."
The study findings are based on newer technology called probe-based confocal laser endomicroscopy, which combines the slender camera-toting probe traditionally snaked down the throat to view the insides of organs (an endoscope) with a laser that lights up tissues, and sensors that analyze the reflected fluorescent patterns. It offers a microscopic view of living tissues instead of fixed ones.
Using this technology in the fall of 2015 at Beth Israel Medical Center, endoscopists and study co-authors David Carr-Locke, MD, and Petros Benias, MD, saw something strange while probing a patient's bile duct for cancer spread. It was a series of interconnected cavities in this submucosal tissue level that not match any known anatomy.
Faced with a mystery, the endoscopists walked the images into the office of their partnering pathologist in Theise. Strangely, when Theise made biopsy slides out of the same tissue, the reticular pattern found by endomicroscopy disappeared. The team would later confirm that very thin spaces seen in biopsy slides, traditionally dismissed as tears in the tissue, were instead the remnants of collapsed, previously fluid-filled compartments.
A New Bodily Space
For the current study, the team collected tissue specimens of bile ducts during twelve cancer surgeries that were removing the pancreas and the bile duct. Minutes prior to clamping off blood flow to the target tissue, patients underwent confocal microscopy for live tissue imaging.
Once the team recognized this new space in images of bile ducts, they quickly recognized it throughout the body, wherever tissues moved or were compressed by force. The cells lining the space are also unusual, perhaps responsible for creating the supporting collagen bundles around them, say the authors. The cells may also be mesenchymal stem cells, says Theise, which are known to be capable of contributing to the formation of scar tissue seen in inflammatory diseases. Lastly, the protein bundles seen in the space are likely to generate electrical current as they bend with the movements of organs and muscles, and may play a role in techniques like acupuncture, he says.
The other first study author was Rebecca Wells of the Perelman School of Medicine at the University of Pennsylvania, who determined that the mesh in the newfound sinus was comprised of collagen and elastin bundles. Also study authors were Jason Reidy of the Electron Microscopy Lab within the Department of Pathology at NYU School of Medicine; Heather Klavan, Markus Miranda, Darren Buonocore, Susan Kornacki, and Michael Wayne of Mount Sinai Beth Israel Medical Center; and Bridget Sackey-Aboagye from the University of Pennsylvania. Carr-Locke is currently clinical director for the Center for Advanced Digestive Care at Weill Cornell Medicine. Benias is an assistant professor at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health.
This work was funded in part by a grant from the National Institutes of Health (DK081523).
https://www.sciencedaily.com/releases/2018/03/180327093954.htm
Scientists isolate cancer stem cells using novel method
Date:February 22, 2018 Source:University of Texas at Dallas Summary:Researchers have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers -- a significant step toward developing new drugs that might target these cells.
Researchers at The University of Texas at Dallas have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers -- a significant step toward developing new drugs that might target these cells.
"Our lab is interested in finding ways to prevent cancer recurrence," said Dr. Jiyong Lee, assistant professor in the Department of Chemistry and Biochemistry in the School of Natural Sciences and Mathematics at UT Dallas. "The problem is, not all cancer cells are equal.
"There is a small population of cancer cells that is much more aggressive than others -- cancer stem cells," Lee said. "These give rise to secondary tumors, even after the primary tumor has been successfully treated. The cells are notoriously difficult to find, let alone eradicate."
Lee and his colleagues used a two-step process to sort through a library of 40,000 chemical compounds, looking for any that would selectively bind to breast cancer stem cells, isolating them from standard breast cancer cells.
The screening process identified five compounds, called ligands, that bind specifically to cancer stem cells, and the researchers selected one of them for closer study. The results were published online recently in Chemistry -- A European Journal.
While similar methods have been used to separate cancer cells from normal healthy cells, Lee said the results mark the first demonstration of a technique that separates cancer stem cells from other cancer cells.
"We have approached this problem in a novel way, and for the first time have isolated a ligand that binds specifically to cancer stem cells," he said.
How Cancer Recurs
Stem cells are in various tissues in the body, and unlike regular cells, which have a limited lifespan, they can divide and renew themselves for long periods of time. They are also unspecialized, meaning that when one of them divides, the resulting cells can transform into another cell type. For example, stem cells in bone marrow can become bone, fat or blood cells.
Similarly, cancer stem cells -- believed to reside at the heart of tumors, fueling their growth -- are also thought to be unspecialized and able to self-renew until they transform into new cancer cells. Most effective treatments for primary tumors leave cancer stem cells unscathed. Even if a primary tumor is successfully treated, cancer stem cells can travel unnoticed by the immune system through the bloodstream to seed new tumors elsewhere, a process called metastasis.
Such secondary tumors can appear years later and are often more aggressive and harder to treat.
Challenges of Targeting Cancer Stem Cells
Many researchers, including Lee, believe killing cancer stem cells in a primary tumor should eliminate it by removing its renewable source of cancer cells, while also preventing the genesis of new cancers. There are currently no clinically proven drugs directed at cancer stem cells, he said.
The challenge: You have to find cancer stem cells before you can kill them.
"Research in this field has been difficult because specifically targeting cancer stem cells has been hard," Lee said. "There are limited methods for even detecting these cells."
The Experiments
Using available data on physical factors that differentiate cancer stem cells, Lee's group incubated a mixture of both breast cancer stem cells and non-stem cancer cells together with 40,000 tiny plastic beads, each coated with multiple copies of one ligand.
After two screenings, Lee identified a particular ligand that he believed bound to only the cancer stem cells and used it to separate them from non-stem cancer cells. To confirm this, he injected each set of cells into mice and monitored the animals for tumor growth.
"In the cancer stem cell group, we got rapid tumor growth and bigger tumor size than we saw in the regular cancer cell group," Lee said. "We also saw even more cancer stem cell activity, which helps explain why these tumors were more aggressive.
"It was also exciting that we didn't see any tumor growth in the group that received the cancer cells from which the cancer stem cells had been removed. This data supports the notion that if you eliminate cancer stem cells, you get tumor degeneration."
Possible Applications
Lee envisions the ligands he identified being used in multiple ways, including therapeutics, diagnostics and imaging.
"The simplest version of a therapeutic would be attaching a toxic agent to the ligand, which would then bind selectively to and kill cancer stem cells," Lee said. "It would also be beneficial to adapt these ligands into imaging agents, which would light up the cancer stem cells in a patient and help determine the best treatment options.
"The most immediate application, though, will likely be using our technique to isolate cancer stem cells for further study in the lab, as well as a drug development tool."
Other UT Dallas authors of the study are: Dr. Luxi Chen, postdoctoral research associate; Chao Long, a doctoral student in chemistry and biochemistry; and Kha Andy Minh Tran BS'16, a former Lee lab member.
The research was supported by a High Impact/High Risk grant from the Cancer Prevention and Research Institute of Texas.
https://www.sciencedaily.com/releases/2018/02/180222162126.htm
Next couple of days could get interesting. Something's up..
Avg Vol (10-day) 5.5M.. Today 2.3M
MM's walking this down in the last 20 minutes.
U.S. Stem Cell Inc (USRM)
0.0710 +0.0020 (+2.90%) 03/26/18 [OTHER OTC]
BARCHART OPINION for Mon, Mar 26th, 2018 96% BUY
How Adult Stem Cells Can Help Stop Pain and Reverse Aging
By: Dave Asprey
How Adult Stem Cells Can Help Stop Pain and Reverse Aging
I’m so excited to share one of my latest and greatest biohacking experiments: using stem cells to become younger and stronger. For years, using stem cells for chronic pain, recovery from injury, or even skin tone and texture was thought of as science fiction, a treatment reserved for the ultra-rich, or worse – a controversy. Today, these therapies are widely available and have worked wonders for my family and me.
Here you’re going to learn about what people are really doing with stem cells, what’s real, what’s not, and where to go if you want to do it. As you know, I am a guinea pig and professional biohacker, so I like to try things before I recommend them.
The anti-aging benefits of stem cell therapy
I’ve had stem cells injected pretty much all over my body in multiple countries – so now you don’t have to! In fact, I’m the second person ever to have stem cells injected into my brain for preventative reasons. (The first was the doctor who did my procedure!)
The human body’s ability to heal on its own is impressive. With a little help from stem cell therapy, it goes from impressive to almost unbelievable. And it’s not just about healing injuries – reversing aging is all about healing and recovering from stress and strain like a young person. Healing is core to resilience. Extracting your own stem cells and then injecting them with intention can upgrade your biology in science fiction-esque ways.
Stem cells for medical issues
Stem cells can return sight to blind people[1] and hearing to deaf rodents.[2] They repair connective tissue, helping with everything from spinal injury to a torn Achilles tendon.[3] They may be able to regrow lost teeth.[4][5] They’ve restored the brains of patients that suffered strokes, months after the stroke happened[6]. But there are risks – people have actually lost their vision, and using stem cells that aren’t from your body can cause weird things to happen in rare instances. Like teeth growing somewhere in your body where they don’t belong. Eeewww.
Stem cells to make you younger
Even if you don’t have any medical issues, stem cell therapy offers a lot. It curbs aging by keeping your skin collagen and elastin-rich. It makes your joints stronger and more pliable. It can even increase (ahem…) length and girth.
For the first time, stem cell therapy is becoming legally available to the general public, although it’s in a gray zone. I’ve had a full-body treatment done. Actually, several. And I injected them into my brain three times and plan to do it twice a year until I’m at least 180. Stem cell therapy is one of the biggest things I’ve found that really moves the needle when it comes to anti-aging. (Pun intended.)
Here are my thoughts, along with what you need to know about stem cell therapy.
What is a stem cell?
Stem cells are the play dough of the human body. They’re ready to be shaped into any kind of tissue the body needs. Depending on the type you use, stem cells can turn into muscles, bones, joints, and even brain cells. Or yes, boy parts. Or girl parts, if you’re so equipped. (My wife Dr. Lana did that procedure, and the results are amazing!)
Stem cells in their own are helpful, but they work better when you pair them with growth factors to guide them in the body. Growth factors are like guard rails: they keep the stem cells on the road until they reach their destination.
Stem cell therapy involves pulling stem cells from one part of your body, mixing them with growth factor from your blood, bone marrow, or other sources, and injecting them into another part.
If going to a doctor isn’t in your budget, you can stimulate stem cells and growth factors on your own with a few lifestyle hacks. In fact, most of the practices in The Bulletproof Diet and Head Strong improve stem cells, in part because mitochondria (the power plants of your cells and the main topic in my books) heavily influence your stem cells.
More on that in a moment. First, let’s talk about how to use stem cells.
What kinds of stem cells should you use?
When I did my stem cell therapy, I used mesenchymal stem cells. They’re in every joint in your body, working to keep your connective tissue strong.
Over time, normal wear and tear can break down your joints, especially if you put them under a lot of stress. Mesenchymal stem cells release proteins that curb inflammation, keeping your joints strong. They also signal for repair, bringing in nutrients that fix damage. Stem cells can also turn into the type of tissue your body needs, replacing tissue entirely.
As you age, stem cell production drops. Your body often can’t keep up with repair, especially if you injure yourself. I’m doing fine, but I wanted to boost my stem cells before any real problems came up. I worked with Dr. Harry Adelson (hear him on Bulletproof Radio here) to get treatments all over.
Some anecdotal benefits of stem cell therapy:
•Smoother skin. So many friends have started asking me what I do for my skin because of the obvious changes. Stem cells are a big part of it. (So is eating Bulletproof Collagen, and using Alitura skin care.)
•Flexibility. I was able to get into yoga poses that I’ve never achieved, even though I am way out of practice.
•Range of motion. My wife, Dr. Lana, fell out of a 30-foot tree as a kid and landed on her shoulder, freezing it her entire adult life. Acupuncture, chiropractor visits, adjustments – none of them improved things in any measurable way. Stem cell therapy opened up her shoulder’s range of motion dramatically. In three days.
•No pain. Every injury site I have has enjoyed a stem cell treatment, and I don’t have chronic pain. (Unless I eat inflammatory stuff, in which case I deserve it.)
•Cognitive results? It’s hard to say what the stem cells did or didn’t do, given that I’m doing the Bulletproof nootropics, new Head Strong techniques, 40 Years of Zen neurofeedback, and light therapy. Basically, I’m all in when it comes to my brain and stem cells are a part of that. It’s working better than ever!
•Dangly bits. You can get up to 20% more length and girth from the P-shot (stem cell injections into your bits), no kidding. But you have to use a medical grade pump for 30 days after the procedure to create micro-tears in the corpus cavernosum so the stem cells cause them to heal. But pumping takes like 40 minutes a day, which wasn’t really worth it to me. But still, “more youthfulness” is something that happened. ?? When Dr. Lana had stem cells into injected into her vaginal walls and clitoris in a procedure called the O-shot, it also lived up to its name. Without getting too graphic (she’d hit me), let’s just say that those parts are waaaay more youthful too. She recommends it to all her friends and to many of her fertility coaching clients after childbirth.
•Heart health. A family member had a heart valve problem that was life threatening and required surgery to repair. Six weeks after getting intravenous stem cells, the problem spontaneously resolved to the astonishment of his heart doctor. Surgery canceled!
•Longer life. For Christmas, I got my parents stem cell treatments so they will be around longer. Both experienced a reduction in pain and increased healing.
How is stem cell therapy done?
Stem cell banking
When you get your stem cells extracted, it requires either liposuction for fat stem cells, or bone marrow, or both. But those are painful procedures so some doctors will allow you to send your stem cells to a facility that amplifies the stem cells and stores them for later use. Do this if you can afford it. This is a legal gray zone (the FDA says that if they are amplified they’re a drug, yet many physicians will offer it outside the U.S.) The reason you want to do this is that if you are ever injured, say with a traumatic brain injury or any major trauma your stem cells could save your life. The younger you are when you get your stem cells banked, the better off you are, because stem cells are more effective when you’re younger.
I was fortunate to be able to get my stem cells legally banked, so I have them available for regular use!
Where to get your stem cells done
If you’re looking into stem cell therapy, you’ll likely find doctors in two camps. Doctors extract stem cells from either bone marrow or fat.
•Bone marrow: Stem cells from bone marrow are better studied, so there’s a good amount of data suggesting good results. They work for almost everyone…but you’re only getting tens of thousands of stem cells from bone marrow.
•Fat: Stem cells from fat are newer. There’s less research on them and results are less consistent (about 30% of people don’t seem to respond to fat-derived stem cells). However, you get millions of stem cells from fat and those who do see results see significantly better healing.
I worked with Dr. Harry Adelson at Docere Medical because he’s a pioneer. He uses both kinds of stem cells – bone marrow and fat – because he finds patients get the best of both worlds: the consistency of bone marrow-derived cells and the more impressive healing of fat-derived cells. I’ve also worked with Kristen Comella and Dr. Robyn Benson, both of whom I’d recommend.
Lifestyle hacks for stronger stem cells
If you don’t want to go all-in with stem cell therapy, here are a few other ways to activate your stem cells.
•Sleep. A Stanford study found that sleep deprivation decreased stem cell activity in mice by about 50%.[7] How long you sleep is less important than the quality of your sleep. Here’s a guide to hacking your sleep.
•Stress. Decreased stress makes your stem cells better at repairing DNA damage, which slows down your aging[8] and makes you more resilient to injury. Destress with this biohacker’s guide to meditation, or use these six ways to manage stress.
•Fasting. Going without food for a few hours boosts stem cell activity by about 20% in both mice[9][10] and humans.[11] Try Bulletproof Intermittent Fasting to get the benefits of fasting without the hunger.
•Cut out sugar. Decreasing sugar makes adult stem cells live longer and run better.[12] Increasing sugar actively destroys stem cells.[13] Stick to a low-carb diet like the Bulletproof Diet to supercharge your stem cells (get the complete one-page illustrated Bulletproof Diet for free here).
•Spirulina. Mice fed spirulina for 28 days grew new stem cells, and the ones they had were more resilient to stress.[14] No studies in people yet, but Spirulina could keep your stem cells thriving and has other benefits as well.
•Colostrum. Colostrum is what many baby mammals eat first few days of their lives. Bovine (cow) colostrum contains dozens of unusual compounds, including a number of growth factors that stimulate stem cell production.[15] Bulletproof Upgraded Whey contains colostrum.
Want a more in-depth look at stem cells from some of the world’s experts? Check out these episodes of Bulletproof Radio:
•The Healing Powers Of Stem Cells
•These Ain’t Your Neighbor’s Stem Cells
•The Real Deal On Stem Cell Therapy For Pain Conditions
•Treating And Curing Erectile Dysfunction With Stem Cell Therapy
Thanks for reading and have a great week!
https://blog.bulletproof.com/how-adult-stem-cells-can-help-stop-pain-and-reverse-aging/
Researchers create first stem cells using CRISPR genome activation
Activating a single gene is sufficient to change skin cells into stem cells
Date:January 18, 2018 Source:Gladstone Institutes Summary:In a scientific first, researchers have turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important insights into the cellular reprogramming process.
In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important insights into the cellular reprogramming process.
"This is a new way to make induced pluripotent stem cells that is fundamentally different from how they've been created before," said author Sheng Ding, PhD, a senior investigator at Gladstone. "At the beginning of the study, we didn't think this would work, but we wanted to at least try to answer the question: can you reprogram a cell just by unlocking a specific location of the genome? And the answer is yes."
Pluripotent stem cells can be turned into virtually any cell type in the body. As a result, they are a key therapeutic resource for currently incurable conditions, such as heart failure, Parkinson's disease, and blindness. They also provide excellent models to study diseases and important tools to test new drugs in human cells.
In 2006, Gladstone Senior Investigator Shinya Yamanaka, MD, PhD, discovered he could make stem cells -- dubbed induced pluripotent stem cells (iPSCs) -- by treating ordinary skin cells with four key proteins. These proteins, called transcription factors, work by changing which genes are expressed in the cell, turning off genes associated with skin cells and turning on genes associated with stem cells.
Building on this work, Ding and others previously created iPSCs not with transcription factors, but by adding a cocktail of chemicals to the cells. The latest study, published in Cell Stem Cell, offers a third way to turn skin cells into stem cells by directly manipulating the cells' genome using CRISPR gene regulation techniques.
"Having different options to make iPSCs will be useful when scientists encounter challenges or difficulties with one approach," said Ding, who is also a professor of pharmaceutical chemistry at the University of California, San Francisco. "Our approach could lead to a simpler method of creating iPSCs or could be used to directly reprogram skin cells into other cell types, such as heart cells or brain cells."
CRISPR is a powerful tool that can precisely manipulate the genome by targeting a unique sequence of DNA. That sequence of DNA is then either permanently deleted or replaced, or it is temporarily turned on or off.
Ding's team targeted two genes that are only expressed in stem cells and known to be integral to pluripotency: Sox2 and Oct4. Like transcription factors, these genes turn on other stem cell genes and turn off those associated with different cell types.
The researchers discovered that with CRISPR, they could activate either Sox2 or Oct4 to reprogram cells. In fact, they showed that targeting a single location on the genome was enough to trigger the natural chain reaction that led to reprogramming the cell into an iPSC.
For comparison, four transcription factors are typically used to create iPSCs using the original method. What's more, one transcription factor typically targets thousands of genomic locations in the cell and changes gene expression at each location.
"The fact that modulating one site is sufficient is very surprising," said Ding. "Now, we want to understand how this whole process spreads from a single location to the entire genome."
https://www.sciencedaily.com/releases/2018/01/180118162449.htm
Technically today was positive for USRM..
Need that little bump so we can end the day in positive territory
FDA don't care about anything but lining their pockets and the pockets of lobbyists. #FDA does not own my body.
Price action's encouraging.. Something's up..
USRM Demonstrates 99% Reduction in Severity of Psoriasis Utilizing Autologous Stem Cells
Posted by U.S. Stem Cell, Inc
Autoimmune Skin Condition Affects More Than 7 million in the United States
___________________________________________
SUNRISE, FL – March 21, 2018 – U.S. Stem Cell, Inc. (OTC: USRM), a leader in the development of proprietary, physician-based stem cell therapies and novel regenerative medicine solutions, today announced it has published in the scientific literature that it has successfully demonstrated a 99 percent reduction in-human of the severity of psoriasis using a patient’s autologous stem cells.
The scientific paper, which is authored by USRM Chief Science Officer Dr. Kristin Comella and her USRM colleagues, is published in the International Medical Case Reports Journal, 2018:11 59-64.
To the best of USRM management’s knowledge, this is the first result in the world published using stromal vascular fraction (SVF) and autologous stem cells in the successful treatment of psoriasis.
“This is a breakthrough for the more than 7 million Americans suffering from psoriasis, and is another example of how a patient’s own stem cells offer healing modalities for autoimmune conditions,” said Dr. Comella. “Although we require additional studies to further develop more extensive protocol in treating patients with this condition, this is a benchmark indicating there is significant reason to believe the use of autologous stem cells is beneficial in combating this disease.”
Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells) obtained from a patient’s own fat tissue. Approximately 60 mL was collected under local anesthesia via a mini-lipoaspirate procedure, which was then separated from the adipocytes via centrifugation after utilizing USRM’s AdipocellTM kit to apply enzymatic digestion.
The cells were then resuspended in normal saline and injected via intravenous bolus push. The subject was monitored over a period of 12 months, and demonstrated no safety or adverse events. The subject demonstrated a significant (99%) decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up.
Overall, the subject reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis.
In this scientific paper, Dr. Comella et al. describe the rationale and, to their knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis.
“We are so proud of the work Dr. Comella and our team are doing to forge novel applications of autologous stem cells to treat a whole host of autoimmune issues,” said Mike Tomas, USRM’s Chief Executive Officer. “What better fit for a patient than their own stem cells as a healing treatment. We look forward to continued investigation of this and other conditions to treat with autologous stem cells.”
Psoriasis is an autoimmune disease affecting 2 percent of the population worldwide and approximately 7.5 million people in the United States1. Psoriasis patients present with erythematous scaly well-defined plaques, with the scalp, knees, elbows, hands, and feet being the most commonly affected areas.2 Approximately 20% of psoriasis patients present with moderate to severe psoriasis, with more than 5% of the body surface affected. Fifteen percent of patients with psoriasis will develop psoriatic arthritis, occasionally with joint complaints such as dactylitis, sacroiliitis, enthesopathy, and spondylitis, occurring before cutaneous psoriasis. This condition can cause joint destruction due to the chronic inflammation. There are also significant comorbidities associated with psoriasis, including a 58% risk of cardiovascular disease and 43% increased risk of stroke. The risk of diabetes is 30% higher in patients with severe psoriasis.
Multipotential/Mesenchymal adult stem cells (MSCs) are currently being studied by USRM in a variety of diseases and injuries. MSCs can be found in many tissues throughout the body and are thought to play a critical role in a patient’s healing cascade. When MSCs are placed into culture or in vitro, they demonstrate an ability to differentiate on several different tissue pathways. MSCs are part of the body’s natural healing mechanism and as such represent a potential therapy in a variety of diseases, including having immunomodulatory properties and stimulating a healing response by reducing inflammation. For this reason, MSCs may be beneficial for patients experiencing excessive inflammation, as is present in autoimmune diseases like psoriasis.
Dr. Comella, who has more than 20+ years’ experience, is recognized worldwide by her peers as an innovator and world leader in the development and clinical practice of stem cell products and therapies. She has also been instrumental in developing and bringing to market USRM’s proprietary AdipocellTM product, a stem cell kit which enables physicians to separate potent stem cells from a patient’s own fat, a naturally occurring tissue in the body which happens to contain a robust supply of stem cells.
USRM has been involved in more than 10,000 stem cell procedures in the past 19 years for a variety of indications including orthopedic, autoimmune, degenerative and neurological diseases. USRM also trains and certifies physicians in stem cell therapy — to date, more than 700+ physicians worldwide — and has engaged with more than 287 clinics.
U.S. Stem Cell, Inc. is an emerging leader in the regenerative medicine / cellular therapy industry specializing in physician training and certification and stem cell products including its lead product AdipocellTM, as well as veterinary stem cell training and stem cell banking and creation and management of stem cell clinics. To management’s knowledge, USRM has completed more clinical treatments than any other stem cell company in the world.
1 Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014;70(3):512–516.
2 Helmick CG, Lee-Han H, Hirsch SC, Baird TL, Bartlett CL. Prevalence of psoriasis among adults in the U.S: 2003–2006 and 2009–2010 national health and nutrition examination surveys. Am J Prevent Med. 2014;47(1):37–45.
Forward-Looking Statements: Except for historical matters contained herein, statements made in this press release are forward-looking statements. Without limiting the generality of the foregoing, words such as “may”, “will”, “to”, “plan”, “expect”, “believe”, “anticipate”, “intend”, “could”, “would”, “estimate”, or “continue”, or the negative other variations thereof or comparable terminology are intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements and represent our management’s beliefs and assumptions only as of the date hereof. Except as required by law, we assume no obligation to update these forward-looking statements, even if new information becomes available in the future. The Company’s business and the risks and uncertainties of the business are described in its filings with the Securities and Exchange Commission which can be found at sec.gov.
http://us-stemcell.com/usrm-demonstrates-reduction-in-severity-of-psoriasis/