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Thanks for posting!
In the article it states, “These weak findings, bolstered by anecdotal reports and media attention, have fostered widespread belief in the efficacy of these agents,” according to a separate warning about prescribing the drugs issued Friday alongside the new JAMA study.“
Believe is evidence-based medicine - NOT ANECDOTAL!
I did say it was crazy - but certainly not impossible.
Once we have good data we can lean on, you won’t be able to keep the lid on this jar.
I would love for a reporter to ask the coronavirus task force: With some recent research not looking promising for HCQ and remdesivir, are there any other therapeutics that are being studied?
But that’s exactly what you’re supposed to do with the results of a study - all those fancy verbs.. Then you re-test that hypothesis or adjust it (I’m sure I don’t have to explain this to you). In an ideal world, we would only have studies with a statistically significant population, but sometimes you have to start smaller and build from there. Since my words are being minced, I’ll rephrase for you: The newest research from Gilead’s remdesivir study SUGGESTS an increased mortality rate for covid-19 patients versus standard care; however, more research is needed to determine this.
Well, here is my crazy conspiracy theory:
Leronlimab can and will disrupt billions of dollars in multiple, big pharmaceuticals’ revenue. The FDA executives are a revolving door of former big pharmaceutical executives. I’m not saying it’s happening, but I have a feeling the FDA is sand-bagging this drug.
Shhhhh, both of those drugs work! Plenty of doctors are saying they work!’
Exactly, they essentially said it was significant in the second paragraph I quoted. Having personally looked at a majority of the drugs/therapies/treatments out there, leronlimab truly stands alone.
“According to the summary of the China study, remdesivir was “not associated with a difference in time to clinical improvement” compared to a standard of care control. After one month, it appeared 13.9% of the remdesivir patients had died compared to 12.8% of patients in the control arm. The difference was not statistically significant.”
“If there is no benefit to remdesivir in a study this size, this suggests that the overall benefit of remdesivir in this population with advanced infection is likely to be small in the larger Gilead trial,” said Andrew Hill, senior visiting research fellow at Liverpool University.”
Not only have remdesivir and HCQ been shown to not be effective, but research is suggesting these drugs are actually increasing mortality when being taken! Leronlimab and plasma transfers seem to be the only effective treatments - and the administration of plasma transfers are not scalable for the global population.
The study has been submitted and not peer reviewed; however, it is reviewed retrospectively in a well controlled manner for the population it was observing. There still is no good science support HCQ for covid-19. I welcome you to provide it.
I think you nailed it. I invested in CytoDyn for tremendous results in HIV. MoA is very clear cut in that disease state: CCR5 antagonist. Truth be told, I Initially wrote off leronlimab for use in covid-19. Now we have additional research which you pointed out, that leronlimab seems to prime bodies macrophages/immune system so that it can fight against the virus on its own. You’re talking prophylaxis treatment at that point, and again like you said, very lucrative.
Great catch and thanks for the post!
In the article, Dr. Saag says in regards to using HCQ+Z-Pak on himself, “I'm a little bit ashamed of myself, because I could have put myself into harm's way in terms of sudden death. That can happen when you use those two particular drugs together, because they can cause a fatal arrhythmia ..”
I’m glad he’s bringing attention to the irresponsible use of unsubstantiated medications for covid-19.
“Researchers analyzed medical records of 368 male veterans hospitalized with confirmed coronavirus infection at Veterans Health Administration medical centers who died or were discharged by April 11.
About 28% who were given hydroxychloroquine plus usual care died, versus 11% of those getting routine care alone. About 22% of those getting the drug plus azithromycin died too, but the difference between that group and usual care was not considered large enough to rule out other factors that could have affected survival.”
In this study, you were 2x more likely to die from taking HCQ than if didn’t take it at all. Still crazy that people refuse to accept the importance of evidence-based medicine.
There was NEVER any good evidence-based science to support HCQ for treating covid-19. In fact, we know HCQ is immunosuppressive, so it’s actually not that surprising that it is causing an increased mortality rate. Someone once told me in regards to taking HCQ for covid-19 that I, “... clearly have NO idea what [I’m] talking about.” That’s really funny in hindsight.
Placebo was mostly analogous, but it looks like those taking HCQ for covid-19 were more likely to die than those who did not:
https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1.full.pdf
“What do you have to lose?”
You mean the guy who doesn’t believe in vaccines? I hope Nader is familiar and stays as far away as possible.
If he did take leronlimab, and they didn’t mention that he tried an experimental treatment after receiving a 50:50 chance of survival when he entered the ICU - it would be almost criminal
Truly a “generational drug”
What does the evidence show?
The French study followed work by Chinese researchers which suggested that hydroxychloroquine can slow infections from Sars-CoV-2, the virus behind Covid-19, by blocking it from entering cells in the body. But more recent, albeit small-scale, research from China has shown that patients who were treated with the drugs fought off coronavirus no more quickly than those who didn’t get it. Indeed, one patient given hydroxychloroquine severely worsened in condition while four patients on the medicine developed signs of liver damage and experienced diarrhea.
https://annals.org/aim/fullarticle/2764199/use-hydroxychloroquine-chloroquine-during-covid-19-pandemic-what-every-clinician
What do you have to lose by trying HCQ? Your life!! ~96% of patients get better on their own!
Right? Let’s placebo effect it away. There is actually some interesting research to support a placebo effect in certain conditions. But, what if the placebo can actually be harmful and is already known to be ineffective? Seems silly to still keep that as an option, no?
Fox guest describes malaria drug as 'quack cure' for coronavirus
"That is nonsense. Complete and utter nonsense," Haseltine said of anecdotal evidence suggesting that the drug could treat or even save the most seriously-ill patients. "In any situation there are always going to be people who promote one kind of quack cure or another and there are Lazarus effects. In every epidemic I’ve ever looked at that is the case."
In case you’re wondering about Dr. Haseltine, a little bit on his background:
He is known for his groundbreaking work on HIV/AIDS and the human genome. Haseltine was a professor at Harvard Medical School where he founded two research departments on cancer and HIV/AIDS.
https://thehill.com/homenews/media/491441-fox-guest-describes-malaria-drug-as-quack-cure-for-coronavirus
Perhaps you don’t understand the difference between anecdotal and clinically validated. Again, another link about a persons personal experience about how they think HCQ affected them. Why do you keep posting these links? Do you think HCQ is an effective treatment?
Thank you for replying with a post about one doctors’ anecdotal story about using HCQ for covid-19. I’m sure you’re familiar with the difference in anecdotal vs clinically validated.
Do you think that HCQ is effective for treating covid-19?
JPG77-
I could see how this can be an extremely difficult question to answer, so I don’t blame you for not replying. While you understand the science behind leronlimab, the President continues to push the ineffective drug HCQ. A lot of people would probably opt for HCQ - understandably so.
“The party told you to reject the evidence of your eyes and ears. It was their final, most essential command.”
-George Orwell
Because you’re invested in CytoDyn and active on the board.
If you or a loved one fell ill, would you ask for HCQ?
What do you think, JPG77? The prime minister should be given HCQ like President Trump said, right?
Dr. William Haseltine on Fox News just now in reference to HCQ being used to treat covid-19:
“I am sad people are promoting this drug. At best, it will have a mild effect, AT BEST.”
So you’re suggesting it’s willful, rather than solely inept? I agree.
Dr. Siegel on Fox News pushing HCQ yet again. He’s now claiming that the drug works for cytokine storm!?!? Why does Dr. Siegel and President Trump continue to push this ineffective medication?
Because they’re choosing to ignore facts and science.
TRUST ME - I know that’s all you know.
I was asking why you think the president would push an ineffective drug over leronlimab which has been proven effective without a single serious adverse effect.
I’ve been invested in CYDY for 5+ years and done plenty of DD. One is an anti-viral drug, the other modulates inflammatory mediators. One is toxic, the other has not shown to be. One has been shown to be ineffective in treating covid19, while the other affects the mortality factors.
So why does the president continue to push the ineffective drug(s)?
It could be. The president clearly prefers HCA+Z-Pak over leronlimab. Not sure why he feels it necessary to push a more ineffective drug.
Why does the president continue to push this ineffective drug combination when leronlimab has been shown to be much more effective!?
Why does the president continue to push this ineffective drug combination when leronlimab has been shown to be much more effective!?
I was actually referring to the PREDICT Project. You can google it.
Sorry you don’t enjoy facts, statistics, and quotes from respected people, but please continue to send me private messages calling me names if that’s what makes you feel good.
Pence’s handling of the Indiana HIV outbreak is a case study in mismanagement of a public health crisis. His inaction as governor gave Austin, Indiana with a population of around 4,200, a higher HIV incidence than “any country in sub-Saharan Africa,” said Dr. Tom Frieden, former director of the CDC.
The coordinator of our current pandemic allowed for a higher HIV incidence than any country in sub-Sahara Africa.
That’s exactly what it is though. Anytime you remove the TOP person/people, it’s a gut job. If a sports team cut LeBron, Trout, Crosby, etc., I’m sure you’d call that a gut job. It’s not about how he re-allocated some assets, or rolled up responsibilities to another entity - it’s what he did to the best people who could have responded to this crisis. He got rid of them.
Sure. Consolidated the foremost experts regarding a pandemic response right out door.
Whether the office was disbanded or streamlined, there's no question a number of top-notch global health experts left the administration in the wake of Bolton's decision. At the top of that list: Rear Adm. Timothy Ziemer, who had been Trump's senior director for global health security and biodefense at the National Security Council. Before that, Ziemer led a global anti-malaria initiative in the George W. Bush administration.
Bottom line: he removed the worlds foremost people for handling such a crisis as covid-19