Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
It's pretty important bub! K could be a first and what has me the most excited! Talk to Dr B about K....it's not in his wheelhouse like the Derma drugs, and he thinks the world of it. He believes it could be a multi blockbuster drug.
IMO. The silence on K may be for partnering reasons.
Kevetrin Fact: from phase 1 trial
IPIX had p21 biomarkers observed for the first 31 patients. P21 is a biomarker to read activation of P53 (in my terms)
Here are first 31 patients- remember dosing was ONCE a week for 3 weeks!!!!
Cohort 0 - 3 patients - 10mg
Cohort 1 - 4 patients - 20mg
Cohort 2 - 3 patients - 30mg
Cohort 3 - 5 patients - 50mg
Cohort 4 - 3 patients - 75mg
Cohort 5 - 3 patients - 110mg
Cohort 6 - 3 patients - 165mg
Cohort 7 - 4 patients - 215mg
Cohort 8 - 8 patients - 350mg. (Only 3 of these were included in data)
So! Results;
21 of 31 patients had an INCREASE in p21 expression (68%)
15 of those 21 had ATLEAST a 10% increase
Again, the first 3 cohorts (10 patients) were only up to 30mg m2. And this was only ONCE A WEEK dosing for 3 weeks.
We now are dosing 3 times a week and starting at 250mg m2 and 350mg m2
I will bet my shares this phase 2 trial has some pretty interesting data!!!!
I believe 60 days.
Right. Let's wait for results...but that other drug is all speculation as of now....it's been in the clinic for other indications and they see a parallel for OM.
It's crazy. Leo must have sent a Christmas card this year! Lol. I'll never forget who is who....
Hopefully trial results are excellent and we can add more weight to Up/UC indications as well as being the front runner to an untapped market.
I like this from today's article:
"Looking ahead to the upcoming data set from the Phase 2 OM study, if such low incidence (22.22%) can be safely achieved, IPIX will be in an enviable position. As Dr. Sonis conveyed, a large percentage of head and neck cancer patients normally progress to severe OM even with today's preventative measures. Another important part of un-blinding the data will allow IPIX to glean important info on the drug's effect against certain types of tumors and therapies to determine parameters for a registration study if the data warrants. In any case, a substantial decrease in incidence and duration in severe OM for a rinse-and-spit drug delivery method puts IPIX amongst the leaders in the OM space, which is why investors will be watching closely for the data."
A lot of data to be analyzed. Good thing we just want topline data now and the company can dive into the details later!
Wow- good volume again 1.20 into trading day. 230K
Thanks!!! What perfect timing....hmmmmmn
Bahhhhhhhh! I've heard from my nephews neighbor who delivers pizza to the Cumming building that a bunch of suits were in the building. All had Pfizer leather notepad books. Someone screaming 13.7 billion offer!
I hope Leo denied it...we need much much more
My post is comparable to yours.
Nice. Almost 200K shares in just over 2 hours! Just wait for partner and uplist...we will be seeing millions
Lol! Agree. Let's double that to include actual trial results and progress. Let's go to $9 please ;) for starters.
Exactly. Really weak data and very good deal for that drug. BOM will hopefully post a 40-50% spread. And preventive is the key here. If approved will gain 100% market share . It will not be used to limit duration it will be used to prevent. That means all HN patients and possibly other C&R patients.
Leo meeting with congress on potential pricing is a good sign. Imo
George- I like your dream. And hopefully we com a 3rd of the way and I'll be happy....but I think we see some unbelievable results.
Excellent;
"People refer to Brilacidin as a potential gold mine. Let’s run with that analogy. If you were a miner in the California gold rush and found a nugget in the stream , would you abandon the search, or mine the source? "
I'm setting up camp until I mine the entire grid.
Sounds like Bullish on Kevetrin....clinical trials will prove it
Thanks bud
Mine was in the Spam folder for first time. Weird. Check your spam folder
Did anyone get the email today? The pr email?
It will be okay.
But do they collect data now? Since it's a powered double blind placebo trial....I'm pretty sure the data is not collected until the trial is complete...but I honestly do not have proof of my opinion.
I would guess data in Feb or March for 31 sites and 199 patients. That's slot of leg work to ensure accurate data. Jmo
Reminder: B-OM results will also help solidify B-UP/UC indication.
It is quite possible these OM results tie into "licensing agreements" for UP/UC.
"...Some of these partnering conversations have matured to the point of potentially structuring mutually beneficial licensing agreements, pending the final Phase 2 study results."
OM release imminent.
Nice Volume! Tic toc. IPIX
4 week follow-up puts this trial completion right on schedule for end of year. Again, IPIX delivers.
This monkey on our back is losing a lot of weight....each and every day! Can't wait to shed it.
Great update IPIX!!!
This is not some fantasy...these words are legit. IPIX does not mislead. Their management has always been shareholder friendly and caring (since Leo took control). Time frames and delays happen...but Leo's words have never mislead. There will be a partner. These words in the PR are very strong. It all depends on data and data is not a gimme...we as investors understand that this is a risky sector...if not the most risky. But I understand what the company told us: IF DATA IS GOOD, THERE WILL BE A LICENSE AGREEMENT OR AGREEMENTS WITH BP's IPIX IS CURRENTLY UNDER CDA WITH.
Now we wait for that data.
I'm super Bull and have posted some long DD on P in the past, or ATLEAST opinionated DD ;). I think P stands up to Otezla if not shows superior results. I did post a while back...I have a friend who is much older and wiser than I who has degrees from prestigious institutions and accumulated great wealth. I turned him on to IPIX years ago. He exited a long time ago however told me in the past months he is coming back in prior to P results.
I know for a fact he does not read this garbage site so that's why I say this and would be embarrassed if he knew I was saying this. Take that for whatever it's worth, but I've poked and joked with him like....what happens if OM is unreal, or what if we partner prior and the share price is 20 bucks prior???? He laughs and says...my hundred K goes in sometime prior to P results. Lol. So imo he is confident....makes me even more confident in P!
Bottom line, results will come when they are ready. Putting time frames out there create anxiety and fuel the "you know who's"
I'm in a huge industry and we did no business, just put out fires if they spawned. My entire team was scattered on vacation. I don't know for this example, but normally people have Thanksgiving off and most likely Friday.
Yes it's tough to gauge biotech. I'm unsure on the potential gap due to just how undervalued we are. IMO when and if we post stellar phase 2 results and then partner......just how manipulated was this stock will determine that answer. Once we have real investors and a grand audience I believe the truth will set IPIX free. We are currently trapped with a "you know who" audience.
My first sell will be around 20 dollars as I feel that is about right for me. I don't trade so when I sell those first few shares, I will take my cost out and have a good return. I will then wait for over 60 for my next sell unless Leo sells the company. The markets our drugs are in are in the MULTIPLE BILLIONS, all of them. I do believe B is the next Humira type drug...so my belief on that puts this stock in the 100's of dollars with our OS. I believe Kevetrin is the HOLY GRAIL of cancer research.
Obviously if results are bad things will change, but that is my plan and I see no reason to stray at this point. Biotech is a long haul...I started maybe 5-6 years ago and plan on another 10.
Have a great night and come up with a plan that makes sense to you...anything can happen at any time here! It's biotech!
My thoughts on results: Thanksgiving week was probably a wash and nothing was accomplished for data mining. They have 13 sites to go through and probably 41 patients to crunch the data and double/triple check reports.
Then compile the data in a readable format and then come up with a PR to relate shareholders to the data. All of this while keeping open communication with possible suitors. Also Leo should have a grand plan to time other enormous news releases to really pop this share price back to 3-4 dollar range. Bring in the new year with record highs. IMO.
I can only imagine what is really going on in IPIX headquarters. Phase 2 results on 3 major platforms are about to drop. Things must be heating up...imo.
Great question! I was discussing that with a co-worker today. He did not know either but we had a great discussion. Both sides discussed
I think it will go more like: Release OM results. Get an update on Kevetrin. Get news of final patient visit for Prurisol and hear about what's next for IBD. I'd say that is a fully packed couple of weeks.
I promise you this stock will be well above $2 very soon
IPIX will rebound to the 4.80 high in a blink and double or triple that. The science here is too strong in large markets. Large is an understatement.
I've been investing dollars here and there for years upon years. I'm no rich human and work 9-5. I have a 401k but everything I can find under a cushion or on a tax return....goes into my IPIX collection. There is no flinch or gulp to this day and I plan on adding all the way up to where I believe this should be.
God bless and Hopefully one day in the future I can look back at this roller coaster and smile holding my grandchildren and knowing I can support them and their grandchildren. Maybe I'll even buy a new car.
Go IPIX.
I like the Mako example. Unreal what these groups do. IMO. They are no different than the POS's that shoot innocent people out of hotel windows, They are financial terrorists. Period.
Sad what this world has become by using technology and media outlets.
Thanks for sharing.
They are always working when most here just spout their mouths waiting for moms meatloaf. Great catch
All will be just fine and very valuable. It's getting the first deal done ----- the monkey they call it! Get that mofo off our back and we roll!!!
Do some DD on OM drugs in the clinic. The data is very weak from what I have read. And almost all are for cutting down duration time of SOM, not preventing.
I don't know if we can stick interim like numbers for the whole study...but if IPIX does.....watch out. I will guarantee an expedited approval
I do find it interesting when you search Clinical Trials at Mary Crowley in TX you cannot find Kevetrin any longer, however you can at Datmouth.
I know for a fact Kevetrin was listed at MC a while back.
Thanks for all your insight
Oral news for K will make this company extremely more valuable
Do you think we will get a "dosing is done" for Prurisol? Like we did for OM? Just curious if your thoughts and if you think Leo will stay consistent with timing? I'm still also curious on K. Normally he would have alerted shareholders cohort advancement.