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Hanuman.........John, notice the part of Dutton's NA on terrorism safeguard regarding the latest Sepsis experiments - defense against anthrax (and smallpox) etc as you emailed and wrote the CYGX board sometime ago.
I'm sure they have been looking into this for time but it was not just a good idea by you but you sending it to CYGX.
Many brains together canbe very powerful!!!
Thanks and best - Rick
Paulness.........email sent to Dr. Chen regarding the company you found "BIOJECT". I'm should he will appreciate the information.
Never want to brother someone doing research but you can never tell when the information maybe of value now or later.
Thanks - Rick
Paulness........Paul, that is interesting. Have bookmarked it.
Suggest you email it to Dr. Chen and CEO (malcolm) or I will do it for you, if you perfer. It maybe a waste of time but the one time we don't, it could something impt. missed out on. The more involved on this, the better.
Just don't want to take a chance like that at anytime.
Thanks - Rick
Email addresses directly to each one on website page (or I will get them for you - LMK)
Paulness........all things are possible - should be tried - and will be by someone.
I think in medicine - only the tip has been touched - we're not even at the waterline.
Present medicine is just turning a corner - we will look back at present day medicine as medieval.
I like you thoughts - which will be examined by someone - someday.
Downregul8 & Griffin.........this is true regarding ssDNA plasmid but I can't help but to entertain the possible use of the CYGX plasmid in a resversed role of delivery of proteins such as to the mitachrontria in the future as opposed to the "gene silencing" as presently proposed and used now.
This is all way down the road if possible but intriguing to me and reminds me also of the news on HIV and the new protein discovered protecting Rhesus Nonprimates against the HIV retro-virus. All things are possible but one must consider all roles - even the ones not meant to be used.
I f we can stop a toxic protein - can we deliver a "good protein"? Or can we stop the "toxic protein" to enhanced a "good protein"?
Rick
Locus & CYGX Board........MM's are short and couldn't care less about the NA accept it bought alot of volume in (buying). I personally think the MM's are in trouble with this one. They are use to games with the usual suspects on OTC-BB and when something impt comes along they can't tell the difference.
And Yes - Locus - the average investor with a few exceptions, do not believe and/or understand what CYGX is all about. I have always said, this is complicated - very complicated.
The NA on early animal studies was exceptional - 100% exception - that is unusual but we have not gotten the details to fully appreciate it yet.
What do you think the MM's thought of the NA on early animal studies. These creatures don't thought - they trade stocks with manipulations - and now I believe they have alot of shorts maybe back to july 2003 - who knows?
Things are changing in April 2004 - NO NAKED SHORTS!!!
If we continue to get NA's, which I believe we will this early spring into the summer and so on, this could turn into a real nasty SHORT SQUEEZE!!!
DON'T SELL!!! Hang on to what just might be the largest thrill of your life.
Rick
Captain..........Agree completely about the excellence of the CYGX board. Frankly, I have not seen anything remotely like the CYGX board.
Arnold and Peace_2_all were adding a nessecary balance to the discussion and this is a help to all - they are both long with questions we need.
Again, to all who contribute so much to this site, Thanks so much and please continue to be the huge asset you are.
Rick
Doxi.........Excellent point. Buying CYGX on dips. I have and will in future. Remembering that CYGX has a long, long way to go. Could you dream of buying shares in Flemings Penicillin (it's called Wyeth) in the late 1930's?
The one point that always intrigued me was that one patent belonging to CYGX (ssDNA Expression Vector) could possibly be turned into over 800 other patents (combination of CYGX patent and 800 other patents which worked together successfully) plus the HSV and Sepsis Rx and much more to come.
Will be interesting now to see what funding becomes available now (?)
Rick.
CYGX Board & Chipped2003.......Right, about a very good point - 1st success PR from CYGX from a living entity vs test tube - thats very impt.
Believe, Thalio will come in shortly. He's still here lurking - has been quite busy of late and did state 3-4 wks ago that he would come back in when the news broke.
So all CYGX'ers concerned with his recent absence - don't worry. He loves the science!!!
Rick
Chipped 2003........Hi!!! Thanks too for starting this board and the fine work you have done for all of us. We all appreciate it alot and in general the board has been a fine source to us all in this incredible future of medicine.
Best to you - Rick
Hanuman........John, the 100% success is fantastic!!!
No one died, even of old age? CYGX with just HSV and Sepsis Rx / cure will be a monster and there's much more to come.
John, I would say IV or IM but there has been some mention of oral which would be quite incredible. Would also depend on route of infection - thinking of IP here as route for both. Something for us to look forward to futurewise.
I and others had a feeling of news coming but 100%!!!
Thing is there will be continual news to come over this entire year during the testing of HSV and Sepsis -
looks like the stories on Spesis are increasing -
the story posted from New York Times was very interesting. Sepsis is beoming very mysterious - believe the medical community is in great fear of something that is snowballing into the most impt. problem not just in surgery but in medical Rx in general.
NY Times story gives a new feeling for the current medical problems.
Perhaps the Dr's Conrad and Chen and CYGX have appeared just in time.
This is all very exciting and as many have stated it is just the beginning.
Rick
Percy and gdepc.........insider holding is excellent!!!
Who more than management knows better where the science and business is going.
I think the CEO and CFO know full well what they are possibly sitting on - why sell for pennies what could become numerous dollars in time.
Arnold brings up a valid point here. There is no official German document on this CFO statement to a German financial company that has been released to my knowledge yet. We were looking for an uptick in CYGX after this German story was found - some volume did come into the stock late today - maybe the German story has been released.
Meanwhile, I think what Arnold is getting at - CYGX had limited funds late last year, now they are telling a German firm they have more money than their balance last year. Somewhere money must have come into CYGX but we never recieved notice of same. This what Arnold is getting at in this statement. If monies come into CYGX, it should be NA. Right(?)
CYGX does continue to function!!! Which is good.
"T"..........no see long time, good to have you back.
Chart didn't download, I'm on a IMAC system - could be the problem on my end.
I noticed the price range today attacked the dorsal (top) Bollinger Band - a positive sign usually followed with positive movement immediately in past.
Peace_2_all...........I am sure that "skooby" is still long and stronge on CYGX. He's probably off on vacation - believe that happened once before (since last summer2003).
As for the management of CYGX - I have a feeling that there is something up (developing in a positive way) that cannot be made public until it happens. Suddenly funding will happen in the form of an NA one day without fanfare and/or rumors before. This will be followed by several good NA's.
The report by the CFO to the German financial firm said quite abit. Worth a reread to get it's signficance.
I have gotten mostly good reception - a minor bad from management. No corporation and it's management is perfect and they too have their good and bad days.
Frankly, I rather be concerned with them doing their jobs - getting funding - joint ventures - patents filed and completed - and HSV Rx's into FDA P1&2 - and alot more. How they react to me = unimportant!!! That is a show of their class - show me the results, which benefits us all: management - shareholders - mankind's medicine and science.
You are absolutely correct about what bad management can do to a corporation and unfortunately many corporate managers have disdain for the shareholder. It's just bad corporate relations and is very unwise and is somewhat universal.
I believe news (NA's) is eminent and we will be pleased but this is still a long term project with the exception of the HSV Rx which will be a pleasant surprise this 2004 late.
As for management in CYGX case - they themselves do not make the "big money" unless the science works. If it works - money will follow.
Wise management (including the BOD) will make the difference in the amount of a successful outcome. Time will tell but CYGX will not cut their own throats with the success possible with this science.
Best to you - Rick
JSGatt...........John, great post. Brings everything you speak of, into clear focus.
The NA on CYGX funding will just suddenly happen one day and that will be that. I hope the MM's all get surprised on theirs shorts (down).
Neo43.........you are completely correct about testing in animals giving one result where one could get completely different results in humans.
I also agree that the Herpes simplex topical Rx should have a good result in human (actually it already, very unofficially, has) and be very good marketwise (both markets - for the Rx and PPS).
In regards to the Spesis Rx, which would be the gaint star for CYGX, yes the results are very far away and I too have some "hold my breath syndrome" on the human results and even animal results and the variations among Gram Positive Bacteria organisms. Mutations again.
Meanwhile, we have a possible chance (double negative???) of having CYGX get the Herpes simplex Rx going with success and lots of coverage news wise while the results are depending on Spesis Rx for the next year or three (2005-2006). So 2004 will be the year (probably late 2004) for HSV Rx and perhaps a HSV cure, then more and more of a build up for Spesis experiments results which hopefully will move with success in animals them P1&2 in humans (2005-2006).
Perhaps there will be more than that to talk about in CYGX.
One other note - this CYGX work with HVS has been going for at least 4 years now.
HSV success we could have a mid double digit PPS but Spesis Rx - sky's the limit = triple digits even with 300mil outstanding shares. Spesis success would be incredible but as you point out, we're not there yet.
HSV , I believe, is much more impt than even CYGX realizes because of the secondary problems healthwise with HSV infections. Which someday will make alot of news - positive NA's left and right.
Like you, I am positive with some reservations, which we should all have.
Balance Builder.......you're right, PPS would take off with a funding announcement and Monday will be March 1st without any NA's from CYGX for months.
I think this is why everyone reacted to the Germany interview the way they did - "how about us in English".
The company needs to keep the owners informed in a reasonable fashion.
Hanuman and Neo43.......your points are correct but I tend to agree with John (Hanuman) abit more here. Neo, I am somewhat disappointed with the results of angiogensis given in the limited time period (5 months) its adds possiblily to a patients misery of chemotherapy - I think that the time factor will improve or I least I hope so. Meanwhile Neo, yor are totally correct that ssDNA plasmids are not proven yet in humans and that is a fact, we remain in speculation.
But if the CYGX system does have good human results, we are looking (as Hanuman saids) at a revolution in medicine with a Rx without the horrible pain of chemotherapy, limiting the incredible expenses and a future of the hope with a cure.
Say a prayer - but it does move slowly.
Rick
BB and Gimble........good points by you.
Frankly I never thought the board was for anything else but education to ourselves and maybe a few new people, a sideline source of entertainment, staying up to date again for ourselves and maybe venting some frustration.
But never, would it influence the PPS. Thats done by big time investors and MM's and NA's by CYGX.
When we get some real news - the tone of the board will improve - it's still an excellent board as boards go.
Rick
HANUMAN..........John, I remember the WSJ article and time to cover the "software" thing - it's a great story (cover story?). Could be quite innocent or the truth but when it comes to the MM's - "don't trust anything" that names itself after a candy!!!
Have a great weekend, John and all CYGX'ers.
Rick
Specul8..........interesting what you are pointing out regarding the MM's and the strange trading that is going on.
There is some trading (block sizes-amounts of trades-etc)
that screams signals and "monkey business".
I have felt for sometime that many of the MM's are short. I can't prove this but it's a strong feeling.
With the new rules, forbiding "naked shorts" now going into effect, I believe, in early April - there is probably a wild scramble to cover what they can - thats probably why it was postponed from late Feb.
Just look forward to the day when we can trade on on a legitimate board like the AMEX-NYSE-NASDAQ. It will make a difference.
Rick
Neo43 - CD98 - Maskers - CYGX Board..........short email sent to Dr. Chen with link to Nature article of new protein found in Rhesus Monkey protecting it from HIV.
Thank for your posts and help. Excellent posts.
Rick
Percy........alast I thought it was just me, I haven't gotten an emai for years. Dell Gibson brought a nice friendly and professional feel to CYGX. When he left to form a veterinary division, I guess, all that left too and has yet to be replaced. So you do not receive emails - perhaps no emails are sent out (for years?).
Neo43............Agree, re: the HIV preventative protein found in Rhesus monkeys and a "quick" email to Dr.s Rossi and Chen - cannot hurt and it is a very impt science story.
Could give a large insight to HIV Rx and/or cure.
Just hope these emails get to the proper people.
(terrible to have to say or even think that)
Rick
Arnold.........excellent posts and I fully agree that CYGX should approach us in direct communications, which are free too, in the same manner and content.
I would be interested in just who, how, the nature of and the reason for - the CFO was giving this excellent and very positive description of CYGX. What reaction has this performed in the German markets? Should be good!!!
There is quite abit lost in the translation (thanks suky again for your fine work here!!!) but we can all make it out clearly. As was stated - where is the English version of same?
The Dutton reports were costing CYGX 10K each and were good reports (but expensive) - the TV spots are nice and helpful but also cost money. CYGX posting detailed reports such as this German report, at their website, would free and would educate all here, plus many more.
Makes sense to me (and its free)
Nature Article Posted by Maskers and later by CD98 on HIV and new protein as found in Rhesus Monkeys protecting them.
Neo.....I'm thinking about this remarkable finding and while it goes just the opposite to the gene silencing delivery system of CYGX's product, I am trying to figure out a method of how CYGX could be of some value Rx-wise in this new find.
Thus I thought it might be of value to Dr. Rossi attention. But now that I find it published in 2-26-04 Nature, I'm sure he will know about it.
Rick
HANUMAN.........John, They do watch the postings perhaps more than most. The person watching the board the most - CFO which is fine because he is interested in the business aspects of CYGX trading. Why the CEO would be tense about what you have mentioned is somewhat sad and perplexing. Dr Chen is not involved in any of this stuff except the science.
Lets hope, for business reasons that the BOD has the means of guiding CYGX to success (especially Ocampo) and that the magnitude of the science of CYGX overcomes any short comings of the upper management - Almost all corporations have shortcomings in upper management - thats why they are put there (by someone called Peter Principal - know what I mean)
Rick
By the way - all these comments being made are quite good.
maskers...........interesting article - thanks for sharing it with us.
I consult and work at a primate lab where most of non-human primates are Rhesus - will be passing the article around tomorrow.
You might want to forward this when you have a chance to CYGX - attention Dr. Rossi. They usually know about these things but you never know! Besides it stirs the neurons up.
Rick
******There is a very interesting detail about descendants who survived the Bubonic Plague (circa 1350's) - The Black Death and their resistance to HIV but this is a genetic deal but thats how proteins are made - its all inter-related.
The "Black Death" was actally the first known use of "Biological Warfare" in the human race (wasn't very humane but was terrifying).
Answers exist now waiting to be discovered!
JSGatt..........Thanks John, great contact and find for us.
sukycospito.......you took the words out of my mouth. Why on earth (in English) haven't we had such an excellent outline of CYGX current position with projections and so on. This is very excellent!! to say the least.
Thanks very much for the translations and insights "suky".
You are a tremendous asset to our understanding of CYGX. Can't thank you enough for this and all you posts in the past.
John (JSGatt)........this is a very interesting report (understatement) - how did you come across it and who was it being presented to? Thats the interesting point - who it was being presented to? It comes across as a very detaied presentation, like to an investment banker or an outline of the entire CYGX project to an investment firm. Questions (good ones) are being asked and answered well with very positive responses. Excellent find - made my day and makes me want to increase the postion.
Thanks guys - great work!!!
Take care - Rick
specul8 & CYGX board.......I'm here long and very stronge and looking to a great year to develope here.
Chipped is over at MoMo trading board and does check in - elsieCat is here and posts at times - same with skooby and percy. Thalio is still long and stronge but his doings have him going (very busy of late) - he did say that he would not be posting until the science is out to post on but he lurks at all times.
I have made some comments about this rather frustrating trading of late - today a low volume day (extremely low) but we have had some volume of late but limited movement in price.
Obvious to me alot of this trading is being controled by MM's and a few buyers who have been accumulating for sometime and buying rather well for them.
I would say, in general, we are in a gaint holding peroid (about to end) with a large buyer out there and with a large amount just waiting to be released. We know what some of this news is i.e. grant for lung aeresol (NIH) etc.
Frankly, I don't see anyone, without extreme circumstances, dropping out. There is just too much to gain and once CYGX starts to move - it will MOVE!
Check out that tape from CEO (macolm) that was just posted - it is new material and very encouraging for this year. Good for 2 listenings.
Best and Take Care - Rick
Paulness........thanks for keeping your eyes on Berlin etc -
is it possible traders / investors are getting a different price in Berlin and are playing the spread?
I don't follow it myself - but this can happen in some markets (i.e. Hong Kong / USA).
How about the volume? Price is up 20% but what is volume (hopefully up also)? Or like you said - there might be news / rumors in Germany and / or Europe.
TIA - Rick
Trading still mysterious.......but I'll take it.
News feels like its coming but in a way thats a immense understatement.
We all knew news (several items) was coming --- patents (several) applications to be announced --- animal studies possible at anytime --- grants to be made public --- and always that unexpected event we don't know about and / or have forgotten about --- fundings explanations to be made --- constant possible announcements of new projects (i.e. anti-inflammatories - animal and human) and associations with other BioTech's.
Basically exciting times with a nice long year of 2004 with many changes to come.
Have a great weekend all - Rick
A Genta relationship ?.
Do we dare consider that the increase, just voted in at the shareholders meeting, of valuable and ready to use outstanding shares, could be used to acquire a BioTech for a mutual benefit?
This is a "wild theory" only ( merely insane desparate speculation - but interesting) but it would accomplished quite abit to benefit all parties concerned. If not this relationship - possibly another similar to it.
sukycospito...........very interesting!! to say the least. I wondering why they would to this extent to disguise what we know to be related.
Only time will - Dr Stein is a CYGX BOD? And the original working relationship speaks for itself. CYGX plasmid was to used as an adjunct to the chemotherapy.
Good find - post (as usual)
Rick
CYGX Trading lately..........I wouldn't be surprise if there was some "naked shorting" (maybe alot!) in CYGX even with the relatively low daily volume in CYGX. Its a BioTech and MM's and day - momo traders seem to be good at trading this type of stock.
I still feel we are just around the corner from a bit of news (several bits of news) and for that matter, continuous news for 2004.
Just wish (or look forward to) where we could get out from under the MM's and the OTC-BB and get on the AMEX or NASDAQ.
Then CYGX will be valued at it's intellectual property and future events. And we will get out from what feels like some illogical trading. This corporation is worth, for the future, sp much more. But meanwhile, one can accumulate more.
Any insights from posters on the trading patterns of CYGX and various possibilities on just what could be going down here?
I'm seeing and reading constant stories on Sepsis.
There is a serious moved on to require hospitals to make public there rates of Sepsis in their institutions (what a possible embrassment !!!). The journalists aren't going to stop on this story and unfortunately Sepsis (mortality rate) will only increase in the near future.
Take care all - Rick
CYGX Board......02-16-04 Monday, what a terrible day trading CYGX.
Couldn't get an order execueted!
No volume - price trouble!
I mean this is terrible! Worst day yet!
What?.............
What>>>>>>>>???
Oh ----------------- the market was closed.
NEVER MIND
PERCY.........AMEX is a very good idea and one I thought was being considered for a number of reasons.
This small cap thing is just that.......
hogger........as neo43 points out, the CYGX plasmid will stop bacteria reproduction and then the bodies immune functions will gracefully eliminate the existing remainer of bacteria. It would not be desireable to say into an hours or even a number of hours to destroy all bacteria at one time because of the toxic shock that would take place and possibly cause death.
Each medical case is somewhat (or very different) different with various things to consider - such as a culture / sensitivity to identify the organism and also as of now idenified what medication it is sensitive to - hopefully one does not have an antibiotic resistance bacteria the "GOLDEN STAHY. AUREUS organism drug resistant (or they better hope that CYGX plasmid is being used and does work very well) - all organ systems must be evaluated for function and damage cause by the sepsis (i.e. kidney function, liver function, cardiac function, neurological function, etc) and supportive RX must be started immediately and continued while all is monitored.
This could be an example of a post surgerical infection - lets say you have a surgery on a thrusday, you are not given antibiotics (bad idea but it happens or you are given antibiotics) that thrusday, Friday-Saturaday-Sunday you appear to be okay except you have been contaminated with a Stahy. aureus bacteria and it is growing and beginning to spread throughout the body - immune system is fighting it off but by Sunday night you seem to have a fever , night sweats, and basically feel like hell - you see the doctor or ER that Sunday night. At this point you must be worked up - blood chemistry tests for all organ systems, complete blood cell count, and blood cultures including a culture / sensitivity test and of course now started on say a third or fourth generation pencillin antibiotic pending the results of the various blood tests which may change things (you hold back on the big guns like Vancomyacin) - also IV fluids (lactated ringers, maybe 5% dextrose maybe not! this might enhance the problem) and sodium bicarbonated if you are somewhat acidotic (blood gases were also taken - urinalysis often - Chest radiograph and a radiograph of the surgical area (i.e. a bone - abdomen - etc) along with a through phyical examination including an electrocardiogram and a head or better still full body CAT Scan. Thats just the basics and done within several hours (if you are getting the proper RX). Now that alot of expense (did you bring your insurance card?) has been incurred and now the variables begin. Like can the bacteria infection / sepsis be controled - is it responsive to RX - how much damage has been started on the heart (caridac output and valvular function), liver, kidney (urine output), neurological sytem - do you have any bleeding tendencies (more blood tests) hopefully no septic infaracts and of course you have set up on at least one venocath. to deliver fluids and so on. There should be pain control as needed (if needed) and the hours later more blood tests are taken to see again where organ function is going and how the body / immune system is responing to "mother nature" - medical RX - tincture of time and divine providence plus the doctors and nurses. Various things are monitored such as respiration, blood presure, ECG's,
urinary ouput (very impt!!! with records recorded). Other tests and Rx's are done according to what is and is not working. It's almost Monday - how do you feel? Numerous Histories have been taken (this is annoying but very good - everyone checking everyone)
Really depends on the organism involved - site of original infection and the condition of the patient (which is a big variable!!!).
I might add here that some serious infections do not become apparent for 7 to 14 days post operative. But meanwhile there has been further damage to the body in general because of the toxins given off by the bacteria.
Next we hit a very hot infection. You can literally watch a hot infection move say up your arm from you finger or hands - measure its progress by the inches in hours. Its quite horrible. Thats where something like CYGX plasmid would be critical if it works and some fast decisions (in the future) would have to be made within hours.
I have left alot out here but my point is - its very dangerous, very expensive, rather painful and emotionally a downer and very often has long term and/or permanent damage (i.e. heart values) to the unfortunate patient who probably never knew this could happen to them.
Plasmids would be given IV with fluids over time.
These are excellent questions and answers hogger and neo43 and are helping everyone with our understanding of CYGX. Thanks guys.
Rick