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"CEO is an employee of the company owned by SH."
The CEO is also the CFO, IR contact, and apparently the secretary(Anita Menon Beacon no longer there?-never picks up the phone) and mail room clerk.
He should cut his salary some and hire a good secretary/office manager from the likes Kathleen Gibbs Secretarial School for $1500-$2000/week. That would leave Leo's take home pay at about $7000/week. He could then focus more(on the 20ncda's, finding a new office location, negotiating, MANAGING) to expedite the process.
Here Today,
"I'm not sticking up for Boo being overly optimistic, but when someone on here flat out lies to everyone on the board that P 2b has failed when the results have not been unblinded yet, why do you not question as to where that person received their facts? Just wondering?
The discontented are not content by what they hear from LE or KM, a retail investor has no access to Bertolino(please advise me of his extension so one can question the "expert" directly).
Those previously contented ones are shifting, I believe, based on dragged out results.
Anyone can, and has lied, except one.
The question is, to us minions, what is the truth?
You have contact with your contact.
How's she doing today?
Please advise.
Thanks
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=135024214
Simple,
Do people lie? Simple answer.
Enron, Madoff, Bulger, WALLSTREET(I could endlessly go on).
Do you trust the latter 100%?
petemantx,
"We talk about blue sky when the SP gets to levels that it had never previously reached, well, IPIX is in blue sky territory concerning the importance of this next PR so IMO all prior rules/patterns regarding PRs go out the window."
1. "We talk about blue sky when the SP gets to levels that it had never previously reached"
Do you speak of current or past(highs or lows)
2. Do you consider "blue skies" to be both the highest, and lowest sp's?
3. Please share your detailed understanding of why "IPIX is in blue sky territory concerning the importance of this next PR so IMO all prior rules/patterns regarding PRs go out the window.
A talk with Tammie Jo Shults may not hurt..
BooDog,
Appriceiate your enthusiasm, but please remember, when it comes to biotech investments your quote: "You betchya! Going to be quite the party when it finally happens!" that the word, "when"
is generally followed by two other words, those being "and if", particularly in biotech.
I'm no liguist, but do know that the word "the" is the only definite article, all other articles are indefinite.
There are no gaurantees. Your post suggests otherwise. Prove your post, as you seem to know more than the company, the investigator's, or anyone else.
Do you work for the CRO overseeing results?
I should add that the latter part of this past New England winter saw some harsh weather. Sometimes the mail did'nt even get delivered, yet rumor on the streets of Beverly are that LE was at the pay phone unswayed, leaving out of towners confused and wondering if they were in nearby Gloucester witnessing the resurrection of the Gloucester fisherman calling in for exta life preservers(while the mailmen watched from the coffee shop across the street with shame knowing they broke the postal creed and skirted work("Neither snow nor rain nor heat nor gloom of night stays these couriers from the swift completion of their appointed rounds").
in response to
"Either Leo talks too much or he talks too little! Hard crowd to please. LOL!"
I believe it to be a simple matter of money. With 20 cda's +- there're a lot of phone calls to make which weigh on things(not just one phone call to one company). That's a lot of coin, and with limited number of payphones now a days, LE not only has to wait in line for a while at the phone booth, he also has a wagon behind to carry all the coins, the shear weight of which would certainly rip his trouser pockets, likely ending up in a catch basin only to wind up in Beverly sound and the operator saying "25 cents please, please deposit 25 cents for the next one minute".
"Either Leo talks too much or he talks too little! Hard crowd to please. LOL!"
I believe it to be a simple matter of money. With 20 cda's +- there're a lot of phone calls to make which weigh on things(not just one phone call to one company). That's a lot of coin, and with limited number of payphones now a days, LE not only has to wait in line for a while at the phone booth, he also has a wagon behind to carry all the coins, the shear weight of which would certainly rip his trouser pockets, likely ending up in a catch basin only to wind up in Beverly sound and the operator saying "25 cents please, please deposit 25 cents for the next one minute".
;). Need a bit of humor around here.
Can I borrow your glasses?
centillion,
I hear you(as a frustrated long). I try to believe Mr. Erhlich speaks truthfully via company pr's, but, at the same time , do wonder how his lines fail to catch any fish? Beverly is a shoreline community in MA, a stones throw from major bio-investment firms/venture capitalists in Boston, and the Northeast region.
All company officers(Mr. Ehrlich and Dr. Menon, as well as others(Dr. Bertolino) are on record.
They even went to the bother of hiring the Ashcroft-Sullivan law firm.
JTORENCE,
" If he was close to a deal with BP there would not be a need to sign this type of contract to bulk produce "B" IMO "
Who knows what their plans are? Evonik is a major international company with offices/manufacturing sites situated all over the world, including the U.S. Perhaps ipix will maintain B rights in the USA or even the America's, and license out the rights to one, or a few BP's to the other regions of world.
TIAB,
I don't get it either. Hopefully, "there is nothing to fear but fear itself" doesn't trip anyone off balance.
Anyone can do it.
Happy Mother's Day tomorrow to all the Mom's out there. Remember to call if you can't visit, reflect if neither are possible.
When all the others were away at Mass’
When all the others were away at Mass
I was all hers as we peeled potatoes.
They broke the silence, let fall one by one
Like solder weeping off the soldering iron:
Cold comforts set between us, things to share
Gleaming in a bucket of clean water.
And again let fall. Little pleasant splashes
From each other’s work would bring us to our senses.
So while the parish priest at her bedside
Went hammer and tongs at the prayers for the dying
And some were responding and some crying
I remembered her head bent towards my head,
Her breath in mine, our fluent dipping knives–
Never closer the whole rest of our lives.
Seamus Heaney
TIAB,
I've searched the history, based on clinicaltrial dates and various companies pr's, in an attempt to determine "the average turn around time of trial final completion dates to trial result announcement dates" of past ph 2 moderate to severe psoriasis studies. They appear to be all over the place, and 142 days is well within the range from what I can discern.
You are a doctor, correct? In the Boston area? Spend a little less time on this board, and do all a favor, including yourself, and take you and your questions a 30 minute drive(if that) north to Beverly, and get your answers from the horses mouth.
"He is about to deliver."
No doubt. Deliver what is the question.
Thx, clear as day.
PP,
In response to your post, who knows? The company, apparently, has had successful drug trials, a court trial, yet Leo negotiated a bottom price of 25 cents a while back, when the sp was well above 25 cents?
I've said it before, I'll say it again now, Sullivan(Atty Michael Sullivan-Ashcroft and Sullivan) has put his reputation on the line. If you don't think MA. atty general Maura Healey won't go after them like a pit bull for securities fraud if ipix is strecting the truth,
one must be unfamiliar with MA AG's(Sullivan was one).
If the company(ipix) has been disingenuous, Sullivan would drop them like a rock.
Sullivan shall prove to be our savior((if ipix is a fraud(doubt it) he'll go right back after them)), or our salvation(the mako case).
LR,
Spare me the suffering. What page of the 10q?
thx
George,
To date, most of your projections have not been realized, one oft repeated by you last year, far from close.
I do, however, hope you are correct that this 10q is good news.
Thx for the response tryz,
I was just asking where the figure is noted. Is it in the 10q(Idid not see it), or was it an estimation on sox's part(he's probably watching the red sox-yankees game and not following the posts)? Even if they did raise $2M from 4/1/18 till today, just their operating expenses + rent per calender day is $27,236 based on todays 10q. Multiply that by 40 days= $1,089,440 gone. There are other expenses.
In response to:
"That's right learn the math with the additional 2 million raised between April to May 9th = 3.3 million......Gonna be some sort of excitement coming in the way of investors in the coming weeks....Boom time as taken from another poster here.....enjoy,tryz"
I do feel the same as you regarding the future, just wondering if I missed something in the 10q.
sox040713,
Where did you see they have 3.3M in cash? The cash flow summary shown on page 6 of the 10q issued today lists cash at end of period(3/31/18) as $1,336,000.
NanoEngineer,
Agree with all you said. I'll add that I believe they are quite aware that a deal is needed sooner rather than later and I think the B-OM results will expedite a deal(s). The agreement with Evonik has been made which should bring some credibility to the company. Evonik is a big name in the industry.
I've got to think, based on the results, that the doctors who took part in the study must be talking. From the ipix 4/16/18 pr: "Positive OM assessment endpoints are additionally supported by zero (0) of the patients in the Brilacidin-OM group having unplanned office visits, ED visits, or hospital admissions due to OM, compared to four (4) patients in the placebo group."
Zero unplanned visits compared to the 12/5/17 article in BayStreet: "For cancer patients receiving a standard regimen of chemotherapy, it’s estimated that 40 percent will develop OM. The Centers for Disease Control and Prevention estimates that about 650,000 cancer patients receive chemotherapy in an outpatient setting each year in the U.S. Generally speaking, there is a consensus that about 500,000 cases of OM occur in the U.S. annually right now.
Add in the economic burden and the market opportunity to address OM becomes even more clear. Estimates from a study published on PubMed pegged the supportive care costs of severe chemo-radiation-induced OM at $17,244 more than similar cancer patients without severe OM. It’s worth noting those figures were from nearly a decade ago and likely higher now. Not to say that every patient develops severe OM or tips the high-end of the supportive costs, but the metrics of 500,000 cases and $17,244 more per patient equates to a potential annual savings around $8.6 billion." That just the U.S- savings of ~8.6B because of unintended supportative care(estimate was ~10 years ago).
Granted, the BayStreet article covers all chemo induced OM whereas ipix tested OM in head and neck cancer patients. I'll it work as efficiently in all forms of OM.
Those results should get peopole's attention. IPIX should contact the Boston Globe to write a story of interest.
George, TY for the kind reply.
When shall we see the price triple?
"First....contrary to the naysayers......the PR today was excellent. I think it is somewhat ambiguous because I believe the company has a number of great options at this point that they are reviewing that will increase the share value significantly."
falcon74, I agree.
I've modified ipix's display of todays pr by replacing designations with a capitalized letter, and enumerated the subsets associated with them(A2,B1,C2,etc) in the event I need to refer to them.
Agree.
A. Reduced Incidence of Severe OM (Primary Endpoint)
1. Placebo 60.0%, reduced to Brilacidin 42.9% [Modified Intent to Treat (mITT) Population].
2. Placebo 60.0%, reduced to Brilacidin 36.8% [Per Protocol (PP) Population].
B. Delayed Onset of Severe OM (Secondary Endpoint)
1.For those patients in the Brilacidin group who did experience Severe OM, onset occurred generally later during radiation therapy.
C. Reduced Duration of Severe OM (Secondary Endpoint)
1.Severe OM median duration was 0.0 days for Brilacidin (mITT and PP Populations), indicating that more than half of all patients on active treatment did not experience Severe OM.
2.Overall Severe OM median durations for placebo were 3.0 days and 5.5 days for the mITT and PP Populations, respectively.
D.Reduced Incidence of Severe OM, 21-day Cisplatin Regimen subset
1.Placebo 71.4%, reduced to Brilacidin 25.0% [mITT Population] (p=0.048).
2.Placebo 72.7%, reduced to Brilacidin 14.3% [PP Population] (p=0.025).
E. Delayed Onset of Severe OM, 21-day Cisplatin Regimen subset
1.The time to onset of Severe OM was delayed with Brilacidin treatment compared to placebo, even more markedly in the 21-day cisplatin regimen subgroup.
Quote from Dr. Stephen Sonis relevant to his advisory role with another OM company:"Concomitant chemo-radiation induced oral mucositis remains a significant unmet medical need. Probably 60 to 70 percent of patients with cancers of the oral cavity, oral pharynx, hypopharynx, and nasopharynx, develop severe mucositis of such severity as to require increased hospitalization, emergency room visits, or breaks in treatment," explained Dr. Sonis. "The mechanism of action of EC-18 supports its use as a potential intervention in mucositis, as well as other radiation-induced injuries such as dermatitis, enteritis and pneumonitis."
The referenced company, who filed their 84 patient ph 2 study with clinicaltrials in June, 2017, is not yet recruiting(go get em tiab).
Baystreet considers them, and us, top contenders:
http://www.baystreet.ca/stockstowatch/2658/A-Billion-Dollar-Market-Just-Waiting-for-a-New-Oral-Mucositis-Drug-Five-Companies-That-Want-It
Today's pr was the best they have ever put out, and backed by FACTS.
p.s A breakthrough therapy designation can be assigned to a drug if "it is a drug which is intended alone or in combination with one or more other drugs to treat a serious or life threatening disease or condition" and if the preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development."[5][7]
Re-read Sonis statement about the inability to eat or drink because of severe OM.
Good night Irene.
Remembering the good old days of mid February, 2018.
"Brilacidin OM could be partnered any day or the whole franchise for that matter.... "
"Any day now ------ Prurisol data will be released."
It appears none of we longs have been accurate with predictions. Nor does it appear management is too concerned about shareholder value. To bad Boston is viewed as a hick town by some. There's big money players always looking for a good return.
".38 cents"(.0038), yeah, I doubt it was Aspire
"I’m positive the investor was NOT aspire who was asking .38 cents. "
Was it you George?
"Not true, the FDA has to first clear OM before any alliance"
The fda has been overseeing, and analyzing, trial results by companies attempting to "clear" OM(oral mucositis) for years-decades.
Read the pr again. These results are, oh, what's the word...
petemantx,
Classy reply(not seen often).
TY
pss, my guess to the mystery guest(responder), is LR. Bruins could have used him the other night(not much gets by him(LR)).
Hope your statement proves false.
"Sounds plausible. Breathing lasts gasps while some people will get an awesome retirement after this “shell” game is over in Boca Ratón."
Have two local inquiries(near to ipix, and have worked with the company(ipix). M.R advised she would have one of the handlers call me back. Also left messages with M.S and D.S who have multiple, publicly transmitted exchanges with ipix(ctix).
Don't see the logic of either the company spending the time and money to defend themselves, nor the same effort displayed by their defenders, less there was(is) good reason.
what did you ask him, and what was his reply?
"THE TRIAL IS BLINDED!! THERE IS NOTHING TO COMMENT ON!"
After study completion, investigators and/or sponsors clean the data, derive additional variables, adjudicate endpoints, lock the data set to create the full analyzable data set, carry out prespecified and additional analyses using software programs (the analytic code), and prepare manuscripts for publication. Investigators also can use parts of the analyzable data set to prepare analyses for presentations, data exploration, and hypothesis generation. A biostatistics best practice is to freeze a copy of whatever data were used in an analysis so the results can be repeated later if necessary. It is also desirable to store the analytic code that generated the results (i.e., the computer program), especially for any derived data.
Sorry, must have confused you with someone else.
Under current conditions, how long do think that 3.1 Million dollars
lasts?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=140611289
"Last I read they had 3-4 million? Per the sec docs"
How many ph 3 trials do your figures cover? And please, do not include any speculation that ipix will get a deal. Let's leave that to the professionals at ipix.
thx
My main(first) question was to your response to Snaye, when you said "Snaye, understand that ipix could very seriously go out the way Polymedix did. "
My first and main question to you was "What makes you so confident that ipix avoids the polymedix way?"
I'm a Libra, please balance your above noted quote in the opening paragraph with your closing quote of same post, when you said:"I personally dont think that will happen, but biotech doesnt always pan out as expected; rather infrequently actually. "
Please justify, to this minion, why you pump ipix yet, at the same time reveal no confidence("Snaye, understand that ipix could very seriously go out the way Polymedix did.) " Then, shortly thereafter, in response to me, you replied "I personally dont think that will happen, but biotech doesnt always pan out as expected; rather infrequently actually. "
Justify your statements.
"Snaye, understand that ipix could very seriously go out the way Polymedix did.
I personally dont think that will happen, but biotech doesnt always pan out as expected; rather infrequently actually."
What makes you so confident that ipix avoids the polymedix way? Your reasoning must be solid, as an earlier post of yours today noted that you bought more today. You've stated previously that you own a fair number oif shares(wht buy at thses levels if your already heavily invested, and knowing the sp will eventually rise to Georgr like projections?)
Please explain what you know, perhaps discerned is a better word, as to why you continue to open your wallet and not question operations.
thx
Not yet anyhow. SP is down 43.6% over the past 12 weeks thru last friday. If it closes at .375 today,looking at -48.4%.
Liars can figure but figures don't lie.
"At least we're not yet trading at the split adjusted price of Leo's first venture into biotech..a cool $0.22!"
You are consistent. On the day of your post the sp closed at $2.61.
"I am confident that Leo has a lot more arrows in the quiver."
As far as MOST investors are concerned, LE has performed more like a one armed wallpaper hanger rather than a skilled archer. At best he's pierced himself while reaching for the quiver.
Are you saying time is of no consequence?
"Back up the truck and load up imo." Sounds like reverse the decline
via a split.
Sorry to say it, but me thinks your head hurts.