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Echo20.
¨25 business days are five weeks.¨
I don¨t know who posted it, but supposedly ipix management has now imposed upon themselves ¨working lunches¨ and, even weekends(GASP!).
Not sure, but I think the clip below is recent live footage of LE, KM, and Dr. B hard at work.
George,
Remember(don´t forget) all of Ehrlich´s prounouncements? What is his rate of accuracy?
You seem to be good at numbers.
thx,
kfc
Echo20,
¨Lots of time before September 30th.¨
Not the way I would phrase it.
If the 25 business days remaining until 9/30/18(39 calendar days) is ¨lots¨ to you, so be it, other´s view it differently I guess.
I suppose that day they announced the new Aspire arrangement(6/29/18, 54 days ago) should be described as an eternity ago.
kfc
tiab,
Bite your tongue young(Bunker Hill?) man! Don´t shoot til you see the white of their eyes. Hopefully, they are not operating with lids closed(talk about a head scratcher):).
LR,
Thanks for the cross checking and correction.
I meant line #6 to read ¨time from data analysis release to BTD announcement but errounously said ¨Time from primary completion date to BDT announcement.¨
Corrected version:
6. Time from release of data to BDT announcement. ipix=tbd(hopefully) vs galera 73 days (equivalent to ipix hearing by 7/20/18)."
foot note. Galera announced data figures on 12/18/17 anf btd on 2/28/18. Ipix announced data figures on 5/9/18 and btd hopefully is forthcoming.
A few comparisons between ipix ph2b OM trial and Galeras ph2b OM trial.
1. Duration form start date to actual primary completion date:
ipix=1197 cal days vs galera´s 708 cal days
2. # patients enrolled. ipix= 61 vs galera 223
3. # outcome measures.ipix 2 pri+ 16 sec=18 vs gal 1 pri+7sec+14o=22
(pri denotes primary, sec denotes secondary, and o denotes other)
4. # of study sites. ipix=16 vs galera 61.
5. Time from primary completion to data reveal. ipix=169 days vs galera= 92 days.
6. Time from primary completion date to BDT announcement. ipix=tbd(hopefully) vs galera 73 days (equivalent to ipix hearing by 7/20/18).
Galera clearly operates much more efficiently, just making comparisons. Someone asked the question if they hit it out of tbhe park. They clearly knocked in a few runs and got the fda´s attention. Ipix also has some stat sig results which hopefully being reviewd.
Next step is to review both data releases and compare similair outcome measures.
note- galera´s trial does not end until August 2019 per clinical trials.
Lilkahuna,
Please. Simply state what you mean.
(good luck deciphering your own message)
kfc
LR,
You state: ¨I don't think I understand how the odds of approval drop over time. There's just less time until 9/30 for the approval to be granted.¨
Fair suggestions.
Let one not forget the original timelines given by the company, for the various compounds being studied, and where we are today(both investor´s, and the company).
All milestones have now been streamlined to 9/30/18, which matches their lease agreement signed five years ago, and expires on the same day(9/30/18).
Twood be good if they could pick up the phone, nary can, and here we are.
Hopefully they pull through, and we are not laced with this
"I´ve espoused to you b4"
You guys were married???
She´s quite the dish.
You´re hunches are quite wrong in your accusation. Husband(male) and wife (female).
kfc
LR,
Hear it from the horses mouth, not me, which is why I left the telephone #.
I may be wrong, but doubt it, and think you´ll agree. Beget your information from the source(when they answer) when you can.
Aspire Capital
155 North Wacker Drive, Suite 1600
Chicago, Illinois 60606
View Map / Get Directions
Phone: (312) 658-0400
Fax: (312) 658-4005
glty
SS,
Sorry to say I do not subscribe to pm. My understanding of ihub is fridays, 4-5?, messages can be exchanged at no charge. Not sure of the time, but quite sure there is a 1 hour allowable window to exchange messages on ihub free of charge on fridays.
All Ill say is, as I´ve espoused to you b4, not a big fan of yours, but neither a foe. Open discussion I value.
Please send me your notes, which I´ll review and respond to, pro or con(tbd), next friday within ¨the window¨.
kfc
Is that to say you´ve spoken with him?
Aspire Capital
155 North Wacker Drive, Suite 1600
Chicago, Illinois 60606
View Map / Get Directions
Phone: (312) 658-0400
Fax: (312) 658-4005
SS,
In reponse to:
¨Not filing an 8k on the first cutthroat aspire deal was illegal.¨
Don´t take it up here, call THEIR lawyers and demand answers.
I spoke with Steve Martin(not the comic) on friday.
Suppostions, combined with inquisitions, frequently reveal the truth.
In response to:
¨I’m just going by what that poster with the Leo connection said - IPIX has plans for an office now and in the future. There would be no company if Leo sold IPIX and there would be no IPIX office in the future. So we can conclude at this point that Leo has no plans to sell off the entire company. So what is next? Partnership, selling off a part of the company, a titular office of dreams. We shall see. To steal the Bunny’s carrot - September is just around the corner.¨
Aren´t we all curious? Tis why I called one of their neighbors after multiple recent no pick ups at HQ(having been there, their office is a fish bowl(head to toe outside glass walls) to inquire about office acivity, to which their response I will not share, as it is only someones observation and opinion((I won´t speculate, but encourage others to inquire/question within the next WEEK(I won´t wait)).
kfc
Interesting. Glad Eli doesn´t play for the patriots. As Tom Brady has proven, it´s ¨easy¨ to get to the superbowl, a little harder to win it each and every time(he´s batting .625(5 for 8)).
Are you suggesting that Ehrlich has proven to be an average ceo/cfo/receptionist? His previous attempts are 0 for 2, with ipix results in the balance.
https://www.forbes.com/sites/briangoff/2017/09/25/eli-manning-an-average-nfl-quarterback-with-two-super-bowl-rings/#2a59e5661791
Why ask on a mb?
Just call them and ask Aaron Smith (978) 922-9000
http://looplink.cummingsproperties.com/ll/6257335/100-Cummings-Ctr/
¨I can’t believe Leo threw a Hail Mary or that Aspire would sign onto one.¨
Ehrlich is no Doug Flutie (or Tom Brady). Believe me, I played against Flutie(and his brothers) in high school. Same league, and our turkey day rivalry.
LE has shown his arm is not strong enough to pick up the phone, and his mind appears to be even weaker.
He may surprise all, we´ll see, but hope diminishes with each passing day.
DaubersUP,
I? gona vote for you in the next presidential election.
Things are about to get interesting based upon my last couple calls.
gltu.
Over and out.
kfc
Thanks Duabers
DaubersUP,
Curious post. Why buy another 7850 shares when you stated¨Let the Prurisol 52% PASI 75 results lose!!!!¨?????
I´ve found some europeon real estate you may be able to afford if your prediction proves true(ipix comes out on the losing end) of your ipix investment. I do wonder, if you feel LE & Co are losers, why exonerate them and continue to load up? If I may ask, how many shares to you own after todays purchase(understand if you care not to answer)?
Leaves me to think you´re short this stock.
Curious post.
Thx
kfc
petemantx,
are you a football scout?
¨Understand that MM’s know everything is coming mid to late September...¨
I learn something new very day here, ty.
Something to be said for selective memory- I guess.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=141643047
Georgejjl,
You state: We know that Prurisol potently inhibits noncoding RNA, PRINS. ¨
...¨PRINS might be part of a regulatory complex formed with NPM. The resulting complex may play a role in the regulation of proliferation and differentiation and in the stress response of cells. We hypothesize that the abnormal functioning of this complex contributes to the pathogenesis of both malignant and benign hyperproliferative diseases, such as psoriasis.¨
I don´t understand how you infer the words might, may, or hypothesize as knowing.
kfc
Here´s a true fish tale while we wait(the video is below the article(scroll down after clicking the link).
https://patch.com/massachusetts/barnstable-hyannis/video-great-white-shark-snatches-boys-fish-cape-cod
DaubersUP,
The 5 day average sp was .4186 as of last friday(8/10/18).
If it closes at 50 cents today, the 5 day average becomes 43.26 cents giving Aspire a 13.48% discount(based on 50 cent close today).
kfc
Echo20,
¨Plus the 20 PHARMAS that keep their data transmission eyes on Leo and IPIX.
Then the SEC and the BTD inspectors.
Leo needs to be careful.¨
I hope you´re right, but to me
tiab,
I think LE was interupted by yesterday´s heavy rains(7¨-8¨ in north shore area) making an emergency P delivery and is still waiting for the waters to recede(and hoping the van will start b4 9/30/18). It´s a good thing he thinks like a Boy Scout(always be prepared) because the van is loaded with nothing but food and a commode(the P is in the commode).
He´s known as the ¨New Gloucester Fisherman¨ of the north shore because of the potential big haul. I believe the BBJ has compared ipix´s potential to the pharmaceutical industry to Georges Bank and the fishing indusry.
kfc
https://patch.com/massachusetts/swampscott/north-shore-flooding-route-1-closed-7-inches-rain-cities
https://en.wikipedia.org/wiki/Georges_Bank
A little history never hurts. There´l be a test tomorrow.
petemantx,
You stated: ¨Believe one of the secondary observations of the trial could be that patients, in addition to having their psoriasis symptoms relieved or cured, also had some sort of reaction to their arthritic pain as well. Hopefully, it was greatly moderated or relieved and the patients noted same on their Quality of Life questionnaire.¨
Which one of the seconday endpoints:
1. Proportion of subjects achieving a static Physician Global Assessment (sPGA) score of clear (0) or almost clear (1) with at least a 2-point reduction from baseline [ Time Frame: 16 Weeks ]
The static Physician Global Assessment reflects an overall severity of the erythema, induration and scaling across all psoriatic lesions on a 5-point scale, where 0=clear, 1=almost clear, 2=mild, 3=moderate, and 4=severe.
2.PASI75 response at time points through Week 16 [ Time Frame: 16 Weeks ]
The Psoriasis Area and Severity Index (PASI) quantifies the severity of psoriasis based on lesion severity and the percent of body surface area affected. It is a composite assessment, across body regions, reflected in a single score: 0 (no disease) to 72 (maximal disease).
3.The actual and change from baseline in patient-reported itch severity score [ Time Frame: 16 weeks ]
The severity of itching due to psoriasis will be assessed on a horizontal numeric rating scale, anchored by the terms "No itching" (0) and "Worst possible itching" (10).
4. Assessment of patient-reported quality of life by the Dermatology Life Quality Index (DLQI) [ Time Frame: 16 Weeks ]
The Dermatology Life Quality Index (DLQI) is a 10-item general dermatology questionnaire that assesses patient health-related quality of life in adult subjects with skin diseases such as psoriasis
5. Assessment of patient-reported quality of life by the Short Form-36 Health Survey (version 2, acute form) [ Time Frame: 12 Weeks ]
The SF-36 is a widely used general health status questionnaire that assesses 8 domains of functional health and well-being: Physical Functioning, Role Limitations due to Physical Health Problems, Bodily Pain, Social Functioning, Mental Health, Role Limitations due to Emotional Problems, Vitality, and General Health Perceptions
6. Assessment of patient-reported quality of life by the Euro-Qol 5 Dimensions Health State Profile [ Time Frame: 12 Weeks ]
The EQ-5D is a generic instrument designed to assess a subject's general health status. The instrument consists of a questionnaire and a visual analog scale (VAS)
7. Assessment of Patient Satisfaction with Study Treatment (PSST) [ Time Frame: 12 Weeks ]
Overall patient satisfaction with study treatment will be assessed on a 7-point rating scale, with response options range from "very dissatisfied" to "very satisfied"
8. Plasma concentrations of Prurisol [ Time Frame: 4 Weeks ]
Measurement of Prurisol (abacavir glycolate) from a subset of subjects in the trial
9. Plasma concentrations of abacavir [ Time Frame: Timeframe: 4 weeks ]
Measurement of abacavir, a metabolite of Prurisol, from a subset of subjects in the trial
thx,
kfc
DuabersUP,
Many ¨shoulds, mays, and hopes¨ in your, and other´s statements. LE FORWARD LOOKING Statements is all your ilk recite, which the DOJ, Mueller, can never ¨legally refute¨ due to then¨laws¨ passed, imo.
gltu
LR,
You are correct, my bad.
I´m surprised, upon many levels. primarily based upon company statements, how we(the company) are wher
e we are?
idk
Thx Karin,
I actually anticipated the company wou;ld request compassionate use of B for OM based upon(ipixs) their press releases.
Their approach is not how I would forge ahead.
WDIK?
kfc
BooDog,
If ¨spit and rince¨ Brilacidin for OM(ipix definition) was SO successful, and better than all others, why the need to tack(change course)?
Why not modify design when the money starts rolling in?
kfc
Perhaps this is why they do not answer the phone:)
With an investment like this, one must learn to laugh, while,pursuing questions from company officers.
Hopefully we haven´t been hit by a bucket of bricks:).
Laugh while we wait.
Is this Steve Martin and LE in the last deal? Looks like Martin sees promise as he chases SH past the trailers, parked.
Is this the Steve Martin(Aspire) that LE cut the deal with?
BooDog,
U da man!
BooDog,
¨And as the catalysts approach over the next 7 weeks or so, we'll just see what happens.¨
Hope you´re right, that the catalyst approach and not moving trucks(with forwarding address).
kfc