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Hey! Please calm TF down..lol
I'm just here for the potential of a drug that is one of the few, if only, that can help an intubated COVID-19 patient.
If it has promise, this is an excellent entry point, imo.
But I can't help, from doing a little research, there are some "red flags" here.
Some I am painfully aware of based from previous/current investments.
Slow enrollment means Hot, Sideways Action for months upon months. I would rather wait until the finish line can be clearly seen.
When the last patient is dosed, the clock starts. Investor's will begin to line up to purchase potential lottery tickets, leading to, and hopefully running northbound, into data results.
As for the Red Flags...
I don't like how Dr. Javitt made such grand proclamations without having conducted a study with a control group, the Gold Standard.
Seems reckless and too much about self-promotion.
Hmm.. who does that remind me of?
And to the safety board issue.
While I am aware the good Dr has disputed it, the Politico article is what I am referencing.
Quote... "Politico raised questions about the DSMB’s composition. Javitt, they reported, had picked mask-skeptic Republican congressman Andy Harris and two other acquaintances to run the board, raising concerns from some ethicists who questioned how independent they could be and how qualified they were to assess whether a trial should continue." Endquote.
Just a few issues I'm working through.
I know the risks involved in the OTC, where 90% of investors lose their a**.
Been burned before, just poking around for some info, no need to get too bent outta shape.
LS5
Lol.. as if anything coming from the Whitehouse can be believed.
...gimme a fuc*en break.
So the safety monitoring board consists of "insiders" connected to the company principle's?
...I sense shenanigans.
You think? You guess?
You are one extremely optimistic MF.
Good for you!
But is it based in an unbiased reality?
To quote... "won't need a biostatistician" (sic).
...probably not.
Thanks Shell.. im learning slow but sure.
Btw.. quote: "he hides his AGNPF"
The "he" you reference, I assume, you are speaking of the infamous, notorious one, who I will also, not mention by name.
Let's just refer to him as Special K, for now.
At least until I cash out..lol.
For all of his scheming, I made out very well with the sis.. and remain here, basically for free.
Still don't trust him, as my mother would say, as far as I can throw him.
Oh well.. we've been pushing this boulder uphill for too long.
So whether we reach the top, and finally get this thing rolling downhill.. toasting Dr. Mark in Vegas.
...Or the rock crushes us.. resulting in, hopefully, a quick, painless death.
Either way.. it'll be a relief.
Hang in there fellow Algernaut's! The end to the Long and Winding road is near.
LS5
So... I'm guessing the "green" #'s are a good sign??
Sorry for the ignorance.. still a newbie here.
Money.. but no expertise.
LS5
Ahh.. the much-ballyhooed "Point of Inflection".. Perhaps?
Nice looking chart.
Fire the main engine.
May godspeed (well, if you believe in that sort of thing)...fellow Algernaut's..
LS5
I accept condolences for now.
Congrats!..?.. hopefully coming soon.
Good Luck Sir.
Yes I'm aware of this interview and what what was said.
We both agree on everything except whether it moves directly into Phase3. It's a matter of semantics, in my opinion.
While there will be delay to the start, based off Phase2 data of which will be calculated into Phase3 enrollment, it's only to assess the data from Phase2.
There will be no "application/approval process". It is already authorized.
As he states at 18:30, it's a Phase 2b/3 study.
As for the Summer of '21 projection..
I will be (nearly) long gone by then.
This has always been an, as you stated, "Option 3" best-case scenario for investor's.
I've been invested for nearly 4yrs. After contemplating total sell-off after the reverse-split, I became interested in the "repurposed drugs" idea (thanks to the great DD offered here by the Band..lol).
COVID-19 came and the connection to what the company was already investigating, and, it should be noted again.. unlike most pursuing a treatment/therapeutic, COVID-19 came to Algernon.
So I increased my position.
I will always stick around with a few tickets to see where my original investment goes with IPF/Chronic Cough.. and the other 3 in the pipeline. But the COVID-19 angle is coming to a Day of Reckoning, and soon.
Good luck Algernaut's... commencing Countdown.
LS5
Not at all.
Safety has been established through 50 yrs of legal use in Japan and S. Korea.
Euphoria is a side effect.. if that even rises to the definition of a side effect.
Safest drug currently in PhaseII...imo.
Not true.
The CEO stated the proper procedure is to update the market with a press release BEFORE trading on a particular day, unless a material development happens during trading hours, which would require a halt so the market can digest.
Please elaborate...
Sorry for got to premise the statement from CEO is in regards to IPF/Cronic Cough trial.
Not necessarily true.
It's a Phase 2b/3 for a reason.
Meaning it will move IMMEDIATELY into Phase 3 with positive data. No submissions, waiting for approval, etc.
Negative data sinks the COVID-19 angle forever, not until summer
On the other hand, per the CEO, Some preliminary data results are expected Q1 of 2021.
Hope this helps. Good Luck!
LS5
Agreed.
Minus the "trial of which we shall not speak it's name" (Korea), the dynamic duo has hit every milestone, which should be noted is a feat, in and of itself, when considering the new world in which we now live, and must quickly adapt to without the guidance of any, as of yet, proven blueprint.
Oh yea. Quote.. "Lord knows I've tried".
That had me for real laughing out loud.
Your comedic skill, even during frustration, should also be duly noted for it's greatness.
It really does/has helped me "Through The Storm"... this is where, if I had your "gadget" skills would have included a link to "NBA YoungBoy".
Ahh the things my boys got me listening to..lol
Good Luck and Good Night Algernaut's!
LS5
Damn from back in May! Now thats a reckoning.
Anyway.. to the best news around here in a damn spell..
It's like a Fleetwood Mac reunion around here.
We got Medchem's genius back on lead guitar.
Fingers crossed he and our lead vocalist can harmonize us to the top of the charts. (You know who you are).. starts with an A.
Ssbains.. we need you to get our rythem section back on point with your intellectual bass guitar.
Danny D..grab your sticks and get yo a** over here!
Shell3.. of course always the Songbird, singing the #'s like a lullaby.
For those who made it thru this..
Thank you for your time, I'm a little star-struck and feeling optimistic about things coming to an ultimatum, of sorts, here very soon.
PS.. I can't forget a very special shout-out to our guy smoki keeping the dials right in the control room.
Now... Let's Get It!!
LS5
The darkest hour of night is just before the dawn.
...or at least I fricken hope so..lol
What rule change?
What did I miss?
Gonna merge with the sister.. a way out of the Grey abyss.
Welcome back Sensei Medchem!
Wait! Where is all this action going on at?
Quote: "back and forth going on over there".
Nothing but crickets over here.
LS5
Thank you sir.
Always nice to get an enrollment update, but Chris basically tells the same, while great, "30,000 foot summary".
Dr. KSS makes the science behind Ifenprodil easier to digest. Which makes for better updates. IMO anyways.
LS5
All good Mac.
My mother passed from Dementia in 2013. Sweetest person I've ever known. Cancer survivor in '03. Diagnosed with Dementia in 2010. It moves fast and is a horrible thing to watch progress.
Nobody deserves the outcome of that terrible disease.
I hope Ifenprodil has potential and I wish you my heart-felt best wishes in your pursuit to find help.
LS5
So.. are you suggesting that Ifenprodil can help as an sr1 inhibitor and researched for memory protection and associated adverse brain conditions?
Sounds great, but not relevant to where Algernon is going with it. Would require them to redirect focus and limited resources.
I'm all for it! Even for the previously mentioned in a biopub for addiction.
But right now the focus is protecting the lung. And I, for one, have been sweating this out for far too long now.
First things first.
LS5
Anyone have the recent BioPub interview?
TIA
Awesome! Any links?
Completely agree.
Investor's are out chasing the "flip-o-the-day". No use parking funds here until developments are on the horizon.
Once last patient dosed is announced, a "defined timeline" will be established, signaling investors to buy their lottery tickets. IMO.
LS5
If it goes any lower I may mortgage the house and buy more!!
I serve on the tribal council for my tribe located in SW MN.
Just off the phone with casino GM, will be initiating contact with Oxi-Thyme reps for pricing.
Currently casino housekeeping uses corded spraying system.
Oxi-Thyme's cordless fogging system would be far more superior then our current equipment and will save time and convenience with the cordless unit.
Also have had discussions with our rec dept for disinfecting Recreation Center, as we have over 50+ kids at all times.
I'll keep the board posted.
LS5
Like always with these "twisted sisters", it's anybody's guess what lies ahead/beneath.
What I do know from the pharma investment world is that drug development from the pre-clinical stage is a long way from home.
Need to test efficacy in Murine (mouse) model, then a double-blind study (gold standard) in humans at some point.
Submission of testing protocols, methods, endpoints, dosing levels, ethical standards, etc.
All the while monitoring safety and effectiveness.
Many years and many millions of dollars.
Could be many years before FDA approval.
So.. where does it leave us?
Maybe PAOG is busy talking to the sister about how they merge?
Is it Oxi-Thyme?
LS5
Buying opportunities
Continued amazing DD RocketMan.
These low volume Red days mean nothing other than weak hands giving up.
If it was 100M+ I would think otherwise.
The volume will come with the next PR.
We're on the launchpad fueling up, preparing for blastoff.
LS5
Excellent analysis BOB.
You've managed to predict the "inflection point" better than CJM has.
Makes sense, and something I haven't seen postulated here, that investor's will have time to play other opportunities until the "build-up" after last patient dosed.
In that case, let's bring this down to .10 so I can get back to pre-split levels.
LS5
So hard to figure this out.
Hard to imagine being in the greys and making it "out alive". Many have tried, nearly all have failed.
But! We have revenue!!
Not only unheard of in the OTC, but surely a "blue moon" occurrence in the grey market.
This will be a true test of testicular fortitude when/if it drops hard on Wednesday.
But could possibly be in a "Forrest Gump" shrimpin' boat scenario when/if the storm clears.
GL2ALL
LS5
Were any of them producing revenue at the time of suspension?
I'm intrigued by the amount of "loyalty" to the company here.
Even to the point of questioning the SEC's ethics.
I hold a modest position here, around half million shares, freebies from the last company iteration-to-flop (trips).
I'll stick around to see how this plays out, just curious as to your previous experiences in the ghostown know as the "Grey Market".
LS5
Dude..
You're an obvious joke.
I lost track of how many "life changer" or "once in a lifetime" stocks you have "hyped" in reading through your short Ihub lifetime.
I hope you're not a paid pumper. Otherwise I have lost much respect for this company, if they in fact paid for such a POS attempt at hype.
LS5
Doesn't matter
...it's Boom Time!!
Don't worry, I'm not like "Cougar".
To add more to your last post..
The talk about a vaccine taking away Ifenprodil's opportunity should also include the long term applications.
Ifenprodil, should it perform well against COVID-19, will have shown effectiveness against 2 viruses that attack the lungs.
The outlook on a future avian-born virus will not look as bleak with Ifenprodil.
Also... While I know you have clearly stated.. long gone after PhaseII data, I'm looking forward to more focus on the rest of the pipeline in Algernon's arsenal.
At least leave a few (hopefully) freebies.
LS5
Ahh... here to save the day once again. You never cease to amaze.
Beautifully summarized.
I would only add to the part you referenced could be talked at length about.. early data "leaks".
Everyone involved (patients, hospital staff) has undoubtedly signed many "confidentiality" forms.
And if the first 5 patients walk out fully recovered, does that mean "clinical significance"?
Point being, any early indication, either way, would be premature, and by recent publicity, meaningless to the market.
Only final determination of clinical significance will move the sp, imo.
LS5
Just sayin..
It's holding because nobody can sell.
Oh I get it.. You're being sarcastic.
Aren't you?