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Dr. J. Joseph Kim, Inovio President and CEO, said, “Inovio is utilizing our versatile immunotherapy and vaccine platform to target and develop the most advanced preventive vaccine for MERS, a virulent viral infection with no medical countermeasure. This trial further demonstrates Inovio’s commitment to fighting emerging viral threats while also continuing to validate consistent high levels of both immune and antibody responses across our infectious disease platform. We look forward to continuing this development in a partnership with GeneOne and CEPI for developing novel therapies for MERS.”
In April 2018, Inovio was awarded $56 million to develop a MERS vaccine through Phase 2 by The Coalition for Epidemic Preparedness Innovations (CEPI). The shared goal of Inovio and CEPI is for the MERS vaccine to be available for stockpile as soon as possible for emergency use. The CEPI funding also included support for Inovio’s vaccine against the Lassa virus.
In collaboration with GeneOne Life Science, Inovio plans to begin a Phase 1/2 study for MERS in the third quarter of this year. The study will be conducted by GeneOne Life Science in Korea and fully funded by a $34 million grant from the Samsung Foundation through the International Vaccine Institute.
Could tou explain why INO is seeking a CEO?
Birinapant:
Official Title: A Phase 1/2 Multicenter, Single-Arm, Open-Label, Dose-Escalation Study of Birinapant in Combination With Pembrolizumab (KEYTRUDA®) in Patients With Relapsed or Refractory Solid Tumors
Actual Study Start Date : August 4, 2017
Estimated Primary Completion Date : June 2021
Estimated Study Completion Date : June 2021
https://clinicaltrials.gov/ct2/show/NCT02587962
INO has a CEO!
Get in early, never get out. And avoid advice from shills in DFW and WPB.
A little action!!
Interesting.
More action than in some of the allegedly dead posters hereabouts.
lol
I love shorts - wear them till they are worn out.
Hallelujah.
Boy, that sure throws one for a LOOP, don't it.
Prostate, HIV cancers, what's next.
Looks like cancers of any kind are well on their way out.
All for only $5/share.
Should be $500/share.
Inovio Pharmaceuticals Demonstrates PSA Stabilizing Effect of INO-5150 Immunotherapy in Phase 1b Study for Prostate Cancer
PLYMOUTH MEETING, Pa., May 17, 2018 -- Inovio Pharmaceuticals, Inc. (NASDAQ:INO) today announced a poster presentation of additional prostate cancer data (Abstract #229675) at the American Society of Clinical Oncology (ASCO) annual meeting to be held in Chicago, June 1-5, 2018. Previously reported data from a Phase 1b clinical trial demonstrated that Inovio’s cancer immunotherapy (INO-5150) slowed PSA rise in patients with biochemically recurrent prostate cancer. Additional analyses show clinically meaningful PSA stabilization post-administration of Inovio’s immunotherapy in patients with no documented disease progression during the study. Of note, this effect was also observed in the patients with the fastest PSA doubling at the time of study entry.
The multi-center Phase 1b study enrolled 62 patients with biochemically relapsed prostate cancer following definitive local therapy. Under the trial design, eligible patients received INO-5150 (DNA plasmids encoding prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA)) alone or co-administered with INO-9012 (IL-12 plasmid) delivered intramuscularly followed by EP using the CELLECTRA®-5P device. Of the 61 evaluable patients, 77% (47/61) demonstrated T cell immunogenicity, and 38% (19/50) exhibited CD38+, Perforin+CD8+ T cell responses. Additional analyses are underway to elucidate the correlation between immunologic efficacy and clinical benefit. For more information, please visit ClinicalTrials.gov (Identifier: NCT02514213).
Dr. J. Joseph Kim, Inovio’s President & CEO, said, “The additional results from our Phase 1b INO-5150 study continue to support our rationale that Inovio’s T cell generating INO-5150 could be an important agent as an immunotherapy as it provides strong and durable immune responses in a particularly difficult-to-treat prostate cancer patient population. We remain diligent on establishing an outside partnership to further advance INO-5150 and I look forward to sharing additional observations from our prostate cancer development program later this year.”
INO-5150 was generated using Inovio's proprietary ASPIRE™ technology process to enable significant production of engineered PSA and PSMA antigens with genetic sequences differentiated from native human PSA and PSMA sequences. This patented approach is designed to help the body's immune system overcome its "self-tolerance" to prostate cancer cells and mount a strong targeted CD8+ killer T cell response to eliminate the cancerous cells displaying these antigens. PSMA is also one of 3 antigens comprising INO-5401, which is being tested in two separate Phase 1/2 trials as an immunotherapy to treat glioblastoma and metastatic bladder cancer in combination with Regeneron and Genentech/Roche’s checkpoint inhibitors, respectively.
Independently, two additional posters are being presented at the ASCO meeting that provide details on the ongoing trials of AstraZeneca/MedImmune’s MEDI0457 (formerly called INO-3112 which MedImmune in-licensed from Inovio) in abstract #TPS6093 and #5525.
About Inovio Pharmaceuticals, Inc.
Inovio is a late-stage biotechnology company focused on the discovery, development, and commercialization of DNA immunotherapies that transform the treatment of cancer and infectious diseases. Inovio’s proprietary platform technology, ASPIRE, applies next-generation antigen sequencing and DNA delivery to activate potent immune responses to targeted diseases. The technology functions exclusively in vivo, and has been demonstrated to consistently activate robust and fully functional T cell and antibody responses against targeted cancers and pathogens. Inovio is the only immunotherapy company that has reported generating T cells whose killing capacity correlates with relevant clinical outcomes. Inovio’s most advanced clinical program, VGX-3100, is in Phase 3 for the treatment of HPV-related cervical precancer. Also in development are Phase 2 immuno-oncology programs targeting head and neck cancer, bladder cancer, and glioblastoma, as well as platform development programs in hepatitis B, Zika, Ebola, MERS, and HIV. Partners and collaborators include MedImmune, Regeneron, Roche/Genentech, ApolloBio Corporation, The Wistar Institute, University of Pennsylvania, the Parker Institute for Cancer Immunotherapy, CEPI, DARPA, GeneOne Life Science, Plumbline Life Sciences, Drexel University, NIH, HIV Vaccines Trial Network, National Cancer Institute, U.S. Military HIV Research Program, and Laval University. For more information, visit www.inovio.com.
CONTACTS:
Investors: Ben Matone, Inovio, 484-362-0076, ben.matone@inovio.com
Media: Jeff Richardson, Inovio, 267-440-4211, jrichardson@inovio.com
Not yet.
Tell the SEC and FBI - they will add it to their files.
I've been providing questions and info to the SEC concerning SNST and its promoters for years!
And I'm certainly NOT important.
Maybe I am.
Reminds me a bit of Best.
And PTOI, too.
These guys just love to throw money away:
https://www.pyrolysis.biz/
https://splainex.com/index.html
http://www.blest.co.jp/eng/
Can PTOI compete with this?
Kitchen gadget turns rubbish into ENERGY
Amateur inventor, 48, creates a £3,500 'washing machine' incinerator that fuels hot water for your home
The Heru machine uses a process called Pyrolysis to turn solid waste into an ash, gases and thermal energy. By harnessing the products of this reaction Mr Spencer believes he could have found a way to drastically improve recycling and reduce utility bills
Nik Spencer, 48, from Worcestershire built the recycling machine on his own
The Home Energy Resource Unit (Heru) turns rubbish into energy in eight hours
Roughly the size of a washing machine, the Heru recycles plastic and food waste
The machine could save consumers money and energy and free up landfill sites
Prototypes are currently being trialled in a home and a cafe in Worcestershire
By Claire Duffin For The Daily Mail and Joe Pinkstone For Mailonline
PUBLISHED: 10:49 EDT, 8 May 2018 | UPDATED: 17:19 EDT, 8 May 2018
A father has invented a waste incinerator which allows his family to recycle their rubbish at home.
Nik Spencer, 48, says the device, which is about the size of a washing machine, can generate enough energy to heat a house.
Prototypes are being tested and he hopes that one day the incinerator will become commonplace, fitting under work surfaces alongside dishwashers.
Nik Spencer, 48, (pictured) from Worcestershire created his device which slowly burns waste overnight to create a charcoal-like substance
A small machine can turn household waste into hot water. The Home Energy Resources Unit, or Heru (pictured), can recycle anything from plastic cups and milk cartons to food waste and dirty nappies
Mr Spencer’s invention – called The Home Energy Resources Unit, or HERU – can recycle most household waste, including nappies, coffee cups and plastic.
It works by heating up the rubbish and turning it into a small amount of ash, which can be flushed safely down the drain.
The Heru is plumbed in to an attached boiler, which ensures potential dangerous gaseous emissions are filtered out.
On the way to the boiler, the waste gases pass through a patented filtration system, which removes any noxious chemicals and any unwanted odours.
It is then also passed through filters in the boiler, which make the final gas emissions harmless and odourless.
WHY IS THE HERU LEGAL AND WHY DOESN'T IT SMELL?
The Heru works in much the same way as an incinerator.
The difference is that an incinerator belches out toxic chemicals, depending on what is being burned.
The Heru is a fully sealed, self-contained unit which has several provisions in place to stop this happening.
It is the lack of dangerous chemicals emitted which makes the Heru safe and legal to use in the home.
The device uses high temperatures to reduce waste to ash, which is harmless and can be flushed down the toilet or put down the sink.
Chemicals and gases are also produced in the process but are rendered harmless by the device.
The Heru is plumbed in to an attached boiler, which serves two main purposes.
The first use is for transferring the heat form the Heru to the boiler, where it warms the water.
Secondly, the plumbing also ensures potential dangerous gaseous emissions are filtered out.
On the way to the boiler, the waste gases pass through a patented filtration system, which removes any noxious chemicals and any unwanted odours.
It is then also passed through filters in the boiler, which make the final gas emissions harmless and odourless.
One eight-hour cycle can produce enough energy to heat a tankful of hot water, as well as burning rubbish which would otherwise end up in landfill.
It does not recycle metal and glass – which require much higher temperatures to break down – but if those items end up in the machine accidentally, they will not cause any harm.
Mr Spencer, who lives with his wife Jodie, 46, and their two children in Evesham, Worcestershire, came up with the idea while running a recycling plant which sent out a fleet of lorries to collect renewable materials.
He calculated that it was possible to save huge amounts of carbon if waste material was incinerated at home instead transporting it to larger sites – or even abroad.
Mr Spencer, whose invention cost £12,000 to build, said: ‘I can see a time in the future where waste collection is completely eradicated and the only materials being recycled are glass and metal.
‘It is completely inefficient to collect recycling from a home to be taken to a site to be incinerated to generate heat to be used to fuel someone’s home.
One eight-hour cycle from the Heru can produce enough energy to heat a tankful of hot water. It also burns rubbish which would otherwise be sent to landfill
HOW DOES THE 'HOME ENERGY RESOURCES UNIT' WORK?
Amateur inventor Nik Spencer, 48, has created a 'washing machine' incinerator that turns rubbish into fuel.
Amateur inventor Nik Spencer, 48, has created a 'washing machine' incinerator that turns rubbish into fuel
The machine, dubbed the 'Home Energy Resources Unit' or 'Heru' works by filling up the machine's main chamber with rubbish and food waste.
Plastic coffee cups and bottles, food trays, nappies and even grass cuttings are placed inside the cylinder which is the size of a washing machine drum.
The chamber is heated to 100°C (212°F) which dries the waste and creates vast amounts of steam.
This steam passes then transfers some heat to the water supply.
After the initial burst of heat, the temperature in the main chamber of the machine is then ramped up to 300°C (572°F).
This then triggers a process called pyrolysis, which turns the rubbish into a charcoal-like substance.
At this stage of the cycle oxygen is pumped back inside the chamber and the pyrolised waste is then burned.
The energy this process produces is then used to heat water in a boiler.
One eight-hour cycle can produce enough energy to heat a tankful of hot water as well as burning rubbish that would otherwise end up in landfill.
‘What I wanted to do was to effectively cut out the middle man and build something that could do the job of using these materials to generate heat on a smaller scale.’
The HERU works using low-temperature pyrolysis – the decomposition of matter in the absence of oxygen.
Mr Spencer said similar processes happened in nature, and likens it to taking a dinosaur and a tree and burying them, with no oxygen. Heat from the earth’s crust over millions of years produces oil, gas and charcoal.
The Heru uses several stages and combines different processes to fully recycle the waste. The three main stages are shown here. The temperature increases and the oxygen intake is manipulated with the end result being a small pile of ash and a boiler full of hot water
Mr Spencer believes a full load of 2.5kg (5.5 lbs) rubbish produces 44 per cent of a household's hot water. There are currently Herus being trialled in a home, a cafe and another business in Worcestershire
The HERU speeds up this process using heat pipes.
Rubbish is put in a cylinder which is the size of a washing machine drum. The chamber is heated to 100C (212F) which dries the moisture from the waste to create steam.
This steam passes over heat exchangers which transfers it to heat the water supply. The temperature is then ramped up to 300C (572F) which triggers the pyrolysis and turns the rubbish into a charcoal-like substance.
The Heru works by filling up the machine's main chamber with rubbish and food waste. Plastic coffee cups and bottles, food trays, nappies and even grass cuttings are placed inside the cylinder which is the size of a washing machine drum
The only things that cannot be placed in the Heru are glass and metal, these items will still need specialist treatment at a recycling plant
Oxygen is then pumped back into the chamber and the pyrolised waste is burnt. The energy produced is used to heat the water in a boiler.
After a full cycle, users simply flush the remaining ash – about a teaspoon full – down the drain. The process takes between five and eight hours.
Mr Spencer said: ‘The ash which is left at the end of the cycle can be safely washed into the sewers.
After a full cycle, the only thing left of the original rubbish is a small pile of ash which goes down the drain.
Mr Spencer of Evesham, Worcestershire, came up with the idea while running a recycling plant which sent out a fleet of lorries to collect renewable materials. He calculated that it would be possible to streamline the entire process process if people could incinerate their own waste
‘While looking into the ash we discovered it contained lye which has a very high alkaline content and is excellent for cleaning sewers and breaking down fatbergs.
‘Lye was used by the Victorians to wash out the sewers so even the material which is left has a beneficial effect.’ The HERU connects to the water main and drainage and runs off a normal 13-amp domestic plug.
Mr Spencer, who describes himself as a ‘serial entrepreneur’, says that for every 1kWh of power required, it produces 2.5kWh.
WHAT IS PYROLYSIS?
Pyrolysis is the scientific name given to a chemical process that breaks down certain materials through the application of heat.
Pyrolysis transforms organic materials into their gaseous components, a solid residue of carbon and ash, and a liquid called pyrolytic oil (or bio-oil).
Carbon-based products, such as plastics and organic matter, are decomposed at high temperatures.
The process also occurs in the presence of little of no oxygen, which differentiates it from combustion.
This lack of oxygen ensures that the matter doesn't burn or catch fire.
It creates a form of charcoal called biochar.
Pyrolysis is often combined with other processes which to make use of the waste.
The dad-of-two believes his invention - which cost him £12,000 ($16,000) to build - could become a common feature in people's kitchens in the future
The Heru machine uses a process called Pyrolysis to turn solid waste into an ash, gases and thermal energy. By harnessing the products of this reaction Mr Spencer believes he could have found a way to drastically improve recycling and reduce utility bills
The emissions it produces are odourless and expelled via the boiler exhaust, and are similar to those expelled by normal boilers.
Mr Spencer, who now works full-time on the HERU, believes a 2.5kg (5lbs 5oz) load of rubbish produces 44 per cent of a household’s hot water.
HERUs are being trialed in a home, a cafe and another business in Worcestershire. Mr Spencer hopes to begin production in 2020, with an estimated price tag of £3,500.
Read more: dailymail.co.uk
http://www.dailymail.co.uk/sciencetech/article-5703849/A-British-inventor-created-machine-turns-plastic-waste-leftover-food-hot-water.html#ixzz5FIml0PHb
PS:
Wayne Rooney will play the rest of his career at Evesham!!
It's going to $100?
Good enough reason??
I guarantee it.
Trust me or sue me for damages.
Please?
Just kidding before I kick off this mortal coil.
Virus free I will be, though.
Thanks to Seymour, Diwan, Rawnoc, Arvitar and all the rest of the NNVC supporters, particularly yours truly.
You're WELLCOME.
Very wise!
I trust no one and nothing about this Florida outfit.
I get bad vibes!
I'll stick with OJ (the fruit juice!) from Florida and sunshine.
Sunset....no, just the one at Naples - SPECTACULAR!!
What scam?
Get serious; any bloody fool can see this has $100 potential, easy.
And with a little financing now in hand, peasy.
This certainly is a once in a lifetime opportunity.
Not to be missed.
Whenever I asked, he guaranteed 539% accuracy.
Of course we were both qualified geriatric clowns.
An infringement search would undoubtedly reveal that this now ancient technology is in the public domain and ANY existing in-force patents are invalid since 1980-2000.
But Fleming was a well known geriatric clown.
Thanks for the endorsement.
In fact, I believe he lives in DFW.
Check out penicillin's history!
It took 25 years from Fleming's windowsill to Merck's bottom line.
FWIW.
HepesCide will take less.....and provide a much larger bottom line.
https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html#wwii-penicillin-commercial-production
https://en.m.wikipedia.org/wiki/Alexander_Fleming#Accidental_discovery
You perform like a 2 bit outfit, you become a 2 bit listing.
Grey me.
No interest in NNVC here on iHub.
Help!!!
Now all that remains is to get Diwan, the present NNVC CEO, interested in this amazing moneymaking proposition.
PTOI's latest effort - a home sized plastic furnace/converter to heat /cool/electrify the home/charge the electric car all with used waste plastic as fuel. Even West Virginia coal miners like it.
It will sell like hot cakes.
And get rid of all that waste plastic.
Now to find a good use for the waste CO2 and other effluents!!
Tropicana will enter the bidding war to get the NNVC nano fresh squeezed essence technology.
Nano is more than just viruses.
Much more!!
The n in NNVC is for nano orange juice.
Oh, I thought the only point I missed was the one atop my head.
Thanks for the clarification.
GoPro is teamed up with an extremely large growing company now.
China?
North Korea??
Iran???
No up, no down, no go.
I guess I'll just forget about it.
Here, anyway - just a waste of time.
Hey, Bro, join the club!!
That's 2 of us and counting.
We're the REAL deal.
DYNOMITE!
$20 Monday!!
I'm betting Glaxo wants a clean slate.
IMHHO
lol
Carolyn Myers?
Love your nick - been there, done that!
If GoPro can deliver better there is more of that ahead.
I like it!
Then and soon again.
A hole in the ground!!
Deep enough it gets real hot and free heat! Of course you need to drill the hole.
Sweden does it.
Smart, those Swedes!!
Food and skin products like soaps and lotions contain plastic beads!!
Electric is the power for the future from wind, solar and/or clean fuel like natural gas.
I like plastic to plastic and plastic to resin but not plastic to fuel.
Liquified plastic fuel!!
Eliminate the middle man!
Simple.
It's all in the process.
Right here:
https://www.sciencealert.com/scientists-just-turned-plastic-bottles-and-bags-into-liquid-fuel
http://advances.sciencemag.org/content/2/6/e1501591.full