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2022 lotto on steroids, bio bust GNCA .95:
"Genocea Biosciences’s GEN-009 vaccine trial (NCT03633110) is one of the few Phase 1/2a clinical trials that have shown the best efficacy among the current neoantigen personalization therapies with an estimated completion date of December 2022. The purpose of this study was to evaluate the safety, tolerability, immunogenicity, and antitumor activity of the personalized vaccine GEN-009 for the treatment of patients with solid tumors, which is targeted at a broad range of cancers. The results so far show that 40 doses of the vaccine have been administered, and only a few patients have experienced mild local discomfort caused by the vaccine adjuvant with no dose limited toxicity (DLT) occurred. Ninety-nine percent of the peptides selected for the vaccine produce an immune response, and so far, no patients who have received the vaccine have relapsed (73, 89)."
https://www.frontiersin.org/articles/10.3389/fimmu.2021.672356/full
GNCA .95 cent bet, mentioned in that summary?
"Genocea Biosciences’s GEN-009 vaccine trial (NCT03633110) is one of the few Phase 1/2a clinical trials that have shown the best efficacy among the current neoantigen personalization therapies with an estimated completion date of December 2022. The purpose of this study was to evaluate the safety, tolerability, immunogenicity, and antitumor activity of the personalized vaccine GEN-009 for the treatment of patients with solid tumors, which is targeted at a broad range of cancers. The results so far show that 40 doses of the vaccine have been administered, and only a few patients have experienced mild local discomfort caused by the vaccine adjuvant with no dose limited toxicity (DLT) occurred. Ninety-nine percent of the peptides selected for the vaccine produce an immune response, and so far, no patients who have received the vaccine have relapsed (73, 89)."
Further reading of that summary suggests that the largest "complex" effort ever put together in cancer science is quietly under way in this neoantigen field,...............because in my humble opinion, the causal sufficiency and end point accuracy of this strategy has for years been sidelined by the necessity of mining an infinity of new data, but the recent organizing of the skillful taskings "frisking" the elite contributions of...."36 top biotechnology, pharmaceutical, university, and non-profit research teams, consisting of the National Cancer Center (NCC), PICI, Memorial Sloan-Kettering Cancer Center (MSKCC), MD Anderson Cancer Center, and more than 30 other top neoantigen research institutions", may save eons of time). " The consortium aims to establish algorithms and standards for global neoantigen testing, make concerted efforts to predict more precise anticancer targets, and advance research and application of personalized tumor vaccines. TESLA scientists discovered algorithmic models and core parameters that can better predict neoantigens and accurately predicted 75% of validated neoantigen targets and filtered to exclude 98% of invalid neoantigen targets, whose findings were published in cell journals (81)."
Tutorial summary of immunotherapy for cancer:
"As more scientific and clinical data reveal the remarkable effects of neoantigen-based vaccine therapies in a variety of cancer types, there is ample reason to believe that neoantigen-based therapies will be a promising area of cancer immunotherapy."
https://www.frontiersin.org/articles/10.3389/fimmu.2021.672356/full
Best of last year: The top Medical Xpress articles of 2021:
https://medicalxpress.com/news/2021-12-year-medical-xpress-articles.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
Jan. effect list by not me:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=167005361
“We believe all published work deserves at least a minimum of 3 attempted replicates before being discounted,....”
https://www.nature.com/articles/d41586-021-03691-0?utm_source=Nature+Briefing&utm_campaign=9a2f9f8ce0-briefing-dy-20211209&utm_medium=email&utm_term=0_c9dfd39373-9a2f9f8ce0-44970129
AUUD 2.56 pre-market.
Wonder if there is selling pressure after 2021 tax season, unlike 2018 when $3100 Bitcoin price drop forced fed offset losses against capital other gains then, as Bitcoin and other crypto's recently made new highs?.
MRNA: can't see they will provide evidence of relenting (making nice with ABUS) while this larger problem is culminating:
https://www.nature.com/articles/d41586-021-03535-x?utm_source=Nature+Briefing&utm_campaign=98784a2e58-briefing-dy-20211203&utm_medium=email&utm_term=0_c9dfd39373-98784a2e58-44970129
HCDI: Yes, the proof is in the pudding!
HCDI 2.80:
Possible case for HCDI investment before Jan.:
Had previously owned but always followed.
" If the real estate market conditions continue to be characterized by severe shortage of residential inventory, low interest rates and urban flight, we anticipate operating profitably on an annual basis for the foreseeable future."
https://seekingalpha.com/article/4469612-harbor-custom-development-inc-hcdi-ceo-sterling-griffin-on-q3-2021-results-earnings-call
Today they issued this PR:
https://seekingalpha.com/news/3776888-harbor-custom-development-to-buy-997-unit-master-planned-community-in-blaine-washington
This town is 33 miles from expensive Vancouver, and many commute from there to save rent.
I have not seen the place in Washington state, but $14000 average purchase of a unit is quite cheap from almost any stand point! I have followed this company which has toxic stock (dilution seems part of growth plan) , because they have grown from 20 million to 105 million rev by leveraging their stock for debt and operating expenses during their buying sprees, offset by some advantageous flipping. They seem to have maxed out all they could grab at cheap prices, scaring the heck out of shareholders, who do not know when their next dilution could hit. But they are actually masking GIGANTIC unrealized capital gains.
I could be wrong but I have almost all my investments in similar looking stuff without reviewing all of their material detailed data of their specific reasonable cash flow estimates, or net profit
projections. In brief comparing to a 7 million dollar 4% return on a 150 unit development ( I am involved with) diligently kept up to working class people standards who pay just $400-600 for a one to two bedroom apt in outskirts of Georgia, their lates purchase mentioned today seems "stolen".
So far they are still considered a low float stock, but that can end any time stock makes upward progress, advantaging a new stock selling? issuing spree. Yet, long term insiders own 24%, and think it may be eligible as a no brainer for at least a small Jan.effect buy or eventual
buy out premise?
And there is more!:
If this repurchase program last month still holds, it is even closer to being no brainer in long run? If true no dilution fear but they are not liable if they change mind?
The Board of Directors of Harbor Custom Development, Inc. (“Harbor,” “Harbor Custom Homes®,” or the “Company”), (NASDAQ: HCDI; HCDIP; HCDIW, HCDIZ) on November 3, 2021, approved a new stock repurchase program authorizing the repurchase of up to $5 million worth of shares of common stock beginning November 22, 2021, and continuing through May 22, 2022. The amount of the repurchase program represents approximately 17% of the outstanding shares of the Company’s common stock valued at the closing price on November 3, 2021.
“The Board’s decision to authorize a stock repurchase plan demonstrates their confidence in Harbor’s business and growth opportunities we see over the long term,” said Harbor President and CEO, Sterling Griffin.
The Company authorized management to enter into the trading plan with Piper Sandler in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended, to facilitate repurchases of its common stock pursuant to the above-mentioned stock repurchase program (the “Plan”). The Plan allows the Company to execute trades during periods when it would ordinarily not be permitted to do so because it may be in possession of material non-public information because of insider trading laws or self-imposed trading blackout periods. Under the Plan, Piper Sandler has the authority, under the prices, terms, and limitations set forth in the Plan, to execute repurchases of shares of common stock for the Company. All shares of common stock repurchased will be retired and returned to authorized but unissued status.
Serious investment in Parkinson's:
https://endpts.com/watch-out-roche-novartis-inks-1-5b-deal-to-chase-down-prominent-parkinsons-target/
HCDI (2.80): If this repurchase program last month still holds, it is even closer to being no brainer in long run? If true no dilution fear but they are not liable if they change mind?
The Board of Directors of Harbor Custom Development, Inc. (“Harbor,” “Harbor Custom Homes®,” or the “Company”), (NASDAQ: HCDI; HCDIP; HCDIW, HCDIZ) on November 3, 2021, approved a new stock repurchase program authorizing the repurchase of up to $5 million worth of shares of common stock beginning November 22, 2021, and continuing through May 22, 2022. The amount of the repurchase program represents approximately 17% of the outstanding shares of the Company’s common stock valued at the closing price on November 3, 2021.
“The Board’s decision to authorize a stock repurchase plan demonstrates their confidence in Harbor’s business and growth opportunities we see over the long term,” said Harbor President and CEO, Sterling Griffin.
The Company authorized management to enter into the trading plan with Piper Sandler in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended, to facilitate repurchases of its common stock pursuant to the above-mentioned stock repurchase program (the “Plan”). The Plan allows the Company to execute trades during periods when it would ordinarily not be permitted to do so because it may be in possession of material non-public information because of insider trading laws or self-imposed trading blackout periods. Under the Plan, Piper Sandler has the authority, under the prices, terms, and limitations set forth in the Plan, to execute repurchases of shares of common stock for the Company. All shares of common stock repurchased will be retired and returned to authorized but unissued status.
Possible case for HCDI investment before Jan.:
Had previously owned but always followed.
" If the real estate market conditions continue to be characterized by severe shortage of residential inventory, low interest rates and urban flight, we anticipate operating profitably on an annual basis for the foreseeable future."
https://seekingalpha.com/article/4469612-harbor-custom-development-inc-hcdi-ceo-sterling-griffin-on-q3-2021-results-earnings-call
Today they issued this PR:
https://seekingalpha.com/news/3776888-harbor-custom-development-to-buy-997-unit-master-planned-community-in-blaine-washington
This town is 33 miles from expensive Vancouver, and many commute from there to save rent.
I have not seen the place in Washington state, but $14000 average purchase of a unit is quite cheap from almost any stand point! I have followed this company which has toxic stock (dilution seems part of growth plan) , because they have grown from 20 million to 105 million rev by leveraging their stock for debt and operating expenses during their buying sprees, offset by some advantageous flipping. They seem to have maxed out all they could grab at cheap prices, scaring the heck out of shareholders, who do not know when their next dilution could hit. But they are actually masking GIGANTIC unrealized capital gains.
I could be wrong but I have almost all my investments in similar looking stuff without reviewing all of their material detailed data of their specific reasonable cash flow estimates, or net profit
projections. In brief comparing to a 7 million dollar 4% return on a 150 unit development ( I am involved with) diligently kept up to working class people standards who pay just $400-600 for a one to two bedroom apt in outskirts of Georgia, their lates purchase mentioned today seems "stolen".
So far they are still considered a low float stock, but that can end any time stock makes upward progress, advantaging a new stock selling? issuing spree. Yet, long term insiders own 24%, and think it may be eligible as a no brainer for at least a small Jan.effect buy or eventual
buy out premise?
Iron clad 7.12 interest rate U.S. gov't Series ! bond, no city or state taxes:
https://www.treasurydirect.gov/indiv/research/indepth/ibonds/res_ibonds_ibuy.htm
Thanks for your help. Land going on the virtual reality sites for 2 million and pants for some popular dolls 10K, has to lead to monetary destruction later even while base platforms soar.
I have a front row seat to latest scene, as family members connected to the decentralized NFT generative art scene vital to manage the platform are helping minting new event specific NFT tokens, which fund expansion and promotion and lottery envy selection of free tokens for the collectively judged deservant. So far so good for all the believers who have not yet seen prices drop..something all the politicians wanted to expel in 2006 but they only could only play with no downpayment mortgages, which they prayed would lead to a new generation of poverty wipeouts with no tax increases,............. but someone snitched and said all the derivative linked mortgages were embedded with toxicity.
I smell a lot of toxicity in this scene , but have been astonished to see a couple of people who were struggling harness 20 million and give up ever checking grocery prices, so I suspect capture of some glorious brief spans of time would be worrisome to ignore if this game can be tamed fun?
I am not a computer wiz, but never had trouble navigating a site, yet have money in the base and paid higher commission for small part of my deposited funds. Then signed up in PRO to add more with lower rate, but can't get the money sorted out from moving the money from my base to the PRO.........they seem to take unusual precautions in that it is 2 weeks to have access to funds....assume they keep the commission low in Pro by holding the funds to borrow out so they can subsidize the lower commissions. .I will get it all sorted out but ease of getting out of initial glitch of signing into the base instead of PRO, put me into a clumsy maze.
The ETH may be supreme because it has supremacy of use in many platforms,
I treat it all as a "pinky" dart throw but with incremental progress of converting the populace. while the Blockchain dynamic cements its inevitability. Its all a hedge for me against being shocked by Bitcoin becoming worth a million.
I have same problem buying from the pro when funds in the base, and their help site sucks.
"History is just one damn thing after another."
https://www.collaborativefund.com/blog/how-this-all-happened/
Just bought some ETH from Coinbase, but paid 1 1/2% commission, had trouble getting suited up on their Coinbase Pro where commission is less than 1/2 of a percent.......... Anyone know in Plain English how to join the PRO class asd hear it is an easy jump once I format my input correctly, which I failed to do for some reason.
OCUP now 4.70 sold 1/2 5.75 need 6 for even.
AUUD 1.86 LOD yesterday today back up to 2.16 , think it is just tax loss and ilk attacks, and poradic recovery.
AUUD even $2, joins pack of tax selling varmints all under new transactional tax loss bombardments till end of Dec.
With more deaths from hasty approved Biogen's Alzheimer drug, the revelation of a new clue seems like a perfect starting point to mix old strategies with new areas of discovery at this point in time, especially if this pathway gets to go to clinical trials and can prove transformative?
Today's concerning news:
https://thehill.com/policy/healthcare/581024-biogen-investigating-death-of-patient-taking-alzheimers-drug
New approach provides potential vaccine and treatment for Alzheimer's (medicalxpress.com)
https://medicalxpress.com/news/2021-11-approach-potential-vaccine-treatment-alzheimer.html
AUUD 2.34 with vol. , maybe line in the sand types yielding and pressing bottom button?
GRNQ 1 bought and sold at 1.07 as see the cyrpto ilk decline today is affecting all the needed mania necessary for rapid automatic twitchings up..
MESO price held up for most of yesterday but today down about 10% to almost where it started before the reproduced earlier PR designed to just skirt, the law suggesting breakthrough success.
AUUD 2.26 from the 2.80 high yesterday, now hgeming down and applying for Jan effect loss offset selling to be a great Jan. hol also closer to their campaign issues to out more product.
AUUD 2.28 nice gem down.
Just by the people I know, I am not convinced of an effective treatment for the wet version, and am sort of confused by how effective this new remedy is for maculardegeneration?
Thanks, knew there was a "saloogi" in their PR in some way.
EYPT:Largest winner this morning:
https://seekingalpha.com/news/3770391-eyepoint-pharma-reports-positive-eyp-1901-data-for-treatment-of-wet-amd
What does rescue free mean in this context?
"• 76% and 53% of patients were rescue-free up to four and six months, respectively, following a single injection of EYP-1901."
MESO 6.85 insignifiant reaction to such an unmet illness?
MESO $6.85, I assume this PR is misleading based on small reaction to stock price?
https://ca.finance.yahoo.com/news/breaking-presentation-american-heart-association-001300533.html
HRBR read the 10K.
HCDI 1.67 in Oct, now 2.13, net losses are result of overleverage borrowing but this Co. can soar when all investments ripen, I still ahve not bought as waiting for real proof.
50 markets housing declined:
https://www.gobankingrates.com/investing/real-estate/housing-markets-that-are-turning-ugly/
METFORMIN: Just thinking, considering what it could do for high blood sugar reduction and now perhaps aiding your immunity system to fight cancer, wonder if it would just be more generally prescribed in the same way they were recommending taking aspirin, as a preventative for heart disease for eons, till recently?
https://medicalxpress.com/news/2021-11-reveals-metformin-dependent-antitumor-immunityhtml?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
New wave of protein based Covid vaccines coming.
https://www.nature.com/articles/d41586-021-03025-0?utm_source= Nature+Briefing&utm_campaign=9c614facc2-