Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
CD10 is still currently under review by the FDA for EUA approval. With the strong positive results the trial has shown it is expected to gain approval. This could happen at any moment now, and after approval OWS will be involved for production and distribution. In the meantime CytoDyn is meeting with the UK to discuss a path to bring Leronlimab to market.
So are you trying to say the UK is also stocking Leronlimab in their hospitals??!!! Or is it only the Philippines?
The meeting Wednesday with MHRA will be a game changer. Not only did MHRA request the meeting with CytoDyn they also want to discuss eIND patients. The absolutely incredible results from CD10 combined with eIND patients will earn an approval.
The outstanding success that the Mayo Clinic reported with hospitalized patients is what started making me confident that trial results would be great. And then the UK study that found that GM-CSF is the cytokine responsible for severe Covid and death made it a sure thing. This is why I am an excited about the 60 day data. Lenzilumab's mechanism of action has been confirmed repeatedly over the last couple of months. The mortality benefit was 13.9% to 9.6% at 28 days. But lenz's trial treats people as they are first entering the severe phase. So there will be many deaths in days 29-60. It won't be surprising at all if lenz's mortality benefit increases to the point of stat sig at 60 days.
ass slaps
Leronlimab it’s for any stage
This weekend's homework for Shorts. Lenzilumab is a GM-CSF inhibitor.
Covid
https://www.bbc.com/news/health-56352128
https://immunology.sciencemag.org/content/6/57/eabg9873
https://directorsblog.nih.gov/2021/04/13/mapping-severe-covid-19-in-the-lungs-at-single-cell-resolution/
https://www.nature.com/articles/s41586-021-03569-1
https://www.pharmaceutical-technology.com/news/humanigen-lenzilumab-improves-survival/
CAR-T
https://www.nature.com/articles/s41408-021-00459-7
https://www.nature.com/articles/s41421-021-00255-4
https://www.targetedonc.com/view/lenzilumab-plus-axi-cel-achieves-responses-in-100-of-patients-with-dlbcl-with-limited-toxicity-in-small-study
https://www.healio.com/news/hematology-oncology/20210422/lenzilumab-before-cart-induces-high-response-rates-without-severe-toxicities
Estrada’s cure for COVID-19 pushed, probed
https://manilastandard.net/news/national/353251/estrada-s-cure-for-covid-19-pushed-probed.html
Remdeathisnear got the nod because it was trending toward stat significance never actually reached it but was trending toward
How is Remdeathisnear and Convoluted plasma doing in the S2C Arena
Yes 166% improvement over SOC on NEWS2 scores, meaning the patients did not progress to the next stage
Covid stocks are down today. Biotech is down today. Nasdaq is down today. HGEN is up. It feels nice not having HGEN's stock price brought down any longer by sector wide effects.
HGEN is now unstoppable!
He seemed very assured that a DEU or their version of a EUA would take place
This is 100% wrong , I believe that Dr Nicolas even introduced CYDY to Chiral
Dr Nicolas said , he has no financial benefit from leronlimab , not in any way.
What other drug will save 1 out of 4 patients that are S2C
Leronlimab prevented moderate to become very severe..in over 80% of the patients
More people survived in the Leronlimab arm
"Clinical Signifance" for the Primary Endpoint
We see it working, people are being saved. Nothing changes that fact.
By the way I thought we were headed to 1.50
hyperbolic is the perfect word to describe leronlimab: "of, relating to, or marked by language that exaggerates or overstates the truth"
So if your loved one is dying won’t you turn over heaven and earth to find the money to pay for a treatment that will cure them?
The Philippines government is not paying for leronlimab. So there are 2 scenarios:
1. People pay out of pocket. Few Filipinos will pay out-of-pocket. So essentially zero sales
2. CytoDyn continues to give it away for free. CytoDyn has 1.2 million vials stockpiled and no EUAs on the horizon. Might as well give it away.
Dr. Nicolas stated that many more than 28 patients have now received LL Injections!
They fear if there is a Trial in the Philippines it will be a honest trial.
A molecular single-cell lung atlas of lethal COVID-19
https://www.nature.com/articles/s41586-021-03569-1
Integrated analyses revealed significant alterations in cellular composition, transcriptional cell states, and cell-to-cell interactions, providing insights into the biology of lethal COVID-19. COVID-19 lungs were highly inflamed with dense infiltration of aberrantly activated monocyte-derived macrophages and alveolar macrophages, but demonstrated impaired T cell responses. Monocyte/macrophage-derived IL-1ß and epithelial cell-derived IL-6 were unique features of SARS-CoV-2 infection compared to other viral and bacterial causes of pneumonia.
the FDA certainly has political motivations but I don’t understand why they would get involved with the Philippines.
Fantastic. Do a deep dive on Gaylis next? TIA.
Do a deep dive on Gaylis next?
Sincerely Elmer Fud
This is 100% wrong , I believe that Dr Nicolas even introduced CYDY to Chiral
Dr Nicolas said , he has no financial benefit from leronlimab , not in any way.
We can safely add statistics to the growing list of topics you don't understand.
The half-life of the drug is 10 days. That is most definitely *not* a “theory.” It’s science.
Amazing how patients die when you stop giving them medicine
The trials were poorly designed because CYDY's management is incompetent. The drug works but Nader and Kelly are terrible managers.
Also, my children knew the difference between "there", "they're", and "their" when they were in elementary school. If you want to be taken seriously, I'd suggest you learn the difference.
They have a wonder drug that's better than anything else for COVID
Shorts can run but they can't hide. Their day of reckoning will come shortly.
https://www.bbc.com/news/health-56352128
https://www.targetedonc.com/view/lenzilumab-plus-axi-cel-achieves-responses-in-100-of-patients-with-dlbcl-with-limited-toxicity-in-small-study
HGEN has $240 million in their war chest to ramp up production. They also have CRADA and BARDA assistance with production because of Operation Warp Speed.
Durrant has consistently said that 100,000 patients can be treated in 2021. But many are theorizing that the amount of production will be much higher because of the resources being dedicated to the job.
Durrant has consistently given conservative estimates on everything. That is why he meets every promise and timeline without execption. He is the anti-Nader.
Jock of all trades
They need a trial to prove one way or the other.