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Rest in Peace Dr. Thorpe. Had the honor of meeting you and enjoyed your presentations. Have a feeling you are going to be a big part of medical history.
PPHMownsME thanks for clarification, it makes me feel much better. Lets hope FDA is open to the idea of looking at Bavi as a breakthrough designation drug for multiple cancer indications based on the current data and not just lung cancer.
Novartis just got the breakthrough designation that we should have gotten for NSCLC with approval predicted in 2014. Any thoughts?
Cj is this calculation based on investigators just calling PPHM from around the world reporting the death of the patients as they happen or PPHM collecting and cleaning and then reporting the MOS. I don't think anybody here considers the time it takes to collect and clean the data. I don't think PPHM is obligated by SEC to report MOS based on phone conversations. May be I am missing something here.
It will be a phase IIb/IIIa like somebody else said earlier which I believe is good enough for registration.
PPhmtoolong, thanks for your response. So I guess a phone call from an investigator in Ukraine to PPHM telling them that a certain patient has passed away will do. I like that.
Does anybody here has clout with the IR to ask them if certain data points need to be collected and verified (death certificate, cause of death verification) from the sites (ie. Ukraine) in order to report the MOS. Have a feeling Pancreas MOS was reached a while back.
Thank you all for your input. EOM
Could you please address it for the 101 time
Lets hope that is not the reason for not reporting yet. Only time will tell. We are due for a break.
Thanks Wook. I wonder if the terms of reporting is specified in the 1st line and pancreas protocols.
QUESTION is, is it possible that the MOS was reached lets say 2 months ago and they did not report it because they have to collect all the data from the international sites, review them, clean them and analyze and report them. Or as A pre defined number of patients die, they can report the time to event and then start processing all the data. The difference between the two senarios could easily be a couple of months.
MOS trackers, is it possible that the MOS for the two studies were reached a while back but they cannot report it until they review and clean all the data and officially close all the sites?
pistol1p, it means a little company that is confident to make it big
IF THE DRUG WORKS, a big BP will buy in the company and will basically take over in the background and based on the stage that PPHM is (little start up/mkt cap) will support a small satellite (hey loof) for a while and then completely take over. Hopefully with a good share price for us. Happy New Year All
Biopharm, I have worked for Genentech. ISIS, IDEC/BiogenEdec, Amylin and I have a good Gut feeling that of course could be wrong since I am down in 6 figures :)
Sorry for all the spelling mistakes. It is friday and I am partying. Go PPHM.
Biopharm, You saw the light. IDEC only recieved a small percent royalty on Rituxan and went ove 20 hundred a couple of time and spit the "right" direction and it split a couple of times and that is why I retired at age 45 six years ago.
Once a major partner comes along PPHM will be like
Roche for Genentech ( TPA for heart attack)
Genentech for IDEC (Rituxan)
Eli Lilly for Amylin (once a week diabetes injection)
Basically they will run the show
Once a major partner comes along, they will take control of all the trial activities such as enrollong sites and patients and monitoring the clinical data, processing all the data from the trials and analyzing the data. They basically will preform all the activities that the CRO and contractors have been doing for PPHM. PPHM will be providing the drug and will have some managers involvement at a higher levels.
Right on..... loofman........ party on
Great Post RRdog. EOM
Dawginlife, very good post. The key is that very sick patients are still alive. And hopefully more survival data will be reproted from the other phase II trials confirming the science.
Cloaked, very good post eom
Loofman, there are patients today that are still living when they should have been gone months ago. Also, there are ongoing trials going on in different cancers. I suppose that is the faith that I am talking about. Fot now, I am just going to catch a buzz and try to forget today happened :) down 300K
Loofman this is ku from the dead. This is the pain us 10+ years shareholders where talking about. keep the faith. watch the world news and you will feel a little beter. dont give up yet if you believe in the science
Been in it for 12 years. Had 100k shares before split. Went through all the pain and anxiety for being down couple hundred thousand dolors and currently will not be happy with $20 a share
Freethemice, I will behave on the spaceship as long as I can bring my personal jug of Tequila. I am sure Loofman will be Ok with that since he already welcomed me back from the dead
Loofman, we are old timer share holders that felt the pain, kept the faith as far as the science and patinets and the pocket book goes, stayed on the sidelines appreciating the comment of the knowledgeable ones on this board and now feel that it is going to pay off
Kapitt, been here since 2000..... went through everything you did. Totally understand what you saying and I feel deep inside that we are not going to be disappointed. Right on buddy
Thanks for the clarification EOM
Wasn't the control arms MOS less than 6 months. What am I missing here ?
Reverse Split Question ? Thank you all for your informative posts. I have been investing in PPHM for the last 12 years and had 100000 shares before the revrse split. Then added to my 20000 to make it 50000. Can anybody tell me when is the deadline before being taken off the nasdaq and what are the chances of us having to go through another RS before good things start happening. I don't think I can handle another RS. Any information that anybody can give me regarding the RS will greatly be appreciated. All the best to the PPHM longs.
Reverse Split Question ? Thank you all for your informative posts. I have been investing in PPHM for the last 12 years and had 100000 shares before the revrse split. Then added to my 20000 to make it 50000. Can anybody tell me when is the deadline before being taken off the nasdaq and what are the chances of us having to go through another RS before good things start happening. I don't think I can handle another RS. Any information that anybody can give me regarding the RS will greatly be appreciated. All the best to the PPHM longs.
Dia, I hope you are right. King is a scientist that has been working for 13 years under the same BOD that I am complaining about. I just hope that he is not just a puppet. He always came across as a mellow/nice to everybody kind of the guy in the 5 shareholder meetings that I attended. Again, I am on pphm's side and I hope that the new qulaified management team is running the company now.
In Pharmaceutical and Biotech industries it takes many years and many hundreds of millons of dollars to bring a drug from a test tube to the patients. Therefore, the risks are much higher than the computer industry where there are no human lives and safety at stake. Because of that the financial industry would like to see people that know the ins and outs of the drug development on the BOD rather than a couple of lawyers and investment bankers. Keep in mind that the big decisions comes down from the BOD to the management team and not the other way around. Although, I hope the later is true in PPHM's case.
Lets see a high caliber, industry connected Chairman of the Board and then the financial industry's respect will follow.
nh, no need to appologize, we all want this company to succeed. I appreciate your class though.
I have been following and investing in PPHM for 10 years now. I strongly believe in the science and the scientists behind it. What has been driving me crazy and frustrated is the BOD. I have been to 5 shareholders meetings and saw them just sitting up there looking pretty and try to evade all the questions from the shareholders. Now they don't even take questions during the meeting and want to take them during the little chit chat sessions after the meeting. I, just like you hope that the addition of Dr. Garnick will change things. High caliber individuals like Dr. Thorpe and Garnick with no need for money have so much patience with unexperienced BOD and it would be a shame to lose them. Lets see how long it will take to fill the open position on the Board. That would tell us where this company is going.
I worked for Genentech from 1987 to 1996 and don't recall interacting with Dr Garnick. However, in order to be in that level at a company like Genentech, you had to know what you are doing and be the best at it. I hope he can talk the company into giving a little piece of the pie away to get industry recognition. A little piece could mean just a little license to a big pharma for one of the oncology or viral indications in a small part of the world. You will be surprised what publicity and increase in share price and value that will bring. But as I have mentioned before the current BOD is either too greedy or stupid to make it happen.