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How to write a compelling headline andPR:
Pretend you are ghost writing for a busy reporter and/or an editor who will just print your story verbatim- it's got to "feel" like a 3rd party, independent look at the situation, e.g. read a NYT or WSJ story. Step back and write a compelling, not confusing story. No self-promoting or self-aggrandizing statements. Pick the most important point of the story. Write it out slightly differently, "louder" if you will- that's the headline. Then take out every other word, then take out every little or joining word: "the", "of" "and" "or" "but" "it" "with" "for" . Short Bold All Caps Primary headline, Longer detailed italic secondary.
DO NOT CLUTTER THE FIRST LINE OF THE PRESS RELEASE WITH DATA
e.g.
U.K. MHRA ACCEPTS LERONLIMAB PHASE 3 COVID-19 TREATMENT TRIAL
U.S. Phase 2 Mild-to-Moderate Patients Trial Successfully Completed, Strong Efficacy and Safety Data Sent to FDA; U.S. Phase 3 Severe-to- Critical Trial Patients Underway
(August 21, 2020) CytoDyn Inc. announced today the U.K. Medicines and Healthcare Products Regulatory Agency (MHRA) authorized enrollment for a Phase 3 COVID-19 trial to treat “Severe-to-Critical” patients with their monoclonal antibody drug, Leronlimab. The company recently completed Phase 2 trials on 84 patients, with data and Emergency Use Authorization request sent to the US FDA based on strong efficacy and safety data for “Mild-to-Moderate” patients.
“We are very pleased with the MHRA’s confidence in Leronlimab. Enrollment of patients in our CD12 Phase 3 protocol for patients in dire circumstances begins immediately." said Nader Pourhassen, Cytodyns's CEO/President. "We also requested “fast track approval” from the MHRA for our completed Phase 2 COVID-19 trial for mild-to-moderate patients. "
The MHRA approval is based on CytoDyn’s submitted COVID-19 efficacy data, manufacturing processes and safety profile for this late stage developmental HIV drug. Leronlimab HIV clinical trials include over 850 patients with no drug related serious adverse effects and is expected to launch early in 2021 for this use. Launch as a COVID treatment could come much sooner.
Leading research physicians and virologists postulate the mechanism of action of the novel drug as a CCR5 antagonist. Speculation on viral mechanisms lead scientists working with Leronlimab to suggest it as a COVID treatment, one that could reduce the "cytokine storm" causing multiple organ damage. This compelling science convinced ICU doctors to treat over 65 patients at leading hospitals, including many on ventilators. Excellent results from this "Compassionate Use" lead to these very promising multi-national double-blind clinical trials for COVID-19 treatment.
About Cyto...
About Leron...
PS. IMHO
Hope: I need your guidance. I have $350k I want to put into CYDY and need to know when I should invest. It seems like it goes up and down A LOT and I don't want to loose my shirt. Should I go short or long?
Mtg: My read
>Resolutions both passed - 100M - 65% ; Adjourn Spec Mtg- 67%
>Nice letter from shareholder read- "keep up the good work, don't get tired."
> Amorphous NP ramble about past dilution and comparative enrollment in clinicals.
>Yada Yada on limiting dilution - only diluted 15M shares in 2020 so far. (with SP up 20x in 6 months - frankly who gives a sh8t about 15% dilution)
>NP: Hoopin & hollerin about good sh*t happening.
Kelly: Good stuff happening, crisp clean and to me incomprehensible biochem mechanism discussion
> Mulholan: We are well into week 2 of what usually is a 6 week uplist process. All rocking along. Next move is NASDQ nit-pick letter he expects to get next week... prepared to turn that around fast.
>Kelly: read out Science Advisory Board and some CV's. Impressive gang.
>NP: More about how the M2M P2 safety data is super positive. (If you don't get that think this: With Pro-140 you had lots less AE & SAE, thus you are better off. ) Efficacy data coming, but to me this looks damn good.
>Lots of tech difficulty. This is Comptershare issue- I guess they have to have secure voting capability so had to use that wonky software.
Please hire a copywriter. Perhaps one with some experience in writing about science. Just a thought.
Previous unknown unknown. Future known. Next week?
clay- stop spamming
Misiu: Good to hear from you! your guidance over the years has been helpful to staying the course for me.
Bill Gates Ted Talk from June 29 . Starting at minute 7:30 states to the effect...
"The list of things being tried including, eventually, monoclonal antibodies.." ... " We'll have some additional tools for this fall." "The good news is we have some innovation we should start to have mono-clonal antibodies this fall" "The single therapeutic I am most excited about monoclonal antibodies"
https://www.ted.com/talks/bill_gates_how_the_pandemic_will_shape_the_near_future#t-484693
DonDon: FYI "GBHT (?) - going on" is
Graft Versus Host Disease - GVHD. I invested 5 years ago in CYDY for the HIV indication. I invested further when I learned there was a potential to treat GVHD as a dear friend needed a bone marrow transplant and GVHD is a known complication. He had the transplant, and was impacted by GVHD. He passed last October before we could get him into a Leronlimab trial.
Learn more: https://www.lls.org/treatment/types-of-treatment/stem-cell-transplantation/graft-versus-host-disease
Reminder of Leronlimab's FDA Clinical Trials Interim Data "un-blinding":
COVID Mild to Medium Patients
https://clinicaltrials.gov/ct2/show/NCT04343651
COVID Severe or Critical Patients:
https://clinicaltrials.gov/ct2/show/NCT04347239
Another month we pray we see CYDY's Leronlimab treating 100,000+ patients and this thing being effectively over.
PS. Wear a d*mn mask all the time. Keep your bubble limited. Happy 4th to all!
Humble Howard: GREAT FIND! Thx
Here's the link
http://ft.floatinghomes.org/yellow-ferry-resident-takes-on-covid-19/
Humble Howard: Here's the link
http://ft.floatinghomes.org/yellow-ferry-resident-takes-on-covid-19/
Nice entry price action today- thanks shorts!
See you at the Hilton
Stud: I feel your pain. Only 5% - WTF! hahahahahaha
Close above $4. I bot 100k shares at 40 cents last September. Feeling pretty good today. Especially as they came with 50k warrants. Nice job longs on keeping it above $4. I think we will go white water rafting this week. Just to match how fun and exciting this week will be in the CYDY market. Great outfitter about 45 minutes east of the Vancouver Hilton Hotel if anyone wants to go with on afternoon of July 22. https://www.zooraft.com/
I hope $4 for today, but certainly by July 1!
$ 4 T a r g e t
Dear Clam: Best Technical Guide Ever! Applies to CYDY and every other stock. Particularity, however, I need more guidance on ruler versus any old straight edge. I advocate use an envelope which is helpful for "back of the" calculations as well. But, I am open to how other straight edges apply to CYDY as I have filled the back of 158 envelopes with 5 years of stock movement trigger points. I will have an envelop pinned to my shirt July 22 and a Timbers face mask. See ya all there.
Ya Clinto! Qualified Investors were offered the deal $0.40/Unit of 1 share & 1/2 warrant excersizable at $0.40 - an effective price of $0.26 last September. Just saying it again. Cioulda shoulda woulda. And that was before with only one cancer pt. being treated.
Pro140 off to the races! FDA expanded clinical clearance, $15M funding- way cool conversion is at $4.50...likely today's target price?
Next we need to see a joint PR from Samsung Biological they have started manufacturing bulk.
Action you can do today: We need a $100M emergency guarantee from Department of Health & Human Services to get full bore manufacturing started NOW. Unlike big Pharma, we do not have 1 million doses sitting around. We will know in 10-15 days if this works. Contact your Republican Senators & House Reps to push this up the political power chain.
I like this old saying as we proceed on our individual journeys for a day on this amazing and universal human experience:
Godspeed, my friends, Godspeed.
I bet Samsung Biologist has started production. It would be insane not have the first, if not 10th batch going.
The 30,000 doses of Leronlimab Cytodyne in stock are going to go very fast.
Not as fast as the stock is gonna go Monday.
NY Post!
https://nypost.com/2020/03/28/coronavirus-patients-taken-off-ventilators-after-getting-experimental-hiv-drug/
Not sure if someone else posted, but I am super stoked now. National TV tonight folks. look for it.
As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been confirmed in 125 048 people worldwide, carrying a mortality of approximately 3·7%,1 compared with a mortality rate of less than 1% from influenza. There is an urgent need for effective treatment. Current focus has been on the development of novel therapeutics, including antivirals and vaccines. Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome. We recommend identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext
Today is the day. UK Daily Mail has 1.1 M circulation in print form. #3 newspaper in UK. This will get picked up by network TV very fast.
A new glimmer of hope besides an old toxic malaria drug and a anti-viral with side effects. That's a huge story of hope in today.
Just hope POTUS does mangle Leronlimab when he tries to pronounce it.
Monday? I'd like to take poll: What will CYDY open at Monday?
Today may be the day.
thx z421- nice video!
ALL: Let's see more positive and uplifting contributions here folks. The world is hard enough today.
Grateful to be healthy and making functional and compassionate contributions to my community. One by staying home, two by having work providing PPE to the angels on the frontline and three providing hope to family, friends and pro/trade colleagues that a tiny, local biotech a drug BEING TESTED ON COVID with FDA blessing.
I just went back to an original source of DD on CYDY that got me stoked in the first place: https://aidsinfo.nih.gov/drugs/423/leronlimab/0/patient
Leronlimab
Other Names: PA14, PRO-140
Back to the grind. Stay Home. Be safe. Hold tight on CYDY- its speculative bet, always has been.
haha. cool. when was it?
Do we know when the COVID-19 patients were injected?
Antiviral drugs that had held promise as a potential treatment for the coronavirus did not work in one of the first major studies in seriously ill patients, researchers from China reported on Wednesday.
“No benefit was observed,” the researchers wrote in The New England Journal of Medicine.
The study tested Kaletra, a combination of two antiviral medicines, lopinavir and ritonavir, that are normally used to treat H.I.V.
- NYT 3/18/20 https://www.nytimes.com/2020/03/18/health/coronavirus-antiviral-drugs-fail.html
Q: Does anyone know why Gilead Sciences passed on buying Cytodyn ?
A: Yes.
Ive been buying Everclear. Makes a decent hand sanitizer, too.
thx ohm
Jeef- Look closer its not CTC, its CTM (I think) - a different measure as that patient reporting was early in his/her treatment. I cant find the doc right now... but I remember it was a different metric and I remember at the time that # being "off" till i re-read report. Still bothers me that that was even in there as data reported with no context of comparison and the likelihood for confusion.
STAY HOME & STAY 6 FEET AWAY: COVID-19 IS KILLING PEOPLE.
It is your patriotic duty as US citizens to STAY THE F--- HOME!!!
STOP TRANSMISSION OF THIS THING.
CYDY will do great things this year. I hope they get approval to help those with COVID-19 respiratory issues ASAP. But today:
STAY HOME and STAY 6 FEET AWAY
Confirmed coronavirus cases in the United States have climbed to more than 2,100, even with sparse testing, and the death toll has risen to at least 48. Only West Virginia and Montana had yet to report a known case of the virus by Friday evening. The United States is facing the prospect that those numbers could grow exponentially, as they did in China, Italy, South Korea and other countries. - 9pm EST /NYT
Yesterday that number was 1300.
STAY HOME TONIGHT and stop spreading this thing.
PS- Thanks to LongPenny on other site:
CYDY News is starting to spread...
https://ovariancancernewstoday.com/2020/03/13...d-cancers/
https://www.breast-cancers.com/2020/03/12/cyt...y-patient/
Great conservative investment: Warren Buffet is having a sale over at his place- Only $181.50/share. His company is worth $245B and 1/2 is in cash ($123B) ready to deploy as this disaster unfolds. He's just waiting to pick up BAC at $2.50 again.
CYDY is not conservative. High risk/reward. Welcome to a high risk week.
Loaded up at 0.86.
FDA will approve CV IND in middle of this unfolding crisis.
Weekly cancer results
BLA about to be filed.
Patience grasshoppers. Focus on Patients.
https://www.cytodyn.com/newsroom/press-releases/detail/393/cytodyns-first-mtnbc-patient-in-phase-1b2-is-in
Great day to buy more! CYDY on sale for only $0.93- screaming bargain!
Also: Hope you bot SPXS. Up 35% in 2 days to hedge a bit.