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Most shares already bought and being held..hence the volume.
Progress = All the INFORMATION one needs. :)
Management? No one else could have put together a more powerhouse consortium than KW did.
Patience
Go KW!!!
Go Team PharmaCyte!!!
I believe we’re all sure the funding, regardless of where it will come from, is already available. But contingent upon the final work being successfully completed and the IND getting blessed.
Patience
Go Team PharmaCyte!!!
I wouldn't be concerned about him or the media outlets until the work and submission is a go.
And besides, it's kind of odd that he hasn't even been mentioned throughout the recent media hoopla surrounding the interviews. After all, the interviews are about "the story", right? I mean, wasn't "he" suppose to be the one that would reach out to everyone with our story?
Meh!...oh well. We'll learn soon enough.
Patience
Go Team PharmaCyte!!!
Yeah, not a penny more! lol
I totally agree :) :) :)
Why change your thinking?
Like most, you’re probably more aggravated than you are disappointed.
Look, take any block of time, whether in weeks, months, or years since the consortium was put to work on this project and you have have the same results toward having a working therapy.
Progress.
So, until they fail it’s STILL work in progress.
Sure, we can stack up negative comments all day long, but why?!!!
We’re there.
All we’ve gotta do is successfully finish this last bit of work and submit.
Keep the faith. :) :) :)
Patience
Go Team PharmaCyte!!!
Still seeing nothing posted proving KW as criminal.
Quit wasting your time. You’ll NEVER find anything.
KW is only guilty of being hard working and hell bent on getting CiaB PC therapy to market.
Unfortunately for you, you’ll never be able to post evidentiary proof of that.
Even if he was, that’s not a problem as far as I’m concerned ....it’s business.
Seriously, do you REALLY see a problem with that?
I’ve wondered a couple of times already why the CypCap’s are seen in different colors.
Has an explanation or answer ever been posted?
RC the Certificate of Analysis will come from an outside lab (not the FDA) where the cells will be tested.
It would be the end of the final chapter.
Then we sit and wait. :)
Certificate of Analysis :)
So, according to Gunzburg, if all goes well with the final work and the cells are within the FDA safety specs after thawing, the COA would be in order.
My guess is that the COA would literally be the final piece. It would complete the application. And if so, then I would also venture to guess that upon receiving the COA we’ll have our “next PR”.
And if we are fortunate enough to get that PR, then I believe it will ABSOLUTELY be the turning point of our share price as KW would finally announce the application as being complete and submitted to the FDA. :) :) :)
...Patience
Go Team PharmaCyte!!!
Yes, I believe it will, but ”ONLY””with success in Bangkok and the FDA’s blessing “”FIRST””
Patience
Go Team PharmaCyte!!!
Let’s just keep pushing forward.
After all, we have an amazing team!
I wish us all the very very very best of luck.
Patience
Go Team PharmaCyte!!!
Yes, which KW previously referred to in part as contact inhibition.
Well, KW said that work has been going on for six weeks now, but it’s anybody’s guess as to what has and has not been started.
RC, other than the growth rate data that’s required by the FDA, I’m not sure.
Perhaps Wolfy or 1234 can explain it.
But if I was to guess, maybe the FDA needs to know that the efficacy of our manufacturing process is consistent.
Maybe they need to know that the CypCaps are 100% producible....or patient ready, regardless of which disease and therapy.
I’m just not quiet sure, sorry. :)
Patience
Go Team PharmaCyte!!!
Minutes before and after the 4:50 time mark I’ve been replaying KW’s every word, over and over.
What I hear confirms my concern regarding cell growth BEFORE encapsulation.
He clearly only mentions post-encapsulation improvement.
All statements, or words, ONLY DESCRIBES a “great anticipation” of improvement to cell growth BEFORE encapsulation as they continue working.
Behind his smile and high spirits a problem is evident. And that’s definitely my honest opinion.
All we can hope for is a positive outcome, and that the team’s work ends successfully.
I believe we’re very close, but we’re certainly not out of the woods yet.
Patience
Go Team PharmaCyte!!!
If’s and guesses are all we have.
Let’s just continue to hope they achieve their goals in this final process, and that they have a successful submission.
I appreciate your response. :)
Patience
Go Team PharmaCyte!!!
Not really, I’ve been here in total nearly 5 years. And I’ve always excepted what ever communication I could get.
I just got pissed because he gave one result, but not the other....hell, they were of the same issue, not separate matters.
Oh well.
We can only hope so. :)
Already did...still no response.
No, I wasn’t reading between the lines. What I brought up is in plain sight. And it just got me aggravated.
We had Gilliken literally saying it’s imperative we show a consistent reproducible and robust process so that we have a SUCCESSFUL submission.
We knew the specific changes were made to improve the cell growth because KW gave us the good results of the growth improvement “after” encapsulation.
And that was great, but what happened “before”? I wanted to know if there was any improvement there too.
Not being given those results is a little concerning to me.
In fact, if we heeded Gilliken’s “expert” guidance that improving the cell growth, BOTH before and after, is of immense importance to having a SUCCESSFUL submission, then I think we should have all been somewhat concerned about those missing results.
It is possible there was no improvement “before” encapsulation, and they just moved forward with what they were only able to culture....totally possible.
Regardless, I balked at the information not being provided because, for me, being this close to completion, its as though every potential problem now becomes magnified 10x. That’s my knee jerk reaction.
But I’m sure you have your reasoning as to why those results weren’t given, and I’ll disagree. So, let’s just agree to disagree with each other’s argument. :)
Nevertheless, it goes without saying, we only have that ONE shot. And like everyone else, I just want them to stay on track. :)
Patience
Go Team PharmaCyte!!!
I realize a lot of that, but it doesn’t change the fact that KW gives us the results of improvement for AFTER, but mentions nothing about improvements BEFORE
Wow 1234, you’ve been speculating on what’s already been achieved “without” having any evidence, but now “with” evidence of missing information you have nothing to say?
Doesn’t answer the question esusan :)
If you trust cGMP Validation then those “improved” results are important and needed in the submission.
Right or wrong?
Come on, seriously...what about you 1234...why do you think those results weren’t mentioned?
So what if a video is being made. It’s only natural to record the work in the event they are successful.
The damn video crew means nothing for the time being.
So, am I the only one that noticed nothing was said about cell growth improving before encapsulation after the process changes were implemented prior to Bangkok?
Or is that result information not relevant?
Gee, I don’t know, I was just thinking that since c F’n GMP Validation mapped out a more successful submission, that someone might have something to say about it.
Maybe it just doesn’t matter. I don’t know, I’m not the expert.
Maybe we should just keep speculating about what is and isn’t done, and keep singing Kumbaya because the horse looks better behind the cart.
Geeze!
Yeah, I believe you should catch up on the PR’s. And perhaps you may want to read up on the FDA requirements. Here are the links.
https://www.fda.gov/home
https://pharmacyte.com/
The FDA doesn't care about "most efficient". Profit margins in manufacturing is of no concern to them...””
Nope....that’s not what I’m referring to. But don’t worry, everyone else knows, and understands the need to maximize growth results.
Patience
I “think” someone previously posted they wondered if cGMP Validation would be in Bangkok as well.
I guess I’d like to know too. Simply because we haven’t heard anything about/from them since the May 6 PR.
Anyhow, I’m curious as to why KW reported that the “changes” implemented improved the cell growth “after” encapsulation, but then said nothing about how those changes affected growth “before” encapsulation.
Remember, both needed improvement per cGMP Val.
Is it possible that they were only successful with optimization in cell growth after encapsulation, and not before?
Maybe it’s not so important after all.
I would think so, but I’m not an expert. :)
Could KW have heard and taken “new advice about growth” before and after encapsulation?
Maybe not, but I’d still like to know whether or not growth was improved before encapsulation.
From PR, and before Bangkok...
On the advice of PharmaCyte’s cGMP expert, the company plans to conduct two additional and staggered manufacturing runs IN ORDER TO MAXIMIZE THE CHANCES FOR A SUCCESSFUL IND SUBMISSION given the novelty and complexity of the entire process. In the time since the last manufacturing run, which we reported on in January of this year, those involved with the manufacturing process have been concentrating on CHANGES that can be made to improve the process. WE BELIEVE that these changes WILL IMPROVE the cGMP manufacturing process to the point that the entire process can be shown TO BE CONSISTENTLY REPRODUCIBLE AND ROBUST AS REQUIRED by the FDA, and to ensure that the end-products of these manufacturing runs will convert the cancer prodrug ifosfamide into its cancer-killing form as well as they should.
This intensive effort...
(making the necessary changes)
...has involved several independent tests by Austrianova and Eurofins. The results of these tests strongly indicate that, after the suggested changes ARE IMPLEMENTED, positive results SHOULD BE obtained. When the changes are made to the cGMP manufacturing process, they SHOULD significantly improve the growth of the cells obtained from the Master Cell Bank both before and after encapsulation takes place. PharmaCyte and Austrianova and its team of consultants are in the final stages of optimizing this aspect of the manufacturing process, they should significantly improve the growth of the cells obtained from the Master Cell Bank both BEFORE AND AFTER encapsulation takes place.
**********
Remember, improving the growth before and after was a concern of cGMP Validation....and in my view, they were literally saying we MUST be able to show the FDA our process as being a “most efficient” one.
So, to obtain a consistent reproducible and robust process...and for the FDA’s blessing....my thinking is that we NEED the implementation of those “changes”, to cell growth before and after, to be successful.
Anyways, imo my curiosity of this information being absent is definitely justified. My concern is based on what was said that needed to be done, but never addressed again to any degree.
Certainly leaves room for question.
Look, one minute cGMP Val has got KW saying...
“for improvement we’re necessitating counter measures to re-align and restructure the production process”
Then the next minute, we don’t hear a thing from cGMP Val, and Judd’s in Bangkok after KW’s thanking him for advice.
It’s probably nothing at all and I’m just overthinking it.
And not that it means anything, but I find it odd that KW did not formerly introduce and welcome Judd in a separate PR as he did with other participants.
After all, he is from “Fisher Scientific” They’re a big fish, are they not?!!!
I mean what the hell? :)
Patience
Go Team PharmaCyte!!!
Successful outcome = Video
Failure = No video
Regardless, we should be getting updates via FB and/or PR. :)
Patience
Go Team PharmaCyte!!!
That was well said. :)
Patience
Go Team PharmaCyte!!!
Excellent read! The information certainly gives me more encouragement for our developing targeting technology.
Very insightful...thanks Bio :)
Patience
Go Team PharmaCyte!!!
I absolutely believe we can achieve all that....IF we can just be successful with this last bit of work...submit...and get the nod.
Patience
Go Team PharmaCyte!!!
Lets hope so. :)
Final chapter underway.
Patience
Go Team PharmaCyte!!!
Let’s all hope and pray that there is an epilogue THAT DOES get filmed.
No story is complete without one.
Patience
Go Team PharmaCyte!!!