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This March 11, 2020 Defensins as Vaccines Brilacidin
Academic Literature Supporting Brilacidin’s Vaccine Potential Against COVID-19
Vaccines containing defensins as adjuvants have been shown, both in vivo and in vitro, to activate the primary innate antiviral immune response and mediate other immunomodulatory activities against a number of viruses, including coronaviruses, such as MERS-CoV.
Defensins and their mimetics, like Brilacidin, thus represent a promising therapeutic avenue as vaccines to target COVID-19, the deadly respiratory disease caused by the novel coronavirus SARS-CoV-2, which has emerged as a worldwide pandemic.
Supported by scientific research, Brilacidin is one of the few drugs targeting COVID-19 that has been tested in human trials for other clinical indications, providing an established safety and efficacy profile, thereby potentially enabling it to rapidly help address the emerging worldwide coronavirus crisis, developed both as an intravenous medicine and as a vaccine.
“In addition to their antibacterial and antiviral activity, defensins are one of the strongest central and peripheral defenders against pathogen infection, particularly in linking innate and adaptive immunity against pathogen infection…
I hope they go back to this research.
Thanks. Hoping to make a bit. Everything depends on what Leo has to say.
Today I threw caution to the wind figuring Leo has a rescue plan. No safe place in these trying times. I plan to go back into I-Bonds and TIPS this spring.
I bought more today. Leo's awfully quiet in the face of things.
What he is doing is all in the last press release. There's a lot in there.
He said 2022 could be transformational.. Hopefully we transform into a well funded bio.
“The Company is moving ahead with a strategic focus. Efforts are underway to advance Brilacidin’s clinical development on multiple fronts, as well as to explore potential new pipeline additions that could be transformational for our company in 2022.”
William F. Degrado, Phd
Scientific Advisor, Drug Discovery and Clinical Development
He's still listed on the IPIX board. I would bet it was Dr Degrado that got B into the university viral testing labs. Hopefully we hear news on that testing soon.
From Oct25- "The Company is also pleased to report Brilacidin has been shipped to two academic laboratories for planned in vitro testing of Brilacidin in over 20 acutely infectious viruses, including Ebola, Marburg, Nipah, West Nile and Zika, through a collaboration with U.S. government scientists. The goal of this testing is to further inform the spectrum of Brilacidin’s antiviral properties".
Per update ebola testing did happen so has somebody heard something.
Leo's been quiet since the last press release where he said they were in discussions. Wait and see.
It's been a while I figure next news cycle will have some meat on the bone. I added today and with 2.4m shares traded I'm definitely not alone here. Leo make something happen and getter done.
An effective Brilacidin pill for UC would likely be safer and much less expensive to dose then an IV given monoclonal antibody. But we need a finished pill and a trial to find that out. Ok Leo.
Oh yeah. Good news would put some gas in the share price.
“Among critically-ill patients who received Brilacidin under compassionate use in an open label manner, we were told noticeable improvements were seen in key inflammatory biomarkers shortly after receiving Brilacidin treatment.
Should hear more on this soon. A win here should give further B studies weight.
We need to see a term sheet or grant funding sooner rather then later to really move assets forward. Leo say's he's in discussions to enter in new licensing agreements which sounds like direct talks as there was no mention of Locust Walk.
IPIX management needs a team to help broker as well as lawyers helping work any licensing agreements. Maybe there is a knowledgeable team but we just don't know. B has shown promise to be a multi-billion dollar compound so why not take some cash on hand to add real professionals to build up the company from where we are. Go 2022.
You know you will never leave. Stock runs and greed kicks in maybe it's madness. Wishing all a happy 2022.
Prayers to our nation for healing, mercy and forgiveness.
Leo reported being in discussions to acquire rights to new pipeline as well as to enter into new licensing agreements. We could start seeing results coming in regarding the in vitro studies of the 20+ acutely infectious virus. This is what has my interest. Go 2022
Let's see where this leads in 2022. "Innovation management is engaged in discussions potentially to acquire rights to new pipeline assets, as well as to enter into new licensing agreements".
Hopefully we get more on this soon.
It is of no matter. What matters is what Leo does next.
Elsewhere, Innovation management is engaged in discussions potentially to acquire rights to new pipeline assets, as well as to enter into new licensing agreements.
Ehrlich added, "The Company is moving ahead with a strategic focus. Efforts are underway to advance Brilacidin's clinical development on multiple fronts, as well as to explore potential new pipeline additions that could be transformational for our company in 2022."
Buys can be marked as sells and vice versa due to algorithms. Not sure what your seeing but selling at and below the bid by mm's does happen causing price to decline.
Tells me it will be revealed when they finish. Merry Christmas!
Your describing a broad spectrum anti-viral..Go B.
Yep but it will be tough for the lock down know it all's to give up the cash cow.
And you thought he did..funny.
Yep and compassionate use in which we are now waiting further reporting on those positive clinical changes seen with some compassionate use patients administered Brilacidin longer and more frequently than patients in the covid-19 trial. Longer and more frequent dosing is key here.imo
Good one!! I'm passed regret and heading on to hope. Greed means higher prices.. and back to the slaughter house. I'm not a market player so it's been rinse and repeat for me. Be glad to be able to get out with a little upside.
When it starts going up your liable to buy more and hold right thru .50. That's been my lesson:) I think solid news would get us back there though.
An effective pill or IV mab what you think? A effective non-biologic IBD pill would be well received in my book. Leo needs to get the pill ready and tested. Takes money to make money I see no reason why Leo couldn't partner an IBD endeavor.
Thanks, this is likely to take a while longer like most everything else tied to covid-19. We have been on the slow track nearly two years it seems.
Of course treating doctors are allowing results and likely any notes to be shared with IPIX the drug provider. These are separate but yes trial data absolutely. Hopefully they saw some good anti-viral activity after administering B.
"We are awaiting the data and summary from the physicians and we will update shareholders once received and analyzed".
Good for them. I see Arena had a 1 for 10 reverse split two years ago.
I'm now convinced compassionate use data will reveal benefit in more frequent dosing. Hopefully there's just enough evidence to warrant further clinical or compassionate use study.
"Changes to biomarkers and positive clinical changes were observed, with some compassionate use patients administered Brilacidin more frequently and over a longer duration than patients in the Phase 2 Brilacidin COVID-19 trial".
Pr was bullish. Next quarter is going to be very interesting. Leo either can or cannot make it happen time will tell, words on this board will not change that fact. I say more positive data coming out of compassionate use,, the company timelines the start of it's phase3. There's more to life then IPIX so relax and enjoy the holidays especially Christmas.
Everyday my friend.
My view is they are going to take a deeper dive into why and what was different for patients who saw positive changes in biomarkers. A lessons learned as they say, maybe something that could be used if there was another trial or when we get the all the viral lab data back. Something positive out of this mess couldn't hurt.
"Analysis of the compassionate use of Brilacidin in the U.S. in critically-ill COVID-19 patients who had exhausted all other therapeutic options also is planned. Changes to biomarkers and positive clinical changes were observed, with some compassionate use patients administered Brilacidin more frequently and over a longer duration than patients in the Phase 2 Brilacidin COVID-19 trial".
A reversal on positive compassionate use data could be huge.
I think looking down the road the full ramifications of success here is huge. Remember B is also being tested as a broad spectrum anti-viral against some of the nastiest viruses known to man.
Leo said "Should deeper analysis yield promising data, the plan is to submit Brilacidin for inclusion in government-sponsored COVID-19 clinical trial platforms". Could see some of that government money to advance B. A lot riding on the additional data.
Leo leads the dialog. My interest is in the following- "Innovation management is engaged in discussions potentially to acquire rights to new pipeline assets, as well as to enter into new licensing agreements".
Leo building back better. "Elsewhere, Innovation management is engaged in discussions potentially to acquire rights to new pipeline assets, as well as to enter into new licensing agreements". Hopefully it's non-dilutive unlike government spending.
Yep covid did ipix a solid.
Proving B as a antiviral killer is much farther reaching then covid-19.