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Patience should payoff with $ABVG
“Intelligence will take you to the mountaintop; wisdom will take you to the stars.”
? Matshona Dhliwayo
Hey buddy, Hope all is well. Go $ICBU!
really one tick, thats a crash. go $ICBU
$ECMH 0.0019 0.0008 +72.73 149,959,852 0.0018 0.0019
Greatest thing about being in $ATPT since .0009.
This stock has not been pumped, And it hasn't needed to be!
Close watch, $ICBU
On watch, Real Industry, Inc. Stock Price - $RELY
After Hours
Last Trade Last: $ 0.70 ? 0.05 (7.69%)
Nice, Have a great weekend everyone!
Thats funny, They bought @.0003 sold @ .0002 now trying to buy $ABVG @ .0001 smart!
$ECMH getting started, My average .0012 lets see where we go!
I'm in to many pennies, Some i'm long.
You no what long is? One that doesn't work out. lol
Gota love it, flippers had to chase $ATPT. Not bad!
Pennies are exhausting, Take up a huge amount of time!
$ATPT hit my first target price .005+
Bought a starter of $ECMH
Looking for possible entry, $ADHC .0029
https://www.otcmarkets.com/stock/ADHC/profile
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=131020425
Close watch for entry,ECMH 0.0015 0.0003 +25.00 158,367,802 0.0014 0.0016
Shares Outstanding 296.93M
Float 6.4M
$PVCT,
Provectus News
Provectus Biopharmaceuticals Receives Second Cancer Combination Therapy Patent from the United States Patent and Trademark Office
- Protection expands coverage for combinations of intralesional PV-10 with anti-PD-1 and anti-PD-L1 agents for melanoma and cancers of the liver -
Tuesday November 7, 2017
KNOXVILLE, TN., /Globe Newswire/ -- Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT, www.provectusbio.com), ("Provectus" or the "Company"), a clinical-stage biotechnology company leading the development of the first small molecule oncolytic immunotherapy, PV-10, as an investigational single agent for locally advanced disease as well as in combination with another agent for widely metastatic disease, both for multiple cancer indications, today announced the United States Patent and Trademark Office (the "USPTO") has granted U.S. patent ("USP") 9,808,524 for the combination of intralesional ("IL") PV-10 with systemic immunomodulatory therapy, including anti-PD-1 and anti-PD-L1 agents, for the treatment of melanoma and cancers of the liver. This new patent is a continuation of USP 9,107,887, Provectus' first cancer combination therapy patent granted by the USPTO in 2015. Pfizer, Inc. is a co-assignee on both patents.
PV-10 is an injectable formulation of rose bengal disodium, and represents nearly a decade of work by Provectus to optimize the synthetic process for manufacturing rose bengal and its related halogenated xanthene analogs to meet modern global requirements for pharmaceutical use. IL injection of PV-10 can induce immunogenic cell death that results in tumor-specific reactivity in circulating CD8+ T cells.
Provectus recently presented preliminary results from the Company's ongoing Phase 1b/2 study of IL PV-10 in combination with KEYTRUDA® (pembrolizumab), Merck's systemic anti-PD-1 (programmed death receptor-1) antibody agent, at the Society for Melanoma Research 2017 Congress, held in Brisbane, Australia on October 18-21. Adverse events were consistent with the established patterns for each drug, and there were no unexpected toxicities or evidence of compounded toxicity. Preliminary overall efficacy included 10% complete response, 50% objective response, and 60% clinical benefit, with the highest responses observed in Stage IV M1c melanoma patients (all per RECIST 1.1).
The Phase 1b portion of the study continues to enroll patients at clinical sites in the U.S. and Australia (NCT02557321); Stage IV patients with at least one injectable lesion who are candidates for KEYTRUDA are eligible. A total of up to 24 patients would receive the combination of IL PV-10 and KEYTRUDA every three weeks for five cycles (i.e., for up to 12 weeks, with no further PV-10 administered after week 12), followed by only KEYTRUDA every three weeks for up to 24 months. The primary endpoint for the Phase 1b trial is safety and tolerability; objective response rate and progression-free survival are key secondary endpoints (both assessed via RECIST 1.1 after five treatment cycles, and then every 12 weeks thereafter).
Dominic Rodrigues, Chairman of the Company's Board of Directors, said, "This patent continues our work to expand intellectual property protection of PV-10, and to augment the potential commercial value of Provectus' clinical development program in cancer combination therapy."
Mr. Rodrigues also said, "Provectus' ongoing Phase 1b study of PV-10 and KEYTRUDA is based on a rational study design for Stage IV melanoma patients with visceral disease, and provides for the investigation of the potential for small molecule oncolytic immunotherapy to demonstrate orthogonality to and synergy with checkpoint inhibition, combination therapy measures of safety and efficacy, respectively."
Mr. Rodrigues concluded, "Numerous players around the world, with approved or investigational drugs within each class of systemic immuno-oncology agent, are pursuing smaller and smaller pieces of market share because drugs within each of these classes may be similar or, indeed, equivalent. Assuming a rational clinical basis for combination, another form of differentiation is needed to gain and protect market share for cancer combination therapy. We believe this aspect of our company's patent estate provides for proprietary combinations with protected agents."
The complete press release is available at http://www.provectusbio.com/news/press-releases/provectus-pr-20171107-1 on the Provectus website. PVCT 0.041
Nice post on $ATPT, https://investorshub.advfn.com/boards/read_msg.aspx?message_id=136031219
I'm loving $ATPT, All of my shares are up way over 100%
Nope, got burned on TOPS before. O'well!
$TOPS also!
$ATPT hit .0105 today, for a split second. lol
Soon will be there!
NOPE, go $ABVG
On news, $NVCN 1.31 0.00 0.00 20,128 1.40 1.41
Neovasc Receives FDA Approval to Initiate Pivotal Reducer Trial
2 hours 5 minutes ago - DJNF
NASDAQ, TSX: NVCN
VANCOUVER, Nov. 6, 2017 /PRNewswire/ - Neovasc Inc. ("Neovasc" or the "Company") (NASDAQ, TSX: NVCN) announced that it has received approval of the U.S. Food and Drug Administration ("FDA") to initiate the COSIRA-II IDE pivotal clinical trial. The trial's purpose will be to demonstrate the safety and effectiveness of the Company's novel Reducer system for treatment of patients with refractory angina. Once completed, the trial data is intended to support an application to the FDA for approval to begin marketing Reducer in the United States.
Refractory angina is a common and disabling clinical condition, and a major public health problem, which affects patients' quality of life, and has a significant impact upon health care resources.
"Since its commercial launch in Europe two years ago, Reducer has consistently provided relief of severe symptoms in patients suffering from refractory angina, resulting in significant improvements in their quality of life," commented Neovasc CEO, Alexei Marko. "We are eager to replicate our European clinical and commercial success in the United States, by introducing this important new therapy for patients who have no other option for managing their chronic, severe chest pain."
COSIRA-II will be a 380 patient, multicenter, randomized (1:1 ratio), double blinded, sham-controlled clinical trial with up to 35 investigational centers across North America. The COSIRA-II trial design is very similar to the COSIRA study, a 104 patient study previously conducted in Europe and Canada. The positive results of that study were published in the New England Journal of Medicine, February 2015.
Neovasc is currently evaluating start up timelines and funding options for the COSIRA-II trial.
About the Neovasc Reducer(TM)
The Reducer is CE-marked in the European Union for the treatment of refractory angina, a painful and debilitating condition that occurs when the coronary arteries deliver an inadequate supply of blood to the heart muscle, despite treatment with standard revascularization or cardiac drug therapies. It affects millions of patients worldwide, who typically lead severely restricted lives as a result of their disabling symptoms, and its incidence is growing. The Reducer can provide relief of angina symptoms by altering blood flow in the heart's circulatory system, thereby increasing the perfusion of oxygenated blood to ischemic areas of the heart muscle. Placement of the Reducer is performed using a minimally invasive transvenous procedure that is similar to implanting a coronary stent and is completed in approximately 20 minutes.
About Neovasc Inc.
Neovasc is a specialty medical device company that develops, manufactures and markets products for the rapidly growing cardiovascular marketplace. Its products include the Neovasc Reducer(TM), for the treatment of refractory angina which is not currently available in the United States and has been available in Europe since 2015 and the Tiara(TM), for the transcatheter treatment of mitral valve disease, which is currently under investigation in the United States, Canada and Europe. The Company also sells a line of advanced biological tissue products that are used as key components in third-party medical products including transcatheter heart valves. For more information, visit: www.neovasc.com.
This news release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and applicable Canadian securities laws regarding the Company's plans and expectations regarding the initiation and timeline of the COSIRA-II clinical trial to demonstrate the safety and effectiveness of the Reducer system, the size of the trial and the results of the data from such trial. Words and phrases such as "intended", and "will", and similar words or expressions, are intended to identify these forward-looking statements. Forward-looking statements are based on estimates and assumptions made by the Company in light of its experience and its perception of historical trends, current conditions and expected future developments, as well as other factors that the Company believes are appropriate in the circumstances. Many factors and assumptions could cause the Company's actual results, performance or achievements to differ materially from those expressed or implied by the forward-looking statements, including, without limitation, risks relating to the Company's litigation with CardiAQ, including the Company's ability to successfully appeal the validity of the awards as well as the ruling on inventorship, which create material uncertainty and which cast substantial doubt on the Company's ability to continue as a going concern; the substantial doubt about the Company's ability to continue as a going concern; risks relating to the Company's need for significant additional future capital and the Company's ability to raise additional funding; risks relating to claims by third parties alleging infringement of their intellectual property rights; the Company's ability to establish, maintain and defend intellectual property rights in the Company's products; risks relating to results from clinical trials of the Company's products, which may be unfavorable or perceived as unfavorable; the Company's history of losses and significant accumulated deficit; risks associated with product liability claims, insurance and recalls; risks relating to competition in the medical device industry, including the risk that one or more competitors may develop more effective or more affordable products; risks relating to the Company's ability to achieve or maintain expected levels of market acceptance for the Company's products, as well as the Company's ability to successfully build the Company's in-house sales capabilities or secure third-party marketing or distribution partners; the Company's ability to convince public payors and hospitals to include the Company's products on their approved products lists; risks relating to new legislation, new regulatory requirements and the efforts of governmental and third party payors to contain or reduce the costs of healthcare; risks relating to increased regulation, enforcement and inspections of participants in the medical device industry, including frequent government investigations into marketing and other business practices; risks associated with the extensive regulation of the Company's products and trials by governmental authorities, as well as the cost and time delays associated therewith; risks associated with post-market regulation of the Company's products; health and safety risks associated with the Company's products and the Company's industry; risks associated with the Company's manufacturing operations, including the regulation of the Company's manufacturing processes by governmental authorities and the availability of two critical components of the Reducer; risk of animal disease associated with the use of the Company's products; risks relating to the manufacturing capacity of third-party manufacturers for the Company's products, including risks of supply interruptions impacting the Company's ability to manufacture its own products; risks relating to breaches of anti-bribery laws by the Company's employees or agents; risks associated with future changes in financial accounting standards and new accounting pronouncements; the Company's dependence upon key personnel to achieve the Company's business objectives; the Company's ability to maintain strong relationships with physicians; risks relating to the sufficiency of the Company's management systems and resources in periods of significant growth; risks associated with consolidation in the health care industry, including the downward pressure on product pricing and the growing need to be selected by larger customers in order to make sales to their members or participants; the Company's ability to successfully identify and complete corporate transactions on favorable terms or achieve anticipated synergies relating to any acquisitions or alliances; anti-takeover provisions in the Company's constating documents which could discourage a third party from making a takeover bid beneficial to the Company's shareholders; risks relating to conflicts of interests among the Company's officers and directors as a result of their involvement with other issuers; and risks relating to the influence of significant shareholders of the Company over the Company's business operations and share price. These risk factors and others relating to the Company are discussed in greater detail in the "Risk Factors" section of the Company's Annual Information Form and in the Company's Management's Discussion and Analysis of Financial Condition and Results of Operations (copies of which filings may be obtained at www.sedar.com or www.sec.gov, each of which are included in the Company's Annual Report on Form 40-F). These factors should be considered carefully, and readers should not place undue reliance on the Company's forward-looking statements. The Company has no intention and undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
SOURCE Neovasc Inc.
/CONTACT: Investor Relations: Neovasc Inc., Chris Clark, 604 248-4138, cclark@neovasc.com
/Web site: www.neovasc.com
(END) Dow Jones Newswires
November 06, 2017 07:00 ET (12:00 GMT)
$ATPT strong buy! https://www.barchart.com/stocks/quotes/ATPT
Copper miners to see profit grow further in 2018 — report
http://www.mining.com/copper-miners-to-see-profit-grow-further-in-2018-report/?utm_source=digest-en-mining-171103&utm_medium=email&utm_campaign=digest
IMO, $ATPT going to pennyland soon!
Alot of traders long is a week, lol
Go $ABVG
I'm loving both $ONCI and $ATPT i might add again monday!
Some have no patience, O'well. Go $ABVG
Welcome to 'Nasdaq Dip & Rip' Hope all is well!
he he, nice $ATPT smoking!
Doctor day, six month check up.
Have fun!
Not sure, But $ALTAF looks great.
I don't get the huge volume increase yesterday, promo? not sure.
http://thestockmarketwatch.com/stock/?stock=ALTAF
Sure is pretty!
Just bought more $ATPT!