Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Thanks for the link, wonderful article. Shows how B is a very tricky drug to manufacture and how processing systems will allow the volume of production to be greatly increased while maintaining very tight quality controls, both of which are areas I am sure are being looked at currently.
Kind of like the beer commercial where AI is able to tell the large brewery if their new great-tasting beer flavor is suitable for large production or is only able to be brewed in small batches, meaning the large brewery will most likely sell the formula to a small brewery.
Brilacidin is a great drug, but it must be able to be made on a large volume scale to satisfy the numerous indications we all believe in which it will succeed in the next year or two.
This article leads credence to the belief that such volume production will be possible.
Also nice to know that this leading tech firm in France chose Brilacidin as the "lead" drug in their article in which they discuss the possible CV19 drugs. First time I have heard both anti-inflammatory and anti-bacterial used (they said B was developed as an antibiotic) and they also mentioned the immunotherapeutic properties it possesses.
That is why I tried my hand today at posting the same message over and over and over that said nothing. Thought they that have been doing so for a long time must have found something exciting about doing it, but surprise, it is only extremely boring.
Next week I think we start entering the zone for big news but could see it extending into the following week. No problems here with either of those as news release dates.
If we just get the RBL results, even if extremely positive, unless we have an announcement of a human trial OK for Q4 or/and a notice of a nice sized grant the PR could not be as well received (including a major pop in the share price) as our PRs are not splashed across major financial concerns or medical powers so it may take a bit for the finalization to sink in just how important the RBL results are. Also, if we add a news item that B-IV is now available for the human trial and that a site has been established (it won't be named IMO) that will give a real kick to the media grabbing hold of IPIX PR and share price reacting accordingly.
I do think if we get some major RBL results, we should see a definite uptick in news reporting on Brilacidin.
Not getting too amped in case things don't explode next week or anytime in August. They will in the near future, but no guarantee for this early in the year yet.
IPIX is great! Brilacidin is great!! Leo is great.!!!
IPIX is great! Brilacidin is great!! Leo is great.!!!
IPIX is great! Brilacidin is great!! Leo is great.!!!
You familiar w/ Pebble Project? Not Ask Knowing if you get my drift.
We have far different views on politics so I will leave that discussion for other venues. Good luck with IPIX as on that we can all agree since all but a few here are investors.
Maybe not this week, but next week or the week following that should start the unveiling of our drug Brilacidin.
Been a long wait but IMO going to be well worth it.
So basically one is trying to guess the algorithm lines the MMs have programmed in since it is not news changing the price action.
Now why wouldn't the MMs make a beautiful pennant and then go 100% against what the pennant says is going to happen to fleece all those trading based on the chart that is determined by the MMs?
Considering Russia said they had no coronavirus cases until nearly June, doesn't it seem quite odd they have solved the problem in roughly 8 weeks?
So we have in Russia:
No CV19 when the rest of the world had millions of cases (understandable since their living conditions are so far above the rest of the world viruses and bacteria can't live in USSR).
Immediate vaccine development in a matter of weeks YET it is totally proven safe and effective (probably used one of their time machines to make this impossible task happen OR Putin signed a decree stating it was so and that meant it was valid since his word is pretty close to getting it from a burning bush in USSR)
Vaccine already used by Premier's daughter (the leaders of authoritarian countries always want their children to be guinea pigs)
LOL yeah, this sounds about right
So which media are you recommending? True journalism died decades ago.
People that get in now are still taking risks and that is not the type of investment many people want to put a lot of their nest egg into - those that do are the risk takers, us in heavy at the current time.
Instead of urging they buy now, there will still be PLENTY of money to be made when the RBL final reports come out listing Brilacidin as a drug far far beyond anything else they have seen.
I would suggest they keep their money very liquid over the next few weeks to at least the announcement of the human trial and urge them to put in 1/4 of their available investment funds at the PR stating extremely good total investigational scheduled by the end of the month, another 1/4 at the FIRST news of human trial announcement, and the final 1/2 at first news of trial success.
Risk at that point should be quite low to the level most everyone can handle and the rewards still mountainous.
I know I think IPIX is the "golden goose" of investments but I don't want to get anybody in reluctantly. They have to feel good with their investment.
That is my recommendation.
Why does everyone say that IPIX needs credibility, that Leo needs credibility - we aren't the ones providing the critical data that Brilacidin kills CV19 prior to it infecting the body and also being able to kill it should the patient already have the virus. That critical data is coming from governmental labs. How much more credibility can one get?
My point is who tested Rems.... was that an RBL or Gilead's lab? If Gilead, which I expect, could the data be tainted to color the findings in Gilead's favor the same as the trials had to be altered so that Rems... didn't fail miserably? And the mortality figures had to be removed from the trial results, why was that allowed?
For CV19 IMO we need a BP sponsor like we need a hole in the head.
Without a doubt IMO we get grants before peer review. A good friend that is tremendously more knowledgeable about this investment than me assured me that CV19 grants and peer review are two separate lines, not based on one another though later down the line the peer review might be helpful for additional grants for other indications and possibly non-governmental grants.
The human kidney tissue test results were after 1 hour.
I expect they see results in patients within 24 hours, at least to the point that they start feeling better, less lung issues, temperature goes down, and they know they are on the road to recovery.
By day 3 should be quite obvious in the vast majority of cases it is working as expected. For those not responding that much, maybe time for another dose.
IMO
Is the next PR reporting the latest RBL data the straw that breaks the camel's back as to getting Brilacidin in the spotlight of media and governmental attention (as say perhaps a mention that it the only TRUE treatment "cure" coming down the pike)? I would like to think so but to date hasn't worked out that way.
I still firmly believe we need some serious grant money from some source for the general public/world of medicine/etc to take IPIX seriously and finally get the science of Brilacidin known to the general public.
Now coupling such a nice sized grant with RBL data to show this is about the first such grant going to a truly deserving drug, and not one foisted on the public to pay off lobbying payola, that both kills CV19 prior to infection and after being infected to a startlingly effective degree, that would get the attention of America IMO.
At this point in time, the peer review article is just so much noise as by the time it gets disseminated Brilacidin will already be in a human trial and actual patient results will top professional opinion IMO.
This article is a great example of why I feel many peer review articles are absolutely worthless.
Submitted 26 May
Accepted 26 June
Avail. online 4 Aug
Today this article is outdated crap IMO. Maybe in normal times somebody found these massive delays necessary, but in the world of a pandemic it is like having a special task force to respond for a massive earthquake that hits Los Angeles and you station it in Las Vegas. Too little, too late.
I don't see exactly what the journals are adding to the mix here. They cause delays where in today's digital world the article should be online the day it is submitted. This system is like the authors send it to the journal via Pony Express and the journal transcribes it to braille to give to their blind copyreaders who then pass it on to monks living in caves to prepare it for the printers.
Still running this medical regimen with medieval thinking IMO
We know the pre-review should be made available in Sept and that is all we need to advance the Brilacidin program at the current time.
The finalized peer review results is important but that could take some time IMO - as the article has to be accepted by a journal, published, and the peers have to study it and respond. That is still a lengthy project.
But getting the finalized report isn't necessary for advancing B in regards to CV19 IMO. It will greatly enhance Brilacidin for future human trials for other indications IMO.
I think getting the peer review article finalized by the end of 2020 would be moving remarkably fast.
The pre-review(s)IMO should be what knocks the socks off of Brilacidin being relegated to the "quiet" corner. It should start hellacious articles from all forms of media - written articles, radio, TV and even governmental mentioning IMO.
I have known a number of people that have heard from Leo from time to time and NEVER has one ever mentioned that Leo said anything that hadn't already been made public via a PR.
These are the people he would trust with news if he ever had the intention of "leaking" something, but it has never happened from the many I know.
So I take all these jackholes claiming to talk w/ Leo (why would Leo talk to a snake?) and getting inside info is pure malarkey.
Dates on the link are scary to say the least as to submission, acceptance, and pre-review article published
I thought we already have the dosage for IC 90 per the July 20 company PR to wit:
"The new data, using the same assay method, reveal Brilacidin exhibited a similarly potent inhibitory effect against SARS-CoV-2 at an even lower concentration in the same human lung epithelial cell line. Brilacidin achieved approximately 90 percent inhibition of SARS-CoV-2 at a drug concentration that was one-half lower than previously tested."
I could see the govt wanting to keep human trials in USA, but why should they reject grants from Europe since that doesn't buy Europe exclusivity or anything?
It just provides funds that the USA govt won't have to and thus saves them some money -(argument for accepting EU grants).
The only reason I could think of to not accept EU grants is that they (USA) may want to get first look at all data and if a foreign grant paid for the research, they would expect to get info first. What if grant specified only in a EU lab could research be done? Also, possible security leaks to Russia/China. (argument for not accepting EU grants)
B may be something USA wants to keep very close to the vest at the current time. I could well understand that and to keep all lab work done in certified labs they control.
I am only brainstorming here, no actual clue.
Until such time it can be done, the world will be in a semi-lockdown
and industries such as business travel, vacation travel, professional
sports, concerts, and many, many other sectors of world commerce will
be at a standstill.
FDA just needs to change theirs way, get off their ***, and get such a nose inhaler done. Quickly.
Another source, not sure of their medical background, said that the work we have done in IBD will greatly aid in getting an intranasal inhaler designed and in their opinion approved (due to Brilacidin safety profile).
Attached is a good article showing the benefits of a "preprint" to peer reviewed medical articles.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005473
In the world of medicine, is 152.7 as an SI considered excellent, good, average, or other?
Why couldn't you start as a phase 2 and if you keep getting good results with no bad reactions, keep the trial going to a sufficient number to have satisfied a phase 3?
I think with all the testing they are going to have a pretty good handle on al aspects of the dosage level, duration, and frequency.
Hope once they start the human trial they also proceed at warp speed on perfecting some sort of nose/oral delivery spray of some type. Gong to need something that people can take as needed / when needed to allow close proximity functions to again become the norm for society.
If anyone in the media was smart enough to read this PR and understand what they are reading, they would have the scoop of the year IMO.
They could proclaim that a "cure" for CV19 is highly likely and they wouldn't be exaggerating per the data to date. Note that I said the cure was highly likely, not assured, and the said media person could then do a series of articles keeping the general public informed regarding the progress of Brilacidin thru the required trials.
Nothing hyped, politicized, paid for, or questionable about the drug, simply reporting the data derived to date from governmental labs.
And yet here we sit today with the price of the stock for the day moving down. I know it means nothing, but still, it is shocking.
You gotta' love this. Only in America today could such a travesty between fact and perception/hype/criminality occur.
How else could one take it?
Prior data showed that B stopped/killed CV19 prior to it being able to establish in in human tissue.
This data showed that B killed CV19 from tissue that was already infected with CV19.
Note from the PR that they state directly that Brilacidin is showing consistent and robust activity across the viral lifecycle (that means the entire lifecycle of the virus)that means it will prevent infection and also treat patients who already are infected. Brilacidin has proved it does it all - listed as a treatment but actually doing the job of being BOTH a vaccine (except that it doesn't cause anti-bodies to be formed)and a treatement. Could not ask for more.
----------------------------------------------------------------------
"As Brilacidin is showing consistent and robust anti-SARS-CoV-2 activity across the viral lifecycle, the Company believes the drug could be used as a treatment for preventing infection with COVID-19, as well as for treatment of patients once infected."
Chance of us not getting a grant, or more likely grants, is just about zero, nil, nada, zip.
If the sun rises tomorrow, we will get a grant or more likely multiple grants.
You are making a mountain out of a molehill IMO.
PR said new test data showing continued "robust" results. Why should they have to give out all data? We know they like what they see by what they did publish.
This PR was major news for Brilacidin.
Prior to this, all we had was test data that showed Brilacind was highly effective in preventing people from getting CV19.
Today's PR now reports that further test data confirms that Brilacidin works effectively against CV19 for patients that already have CV19. It confirms Brilacidin working against the entire lifecycle of the virus.
To me, that is major news. That pretty much tells me that, although we need human testing to confirm same, that we will see Brilacidin as the go-to treatment for CV19. Brilacidin being the true "golden arrow" to shoot down CV19 has become a much greater possibility due to this data.
I expect the selectivity ratio to be quite high, the human trials to go very well, and Brilacidin to save many lives.
All that is left is then for Brilacidin to be put into some sort of nubelizer-form so that the world's population can take it and allow many forms of activity currently not possible due to social distancing requirements to be revoked. Brilacidin may allow the world to go back to some semblance of what it was like prior to CV19.
If I have a good round of golf tomorrow, I will know that these are signs from up above because that happens about as often as an eagle flying over one's house or a roadrunner crossing one's back yard.
At this time, I think it is more likely trading games being played rather than a news leak of some kind.
When CTIX started, they had one of the best biologic patent attorneys write up the patent requests so I am pretty sure we are completely covered regarding this area.
I have heard from somewhere, cannot validate the authenticity of same, but I was led to believe that B-IV is somewhat tricky to make whereas B-OM in granular form is quite easy and quick to make.
I also seem to remember that there is nothing in Brilacidin that is all that special in terms of rare ingredients or such.
On the one hand, anything is possible and I would not even hazard a guess as to the probability for this to have happened.
On the other hand, there is always the chance that Brilacidin has not risen to the level of attention yet, at least to the highest levels, since it to date has no peer reviewed articles and only in vitro testing, however impressive those tests have been to date.
My statement above is based on the statement that Inka made saying no grant request or drug was put ahead of any other, the time it is taking to get some B-IV manufactured for possible human trials, lack of any mention of it by anyone in a position of authority (both medically and politically speaking), etc. Maybe we stockholders have polished the apple too early when in reality it hasn't made it to the big leagues yet as a possible leading treatment. As usual, I again believe we all are participants in being our own worst enemies regarding timelines for B advancement as a treatment for CV19.
Do not take this in any way a view that B isn't going to become the treatment of choice, as I have total confidence in it, but the timeline to get there is as of right now all based in the 4th quarter at the earliest.
As for me, time to settle back for a long August nap and let the process run its course. Sept will be here before we know it and the good times will be upon us. We all will be feasting off the barbie (as they say in Aussie land)soon but August appears to be the time we have to let the coals reach the right temperature.
Whether you are correct or not regarding the K/B connection to Kodak, the fact alone that a USA company is finally getting back into the game in regards to pharmaceutical chemicals is extremely important.
This is the type of mfg that the govt has to support IMO so that the Chinese cannot drive the prices artificially low to eliminate competition and then have the power to control such end products, to the possible detriment of the rest of the world, in times of need.
Your type of thinking is what this board should be about, posters registering possibilities, brainstorming-type thoughts, even over-the-top type ideas because one never knows.
Many oldsters will remember from Dick Tracey comics back in the 50's his wristwatch phone and how unrealistic that appeared at the time.
Thank you for bringing me up to speed.
Somehow I missed the Kodak connection. Can you direct me to the post or the link that makes them a possible mfr for B-IV?
TIA
PS If you sent me a PM Fri, which I think you did, I accidentally erased it before I wrote your email.
Wonder how Brilacidin-IV would be produced by Evonik
I hope Brilacidin itself could be bulk produced and then sent off to many processing plants that could mix the right dosage from the bulk supply into IV bags.
Slowest system I would imagine is if Evonik has to make the drug and then process it into IV units on its own production lines. I say this as I get the feeling from the time it is taking to get some B-IV produced is that Evonik is pretty maxed out on producing their everyday products at the current time and wedging in the need for a LARGE amount of Brilacidin IV may not be possible - at least not in the quantities needed should B prove successful as the lead CV19 treatment.
Then you have to ask yourself, if it is taking this long to procure a few hundred to a thousand or so IV bags, how long will it take to ramp up production for hundreds of thousands or more?
Would the govt even have the right to tell Evonik, or any other chemical mfr, that they must ONLY produce Brilacidin-IV until a decent inventory is established?
I don't find Trump and Fauci on the same page necessarily in regards to CV and so I agree more with your thoughts in regards to F than to T. I will post straight out I am not impressed with Fauci at all. I find he has been a straw man to date, no substance. Just an opinion, could be way off base.
Not knocking her results at all, but I bet she has a lot of DD working for her as well. I enjoy as much as anyone things I can't explain as to how it is being done and she has certainly been on a roll.