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leifsmith, there are government funded vaccines in clinical trials! Wishful thinking?
It is common knowledge...
NanoViricides, Inc. therapeutic drugs have the science and bio-nanotechnology to boot. It is not so much about scientific theory anymore as we've been down this track before, in 2010.
It was not long ago we read the following in relation to the restart of the Ebola program,...
I read and used the following post/information from 4theduration/connecticutmag.com and wrote to the U.S. Senators from my state exhorting them to join Connecticut/U.S. Senator Richard Blumenthal in moving the testing process along for a potentially safe, fast-acting, effective anti-Ebola drug.
Lvus, good to read your reaction. Yes, we are going to kick some serious Ebola butt soon. It was not long ago I read the following, "...If Dr. Anil Diwan and his team are confident that the latest developed [second generation]EbolaCide candidate will yield a > 90% rescue of subject animals (in-vivo)....
We should soon be on a fast war path with the killer virus! Nanopatent said on reply to your post, "...I'd say days, weeks tops.! Ditto on that!, or as Dr. Seymour once put it, "...I suspect that game-over for that virus, is in the cards...".
And how soon should we be reaching people afficted with the killer virus? With the speed afforded to ZMapp!
We've travelled down this road before, 2010...
NewMoney, since you brought it up this morning, here is more information on TKM-Ebola so that you and NNVC board can better compare the two treatments.
Before, now and coming soon is tomorrow, the conquest of Ebola and Marburg virus!
From Page 47 of 10K:
FORZANANO/nanopatent and other proactive NanoViricides, Inc. investors...
We are just a few weeks away from starting and completion of EbolaCide efficacy tests. First, we should soon find out who is going to be our BSL-4 partner to test EbolaCide for efficacy. Soon.
Since I do believe that NanoViricides, Inc. will soon have dramatically improved EbolaCide candidates I have, in anticipation of great efficacy results, drafted a petition to be posted in different places, government webpage. I want your opinion to improve on this petition that ultimately I hope "longs" will make it theirs.
Echo20...has the FluCide full tox study started?
...perhaps US $17.9 million with an additional US $24.9 million would be nicer...
Excerpt from NanoBusiness Alliance Interview with Anil R. Diwan - 2011
How is it possible you forgot that the accusers of ENRON mega house of cards showed up in the U.S. Court of Law to face the accused? Where is NanoViricides, Inc. dirty, low down, "perp gang", pseudo named Pump Terminator? Hit and run accident?
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In this lecture, tech investor Juan Enriquez explains how the FDA's extreme risk aversion hurts us, and why that behaviour is our fault.
Another_voice_2, keep winning tennis matches for now. It will be just weeks and EbolaCide II will demonstrate what it can do, fast acting, destroy Ebola virus machinery, in the trillions, in a matter of hours. I do have confidence in the genius of Dr. Anil Diwan.
My post this morning began with Leifsmith but I'm sure he knows it was directed to the "big government" mouthpiece that wrote the article, claiming it is not "big government's" fault. But if our 'big government" is betting on Big Pharma vaccine mules you bet I am going to fault the bunch of tin horn dictators.
If the "wild bunch" is hoofs and all into our economy, with all sorts of laws and regulations, you bet I am going to fault the control freaks that came up with the ill conceived laws.
Leifsmith, I do have reason to distrust the government.
1- Pump Terminator attacked our small biotech company and caused the pps to tumble. Damage was done to our small company, our property. When our government had the chance to call on Pump Terminator and ask them to come out of the shadows, face their accused, they failed to uphold the law. If you damage private property you should have your days in court and face the music.
2- If the law/regulations must apply equally to all, and they should, why is toxic Cannabis given a pass and is not required to have clinical trials? Everyone else has to spend time and money on clinical trials but not a drug pushing and lawless drug cartel? Trust our government and unelected FDA officials?
"In frenzied excitement, he eats up the ground. He paws fiercely, rejoicing in his strength and charges into the fray, afraid of nothing, when the trumpet sounds." (Excerpt from Job 39: 21-25)
NanoViricides, Inc. is not just a biotech healthcare stock. It is a small biotech company with great science. I call it Bones "23rd century science" today! Science that could bring Ebola virus to a screaching halt! Why? Because when nanoviricides enters the host it will encounter virus structures in the billions, perhaps trillions, destroy them and stop the menacing virus advance in a matter hours. This quickly translates to alleviation from pain and suffering to the host of Ebola virus, or any other virus. Whatever is left of the virus will be addressed by the host's immune system. Soon to be confirmed, once again, we are makers of low toxity antiviral therapeutic drugs. Unlike other antiviral drug makers, we will soon have a new validated 5kg CGMP Pilot Plant, capable of producing 1000 doses of EbolaCide II to address the killing Ebola virus. We are agnostic to the host, we only care to find and destroy the life threatening virus.
The whole world will soon be in frenzied excitement because the people of NanoViricides, Inc. was there (the 10,000+ and Institutional Investors), when most needed, to prevent a catastrophy of epic proportions. We are not a horse in a horse race but there are some similarities with our small biotech company, in a race: We charge into the fray, afraid of nothing because we know our science and how effective it is. NanoViricides, Inc. paws fiercely, rejoicing in its strength with approximately $41 million in cash and other instruments, enough to move forward with EbolaCide II, FluCide and DengueCide, our triple crown! When the trumpet sounds is because we smell the war from afar, and we will soon be ready to destroy viruses and their machinery, in the trillions, in a matter of hours.
Enough said, fired up, "...lets roll"!!!
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"In frenzied excitement, he eats up the ground. He paws fiercely, rejoicing in his strength and charges into the fray, afraid of nothing, when the trumpet sounds." (Excerpt from Job 39: 21-25)
Fresh Graves Point to Undercount of Ebola Toll
By ADAM NOSSITERSEPT. 22, 2014
Definition of Integrative and Organ Systems Pharmacology: "Pharmacological research using in vivo animal models or substantially intact organ systems that are able to display the integrated responses characteristic of the living organism that result from complex interactions between molecules, cells, and tissues."
AZ ABST Case Study
'ABST' stands for Automated Blood Sampler and Telemetry, the combined solution for integrative pharmacology. Through a collaborative effort between BASi, the maker of the Culex® Automated In Vivo Sampling System, and Data Sciences International (DSI), the gold standard in physiologic monitoring, it is now possible to collect more data from individual animals than ever before. ABST can be used to measure multiple variables in a single animal including heart rate, blood pressure, temperature, blood, urine and feces, dialysates, locomotion, activity and various biopotentials e.g. ECG, EEG, EMG, or ERG. Protocols requiring automated infusion can be easily incorporated and controlled with the BASi system. Contact BASi for further details.
Save Money
This combined system makes it possible to collect multiple streams of data simultaneously from individual animals. The ability to collect blood at the same time as other safety data eliminates the use of satellite groups. Subjects can be re-used after a washout period, leading to further reduction in the use of animals. Since the system is fully automated, it is possible to reduce staff hours compared to traditional methods. Additional money savings arise thanks to better data; the ABST makes it possible to make earlier go/no-go decisions so that money isn’t wasted on compounds that will not make it to market.
Save Time
The ABST system offers full automation for dosing, blood sampling, and the collection of safety data. This allows technicians to use time effectively, for example, an ABST experiment can commence in the morning, followed by a more time consuming manual PK study. Taking this approach can make your staff twice as effective as before. Elimination of satellite groups further reduces the amount of time that is spent on each compound. Finally, early decisions can be made with high quality data, reducing the overall time spent on non-viable compounds.
Gather Better Data
With satellite groups it is difficult to ensure that all study parameters are the same for each group. Indeed, manual pharmacokinetic sampling is often very stressful for research animals, while great care is taken to minimize human intervention during the collection of safety data. The ability to eliminate satellite groups with ABST allows for better control over study variables. Data collection is further refined by achieving a within subject experimental design and capturing inter-animal variability. Additionally, the ABST makes it possible to compare information across organ systems to determine time and exposure-dependent effects. All of these features make it possible to form early and informed decisions during drug development.
With the ABST, it is possible to simultaneously collect:
Urine/Feces for:
DMPK
Metabonomics
Clinical Pathology
Terminal tissue collections for:
Clinical Pathology
Molecular Toxicology
Other biofluids:
Bile
Dialysates
Telemetry Data including:
Heart Rate
Blood Pressure
Temperature
Locomotion
EMG, ERG, ECG or EEG
Serum/Plasma for:
DMPK
Metabonomics
Biomarkers
Clinical Pathology
http://www.datasci.com/solutions/integrated-pharmacology/automated-blood-sampler-and-telemetry
Other related source:
A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery.
http://www.ncbi.nlm.nih.gov/pubmed/22982770
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There are those who complain that the tox studies are delayed. I don’t believe that it is the case at all. Had our drug system not produced such amazing initial tox results, we would be well into the BASi studies at this time. The FDA mandates that we find the toxic dose. To do that requires an inordinate amount of material. When the amount of material needed is produced, the studies will start. I feel that it will be quite soon but I cannot, in good conscience, give a hard date.
Our small biotech company/technology is one that will be stepping on big toes of some big players in Big Pharma. We really don't know who is who posting on this board however, I do know who Scott Gotliebb, MD is. He was once the no. 2 at the FDA and he recently wrote the following when it became evident that Ebola was spinning out of control in West Africa:
You are citing the FDA rule/regulations. Fine. Should FDA allow toxic Cannabis go to market without clinical trials? The law/regulations should apply equally to all companies. Why the exception, the double-standard, with toxic Cannabis? We are a small biotech company with low toxicity, fast acting, effective nanoviricides. Six thousand animal subjects survived lethal doses viruses like Influenza, Dengue, etc., thanks to nanoviricides.
Why does the FDA put hurdles on our small biotech company??? Why find the toxic dose? FDA could have requested the toxic dose for later and that would have been ok. All of this while you see vaccine makers getting all kinds of taxpayers money and I am referring to big cap companies in comparison to our small biotech. And how generous of some companies/governments to donate vaccine doses that were made possible/manufactured with taxpayers money. It is as if they were saying, "...use those vaccine doses quickly because if the virus mutates they will become worthless...". And whatever happened with Tamiflu data? Billions were spent by governments just to find out later that the vaccine was marginally effective.
The PEG molecule is common to all nanoviricides, yes? The difference among nanoviricides What products are out there in the market with PEG that have been, by FDA regulations, required to undergo clinical studies. What were their results and are they in the market today? Perhaps it may be easier to cite the failures, if any.
If EbolaCide tests in BSL-4 facility and if found to be highly efficient, why not employ it right away to fight Ebola? How far did Zmapp go, in meeting goals according to FDA regulations, before it was employed in the US and in Liberia, Africa?
If we are not delayed for FluCide, we are not delayed for 2015. Why would any one say "not delayed" and skip the entire 2015? You said it in one of your posts, time will wait for no one, not even NNVC.
Thirteen weeks (13 weeks)? We are advancing with FluCide in paralell to EbolaCide. Are FluCide GLP full tox studies worth anything in relation to EbolaCide and FDA regulations/requirements?
I don't have the time to post any other questions this morning. Perhaps in the evening.
Here it is nanopatent, niemann-pick c1
Search with the NPC1 mimic (ligand), encapsulate the filovirus Glycoproteins(GP) and destroy most, if not all, in the trillions, in a matter of hours.
http://www.mdpi.com/1999-4915/4/12/3336/htm
So, we do have news coming Monday? Perhaps on low toxicity, fast acting and effective FluCide or more on the low toxicity EbolaCide (that can be dramatically improved) that could soon be fast tracked to Clinical Trials. Of course, synthesis completion, in about 3 weeks (from date started), comes first.
Echo20, if Gilead Sofosbuvir is worth $84,000 for a 12 month treatment period, once we get HCVCide to market it could be licenced to Gilead or other company, maybe. What if the 12 month treatment period cost were to be slashed down to 1/2 or a 1/3 of what it is today?
NanoViricides, Inc. has transformational technology that could reduce the cost of healthcare, the cost of health insurance, etc., slashing them dramatically.
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FluCide GLP full tox study and BASi
BASi has the Culex-L (large animals) and Culex ABC (for small animals).
Dr. Eugene Seymour, 9/27/11
thefamilyman, from an article 2008...
Yes, EbolaCide II is bound to join the group of new drugs and vaccines to treat Ebola and possibly take the lead from Flucide in the race to FDA review/market (WHO review by November 2014). Thank you MDPH1.
cGMP Pilot Plant has been realized and scientists are racing to get it validated. The plant is critical for Clinical Trials in Australia (2015) and possibly EbolaCide/WHO fast tracked clinical trials this year. That cGMP plant is real and critical requirements to be considered as one of the treatments for deadly Ebola, provided we prove dramatic efficacy over other drugs/vaccines. We are a small biotech company now, not a pharmaceutical giant like for example, Glaxo Smith Kline or Merck, but I believe we will be. Save for yourself the shorts narrative. I am long on this small biotech company.
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Stepping on some big toes...
Do you want the CEO to spell plan B because plan A (6 to 9 months) spells trouble for longs? Patience, I honestly believe that the "good news" are coming soon. The new cGMP Pilot Plant is a reality and will soon enough be validated. The new cGMP Pilot Plant is critical for Clinical Trials (2015) and possibly Ebolacide if efficacy is dramatically increased over that of vaccines.
On FluCide full tox study...start of plan B?...
A couple of months ago I spoke with a surgeon, briefly described the NanoViricides, Inc. technology and that they were going to Clinical Trials (2015). That was all, I didn't say buy some shares. Immediately he said, do they have a drug for HIV?
Rawnoc, are you implying projections (forecasts) cannot move and must happen within a year? Oh, I see. If projections were not exact in 2013 and moved, they wont be this time arround. Patience, it is 2014 an the state-of-the-art cGMP Pilot Plant is a reality, critical and operational. Scientists are inside racing to get it validated. Once validated it will be ready for Clinical Trials in Australia (2015) and possibly for fast tracked EbolaCide clinical trials. You do expect the cGMP Pilot Plant to be validated or do you have information to the contrary? Don't forget to reference/quote your sources. By the way, PT is not a reference/source if he/she/them are not willing to come out of the shadows.
Regarding FluCide GLP full tox study, perhaps you could persuade someone with credentials to refute in detail the following. Why not the full tox study in 13 weeks or less?
Thank you for the opportunity to re-post reasons why am I optimistic.
On FluCide full tox study...
Fast tracked clinical trials, efficacy and safety, possible and soon!