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Your awesome! thank you and I am looking forward to the future of IPIX!!
Go Leo & IPIX!
"Meant to say "I'm looking forward to the trading once actual humans are dosed in clinical trials against covid."
Brilacidin has already passed safety benchmarks in multiple clinical trials:
Brilacidin for ABSSSI is ph3 ready. Ph2 was dosed via IV in hundreds of patients.
Brilacidin for OM is ph3 ready. Ph2 was dosed via swish and spit.
Brilacidin for UP ph 2 POC trial was dosed with water enema. Results good enough that Alfasigma licensed Brilacidin for UP dosing with foam, enema, or gel.
Brilacidin for UC ph 1 was dosed with Oralogic tablet.
And, the most recent lab results are very promising.
http://www.ipharminc.com/press-release/2020/5/19/innovation-pharmaceuticals-brilacidin-reduces-viral-titer-of-sars-cov-2-covid-19-by-75-percent-after-only-1-hour-of-preincubation-in-in-vitro-study-at-bsl-3-facility
Quote:
These statistically significant lab results strongly support Brilacidin’s prophylactic treatment potential given the drug’s potent and rapid virucidal activity—a unique ability, different from any other known drug currently in development to treat COVID-19, to inactivate the novel coronavirus prior to host cell entry and subsequent viral replication. A majority of antiviral agents targeting SARS-CoV-2 attempt to inhibit viral replication rather than completely eliminating the virus (virustatic versus virucidal).
Additional time-dependent and concentration-dependent experiments are underway to further delineate Brilacidin’s virucidal properties against SARS-CoV-2.
Regarding your timeline question... I have no idea when we'll see Brilacin covid trials. But, I hope it's soon.
Message in reply to:
Thank you KarinCA,
Would you or anyone else on this board have any idea as to how long this would realistically take. I realize it is hard to estimate but someone on this board may have an understanding. Are we looking at days, weeks months? I realize this may not be a question that anyone on this board with any credibility would want to touch. So if there is no reply I completely understand.
Go Leo & IPIX!
"I'm looking forward to the trading once actual humans are dosed in clinical trials.""
Thank you KarinCA,
Would you or anyone else on this board have any idea as to how long this would realistically take. I realize it is hard to estimate but someone on this board may have an understanding. Are we looking at days, weeks months? I realize this may not be a question that anyone on this board with any credibility would want to touch. So if there is no reply I completely understand.
Go Leo & IPIX!
"I'm looking forward to the trading once actual humans are dosed in clinical trials."
Sounds like you have it figured out. You should approach Leo and see if he will allow you to fix all of his problems.
Go Leo & IPIX!
"It's not share price abuse. The buyers outside of a few; exist on this board.
Locust walk needs to get this information to the mass and off GNW. Until that happens and volume rally's we are here."
Hopefully with the Locust Walk affiliation they can somehow overcome the share price abuse with an interesting strategy.
Go Leo & IPIX!
"My choice would be to have news hit Friday at 3:30 p.m. to 3:45 p.m. and have folks scrambling to buy into Tuesday following week, would be fun wouldn't it. GO IPIX News Friday please, late in day."
Thank you AlanC! Super interesting video/website. Hopefully we survive this.
Go Leo & IPIX!
"The shorts were causing the price to rise when it ran to new highs and then began the selling of millions of shares that did exist to drive down the price, that selling continues to this day. Sure the company sold shares to raise capital, that is why they’d are a public company but the abusive shorting of IPIX is criminal. The next few months should be interesting as this movement gains traction. Go IPIX!!!"
You called it! thanks dp70!!!
Go Leo & IPIX!
Innovation Pharmaceuticals’ Brilacidin Reduces Viral Titer of SARS-CoV-2 (COVID-19) by 75 percent After Only 1 Hour of Preincubation in In Vitro Study at BSL-3 Facility; Demonstrates Potent and Rapid Virucidal Activity
• Experiment supports Brilacidin’s therapeutic potential as a COVID-19 treatment and as a prophylactic agent against COVID-19
WAKEFIELD, MA – May 19, 2020 (GLOBE NEWSWIRE) Innovation Pharmaceuticals (OTCQB:IPIX) (“the Company”), a clinical stage biopharmaceutical company, announced today that its anti-SARS-CoV-2 (COVID-19) drug candidate, Brilacidin, in an in vitro experiment using VERO cells, reduced the viral titer (load) of SARS-CoV-2 by 75 percent after only 1 hour of preincubation prior to infection at a concentration of 10µM as compared to vehicle control.
These statistically significant lab results strongly support Brilacidin’s prophylactic treatment potential given the drug’s potent and rapid virucidal activity—a unique ability, different from any other known drug currently in development to treat COVID-19, to inactivate the novel coronavirus prior to host cell entry and subsequent viral replication. A majority of antiviral agents targeting SARS-CoV-2 attempt to inhibit viral replication rather than completely eliminating the virus (virustatic versus virucidal).
Additional time-dependent and concentration-dependent experiments are underway to further delineate Brilacidin’s virucidal properties against SARS-CoV-2.
The review article linked below more broadly supports the therapeutic and prophylactic potential of Host Defense Proteins/Antimicrobial Peptides and their mimetics, like Brilacidin, against coronaviruses.
• Memariani H, Memariani M. “Therapeutic and Prophylactic Potential of Anti-Microbial Peptides Against Coronaviruses.” Ir J Med Sci. 2020 Apr 18: 1–2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165072/
Brilacidin anti-SARS-CoV-2 research is part of ongoing antiviral studies that are being conducted at a U.S. Regional Biocontainment Laboratory (RBL). An earlier 16-hour post-infection experiment, in VERO cells, showed Brilacidin exhibited a dose-dependent reduction in SARS-CoV-2 infectious viral titers.
The Company is encouraged by Brilacidin’s considerable antiviral potential and believes that its use as a possible potent prophylactic and therapeutic antiviral agent for SARS-CoV-2, and other viruses, is warranted.
Separately, the Company and laboratory researchers (from a different testing facility) agreed that Brilacidin as a vaccine would not be studied further at this time. While the vaccine pathway remains of interest, the Company is prioritizing Brilacidin’s clinical development as a potential novel COVID-19 treatment, and thus is taking steps to rapidly advance Brilacidin into human trials.
Brilacidin and COVID-19
Brilacidin is one of the few drugs targeting COVID-19 that has been tested in Phase 2 human trials for other clinical indications, providing an established safety and efficacy profile, thereby potentially enabling it to rapidly help address the emerging worldwide coronavirus crisis. Lab testing conducted at a U.S.-based Regional Biocontainment Laboratory (RBL) supports Brilacidin’s antiviral activity in directly inhibiting SARS-CoV-2 in cellular assays, with a molecular screening study of 11,552 compounds also supporting it as a promising novel coronavirus treatment. Additional pre-clinical and clinical data support Brilacidin’s potential to inhibit the production of IL-6, IL-1b, TNF-a and other pro-inflammatory cytokines and chemokines (e.g., MCP-1), which have been identified as central drivers in the worsening prognoses of COVID-19 patients. Brilacidin’s antimicrobial properties might also help to fight secondary bacterial infections, which can co-present in up to 20 percent of COVID-19 patients. These data collectively support Brilacidin as a particularly promising and unique (3 in 1 combination: antiviral, immune/anti-inflammatory, and antimicrobial) anti-COVID-19 therapeutic candidate.
For researchers and institutions interested in collaborating on Brilacidin for COVID-19, please send inquiries to: covid19@ipharminc.com
Alerts
Sign-up for Innovation Pharmaceuticals email alerts is available at:
http://www.ipharminc.com/email-alerts/
I have been with IPIX since 2013ish and did not know that. thanks so much!
Go Leo & IPIX!
"A new but old scripted play from the " parasites " playbook? Safer? Says who? You? It has never been tested in humans, so yes, safer maybe in vitro assay and it looked great! And since you are well versed, you should know that antibodies in vitro vs SARsCoV2 aren't necessarily transferrable to humans. Let alone, will it guarantee safety and immunity to the subsequent virus infection. You never heard of mutagenicity? Well, at least Brilacidin is naturally produced in human epithelial cells so it's safe too. It goes from innate to adaptive immune reponse. Take notes. Vaccines? It may not be 100% effective as prophylaxis,but it's still safe."
100% agree TheDane!Hopefully this next couple of weeks is huge for us longs. I don't care necessarily about the sp right now and just want B to advance. Sp increase will be inevitable if BrilAcidin (lol) continues to advance with all indications.
Go Leo & IPIX!
"With this litany of complaints to lodge against Leo, why waste your time here? Cleary you're smarter than that.
Being smart, maybe you see the latest opportunity?"
I don't know, you will have to ask dp70.
Go Leo & IPIX!
Enjoyed! thank you,
Go Leo & IPIX!
"To BrilBlvr: Starting on May 18th there will be transits of the faster moving planets which would indicate the baseline for news to begin. An aspect from transit Mercury, the planet that has rulership of many things and one of them being communication will make an aspect to natal Venus in the chart and at the same time connecting with natal Jupiter in Sag. Jupiter rules publications....all kinds of publications. Venus has rulership over money, partnerships, and one of its medical rulerships is to blood...others are hormones, skin, kidneys, back, immune system through its rulership of Taurus and Taurus has rulership over the thymus which has to do with immune system, it also rules veins, arteries, the part of pancreas where insulin is created (?langerhorn) and more. Not that all of these medical rulerships will have anything directly involving the results. The one that stands out is money and partnerships. And that is not to say on May18th news will come out on that exact day regarding this only that it could be going on behind the scenes. The transiting north node of the Moon is going to connect with the natal Sun in the chart which I would interpret as something being in sync with timing...a good aspect to indicate the company is on the right track for being in the right place at the right time. Transiting Moon on the 18th will be making a Grand Trine to Venus and Jupiter in IPIX chart. The Moon transits are fast lasting only several hours but this aspect could act as a trigger for behind the scenes goings on. Things really heat up June, July, and August where transiting Uranus (which rules revolutionary breakthroughs, excitement, research, and on a more personal level in an individual chart can indicate genius, and rules organizations, technology, computer technology. It is a very progressive plant and can indicate breakthroughs which takes things to a higher level (corporate, government, science, research, etc) in many aspects of society. Just look where computer technology is today. It is the transits of Uranus that indicates the progress in computers, wifi, phones, the internet, etc. So June, July and August transit Uranus is aspecting the natal Mercury in IPIX chart and Mercury rules lots of things: communication, news printed and TV news, and in IPIX case could be the transmission on a big scale of news regarding the labs tests. It is an exciting transit. Also new and full moons act as triggers to the transits and the Lunar Eclipse on June 5th reinforces the Grand Trine I mentioned previously in this post. The Grand Trine is to Venus in 13 degrees of Leo in the chart and to Jupiter at 13 degrees of Sagittarius in the chart...only 2 degrees off from 15 to 13 to a very close eclipse and very powerful. I hope I have not confused others with my explanation but I was asked to do it so I hope you enjoy it. :)"
I agree. I think Leo/Locust Walk will do their very best to stop the manipulation of this stock going forward if B gets the ok to start with human trials. I am sure he understands now how toxic the OTC is and will want to prevent further manipulation. There are a lot of good people on this board that deserve B to be a success.
Go Leo & IPIX!
"News and money might come at any time, together or sequentially. Especially on the OTC, its all about "show me the money" for price appreciation.
There is another OTC baby bio now sporting a 1.5 BILLION dollar market cap with about double the OS of IPIX.
Do the math... and the risk/reward with IPIX at 15 cents is a no brainer.
Don't forget, there have been three different phase 2 trials that showed Brilacidin's safety and efficacy.
I'm ready to hear from the 3 labs and watch what happens next.
Quote:
If we see that kind of volume here with IPIX, the PPS would be in the multiple of dollars in my opinion.."
Thanks GreenBioAnalyst! I am not a scientist so my question to you is if B gets the ok to go forward with Covid19 in human trials; will B go to phase 2 or 3? My understanding is that phase 2 deals with mostly efficacy/dosing/effectiveness? That would have been figured out in the other B phase 2 trials. Any thoughts/opinion on this?
Go Leo & IPIX!
"I'm looking here and I see a lot of petrified shorts, "parasites, " and "criminals" who are planting fear, and uncertainty for you to sell your shares for cheap. Don't let them fool you.
Some are pretending to be bulls, and you can tell how they just wreak with fear and uncertainty of how they're about to lose everything. Should you feel pity and remorse for these stained " criminals"? I don't think you should. Not at all.
As always, just like any previous in vivo assays, I highly doubt the narratives will change anything than proving, yet again, that amplification of Bril in human epithelial lungs inhibits SARS-CoV-2 viral load, replication, and induces anti-inflammatory properties in cytokine reductions. Bril's 3-in-1 action is no joke!
The bears or shorts flipped and shorted this company with impunity and no mercy without really understanding how the science behind Bril actually will work against the CV19 pandemic. Now, Bril has multiple options such as a mono therapeutic drug, prophylaxis, an adjunct to another HIV drug, and/or an adjuvant to a future vaccine( JNJ and BARDA?). Best yet, funding from the government and a potential partnership. I can't wait for them to announce when the IND application is to go along with PII/PIII trials.
This is a hidden gem. This company will trade over $1 and much higher very soon! Jmho. YOU guys earned it for sticking through it. GLTAL!"
Very wise words, thank you and yes life is very good!
Go Leo & IPIX!
“ Perspective is everything.
It’s a mess out there now. Hard to discern between what’s a real threat and what is just simple panic and hysteria. For a small amount of perspective at this moment, imagine you were born in 1900. On your 14th birthday, World War I starts, and ends on your 18th birthday. 22 million people perish in that war. Later in the year, a Spanish Flu epidemic hits the planet and runs until your 20th birthday. 50 million people die from it in those two years. Yes, 50 million.
On your 29th birthday, the Great Depression begins. Unemployment hits 25%, the World GDP drops 27%. That runs until you are 33. The country nearly collapses along with the world economy. When you turn 39, World War II starts. You aren’t even over the hill yet. And don’t try to catch your breath. On your 41st birthday, the United States is fully pulled into WWII. Between your 39th and 45th birthday, 75 million people perish in the war. At 50, the Korean War starts. 5 million perish. At 55 the Vietnam War begins and doesn’t end for 20 years. 4 million people perish in that conflict.
On your 62nd birthday you have the Cuban Missile Crisis, a tipping point in the Cold War. Life on our planet, as we know it, should have ended. Great leaders prevented that from happening. When you turn 75, the Vietnam War finally ends.
Think of everyone on the planet born in 1900. How do you survive all of that? When you were a kid in 1985 and didn’t think your 85 year old grandparent understood how hard school was. And how mean that kid in your class was. Yet they survived through everything listed above. Perspective is an amazing art. Refined as time goes on, and enlightening like you wouldn’t believe. Let’s try and keep things in perspective. Let’s be smart, help each other out, and we will get through all of this.
Life is Good??”
Please sticky this! Awesome post.
“ No worries. I'm glad I could pitch in. Brilacidin looks really good based on what I have researched so far as an antiviral agent vs SARsCoV, MERS, HIV, RST, AIV, Norovirus, etc., etc, both in vivo and in vitro assays. Although no one can really identify how exact Bril will inhibit its antiviral effects against SARs-CoV2, that's what the University is for staffed by renowned virologists to explain and identify its mechanism of action. I can only hypothesize the bilayer lipid membrane is the weakest point of the virus and where Bril would have its antiviral effects by binding, degrading the wall and altering the curvature of the virus and making it porous and unable to bind to other host cells to hijack them. So we are possibly looking at inhibitions by entry and by replication.
Other things I've discovered is the binding site of SARs-CoV2 comprising of both hydrophobic and hydrophilic with excess hydrogen bonds make an ideal and perfect target of Bril! Brilacidin possesses amphipathicity as an antimicrobial agent so why I have postulated Bril will continue to show very positive antiviral effects in human epithelial lungs! See below. Then you power that up with two pathways with how Bril can activate the innate and adaptive immune response, then our drug having immunomodulatory properties will address the cytokine storm and the secondary pneumonia infection associated in some severe cv19 patients. Bril's 3-in-1 action could very well be the best cv19 unknown drug out there that could also rival Cydy's leronlimab ( I'm long too with cydy).
Below are two separate about excerpts about SARs-CoV2 and properties of Bril that investors should be really thankful and excited about:
" The reduction in the hydrophobicity determines a reduction of mammalian cell interactions while favoring the targeting of bacterial cell membranes, as long as the peptide has sufficient positive charge. Refer below.
"Together with the secondary structure, charge, and hydrophobicity, amphipathicity also plays a key role; in fact it allows the peptide to insert the hydrophobic face into the membrane bilayer. Amphipathicity in AMPs usually refers to segregation into hydrophobic and hydrophilic domains and is usually a descriptor used for dissecting the role of amphipathicity in peptide antimicrobial activity; it is measured by the hydrophobic moment of peptides when already in a-helical conformation.
Plus, to postulate the above with how and why Bril will work knowing this below about SARs-CoV2's molecular composition.
"Peptides are known for their structural diversity with ease of synthesis and unique mode of action with limited off-target activity. Peptide-like inhibitors are widely used to treat several diseases like cancer, diabetes, autoimmune diseases, etc. and have high success rates in commercial development (Beeley 1994). Structural analysis of the co-crystallized molecule suggests that compound binding to SARS-CoV-2 main protease hampers the function of the protease and could be a possible target for drug development. The binding site of SARS-CoV-2 main protease is a combination of hydrophobic, hydrophilic and charged residues holding with hydrogen bonds in excess." ”
Thank you for taking the time and clarifying this for the less experienced traders on this board. Makes complete sense.
Go Leo & IPIX!
"Bulls or investors have really little worries or care about this nonsense talks of shorts. There's going to be some serious covering by the "criminals " when the results come out. Then followed by a funding grant from BARDA or NIAID and/or outside licensing partnership with a pharma while simultaneously initiating PII and PIII trials here in the US and Europe. More positive data means more price appreciation. The TIH is going to foot the bill and a pharma deal would entail a cash upfront payment to IPIX, to go along with milestone payments and tiered % payments from future revenues plus a percentage of ownership of IPIX made by a pharma! That's a ton of upside value that will be created before worrying about stoking the fear of dilution when the three separate MTA's are footing the bill. Intentional? Maybe or maybe not.
So who really cares if the CEO sells shares using ATM @ , say, 75c, $1, $2,$3, or $4 per share? BARDA funding, Alphasigma milestone this July plus a potential exclusive licensing agreement? That's plenty of cash runaway to be even worrying about this dilution when you can just use ATM, wouldn't you agree? I wouldn't bet against the government who prints the money and is in desperate need of getting therapeutic and prophylaxis drugs out there. So is Roger being shortsighted?
If and when the trial is initiated, it a more likely that Bril will gain approval in the next four or five months. That's six years of timeline condensed into six months to get a repurposed drug approved! Scary, huh? So Roger is correct, why worry about the " criminals " spreading nonsense about this 300mil float?
Also, you didn't know that a company's valuation is tied into what drugs they have in the pipeline? Idle or not or commercialized? As for the comparators used by Roger, you should know that it's all relative and directly proportionate to those seven companies' assets and revenues vs Ipix. A ton of preclinical and late-stage companies have zero revenues but yet they have valuations. Why is that? It is because it's determined by their pipeline or assets and how soon that pipeline can generate revenues and become profitable using the discounted present value of future cash flows.
In this case, Bril being tested for therapeutic efficacy, dosing, cytotoxicity, and as an adjuvant or adjunct to a vaccine --all bring them VERY MUCH CLOSER to becoming profitable in repurposing Bril for CV19.
So to say that "there is no value whatsoever to comparing their floats to that of IPIX" is actually a false thing. Roger was referring to shares outstanding by naming seven companies as examples. Again, it's all relative and directly proportionate to their assets, pipeline, and revenues. Plenty of preclinical or late-stage bios with zero revenues with a value attached to their floats. Ipix is one of them. So I don't get the what is the fuss about the float?
Lastly, do you understand the difference between authorized shares vs outstanding shares vs float?? You seemed to be confused when you wrote the following paragraph below:
"As to the issue of the CEO taking advantage of the current trading, he's not. All of the share issuances for the last number of months have been as a result of the mfo exercising the rights their deal, made a year and a half ago and since amended in favor of the mfo, gave them. It's the mfo that has been "taking advantage of the current trading", not the CEO. It's their ball, so no one will be entitled to scream 'LACK of FIDUCIARY responsibility' anyway. If they do, they just don't understand the deal.""
Awesome post! If B goes forward to human trial (which I think most of us on this board think it will) and is successful all of these petty shots taken at IPIX will not matter. COVID19 is devastating the worlds economy and IPIX is on the cusp of providing a therapeutic.
Go Leo & IPIX!
"I'm not concerned by dilution.
BMY float 2.26 B SP $61+
PFE float 5.5 B SP $37+
MRK float 2.52 B SP $76+
GILD Float 1.25 B SP $77+
LLY Float 792 Mil SP $153+
Others with smaller float and Larger SP ie. BIIB(162mil) trading at $314,REGN(83mil) at $563+.
300Mil float is a "So?" situation.
If the CEO did not take advantage of the current trading and Brilacidin is hissed off the CV stage, some here would be screaming 'LACK of FIDUCIARY responsibility'.
You know who you are and can go Pound Sand."
Shorting this stock right now would be like playing Russian roulette. Unless there is something I am completely missing.
Go Leo & IPIX!
"Well, not everyone. Shorts would have a pretty bad day.
Go IPIX!"
I wish you would post more on this board. You are very knowledgeable and thank you for that.
"Do you understand what clinical assessment is all about the article?? ?????????? You also wrote:
Considering the length of time of the current trials.
"If Brilacidin has no significant outcome upon initial introduction to lung tissue (either preventing infection by CV or ridding pre-inoculated tissue of live virus fine tuning potential period of therapy is moot."
Brilacidin has demonstrated direct antiviral, anti-inflammatory, anti-microbial in the cell assay: Vero cell. If your presupposition has any remote validity, why even go through the length of testing Bril's potency and cytotoxicity ?????????????????????????????
It has never occurred to you that if Bril didn't have therapeutic benefits against (see HDMs and AMPs in vivo and vitro assays) (3) SARs-COV2 then this additional extensive testing is a waste of time and resources? Otherwise, all other drugs such out there such as Galidesivir, Remde, etc., etc., that demonstrated broad-spectrum antiviral in vitro have zero clinical benefits or that effectiveness that they were repurposed and tested clinical trials. You also didn't get the memo that even if they're effective in vitro, they are not necessarily translated in humans??????? We are seeing that in HIV and autoimmune drugs that are being repurposed for Cv19.
All these testing being done with Bril is just a formality before they start testing it in humans. Bril is a dose-dependent drug so it only makes sense that additional testing is necessary to ascertain it's efficacy, potency, and cytoxicity. Bril's ability to exhibit anti-inflammatory ( to reduce the viral load) and antimicrobial effects are another way the drug has demonstrated in other trials that it has potential therapeutic benefits in treating severe cv19 patients. It is clear to me that you lacked the comprehension and foresight to even understand why this drug even made it this far in testing and as to why it is getting advanced in human clinical trials. ??????????"
Removed - I am not surprised.
Go Leo & IPIX!
Awesome post! and we are getting free testing to confirm this.
Thanks Nick.
Go Leo & IPIX!
In response too.
IMO the additional MTA is for the purposes of Brilacidin to be utilized as an adjunct immunomodulator for a vaccine. It’s why they stated dosing needed for young and old. The young have been mostly spared, thank god, so this points to a vaccine since everyone would get the vaccine both young and old so we don’t have silent carriers through the young moving forward. If this MTA was for a treatment then they wouldn’t have requested young samples as well. I’ll explain further.
An immunomodulator (Brilacidin) is an artificial antibody used to regulate immune mediators (T cells, B cells, monocytes, etc.) in your system.
Immune mediators are the cells in your body that go to war against foreign substances(COVID-19). They are also what provides the symptoms like inflammation, fever, headache, etc... The problem with COVID-19 is that our natural defenses (immune mediators) attack so strongly that it causes massive inflammation throughout the body which is the leading cause of COVID complications.
You can’t just take halfway dead COVID virus cells and Inject them into the body (like first early vaccines) because our immune mediators will react in the same way and give the negative effects that are killing people therefore if there were an immunomodulator as an adjunct to the halfway dead COVID cells then the immunomodulator (Brilacidin) can help keep the immune mediators in check while they fight the half dead COVID-19 while natural antibodies are created from the vaccine without symptoms.
That’s my take to this additional MTA and the scientific analysis of it.
I tried my best to take something very scientific for all to understand. Sorry if it’s still confusing.
You called it TheDane! You said we would have PR Monday or Tuesday... keep up your humour, its entertaining.
Leo Keeps adding to value of IPIX. Sorry, let me rephrase that - the tax payers dollars are adding to the value of IPIX. Yeehaw!! Hopefully we get into human trials soon.
Go Leo & IPIX!
I like the new modification to our web page. Thanks LK.
Go Leo & IPIX!
I agree... I don't hold a lot of long positions but this is one of them and this is the one and only OTC that I will ever hold. I however believe in the science and hope Leo can do this for us.
Go Leo & IPIX!
Your right, it seems vindictive and nothing else. The most that was gain by my estimations yesterday was about $54000.00. That is not worth getting caught is it? I was threatened via pm a couple of years ago (that I still have) that I would lose everything I own in IPIX stock. I am almost convinced that being vindictive is getting in the way of allowing a possible ground breaking drug to be developed and a lot of people making money. I have confidence Leo will overcome this.
Go Leo & IPIX!
Thanks Tickertails and I appreciate your contribution to this board.
Go Leo & IPIX!
Thank you for your two educational posts - very much appreciated. Do you, in your experience see an end to this manipulation of IPIX stock? If yes, what will initiate the end of the manipulation? There were a couple of days recently that traded 25 mil shares and they really kept a cap on the price increase. Thank you,
Go Leo & IPIX!
Thanks a bunch,
Go Leo & IPIX!
I just sent Tucker Carlson a message on his website about B and its highlights.
https://www.foxnews.com/shows/tucker-carlson-tonight
Go Leo and IPIX!
I have no issue with you sharing your opinion for anything I say on this board. If we were face to face I think your responses would be different. I think berating is repeating "jaw dropping" 3 times in your reply to me. Your point is completely missed when trying to make me feel less than you.
Now on to more educational posts on this board.
Go Leo & IPIX!
"No jaw dropping PR is even remotely possible this week or next. The RBL had not even started more testing as of last PR.
3 weeks of no tests for this anti corona home run! Maybe that is how they work. It is still very slow, given the stakes, no?
A jaw dropping PR will be when and if B helps in humans, after initial promising tests already outlined by Leo. Those next steps-if positive- will help the share price but would not count as jaw dropping. Potentially super duper data still months away."
You are so draw dropping knowledgeable on this subject. You are obviously draw dropping smart so why are you berating people on this board? How do you know that Leo won't release a jaw dropping release today. If he does I think it moves the share price a jaw dropping amount. I saw my niece and nephew do this once. You are too draw dropping funny.
I think B is going forward and will be a jaw dropping success. I call it the "reversemako"
Go Leo & IPIX! delete.
"No jaw dropping PR is even remotely possible this week or next. The RBL had not even started more testing as of last PR.
3 weeks of no tests for this anti corona home run! Maybe that is how they work. It is still very slow, given the stakes, no?
A jaw dropping PR will be when and if B helps in humans, after initial promising tests already outlined by Leo. Those next steps-if positive- will help the share price but would not count as jaw dropping. Potentially super duper data still months away."
Pete, well said! I am hoping that this crises is big enough to overcome the nefarious system IPIX is currently in and I hope we get another jaw dropping positive PR this week from Leo. I think Tucker Carlson would take on something like this if he knew about it. Tucker could get some attention for us.
Go Leo & IPIX!
Great analogy!
Go Leo & IPIX!
"11,552 high school football players
30 make it to college
8 make it to pros
2 or 3 are stars
The other 5 or 6 still play.
B just needs to play to blow the stock price up."
Awesome post!
Go Leo & IPIX!
Long time bag holder here hoping what is in my bag turns to gold.
I looked at the PR and liked what I saw. Some feel it is not much different than last PR but it is very different. The RBL study bathed B onto monkey cells with subsequent reduction of the viral load.
This PR highlights a study using computer modeling of the structure of a huge library of drugs to screen for best candidates for binding with the structure of Covid 19. According to the screening B was one of about 30 drugs out of 11,552 with the structure to pull this off with Covid, which confirms the RBL research as a drug of promise. Think of it this way: if you send a ship to the international space station and the docking mechanism on your ship doesn't match the one on the station you are out of luck. Same with drugs and Covid.
There were 3 possible binding sites mentioned in the paper. The PR from Leo only shows the table for the one where B was a match but there were two more. By my count there were 12 drugs highlighted in the group B was in, 14 in one of the others (although only 11 in the table) and 6 in the Spike Protein site (no table in the paper).
Once a drug is bound to the virus many different types of interactions can occur. So binding is important but, once bound, the efficacy of the interaction is paramount. Efficacy is also dependent on toxicity (side effects). Taking all this into account this interaction, a cascade of chemical reactions, will determine the winner of the Covid sweepstakes.
The paper identified the best drugs on the basis of binding but we will have to wait to see how B does with efficacy. The RBL monkey cell data was encouraging in that regard. The upcoming RBL human lung cell study is the next step.
B has the advantage of multiple effects that may prove beneficial. It is an immunomodulator and can hopefully stop the cytokine storm that has killed so many. There is some great information on the IPIX website about the immunomodulatory potential of B. And it can also latch onto many types of bacteria responsible for secondary infection. So it may kill more than one bird with one stone.
Some feel B should be in Covid human trials by now but I think it is understandable from a safety standpoint that already approved FDA drugs showing promise would get first crack at that. As noted in this study of the 3 binding sites, B's group had 3 drugs with FDA approval and there was 1 each in the other two groups for 5 total that have FDA approval. Of course, none of these drugs are approved for Covid but the argument and risk of repurposing them is stronger than it is for a drug with no FDA approval.
That said, time will prove which drug is best. Hope B is a winner.
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John J. Garrity release this stock.
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Maxm - wants to buy IPIX shares at $0 and sell at $1.00. I think there is something fishy going on here.
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Will this be a double press release day? How long can this stock price be held back?
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Would Alphasigma have first right of refusal if we go to human trials?
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Covid19 is still on the IPIX website which is still promising. Lots of good discussions on the board today. Thanks... This could be a game changer for us believers.
Go Leo & IPIX!