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its THEY
but Ok.. i'm not allowed to say this..allthough i'm right about SP manipulation and the reason.
I cant understand WHY people dont want to hear it.
you should form a front with management against this manipulation, otherwise GTCB will be stuck for many many more months..
But apparantly nobody cares about that.
First Patient Enrolled into ATryn(R) Phase II Study in DIC Indication
Monday August 6, 8:30 am ET
FRAMINGHAM, Mass.--(BUSINESS WIRE)--GTC Biotherapeutics, Inc. ("GTC", Nasdaq: GTCB) announced today that its partner for ATryn® in Europe, Canada and the Middle East, LEO Pharma A/S, has enrolled the first patient in a Phase II study of the recombinant antithrombin product in the treatment of disseminated intravascular coagulation, or DIC, in association with severe sepsis. Full enrollment of about 200 patients into the Phase II study is planned to take approximately 12 months with results expected to be available in the second half of 2008.
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Estimates from the scientific literature are that there are over 1.5 million cases of severe sepsis in the U.S. and Europe and over 500,000 of these patients develop DIC, with a mortality rate of up to 50%. A number of preclinical animal sepsis studies, as well as a human endotoxemia study, suggest that ATryn® may have potential in the treatment of DIC associated with severe sepsis if provided without heparin, a critical care anticoagulant. A number of countries in Europe and Japan include the treatment of DIC associated with severe sepsis in the approved uses of plasma-derived antithrombin products.
In evaluating the clinical and commercial opportunities, GTC has determined that applying the cost of existing treatment options for severe sepsis to the estimated annual incidence of DIC indicates a total potential U.S. market of $2-3 billion per year.
The objective of the Phase II study is to establish safety and to determine the optimum dose to be used in a subsequent Phase III safety and efficacy study. LEO obtained Scientific Advice from the European Medicines Agency, or EMEA, on the design of the Phase II study. GTC plans to use the Phase II results as the basis of a discussion with the Food and Drug Administration on further clinical development of ATryn® for the DIC indication in the U.S. GTC retains full commercial rights in the US, Japan, and the rest of the world outside the LEO territories.
ATryn® is GTC's recombinant form of human antithrombin. Antithrombin, produced in the liver and circulated in blood plasma, has both anticoagulant and anti-inflammatory properties. The recombinant form is able to be produced using GTC's transgenic production platform, enabling large volume supply. ATryn® has been approved for use in Europe for the prophylactic treatment of deep vein thrombosis in hereditary antithrombin deficient (HD) patients undergoing surgical procedures.
GTC is also nearing completion of the clinical studies necessary to support the filing of a Biologics License Application for ATryn® in the HD indication planned for the first quarter of 2008. These studies include an evaluation of the incidence of deep vein thrombosis and thromboembolisms in 17 additional hereditary antithrombin deficient patients treated with ATryn® during surgical and pregnancy procedures. A comparative historical study of approximately 35 patients treated with plasma derived antithrombin, and undergoing similar high risk procedures, is also nearing completion. GTC plans on releasing top line data from these studies in the fourth quarter of 2007. GTC is in discussions for potential commercial partnering for ATryn® in the U.S. market.
you "easily" forgot the splits and difference in diseases?
good to hear
but why isnt GTCB doing a Press release on it?
I hope its not.."LEO decides that..", cause imo thats an indication GTCB management have gave away too much control.
and it should be a nice gesture form management they care about shareholders
with respect i've been telling people this for months
its THEY.
THEY have only one intention ..that is to block sp when it goes up and to create panick when market drops.
Is their intention making money.. no its a nice side effect, but main reason is to show them whos in control and that YOU dont earn your deserved money.
But hey..dont believe me.. THEY will win.. cause management GTCB dont care about SP
many sellers are also panicksellers (money problems) from Pharming shareholders which are also in GTCB. That is what THEY are counting on..and that is why THEY are doing is..
THEY dont like people who keep thinking that they know everything cause they know something about a technology or company.
THEY (manipulators) dont care..they have the money and the hedgers behind them and think " we'll show you who's boss"
thats all.. nothing more, nothing less
thats not fair Dew
GTCB was 1,03 intraday in a green market this week.
it has nothing to do with the DOW or sentiment
In a good sentiment GTCB didnt go up at all.
its all played manipulation..
but keep ignoring and denying it.
again good news from the platform in general
Goatmilk helps against deadly nervegas ! (Sarin and VX)
I translated it from a dutch article in my own words..
so it could have some minor errors. Sorry for that
Scientist have accomplished to let genetically man. goats produce a cure against deadly nervegasses like Sarin and VX.
This is done through/using their milk
medicine is called recombinant butyrylcholinesterase.
Its even possible to help people who are allready "infected/afected" by this nerve gass.
this butyrylcholinesterase is allready present in human blood but the amount present isnt effective against nerve gasses.
Scentists from a farmaceutical company in Montreal made a deal with the Canadian and US army, and are now producing this medicine in large quantities from the milk of mod.goats
Geitenmelk tegen dodelijk zenuwgas
LONDEN (ANP) - Wetenschappers zijn erin geslaagd genetisch gemanipuleerde geiten een geneesmiddel in hun melk te laten produceren dat beschermt tegen dodelijke zenuwgassen zoals sarin en VX.
Met het medicijn, recombinant butyrylcholinesterase genaamd, kunnen ook mensen behandeld worden die al aan een gifgas hebben blootgestaan, meldde de BBC vandaag.
Butyrylcholinesterase is in het menselijk bloed aanwezig, maar in zulke kleine hoeveelheden dat het niet helpt bij bijvoorbeeld een aanval met zenuwgas. Wetenschappers van een farmaceutisch bedrijf uit Montreal dat een overeenkomst heeft gesloten met het Canadese leger en het Amerikaanse leger kunnen het middel nu op grote schaal maken met behulp van gemodificeerde geiten.
sounds like good news from Merrimack
finally some start to fight back against manipulation and naked shorting
http://biz.yahoo.com/prnews/070718/law077.html?.v=101
wrong ticker and letter???!!
its just THEY who put pressure on sp..like they do with Pharming
They gamble on panick selling or on people who have to sell cause they lose too much money
THEY control your stock.. thats all
THEY can do this cause they have more money than many of you together and management isnt doing anything in favour of shareholdervalue..
but dont worry..THEY will let it go somewhere..
I'm allmost shocked how little people know about their own public health environment, and really believe that the medication out there is medication good for public health and is safe??
Did you know that the 4th cause of death in USA is side-effects of GOOD prescribed and used medicine?
its no lie..
I find it allmost saddening that people think I'm joking.
People are dying in millions due to medication.
There has never been more cardiac problems and cancer...and other chronical diseases. Its in your food and medication..
people who think this is a joke...?
well .. i'm shocked..its your health, your childeren's life !!!!
but i will drop the issue cause it makes me sad and mad how little people know about their life and HEALTH.
I really wish people would start to think
Jesse
with all respect but the FDA and the EMEA are TWO institutions (and its not unknown the FDA is much worse on this subject), that dont take our health seriously. Only for the money and lobby they approved 70% of all medicines that are life threatening and doesnt even work.
I hope you know that the FDA and EMEA dont approve products that HELPS people , but basicly they just APPROVE products where the farmaceutic kartel earns the most money with and the FDA and EMEA get their cut
Like I said, out of respect of some posters I wont go through the wire here. But there is a difference on HOW something can be approved. On DATA or on something else.
That difference I want to see resolved by management
too know WHAT to believe
Is it that difficult for them to answer me or others that question?
Mblimon
I understand your view in this matter, and respect your comment.
But you know me as someone that isnt into this kind of bashing
you describe.
I dont know if I'm making too much out of nothing.
I would've really liked to know from management how this Atryn story is to be rated ( Lawyer approval).
I still want this too.
But in the respect I have for you , and Okydocky on yahoo and some others I will back down on this matter.
I still want this matter resolved and if you like I will post the answer of Newberry if I get one on this matter (sent him today a mail that I really would like more info on this subject)
But please be advised that IF it turns out to be 100% sure it is done by lawyers, understand that a approval by the FDA would turn out near too impossible.
therefore this matter matters imo
I asked Newberry again today.. so we'll see if he accept this mail and answer it?
I will post his answer if I get one (just this one time i'll post his answer ,cause I really dont like copy paste of mailinfo)!!
the last times they never really answered my questions..and nearly thanked my for my interesting mail. And they never really touched the matter nearly stating that an expert pannel helped them to get approval
I am disappointed about GTCB and my investment here. I honestly stated this. And I also stated that I have to watch out not to get involved in this because I know too much and I feel a bit sour about management.
nevertheless I tell you what I know, i've been saying this for weeks and months (also while I had my position). and nothing in what I say is made up. Its precisely how its got presented to me by some sources.
sorry Dew,
somewhere you missing the point here.
And I dont understand that someone THAT good infored as YOU, dont find this interesting enough to have mentioned it?
Do you honestly believe that IF Atryn is approved by lawyers and not solely on DATA and the EMEA got beaten by a GTCB lawyer that the FDA will allow ATRYN without a fight?
I think you absolutely dont have a clue about these organizations than. and how they work.
I think its ESSENTIAL in the success of GTCB to find this out !!
A nice technology says nothing in this world. If the farmaceutic kartel or the EMEA and FDA oppose you.. you're OUT.
its that simple.
But dont believe me, just hope I'm not proved to be right.
mblimon
Ask the EMEA about what I wrote. Ask them about HOW Atryn got approved and mention lawyers..
Around GTCB,, ask LEO
in the field.. ask institution analysts..
Its not that difficult Mblimon. Just mail mail mail and dont take NO for an answer..
Please feel free to do so. I'm not copy paste my mails anymore.
I have my reasons
Within Pharming I wrote you who and why
Again, I still gave GTCB the benefit of the doubt, and somewhere in me, I still hope GTCB will prove (me) and some wrong. But after a couple of times trying to gently ask them about this, they keep giving no response about this matter.
I wish they solved this issue and start to inform their shareholders thoroughly. Also about plans LFB and pace they progress with DIC. Also the revenues with Atryn etc..
I have to watch out, that my disappointment dont take the upper hand in this matter
the problem is that people dont want to hear things that they dont like ..
there are a couple of things that make this low valuation possible
* first.. THEY are real.. they are a few people that make a hobby out of controlling stocks. You dont believe me , but I know its true. They are not in it for making money in the 1st place.. they just are in there..with one reason that YOU dont make money..and while doing so..they normally make money in the process.
* Furthermore THEY probably knew before many of you.. that GTCB's Atryn got approved by lawyer intervention. and not purely on DATA
This is something management of GTCB never told you and me as shareholders. I confronted Newberry with this and he didnt deny it..but also didnt confirm it.
He was seemingly surprised I knew..
It would be of the utmost importance if management would clarify this rumour that has been confirmed by some in EMEA, some around GTCB, some in the field , some of people working at Pharming.
So its more than a rumour.
If Atryn got approved on DATA solely..then please write this to your shareholders if they ask you in a mail
then we can verify this with the EMEA..and we know
* Atryn is never mentioned in revenues predictions by management. They conveniantly put it in the total amount of costs prediction. But why not give an explicit revenue prediction of Atryn for the next years?
Probably cause they know it wont be much.. otherwise you should and would inform this with everything you got ( if revs were interesting)
* its indeed low valued in marketcap.. but management has done this by continuingly malinforming and malpractise in my opinion. They should have made the right desisions and inform us.. they shouldnt be saying like Newberry does over and ver again that If he was investor he would BUY.
Never heared someone say this over and over again ..but not buy himself or practise shareholdervalue with his company
* Whats keeping the Dic phase 2 ..? nice that you have a plasma partner..but are they for real or just stalling technology and let GTCB bleed slowly..?
* many many things that at least clarify why people can easily manipulate this.
That some dont want to admit ths manipulation, is something they have to deal with.. Its as clear as it can be.. and denying it, makes it even more fun for THEM to do so..
or the ones denying are the ones involved..you never know
anything is possible, but I never understand these questions to you.
"When do you see a partner in Japan?"
I've been answering these type of questions myself at Pharming boards, so I know how obliged you can feel yourself to help and inform people at/to the best of your ability.
BUT Dew can't say this or tell you this. He's not working at GTC.
So anyones quess is as good as his or your owns
I'm allways surprised by the lack of self DD by people and the way they clinch to some peoples info and also the lack of asking questions to the company their investing in..
Do your own DD
and ask these questions to Newberry!!
Ask him about the way Atryn got approved. Save his answer, back it up and sent it to the EMEA. then await their response.
about Dic studies..
It looks to me..it is all about..stall stall stall.. like I allready was anticipating.
Lets hope GTC management or LEO will do someting with the Atryn release .. Allthough their wont be much to report, (cause I dont see huge interest the next year) I hope they'll do some PR
lets hope we see the 1,80-2 dollars this year
DIC phase 2 enrollment ?
When will GTC finally make them public?
If you say H1, than you have to to do this imo.
I have the feeling that GTC has no SAY in anything here.
IMO thats not a good sign.
LEts hope Atryn release will have some impact
Allthough by now everyone should know that Atryn wasnt approved on data alone, you might hope that a few cts will be possible to be added on the sp. 1,15-1,20 looks very low even with all the fuzz around it
But 4 dollars and more the next year(s)??
I cant see how
FDA will not be a pushover after the EMEA echec with Atryn (lawyer approval)
All the other indications seem to run out of GTC hands ( time , control, etc)
No news from Merrimack trials (possibly due to same reasons.. no control )
A bit more critiscism looks justified imo.
Till now , the management of GTC hasnt been completely honest to his shareholders and i've been missing any focus on shareholdervalue
I dont know if they cant do anything about it..
Its a matter of opinion ..
but your welcome, allthough I dont like Sp movement one bit
Your welcome.. I had this for a while.. but today I saw it posted by someone.
Didnt want to put on the boards..cause we all know we only feed the shorties and manipulators.
How this progressed? ( I wish I knew if GTCB did something)
Ask Newberry.. forward this document to him
and see what he answers.
This man (Newberry) is a master in avoiding the truth.
He just wont tell me.. he avoids every real question but allways seems to be able to add..that " these are very cheap prices "
He reminds me off Cox "very exciting times he allways says.."
very exciting for whom? I allways wonder
There are so much more things.. but you never hear them from management or read them on this board.
I'm really surprised about some things.
People keep writing interesting things about the technology and possibilities..but I really do believe many dont understand this business ( and then I mean.. pure the practical site.. how deals for money work.. with whom they do and did business for money..
How the EMEA and FDA work, how the pharmaceutical market works..)
AGAIN I DO NOT MEAN IN THEORY.. (cause thats only to keep you of track in real life)
and How management keep giving you and me half of the story.
I know the possibilities on paper.. I bought on them.. and I really believe buying at these levels will in the end hurt no-one.. but I do not share people 4 a 5 dollars dreams..and let alone people who actually believe in 10-20 bucks a share.
Do they know how Cox works?
How the FDA trials are going..and how the FDA wont be a 2nd EMEA?
Where are the so promised DIC phase 2 studies..?
Like I feared is getting more and more a possibility, .. All their partners arent in a rush.. stall stall stall
I hope i'm wrong on the DIC studies..and they will deliver on time..
I know i'm not wrong about Atryn, EMEA, and the way Cox is doing business.
I'm sorry..I often sound very negative. I probably have that tendency a bit too much.. but I cant get very excited about SP and the way management is doing their job for their shareholders.
I'm really admiring ( allthough sometimes it feels more like a strange suspicious feeling) that many people simply accept the sp and management and really believe in much higher sp.. allthough everyday you can see this wont happen and Atryn wont deliver much revs.
again..I hope I'm wrong.. but for now..I know i'm not
http://www.sec.gov/litigation/complaints/2006/comp19683.pdf
anyone knew about this?
What is management doing to prevent this time and again?
Still no DIC phase 2 ??
Management said q1 than H1.
I hope they will do something right for once
I think his plan will work eventually, but I agree it allmost looks like Phil is allmost NAIVE and a bit blindsighted .
He wants to built a legacy , other CEO's just want to make money over your back
DMOI
Maybe you should ask your questions to IR or NMKT management
I know I did, and I got my answers as far as possible.
Its a dirt game that has been played by Loflin, and sometimes I think PV is a bit naive or way too opportune.
We'll never know the whole truth, cause when NMKT says A, Loflin will say B and vice versa.
that Loflin character played a dubious role in these negotiations.
ask your questions to IR. Maybe he will give some more info
its a NASADQ error !!
E is unjustified is what they told me
NMKTE?? WHY?
yahoo gives an E for NMKT and the SEC dont???
now what?
Swazie .42
Rickhnd .44
Scovillez .45
Eatunder .475
Augie .50
Digitech .55
dckeylargo .52
Lasvegascowboy .46
jagram .63
SBC357 .53
imo most important things are
Filings on time
Dividend
Upgraded listing
I dont think they have fluffy PRs.. they just want to inform as much as possible, but they should do filings on time instead. I'm not saying thats a good or bad strategy to have much PR..but do the important things right please..
I want to know future outlook. And they allready set it LOW, so they can BEAT it.
--
I want to see that besides a good revenue growth THEY stop dilluting soon and stop pushing everything to the latest day ( filings..etc)
Start delivering like a grown company instead of a company that is on the OTCBB
Wasnt this first in Q1?
if your schedule is right than management is behind of schedule
Where is that much anticipated DIC phase 2 begin that should have begun in januari-march?
how much time do they have left to file their 10q before problems ?
1 june.. NMKT latin and NMKT broadband completed
next days more news
probably dividend issued in 2007