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negger0,
Here is a report with the timelines for DNAG's pipeline.
http://www.dnaprint.com/welcome/press/press_recent/2005/1121/DNAG-FinalReport110405.pdf
Frog,
Guess I will answer just one more time, then you can use your last excuse that I have an aversion to answering your questions. It is not your questions of course, it is you I have an aversion to.
What you asked me for was my opinion, I gave it.
Are you asking if it will superceded DNAG work and patents, my opinion is NO. We are far ahead of the pack now.
Now you say
Given that the publication suggests that all the work that has focused on leveraging the ancestry markers can be duplicated using 'any' high density snp panel, doesn't that imply that the rest of the industry has just 'caught up', and the race in now starting over? How does that jibe with your 'ahead of the pack' characterization?
That is you OPINION., it is what you IMPLY and I already said I disagree, see above.
"the publication suggests that all the work that has focused on leveraging the ancestry markers can be duplicated using 'any' high density snp panel,"
YOU are the one suggesting that ALL the work that has focused on leveraging the ancestry markers CAN BE DUPLICATED using 'any' high density snp panel,"
I do not know that "all the work that has focused on leveraging the ancestory markers" can be duplicated. There are many unknown factors here. Both from DNAG and your source. You make many assumptions here. (feel free)
Then you say
Also, while it is quite gratifying that the patents are 'moving' is it not the case that all of the pertinent patents leverage the ancestry based technology that has just been made redundant? If so, how will their 'moving forward' remain relevant?
This is only your claim. If you want me to agree, give proof.
then you said
never said you 'claimed' to be an expert, your responses last time in regard to the intricacies of the work put you in that category regardless of your humble and demure dismissal.
I never said you claimed 'insider' information. I said you spoke like an insider. I'm sure you can appreciate the subtle but oh so significant difference. lol
true, what you said was
Given your excellent understanding of the science and your 'insider' connections, could we prevail upon you to comment?
You did not say I spoke like an insider as you claim, you said I had insider connections. So what your doing is nitpicking, your usual twist and turns,
then you say
Your aversion to debating me and answering my posts directly is not in question, it is your own words. Do I need to go back and produce the relevant passages from your previous posts? .....I didn't think so. lol
You are correct, My aversion to debating you and answering your posts directly is not in question. Either is my dislike for bashers of all kinds. As I said before, I will not help you bash.
Then you say
As I doubt very much that you will respond to this post, good day my friend....it is always a pleasure. You're dismissed. lol
Dismissed. , I have never seen such a big ego on such a small person. LOL
AND NO you can not prevail on me again to reply to your posts. I don't like you,trust you or desire to post with you. Get it.
Frog LOL,
What an ego,
Looks like ole vern will listen. have fun
Can anyone help?
Does anyone know the date of this patent, Has it been granted yet and does the WIPO mean it is an international patent? And if so does it also apply to the US? Behind on my DNAG DD and crazy week ahead. Thanks in advance for any replys
NEWS: DNAPRINT GENOMICS re: WIPO patent:
(WO/2006/053322) COMPOSITIONS AND METHODS FOR INFERRING AN ADVERSE EFFECT IN RESPONSE TO A DRUG TREATMENT
Biblio. DataDescription Claims National PhaseNoticesDocuments
COMPOSITIONS AND METHODS FOR INFERRING AN ADVERSE EFFECT IN RESPONSE TO A DRUG TREATMENT
BACKGROUND OF THE INVENTION
FIELD OF THE INVENTION
[0001] The invention relates generally to methods for inferring a muscle adverse effect due to treatment with a statin, and more specifically to methods of detecting single nucleotide polymorphisms and combinations thereof in a nucleic acid sample that provide an inference as to whether is likely or not likely to have a muscle adverse effect in response to treatment with a statin.
BACKGROUND INFORMATION
[0002] Heart attacks are the leading cause of death in the United States today. An increased risk of heart attack is linked with abnormally high blood cholesterol levels. Patients with abnormally high cholesterol levels are frequently prescribed a class of drugs called statins to reduce cholesterol levels, thereby reducing the risk of heart attack. However, these drugs are not effective in all patients. Furthermore, in some patients, adverse reactions including muscle adverse effect (e.g., myopathy and rhabdomyolysis). Such an adverse response may require that treatment of a patient be changed or discontinued.
[0003] Variable statin responses likely can be explained, at least in part, by genetic differences of patients. Human beings differ by up to 0.1% of the 3 billion letters of DNA present in the human genome. Though humans are 99.9% identical in genetic sequence, it is the 0.1% that determines the uniqueness of an individual. Though our individuality is apparent from visual inspection - anyone can recognize that we have facial features, heights and colors, and that these features are, to an extent, heritable (i.e. sons and daughters tend to resemble their parents more than strangers) -our individuality extends to less apparent features, including the ability to respond to and metabolize drugs.
[0004] An identification of the precise molecule details responsible for individuality is a challenging task. The human genome project resulted in the sequencing of the human genome. However, this sequencing was the result of sampling taken from a small number of individuals. Therefore, while this sequencing was an important scientific milestone, the initial sequencing of the human genome does not provide adequate information regarding genetic differences between individuals to allow identification of markers on the genome that are responsible for our individuality, particularly whether an individual will respond to statins and, if so, whether adverse effects such as muscle adverse effects are likely to occur. If the genetic markers that were responsible for different statin responses between people were identified, then an individual's genotype for key markers could be determined, and this information could be used by a physician to decide whether to prescribe statins, and which statins to prescribe. Such personalized medicine can improve the response rate in individuals, while, at the same time, reducing adverse reactions. Thus, there is a need for methods and compositions that allow an inference of muscle adverse effects in a subject treated with as statin based on an individual's genotype for key markers.
SUMMARY OF THE INVENTION
[0005] The present invention is based, in part, on the identification of single nucleotide polymorphisms (SNPs) that are associated with adverse effects due to drug treatment. As such, the SNPs provide a tool for personalized medicine in that the identification of one or more SNPs allows an inference to be drawn as to whether a human subject to be treated with a drug, particularly a statin or an angiotensin converting enzyme (ACE) inhibitor is likely to suffer an adverse effect due to treatment with the drug.
[0006] Accordingly, in one embodiment, the present invention relates to a method for inferring a muscle adverse effect statin response of a human subject from a nucleic acid sample of the subject. Such a method can be performed, for example, by identifying, in a nucleic acid sample from the subject, a nucleotide occurrence of at least one statin response-related SNP of a marker as set forth in any of Tables 1, 2, 4, 5, or a combination thereof, whereby the nucleotide occurrence is associated with a muscle adverse effect in response to administration of the statin, thereby inferring the muscle adverse effect statin response of the subject. The muscle adverse effect statin response, which can be detected by a patient describing the symptoms or by measuring creatine kinase (CK) levels in the subject, can be any undesirable muscle or musculoskeletal effect, and can include symptoms varying from mild aching to severe pain, usually in proximal muscle groups, muscle stiffness and weakness, myalgia (usually associated with a 3-10 fold increase in CK levels above normal), myopathy (usually associated with CK levels more than 10 times greater than normal), or rhabdomyolysis (usually associated with CK levels more than 40 times the upper limit of normal).
In certain embodiments, the marker is nucleotides 3911-4379 of SEQ ID NO: 134; nucleotides 31264-31822 of SEQ ID NO: 131; nucleotides 22281-23778 of SEQ ID NO: 143; nucleotides 3482-4414 of SEQ ID NO: 134; e. nucleotides 1895-2286 of SEQ ID NO: 132; nucleotides 650-1166 of SEQ ID NO:131; nucleotides 771-1171 of SEQ ID NO: 142; nucleotides 79999-80360 of SEQ ID NO: 133; nucleotides 31264-31822of SEQ ID NO: 131; nucleotides 2440-2560 of SEQ ID NO: 134; nucleotides 23757-24069 of SEQ ID NO: 131; nucleotides 30438-30711 of SEQ ID NO: 131; nucleotides 23571- 24967 of SEQ ID NO: 131; nucleotides 12971-14510 of SEQ ID NO: 143; nucleotides 26896-27098 of SEQ ID NO: 130; nucleotides 8115-8737 of SEQ ID NO: 143; nucleotides 13465-13865 of SEQ ID NO:138; nucleotides 26056-26456 of SEQ ID NO:138; nucleotides 26167-26197 of SEQ ID NO:138; nucleotides 17636-18035 of SEQ ID NO:138; nucleotides 25354-25754 of SEQ ID NO:138; nucleotides 12153-12553 of SEQ ID NO:138; nucleotides 7082-7942 of SEQ ID NO:139; nucleotides 5779-5827 of SEQ ID NO.-135; nucleotides 5851-6442 of SEQ ID NO:135; nucleotides 7909-8504 of SEQ ID NO:139; nucleotides 651-1166 of SEQ ID NO:131; nucleotides 4351-4750 of SEQ ID NO:139. nucleotides 3138-3500 of SEQ ID NO:139; nucleotides 3482-4414 of SEQ ID NO:131; nucleotides 4397-4797 of SEQ ID NO:139; nucleotides 31264-31813 of SEQ ID NO:131;. nucleotides 16240-16589 of SEQ ID NO:145;. nucleotides 25192- 2298 of SEQ ID NO: 145; nucleotides 11344-12528 of SEQ ID NO: 139; nucleotides 2800-3685 of SEQ ID NO: 129; 30350-30631 of SEQ ID NO: 131; nucleotides 750-1110 • of SEQ ID NO: 134; nucleotides 5880-6229 of SEQ ID NO: 145; nucleotides 25192-25479 of SEQ ID NO: 145;. nucleotides 17794-18106 of SEQ ID NO:130;. nucleotides 26895- 27098 of SEQ ID NO: 130; nucleotides 26895-25478 of SEQ ID NO: 130;. nucleotides 34-825 of SEQ ID NO:127; nucleotides 11012-11412 of SEQ ID NO:135; nucleotides 3178-3786 of SEQ ID NO:134; nucleotides 143-518 of SEQ ID NO:140;nucleotides 17795-18116 of SEQ ID NO: 130; nucleotides 3388-3786 of SEQ ID NO: 134; nucleotides 502-902 of SEQ ID NO: 126; nucleotides 23737-24368 of SEQ ID NO: 131; nucleotides 1805-2204 of SEQ ID NO:131; nucleotides 5841-6441 of SEQ ID NO:135; nucleotides 26613-27098 of SEQ ID NO: 130; nucleotides 19968-20369 of SEQ ID NO: 138; nucleotides 19636-21357 of SEQ ID NO:136; nucleotides 2440-2560 of SEQ ID NO:134; nucleotides 5881-6229 of SEQ ID NO:142; the complement of any of these nucleotide regions.
[0007] In various aspects of the invention, the SNP is located at nucleotide 4332 of SEQ ID NO: 134;nucleotide 31683 of SEQ ID NO: 131; nucleotide 23077 of SEQ ID NO: 143; nucleotide 4208 of SEQ ID NO: 134; nucleotide 2098 of SEQ ID NO: 132; nucleotide 860 of SEQ ID NO:131; nucleotide 971 of SEQ ID NO:142; nucleotide 2098 of SEQ ID NO: 133; nucleotide 80160 SEQ ID NO: 131; nucleotide 2500 of SEQ ID NO: 134; nucleotide 23809 of SEQ ID NO: 131; nucleotide 30635 of SEQ ID NO: 131; nucleotide 24272 of SEQ ID NO: 131; nucleotide 13780 of SEQ ID NO: 143; nucleotide 296935 of SEQ ID NO: 130; nucleotide 8462 of SEQ ID NO: 143; nucleotide 13665 of SEQ ID NO:138; nucleotide 26256 of SEQ ID NO:138; nucleotide 26137 of SEQ ID NO:138; nucleotide 17836 of SEQ ID NO:138; nucleotide 25554 of SEQ ID NO:138; nucleotide 12353 of SEQ ID NO:138; nucleotide 7444 of SEQ ID NO:139; nucleotide 5832 of SEQ ID NO: 135; nucleotide 6063 of SEQ ID NO: 135; nucleotide 8004 of SEQ ID NO:139; nucleotide 860 of SEQ ID NO:131; nucleotide 4550 of SEQ ID NO:139; nucleotide 3300 of SEQ ID NO:139; nucleotide 4208 of SEQ ID NO:131; nucleotide 4597 of SEQ ID NO:139; nucleotide 31671 of SEQ ID NO:131; nucleotide 16399 of SEQ ID NO: 145; nucleotide 2097 of SEQ ID NO: 145; nucleotide 11987 of SEQ ID NO: 139; nucleotide 3500 of SEQ ID NO: 129; nucleotide 30434 of SEQ ID NO: 131; nucleotide 930 of SEQ ID NO: 134; nucleotide 6046 of SEQ ID NO: 145; nucleotide 25286 of SEQ ID NO:145; nucleotide 18060 of SEQ ID NO:130; nucleotide 26950 of SEQ ID NO:130; nucleotide 26950 of SEQ ID NO: 130; nucleotide 734 of SEQ ID NO: 127; nucleotide 11212 of SEQ ID NO:135; nucleotide 3671 of SEQ ID NO:134; nucleotide 326 of SEQ ID NO:140; nucleotide 18060 of SEQ ID NO:130; nucleotide 3671 of SEQ ID NO:134; nucleotide 702 of SEQ ID NO:126; nucleotide 24205 of SEQ ID NO:131; nucleotide 2005 of SEQ ID NO: 131; nucleotide 6063 of SEQ ID NO: 135; nucleotide 26806 of SEQ ID NO: 130; nucleotide 20169 of SEQ ID NO: 138; nucleotide 20343 of SEQ ID NO: 136; nucleotide 6183 of SEQ ID NO: 142 orjiucleotide 2500 of SEQ ID NO: 134.
[0008] A method of identifying a nucleotide occurrence of at least one statin response- related SNP can be performed, for example, by incubating the nucleic acid sample with a probe or primer that selectively hybridizes to or near a nucleic acid molecule comprising the nucleotide occurrence of the S]NuP, and detecting selective hybridization of the primer or probeT 'Sele'dtϊve hybridization tt^ example, by performing a primer extension reaction, and-detecting a primer extension re
Dr. Dew,
Thanks for the reply and good luck.
Frog,
I will answer you just this once more.
As to your posted statement. Are you asking if it is true, I don’t follow the company. Are you asking if they can do it, again I don’t follow the company. Are you asking if it will superceded DNAG work and patents, my opinion is NO. We are far ahead of the pack now. Our patents are moving so is the rest of the company. No matter what, I think we will get a slice of the pie. IMO Are you asking what the rest of the board thinks, that seems to be No also.IMO ( no doubt Fru and Stock will agree with anything negitive DNAG)
That’s my opinion.
You have already posted your opinions on the subject. and no one seems to agree with you. You have already tried to get other posters in argument with you using the same lame goading tactics, but no go.
Why don’t you go the shareholders meeting and ask their opnion. LOL
1. You say I claim I have an excellent understanding of the science. I never said that.
2. You say I claim insider information. I never claimed insider information.
3 You say, and I quote “We are all aware of your aversion to being seen talking to me and your fear of debating me” LMAO
We have only been in one conversation, I answered every question you asked fully. I did not back away. True, some of my posts were removed for what I said about you. But that’s from contempt for you, not fear.
I know you wish to incite fear. You seem to want every DNAG investor to be quaking in their boots.
But get real, how can Anyone be “afraid” of another anonymous poster. What would I do, Fear your scathing remarks. Do you have such fears? Ya know, sticks and stones....................but frogs will never hurt me.
As I have said before, you bash, lie (3 above from one post), provoke, deliberately confuse, annoy, goad, twist words, manipulate the facts falsely, put words in others mouths and generally try to disrupt the board. (usually about nothing) IMO
And for some reason, no one wants to post to you. Your right, it must be fear. Whatever gets you through the night.
Hope you enjoyed the post. Now go annoy someone else. I will not help you bash this good stock. Thanks
Luck to longs
OT Dr Dew,
You admonished Zoo twice yesterday.
From your last post to zoo, Post 46075
zooluu,
Please do not keep posting the same info over and over.
Thanks,
Dr Dew
He’s back at it already.
Posts
46090
46097
46103
46115
Is there a limit on how many times someone can break the same rule? Are posters allowed to ignore repeated warnings?
Just curious, you seem interested in cleaning up this board. That would be nice.
It is tiresum reading the same post from Zoo and Fru over amd over.
Thanks
Luck to longs
Fru says
"Absent Zooluu's contributions, this board will shrivel to a sad state."
Good one Fru
LMAO
contributing ...
Hahahahahah
Zoo,
Poor zoo, no one wants to talk with the basher even when she claims to have positive insider information.
Sad, posters here must have a Very low opinion of you. Everyone wants insider information.
Well depends on the source. If you can't trust the source, don't trust the info., don't even ask.
ZOO says,
i'll bet you the people i sent some of these posts to are not laughing !!!!!!!!!!!!!
I sure am, funny posts guys. By the way Zoo, they are making fun of you not anyone else. Just like all the "Zoo" jokes, their funny, get a sense of humor.
zooloo,
The “INFO” you give is not info. It is personal opinion.
i.e. “This stock will never see .03 again”.
Your opinions do no nothing to help new investors as you state. Each investor is responsible for their own DD AND opinion of their investment.
Ann’s posts are almost always links to information about DNAG or DNAG related subjects, which do help new investors. They relate to DNAG info. Get it?
Please do not liken yourself to a respected poster like Ann.
Dr. Dew,
How much longer must we put up with this basher.
Zoo says
45650
I Post only what the company has said them selves.
45946
Virgil, you believe this ? It came from the company !!!
I love the way that you treat information coming out of the company as false lies when a poster points out a positive aspect of the company. And then turn around and use any negative information you can find as fact. LOL
OT Bag,
I am very sorry to hear of your loss. I too am here for personal reasons.
I hope with all my heart that DNAG will find the answers we both hope for. I have scoured stocks looking for a stock that I thought might help my wife. I have found nothing that compares with DNAG. Only time will tell but as time goes by my hopes get higher and higher. IMO
From my Christian point of view, I am sure your daughter-in-law in Heaven appreciates your efforts on her behalf.
PT-201 and 202,
PT-201 and PT-202 should be entering phase 11 trials soon according to the Khandaker Partners report.
From the Khandaker Partners report.
Given EPO’s proven efficacy, the major challange for the new EPO dimer formulation is safety. Pre-clinical study and Phase 1 trial will be most critical in determining if the dimerization of EPO molecules will induce any severe biological responce. This will typically take 1-2 years. If the new form is proven safe, demonstrating equivalence in some aspects of the research should expedite the clinical trial and NDA process typically 5-6 years.
EPO NDA 2009
EPO to market 2010
Here are a few of the words and phrases Fud has used in just the past few days.
serious investors concerns,
investors woes,
delusional denial of the facts
Frustrated,
frightened,
fear,
paranoia,
absolute chagrin,
alarming,
exceedingly painful,
my negative views,
problems which inundate
woeful company,
delusional theory,
boogeyman conspiracy
down to its financial knees,
an unmitigated state of financial disaster,
tragic state
This is just from the past few days, If anyone wants to go back more posts you can fill pages with this paranoid gunk.
Fear monger? Paid basher? Spent to much time in institutions discussing the above? Needs to spend time in an institution discussing the above? Pawn? Sad little man? You decide.
Paranoid savior of the little investor. LMAO
Luck to longs
Fud as CEO LOL,
Now that’s a good one.
I’d like to welcome you to the company. I think you’ll find it a very depressing experience. We have nurtured a very poor investor sentiment and corresponding pps by always letting our investors know every worry, paranoia and worst case scenario we can think of. Plus we put a unflattering spin on everything we can think of and encourage you to do the same.
So welcome, hope you have a very unfortunate, depressing, useless time here and bad luck to you.
LOL
OT
Has anyone else noticed Zoo’s pattern of bashing 24/7, then when good news is posted, he disappears for the day till the price has gone up. Then back again at the end of the day to bash bash bash. What could his agenda be? Hmmmmm LMAO
Just in case anyone was wondering, I answered all frogs questions. Except his last post with the new tangent. Sentence by sentence. His present track is to say I din't. So he has been answered, mykeman left the board, and I am finished with the &%$*& myself. So the thread is finished. I hope
Just thought I should mention it because in a sick way, Frog won. Not the argument of course, he lost that big time from 3 or 4 posters. but his agenda he won. Boy these bashers are low.
Picture me kicking myself.
He always does this at PR time. He is trying to distract us from our lattest news. Our great new patent.
It worked on me, and I distracted everyone. Concentrating on frog poo instead of the facts. He got me.
I have seen him do this dozens of times, how could I NOT see it coming. It was obvious, all those stupid statements he made. I hang my head in shame, tricked by a slimy frog.
Please remember to talk about our new patent. This is big.
Luck to longs, you may need it with me around. Better go on vacation now before I make it worse.
Luck to longs
Frog says,
“anotherday, You're changing the subject.”
Frog changed mykemans words to fit his arguement then changed the subject fo fit his twist. Now he I changed the subject. LOL Funny comeback
Frog says,
”Yes you called Mykelman a liar. He said DNAG discovers SNP's, you said all SNP's are public domain”
This is more frog sht, more twisting, what mykemen said was
"They have machines that sequence the protein-coding genome of all those patients...""
U Said..""They have no such thing. They have never sequenced a single protein in their entire existence.""
Frog is claiming that sequencing the protein-coding genome is the same thing as doing a pan genome sequence. His twist again
He is right you are wrong..
Frog says
Resolve that.
” RESOLVED. to easy”
Frog says
You can go off on your rant about 'paid bashers' later.
I will “rant” about you when I please.
Frog says
Get out of this one first.
I’m OUT
Or slink off into the shadows....again.
LMAO, your ego is too much frog. what a pompous azz you are. I seldom post here because you bashers have made this board into a likeness of yourselves and what an ugly picture it is.
Don’t bother with even more of your twisting and turning words I will not reply to frog directly so he will not get paid more by his bosses to bash.
Frog should go look for a 10 yr old schoolgirl to pick on, their easier to confuse. As I stated earlier, this topic is totally useless to any discussion of DNAG.
Frog is trying to bring the discussions to his own ends, bashing DNAG.
It makes no difference if a poster is wrong here, even frog makes mistakes (of course he never admits it). The subject is off topic for DNAG.
As I said before, when he stated that he WANTS DNAG to fail, you said everything I need to know about you.
All his words are bashing and useless to the board. his agenda is known, he is not here to discuss the merits of DNAG, he is here to bring the share price down.
Count on it, he will add more twists and turns to get out of his last post. Unfortunately, I will not respond to this paid basher trash again on this thread. Don’t know if the rumors that he is a disgruntled employee does kind of make sense, so does paod basher, you decide but keep in mind, He WANTS DNAG to fail. .His agenda, self admitted, is enough to make me ignore him.
If you want to know why his next post is a lie also, just look for the twisting of words and you will find it.
Luck to longs
Lets look at these bashers for a minute.
Why are these bashers here? Well what do we know.
First, they have been doing this for 6 years. When one gets discredited he leaves and shows up with a different name.
Second., EVERY PR is pounced upon the second it comes in.
Third, We know we are being shorted, and by the length of time we have been on the SHO list, it is vary likely we are being naked shorted.
Forth, The vast majority of the bashers show up bashing away, they don’t bother to pump the stock for awhile first so they can at least look like they bought a stock they liked and owned first before bashing. Most recently that dumazz and dumbazzer (zooluu).
Fifth, They post 24/7 on a stock they claim they don’t like.
Sixth, Doesn’t matter how stupid their arguments are, any argument will do. If they can’t think of an argument they go off on some side issue (frog) to get any argument going.
Seven. They have always been about 50% of the board members. We are to believe that 50% of the investors over 6 years have bought this stock, decided they had made a bad investment and the they all stayed around, (owning the stock) just to save all us poor investors from a bad investment. (what nice guys)
Eight, when they decide they have made a bad investment, they DON”T sell, they just hold onto their stock and lament to the board about haw stupid they are for making this investment. LMAO
Nine, If they can find nothing to bash they just use the same OLD lines over and over again. (fud). Isn’t it board policy not to let posters say the same thing over and over again.
Ten, when the price starts to go up, ALL the bashers disappear until it peaks then come bashing back full force to return us to previous prices.
Eleven, They spend 90% of their posts talking to themselves, inciting new arguments so they can agree with each other that they made a stupid buy..
Twelve, They NEVER disagree with negative posts, always with positive ones.
Thirteen, When a good positive post for DNAG is made, they swarm like locusts.
Fourteen, when the board gets positive, they fill the board with dozens of threads full of off topic negative posts.
Fifteen, Doesn’t matter how stupid their arguments are, any argument will do.
Sixteen, If they can’t think of an argument they go of on some side issue (frog) to get any argument going. The further from anything to do with DNAG the better.
Seventeen, their efforts are always orchestrated, and concerted.
In case anyone hasn’t figured it out, these are paid bashers pure and simple.
Well not really pure, rather filthy actually.
They have spent 6 years trying to put DNAG out of business. They did not count on the loyal investors, the great pipeline and progress, thwarting their efforts. I would think that their owners are quite disappointed that they couldn’t put a puny penny stock with poor financial state out of business.
It is obvious that they are paid bashers, it is also obvious that they aren’t to good at it.
What a life, destroying companies, investors and economies for a living.
Stealing from others to get more for yourself.
Frog came right out and said he “WANTS” this stock to fail and he has worked hard at making this happen.
Do not bother to answer him, his agenda is clear. Best to let his ego tell him that he has scared everyone off with is overpowering superhuman intellect.
Even though we know it is his overpowering superhuman ego that drives every one away. Never read a more annoying poster. I think he must post here because he can’t make friends. His grating, pushy, egotistical, and nasty ways can be tolerated by few here, I assume it is the same in his personal life. IMO
In Frogs post, he tried to make it sound as if, not having the ability to Do pan genome discovery is a bad thing for DNAG, nothing could be further from the truth, its just that twisting spin he puts on his words.
Just for the sake of argument, What if DNAG did discover SNPs or do pan genome screening. We do not need it, they have no trouble in the discovery process without it. Our pipeline is huge. As MykelMan17X pointed out, DNAGs process is unique and seems to work well by the looks of our pipeline. IMO
Look at CRA, they did it and look where it got them. Same place we are, looking for a way to make money on their data.
Just an afterthought, look at CRAs pipeline. Even with CRAs money, processing power and head start, (Must be 1000x as more of each)they have a smaller pipeline than we do. Say a lot for DNAG IMO
MykelMan17X,
Those were some great posts. Nice to see some useful facts and opinions after dragging through all the basher garbage. Takes a lot to get me to read one of frogs posts these days but after reading your first post I had to follow the thread.
Poor froggy, can’t even think of a comeback other than, “DNAG does not do pan genomic screening”. LOL You did not even say that in your post. Never seen such a poor loser as frog. NEVER admits when he is wrong.
Hope you continue to post once in a while but understand if you don’t. Frog and the rest of the bashers have made this a cesspool. Shame that, but can’t last forever. Once the price begins to rise they will disappear into thin air. (unless their bosses decide to go long, then they will still be here but pumping under new names).
Some highlights from todays PR
preparing to launch its services contract business for the pharmaceutical and biotechnology industries.
the end result will be a unique solution for optimizing clinical trials.
Even with an imperfect understanding of disease and human physiology, we have shown that we can create highly predictive models that improve the understanding of researchers. We are especially excited to demonstrate to potential clients how modeling can work synergistically with genetic studies of drug response."
The combination of the two technologies will assist developers of pharmaceutical products in identifying important patient factors that impact how a specific drug will affect different groups of patients.
Some of these factors are inborn, such as genetic markers; others are identified by the Company's computer simulations, which will be inherent to the role of the drug in the disease under treatment. The Company will also help identify genetic and other patient factors predisposing patients to toxic side effects
guide the design of actual clinical trials with advanced "intelligence" about the likely outcomes. The likelihood of successful trials, targeted to the right patients with an effective dosing regimen is greatly enhanced; and could lead to reduced time and costs of clinical studies.
We invite everyone to use our services
It will play a valuable role in any company's efforts to pursue the development of drugs which maximize efficacy and minimize side effects by tailoring medications for specific individuals and well-defined population sectors.
......
Now off to the World Drug Discovery & Development Conference in Copenhagen.
Luck to longs
Froggy,
Now that's funny, A goofy joke on top of good news, you made my day even better. Thanks you
thats the truth, not easy being green
Should be an interesting day. Have a good one, got to go
Best newe to date,
Don't know how this will affect sp today but this is truely big news for DNAG. Now we have a chance for revenues in the near term and can put an end all this toxic financing. Big Pharma has not been interested in DNAG to date, this should certainly catch their attention. Time to load up. IMO
Now I understand why we got Kenna at such a good price and why Barbara handelin wanted to come on board.
Luck to longs
Way to go Tony
In 6 trading days our 3rd Qtr report “should” be out.
During the quarter DNAG launched a media campaign for our recreational Ancestry product. AncestryByDna our only source of income at the moment.
They managed to get themselves in the Toronto Globe, Time magazine, and a large artical on the front page of USA Today plus the launched a radio advertising campaign. The hits on their website, were they sell, were up over 250%.
They also added Mitochondrial DNA & Y Chromosome testing which may have helped sales in the forensics market. May be too soon to affect sales.
Assets should be up thru acquisitions: 18% in Bioforntera, Trace, and Kenna. Low priced acquisitions for what we recieved. IMO
They upgraded their genotyping platform allowing them to increase throughput 4 fold without increasing labor cost so cost of sale may be down.
Any thoughts on how this will affect the current uptrend?
OT Snap Hook,
Thank you for the reply, love your board.
I have Lost some money daytrading myself. Dangerous pastime IMO.
I’ve been investing for 30+ years and have made some good profits playing long, pennie stocks are new to me, the few times I have invested in them have been a mixed bag.
You are right DNAG management has diluted their shares from day one. It's disappointing but I think I will hold for another year or so unless another RS is on the horizon. Their products have alot of potential.
In the meantime, I will spend some time on the sidelines and study swingtrades and be informed on charts and investment on your board thru the links and posts.
Time for an old dog to learn some new tricks.
Hope DNAG does well on Monday for us all.
Snap Hook,
Thanks, That's one of the best boards I have ever come across.
Team, Thanks for taking the time to find Snap Hooks study lounge, looks like good reading. There are some sites here I have never visited.
Good luck to you also,
Not that you need luck with all your DD. I can't find the time lately for proper DD so all your posts have been a great boon to me. Thanks again
OT DOC-O, Snap Hook,
I would have sent this as a private reply but I am not a subscribe to IHUB. And I don't expect you'll be back before trading on Monday but hope you see this.
I’ve been impressed by your posts and the fact that you showed up on this board just as we took off. No one here saw it coming (or didn't mention it).
I thought the charts showed we had hit bottom but I didn't see the pop coming. I have watched DNAG drop many times on good news and nice charts. I couldn't believe it.
As I said I'm impressed and I’m always trying to learn new things and get good advice from people I know are smarter than myself. Would you mind answering a question or 5 to help me out? Anything you like, but I would like an answer to the first question the most.
Do you regularly post anywhere else?
Do you always daytrade or do you play long also?
Any other posters you pay attention to?
Do you have any other picks at the moment?
Are there any day trader forums, articles, books, sites, etc. you would suggest?
Where did you learn your skills in daytrading?
DOC-O Will you hold you shares on more good news, or do you stick you you sell price?
Etc.
Luck to longs (No offence, it's my normal sign off here)
Good luck to you two also.
gunnabeoneday, Thanks for the help.
Can anyone tell me what percentage of DNAG shares were traded today? I have lost the number to call for outstanding shares. I'm in the middle of remodeling my house and can't find anything. I did find some new optimism on the board though.
Over 130 posts on the board today so far. Lots of returning and new names. Just an observation.
Luck to longs
DNAOWNER, You are correct we have seen no contract yet, no one knows what the deal is except DNAG and Keena.
The anology that one company can not stand without the other, put forth by frog is nonsense. (The car and wheels indeed)
DNAG is moving ahead very well on it's own but they have been making great associations that enhance their products and eventually their bottom line along the way.
Frog just can't stand that the company he hates so much is starting to do well.
He starts these silly arguements every time we have a PR. He's starting to sound like Fru-cake. Bash Bash is their drum beat. It must be driving them crazy that the price is going up. LOL
Fru, you better sell your short position soon.
Luck to longs
I see a close at .026 by end of day also. JMO Love this volume. Go Go DNAG GO Go Go
Welcome back
Frog,
Well done, I am cut to the quick. LOL
Franklylost,
Still no answer to the yes or no question. figured as much.
As to your giving out information to the board. Answer the yes or no question we and the board will know weather you have given any real information or just blowing smoke.
Luck to longs