Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
High negative predictive value of >99% suggests role for DermTech PLA as a non-invasive rule-out tool for melanoma
LA JOLLA, Calif.--(BUSINESS WIRE)--May 20, 2020-- DermTech, Inc. (NASDAQ: DMTK) (“DermTech”), a leader in precision dermatology enabled by a non-invasive skin genomics platform, today announced that the DermTech Pigmented Lesion Assay (the “DermTech PLA”) is reviewed in the Journal of the American Academy of Dermatology (“JAAD”) by leading dermatologists at the New York University School of Medicine as one of four novel molecular technologies with the potential to address current gaps in melanoma management through improved diagnostic accuracy and prognostication. Since its launch in 2016, the DermTech PLA, DermTech’s non-invasive adhesive patch test for melanoma detection, has been used to assess more than 50,000 lesions and remains the first and only non-invasive gene expression test in dermatology, providing objective genomic data to help guide clinical decisions.
The article published in JAAD summarizes a review of four molecular technologies that analyze skin cells and inherited genetic variations as adjunct tools for melanoma management, providing a comprehensive, evidence-based foundation for clinicians regarding the management of difficult pigmented lesions. The review examined the fundamental principles behind each test, peer-reviewed literature assessing tool performance, and the utility and limitations of each assay. The published summary cites six peer-reviewed studies of the DermTech PLA. Key points from the article in reference to the DermTech PLA include:
The DermTech PLA’s high negative predictive value (“NPV”) of >99% suggest a role as a rule-out tool for melanoma, providing clinicians with additional information to reduce biopsies of benign lesions
The molecular test measures the levels of PRAME and LINC00518, two genes preferentially identified in melanoma
The non-invasive adhesive patch removes only the outermost layers of the stratum corneum and does not impact future histologic examination of the underlying epidermis
Reduction of unnecessary biopsies not only decreases patient morbidity but may reduce costs to the overall healthcare system
Physician follow-up within 6-12 months on negative results, per standard of care, should mitigate any remaining risk of missed melanoma(s)
“This review underscores the growing importance of genomic information and objective diagnostic tools in melanoma diagnosis. The revolution in cancer care brought about by genomics is beginning to take hold in dermatology, and DermTech is at the forefront of this change,” said John Dobak, M.D., Chief Executive Officer of DermTech. “Early melanoma detection is very challenging, and the DermTech PLA can reduce unnecessary pain and scarring from surgical biopsies, while improving the overall accuracy of diagnosis. As the authors note, the DermTech PLA is validated with proven clinical utility and a high sensitivity and low probability of missing melanoma.”
Surgical biopsies are the current standard method for testing suspicious lesions for melanoma, though they can cause discomfort and scarring for patients, and still carry a 17% chance of missing melanoma. Of the 4.5 million skin biopsies performed annually in the U.S. to rule out melanoma, approximately 180,000 cases of melanoma are detected. In addition, 8%-20% of pathologist-evaluated lesions are classified as ambiguous or indeterminate, demonstrating the difficulty and subjectivity in detecting melanoma based on a clinical visual assessment alone.
The DermTech PLA uses a revolutionary adhesive patch technology to collect skin cells from the surface of an entire lesion without a biopsy, leaving the lesion intact to offer dermatologists the option for additional analyses if necessary. The skin cells extracted from the patch are analyzed for genetic data associated with melanoma. The DermTech PLA is validated with proven clinical utility, and has a 91% sensitivity with less than a 1% chance of missing a melanoma (99% NPV).
The recent interview on youtube that Geert did was A+ , just want to say he is an outstanding CEO and he truly cares about helping H&N cancer patients . I can tell in his voice when he talks and speaks. Truly a great man. 30 years of dedication to one goal....find me another Biotech that has had the same CEO this long.
CVM
If Geert blindsides you with Data next week...you will be squeeling like the dirty pig you are. Send you to slaughterhouse.
CVM
Yes, I guess you will get a bigger surprise than you think. All i can think about is what the valuation will be and the buyout price. 8 -12 billion .. If it opens at 30.00 I'm not selling 1 single share. :]
CVM
agree with everything except the 20.00 - 30.00 at least. If i were only expecting 20.00 - 30.00 at least i would have never wasted my time in this stock...
expectations need a higher bar for this...
CVM
I was wondering the same thing, that they already had most of the main part of data compiled already. That is why i am still hoping that Data comes as early as possible. I really want the shorts who have been manipulating this stock with their raids to get crushed. There are some really shady people behind these raids and i badly want them to get hurt.
CVM
Good info to know, since i am not paying attention to all the option and warrant activity..... My focus on holding this stock all the way has never been stronger.
When it comes down to it it does not matter if its 13.00 or 22.00 when data hits ...the valuation over the next few days after will adjust. My only thoughts on this are when i watch Biotechs get really good news its rare to see a move more than 500% in one day. My guess is it will move about 400 % the day data is released.... that is why 20.00 would be good now....100.00 + PPS on the day data comes would be perfect. GLTA longs
CVM
Since i talked to IR today , i am pulling back my timeline to 3 -4 weeks from now until data. Although if it does comes sooner than everyone thinks the squeeze will be better. GLTA
CVM
would love to be a fly on the wall at ErgoMed and ICON right now.....
CVM
He did and said he understood where i was coming from. I am not happy with Geert giving shorts any info that they can use against the PPS....the group of shorts that do these attacks every few months are cordinated in a group that manipulates and they should not have been given info when it was not necessary.
My reason being is if you are truly long we do not need to know because we are holding long no matter what and already knew we were just a few patients away from this ending. I want this stock above 20.00 when data hits so it will get a higher trajectory when news hits wire and shorts get squeezed.
The shorts in this stock are cowards and deserve to get crushed...mad at Geert for not keeping them in the dark.
CVM
I agree with you, although i just talked to IR and he told me that the 298 event just happened recently and that is why they did the PR. I voiced my displeasure in why they did that PR when they did not have to...for all the shorts knew before the PR was it could happen any day ....and giving them timelines to work with was not what i would have done if i were CEO. I would have kept shorts in the dark.
either way ...shorts are running out of time...I believe this was their last raid and they will get squeezed by end of week.
CVM
3rd party as in the FDA right ? ....I think the 298 event happened a month ago and Geert is just now sending out a PR now.
CVM
Ok , mistook you for somebody else. Nice entry at 2.74. GL
CVM
"The CROs involved in study management are generating the remaining queries, performing source data verification, completing medical review, and building the final database needed to produce the final tables, listings, and figures."
They key word in that paragraph is " are generating " all of the things they listed....does that PR say anything about when they started the "are generating." ?
If i were you i would cover your short tomorrow.....the clock is ticking down faster than you think.
CVM
The data base does not have to be locked for them to legaly start compiling data.
CVM
Geert set up the shorts today to get squeezed.......i can see right thru this PR for what it is ...smokescreen the shorts into thinking they have more time. ....but they do not . There was no set date on database or when 298 happened in the PR ...lol
CVM
I will give you a number for next week..... 18.75
CVM
SeaLice is back, "Peaks and Valleys" yeah its going to be Death Valley for shorts soon. ....watching shorts get crushed is my favorite hobby.
CVM
Don't miss Dr. John Dobak’s interview with eHealth Radio. The interview highlights the value of genomics in dermatology and Dermtech’s role in shifting the #melanoma detection landscape. https://buff.ly/2VRAsct
DMTK
DMTKW
break 17.80 and shorts get the squeeze of a lifetime.
CVM
Get your info from Fosco and a few others and ignore him...he is not worth my time.
CVM looking great again today, congrats to longs. ...we are rounding the corner and coming down the Homestretch.... see you in the Winners circle after the race :]
CVM
delayed effect after IDMC news... headed for 16 next week. IMO
CVM
more Buford T justice......"I got him boxed in like a turtles pecker"
.....sounds like he was talking about CVM shorts.
CVM
FBI and SEC raid his house and get a hold of his records and computer they might also find the crooks behind CVM shorting and take them down too. I know a few CVM shorts who work with AF that need to be investigated as well....
CVM
still waiting....you said i do not read well. What did i not read well ?
Did i say anything about timeline like you ? you're just speculating ...no facts. maybe i might be implying that news could come and might be Government Funding or the trial is going well ?
Shorts like to pretend that LEAPS trial has not started and is a non factor.
CVM
I read fine, they are testing it in animals.....show me link where in PR it says anything about no LEAPS news for 6 months ? are you going to take my bet...or just post more nonsense.
https://www.irdirect.net/prviewer/release_only/id/4268498
CVM
How much do you want to bet me we will see big news way before 6 months have happened ?
also " Nothing will keep the shorts from dragging us down until news" Why dont you short it then ....and get crushed soon.
CVM
Management doing a stock buy back as well. Looks good.
VKTX
Even though 298 event has not happened does not mean a major PR could come from UGA on LEAPS....shorts are still living dangerously.
CVM
Sunlight destroys virus quickly, new govt. tests find,
https://news.yahoo.com/sunlight-destroys-coronavirus-very-quickly-new-government-tests-find-but-experts-say-pandemic-could-still-last-through-summer-200745675.html
about re planing a Q&A...Geert was going to go on Dr. J podcast before the SH meeting. and answer questions from Dr. J in a much more relaxed enviroment , Dr J who has been longtime supporter of CVM and is an educated gentleman ...... but nutjob sushi made a big stink about it and complained about to IR and Geert must have changed his mind. Sushi needs mental help and he ruined a good opportunity.
Thank you for the solid info you bring to this board Fosco. ..wish you and other longs all the best in the near future.
CVM
I agree with your statement 100%, for some of us its easy to spot the two faced manipulator. I hope his short position he took this week gets smashed to hell on Monday.
CVM
Things are looking great , It would be like hitting the lotto if we get really good P3 Multikine Data and LEAPS news for usage in the next 30 days....say hello to 100.00 + if it happens.
All the best to all the longs here, there are many that are here for for not only Money but seeing this thru to help cancer patients.
CVM
Happy Easter , Also glad /lucky that COVID19 virus did not happen last year or during the bulk of P3 trial and only just at the very end and will not effect the stats.
CVM
the SEC should take a look at "Birdie" for insider trading since he acts like he knows so much ? we all know who the stock manipulator is now... ....just a thought.
CVM
The Q guy has you figured out.... why be mad ?
He is right, you are a shortseller and a swing trader ..with a crappy website to manipulate...but not a real long .
CVM
Nice move up today, still holding all my shares and warrants, i even bought more warrants today but they sure are acting strange . Picked up some at .37 and then someone must have sold more at .32, the warrants are trading dirt cheap right now. They were just .60 a few weeks ago.
DMTK
How soon will UGA be testing LEAPS on humans ?
CVM
I guess some people complained to Geert about it.and ne backed out. Dr. J is a great guy . Not even sure why Geert moved up SH meeting but am noticing He has been acting restless in a good way and must be close to news.
CVM