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I am not on board with believing that the AZN combo idea was any way predicated on the chemo dynamic.
Are you in the camp that believes the control arm magically had a home run showing in this trial vs a 15 year well documented track record without another variable?
Maybe...but I would be more accepting of the Sunrise outcome failure if the control arm performed as expected with Bavi underperforming.
At this point,the go forward plan or lack thereof is all that matters now.
I appreciate your logic and you make great points.
I would however say, that if there were hot and heavy talks in progress that were leaning towards a viable shareholder benefitting a "real partnership" whereby BP would take over the platform....it would be obvious in the share price and volume.
Leaks are prevalent...surprises regarding these types of events are uncommon unfortunately....the stock price action usually is a reliable barometer.
I understand what you are saying PD.
However, without a material monetary commitment, all the flowery statements matter not and fail to add value and advance the ball with the urgency needed to capitalize on our waning opportunity.
The other well funded outfits in this space aren't about to punt and take 5 while we get our act together.
Define Collaboration...
AZN...pitches in their complementary drug and watches with no real skin in the game as the trial limps along underfunded...
Sadly we are out of funds, out of shares to dilute and out of time.
The following should register loud and clear:
NEXT
Of course...
Those that live in the "nobody was prosecuted so it must have been just a disgruntled employee is living in fantasy land.
The landscape is corrupted...and there isn't much recourse.
Great decision King...always the smartest guy in the room with his go it alone strategy.
The situation is rapidly reaching the point whereby the majority of the shareholders need to present management with our requests to finally deviate from their business as usual "look out for themselves at the expense of the company owners" MOA and act responsibly.
They can multi-task and sift thru the ashes of Sunrise while finally doing to do their jobs and run the company in a responsible fashion...given the sad set of circumstances their poor business decisions have led us to...
In the event they willfully ignore their responsibilities, we need to go out of out way to make their existence unbearable until they do right by the shareholders.
Whar's"sickening" is management's arrogant refusal to act with a sense of urgency in doing what is needed to avoid a reverse split and put this company on anything resembling a stable path forward.
King needs to step down now. Just how many viable deals did you turn down over the past half decade King?
Are you joking....risk their own money on this astronomical platform.
BTW...I wonder how things are progressing on our 4 year long R84 (next generation Avastin) trial? Did King manage to give that compound away never to be heard from again?
If someone drops by Tustin, maybe they can hand a mic under King's desk for an update.
+++No way it can carry the pphm staff.
Are you referring to all the hired staff brought on for bavi commercialization that are still on the payroll?
Makes perfect business sense to keep them on now...
King fiddles while PPHM burns.....through it's cash position.
Perfectly stated...
If that is their business plan...they should be run out of Tustin.
Please let me know if there is any legal justification holding them back from doing so....maybe I am overlooking something.
An open market purchase for a material amount of shares coupled with making public statements regarding obvious measures and cost cutting would have an immediate positive effect on the share price. Care to venture a guess as to why they appear content with the reverse split path while keeping their bloated salaries? It wreaks to anyone with a lick of business sense like droves of shareholders have expressed here.
So all these folks hired on for the approval of bavi are sitting around and adding value how exactly?
The primary directive of the FDA is:
Protect BP profits....period end of story.
Anyone who fails to grasp this corrupt reality is sadly mistaken.
A simple $60,000 question...
If King, Lytle, Swartz et al refuse to purchase shares at 39 pennies on the open market....why would anyone else?
Speaks volumes.
The "Timing" regarding said outfits assigning a value to the our technology via a real partnership before or after ANOTHER devastating RS matters alot for current shareholders. Playing around with the technology via "agrees to study" arrangements ain't cutting it.
I can only imagine the deals King walked away from the past countless years when our bargaining position wasn't in the dismal place it is in now.
Unfortunately...Time is not on our side.
Here is an unpleasant fact....shareholders are staring down the barrel of a future reverse split unless mamagement quickly uses a crowbar to pull there heads out and communicate an enthusiastic and coherant go forward plan.
Wall street will not tolerate any more Charlie Brown's teacher sounding business plan from King. It may behoove him to up his leadership game about now.
In the event there is a RS and you don't sell beforehand, Clubber Lang's prediction of "pain" in the Rocky movie will be paying King's Helen Keller supporters an unwelcomed visit.
In the event we take them at their word and they continue to fund via dilution at 85% of 40 pennies, a second reverse split becomes inevitable. The math doesn't lie. Can you provide examples where a leadership team with 2 reverse splits and a 90% stock price retreat under their direction that has kept their jobs? King foolishly and selfishly choose not to partner after the 2007 and has swam against the tide ever since to the detriment of everyone besides himself and the board.
The game is clearly rigged against small companies in this space. And King is plain and simply a slow learner.
Of course the phase 2 trial was deliberately jacked with.
The control arm of the phase 3 trial did not magically have a stellar showing. Logic leads me to believe that enough patients left the control group in the US that weren't doing well and we're advised to try the newer treatments that had recently been approved. I vote their victory. The control group calculation became "compromised" via the newer drugs that probably entered the mix. I am struggling with any other explanations as to why the two arms had similar results.
Partner now, run a profitable AVID business and place the technology in competent hands...enough is enough.
Jake and toolong have the right ideas for a viable path forward from here. All is not lost if management changes course...Wall Street is currently voting they won't unfortunately.
Causing more trouble????
The audacity of these clowns to announce they plan continue to finance the company in a business as usual manner while failing to announce cost cutting measures.
It is almost as if they couldn't care less about making the obvious decisions to stabilize this stock and heading it back in the right direction.
All these folks care about is how to keep the picnic going regarding their rediculous saleries. They are a group of self serving human lamprey's.
It is past time to do right by the owners of the company. It is pathetic that we even have to go through this exercise with them...beyond pathetic.
+++why don't you tell me how you know Bavi doesn't work with another IO drug like AZN's???
I absolutely believe it can. Unfortunately, our investment will be diluted into oblivion long, long before any of those trials will matter.
Partner now with upfront money...not the pretend "agree's to study" types or current shareholders are done.
We don't have time to waste. The "game" is moving fast.
King's lack of urgency is disturbing.
He should have made it abundantly clear that the company's path forward was a partnership and that he intends to make that happen before the shareholder meeting. His game plan appeared to lack that needed incentive.
Why is that?
Hand the keys to the technology over with a reasonable partnership and step aside. Go focus on what you do reasonably well and run AVID. Sponging off the shareholders via the ATM any more is unacceptable. The company is trading below book value and it is on him.
Care to venture a guess as to what prevented him from making a prepared statement like:
"We are agressively exploring options at partnering the entire platform with viable suitors and are confident we can make this happen shortly"
What exactly has Worley been doing all these years?
King needs to have several "Happy Gilmore to Chubb's" humble partnering conversations..and see if someone is willing take the baton from here.
Time for King and his feckless BOD to step aside and put this technology in competent hands.
King's way failed miserably.
Let's see if the self serving bunch let's the poison pill lapse..that will be the final tell.
Spot on. The smoldering dumpster fire that is PPHM is a direct reflection on King, his reckless go it alone, limp along, put all our eggs in one basket retarded business plan.
And now he stupid enough not to have a viable go forward plan in place.
What a blundering bafoon.
The path forward is so obvious...see Jake's posts since the latest debacle.
Thanks for the brutally honest assessment of our current position..as it relates to longterm shareholders.
Nice post.
Thanks for a reality based assessment.
We are probably only in the second inning of this market sell-off unfortunately. This is not your garden variety market correction...but rather quite possibly a global financial crisis unfolding.
It is Sunrise or bust. The outcomes of all the other trials are to far off to matter.
Hopefully, us longs finally are the recipient's of a well deserved brake come second look-in.
All IMO
Ex...
If the data isn't compelling enough after second lookin to stop the trial...my expectations for a successful outcome diminish greatly in the event we are told to just keep marching by the FDA.
Good call on the Yervoy trial being an obsolete exercise.
Vol...
Your disgust is rightly justified. However, in 6-9 months...probably the latter, we will know beyond all doubt if it will be feast or famine time at second lookin. We have enough participants. Full enrollment is almost a non event.
Conversely...Rob Kirby who fetches gold by the ton for his client and is a derivatives expert proclaimed yesterday that he forsee's the global financial system probably imploding within the next 5 months...
I hope the corrupt stooges can keep the global financial system in tack long enough so that I can finally cash in on my PPHM bet like you before it becomes an
after thought.
Hang in there...we are in the home stretch.
Nah....The limp along poverty plan has served the shareholders and paitent's well in advancing this broad spectrum compound since the 2007 "signal seeking results" for breast and lung.
++This late in the game when we(SHAREHOLDERS) have paid the freight to getting us to within 2 to 3 months of total enrollment it would be criminal to not wait for 1st and 2nd look-in.
Horselover...
We are on the same page...May June July of next year is ballpark of where a deal or buyout should be orchestrated in the event the results are what we are expecting.
The 2017 -18 prognostications are discounting some potential game changing financial events that could spoil our party.
I may re-post my deleted message over on yahoo....(off topic) yeah sure.
Shady and uunsavory goings-on occurs in the dark...vote no and shine the light on these self serving cock roaches. Anyone care to venture a guess the necessity behind this obscene increase ...me neither. What perplexes me is those shareholders who personify a chorus line of lobotomised sea lions at sea world who applaud along without taking into consideration an explanation of the underlying need.
These clowns are diluting the crap out of existing shareholders at these shamefully low share prices and are somehow immune from being held accountable as if this was a private country club.
Shame on any long term shareholders who blindly vote for this nonsense with a publicly released explanation.
Thank you Dr. Thorpe for your marvelous discovery and thank you Rob for steering this ship of fools.
I admit and agree that the upside is 5 to 10 fold...the major problem I have is that it should be from a $5 share price not this financially mismanaged train wreck that reflects our current standing.
Paul,
I am in agreement with your first and second lookin time line projections...I posted the exact months a while back before the post was deleted by the board monitor's. The timelines may be a bit optomistic, but I believe our expectations are reasonable.
The dates may extend out further as this group of patients appear to be healthier than the phase 2 group.
That wouldn't be a bad thing at all.
You are correct...won't be long now..
Thanks for the laugh BDU...
In the event Roy can take time out from his club backgammon dice rolling practice...I trust he will be invited to the celebration party once the trial is stopped after the second lookin sometime next spring.
The one giant gorilla in the room on the horizon regarding dollar based assets is the IMF announcement at or about Oct 20...
A "Male deer testicles" share price may become an unwelcome temporary reality until the trial results are made publicly available as a reprecussion of said likely announcement.
Are you referring to his reply to some random shareholder's comment about the shares he owned in PPHM?
The previous CEO gleefully replied
..." you're gonna be a rich man!!!!!"
At least he had the guts to field calls from retail shareholders unlike the current regime who choses to hide and only take softball questions.
Imagine if this concept would apply with Peregrine.....
From Yahoo Finance Fiscal Times
Time to make CEO pay match shareholder performance
If you are unable to grasp the enormous potential these greedy fools let slip away via their poor decisions, I can't help you. From a dilution and shareholder return perspective....you may want to try to follow realist's math.
I believe Bavi for lung will succeed, whether it is before or after the pending global monetary implosion is another story. The oil derivatives are set to blow up before mid year...and our "too big to fail" banks are on the wrong side of the bet for "trillions".
A partner would be nice about right now.
+++we could be in hundreds of trials in oncology and infectious diseases right now with an army of high end investigators that have been working with that BP for decades.
KU,
There is little use trying convince those who aren't able to figure out that fantastic technology and stooge management can't be mutually exclusive.
If I remember correctly, breast and lung were at the same place after the foreign phase 2 trials. One has to ask themselves where the breast indication would be had it been partnered over half a decade ago. How's that "next generation" Avastin trial coming along...remember...the one where we basically gave away the technology with nothing in return? Yeah...these guys are brilliant alright. Think of every indication that Avastin treats and the trials that "would" be conducted had that been promoted and partnered.
Every share that is used to dilute at these prices is a reflection of their gross incompetence. Period.
I remember reading CP's post the other day whereby he stated that nobody knows about bavi....at this stage of the game, that is a reflection of the subterranean credibility of our esteemed leadership.
All IMHO>
Geo...we are basically on the same side.
Here is what I would like to see a majority "no" vote accomplish..
"They" would quickly come to the realization that the shareholders in fact "own" the company....that awarding themselves endless options with a 12 year stock chart to show for their accomplishments is just plain sick. Like Frustrated mentioned a while back, these guys would have been shown the door years and years ago in a "normal" public company. Maybe I am wrong here...but wouldn't a majority no vote show them that we would potentially consider a buyout in the event they drag their feet in making something happen on the partnership front and having this market cap reflective of where we should be....MD is in the ballpark.
We currently have only 1 trial going on that really "matters" right now and that is a disgrace....
I believe that this team has most likely passed up partnership offers a half decade ago that would make shareholders furious now if they could see how that various programs "would" have progressed had the signed a run of the mill partnership.
This company has basically been run like a private country club for the past countless years by these self serving arrogant clowns.
The game is in fact rigged and slimy. That is why the preferred route was to partner way back....the damage of lost opportunity cost and endless dilution was poor decision making if they were really looking out for shareholders and patients.
King decided to go swimming with the sharks with a gaping cut and got his leg bit off in the Phase 2 trial...thankfully he was able to get it surgically reconnected and limp forward...the cost of that decision...3 years of more lost time.
They have been,in my opinion, extremely poor stewards with company resources. I have been here almost as long as you and have a memory like an elephant...(bad news for the rah-rah brigade/family members/friends of management that post here constantly with what I believe is misleading "fluff" for the new unsuspecting investor(s).
I believe a majority no vote may just slap them back into line for the first time and they would finally be forced to not treat the shareholders with such disdain. These folks simply suck at their jobs as the share prices of the various other companies they mismanage reflect.
They have been in their positions without fearing any consequences thinking that the shareholders would continue to go blindly along without demanding accountability and "results" that would be reflective in the share price.
Track records do matter.
We need folks on the (bod) with a track record of making better business decisions.
Sometimes, voting NO is all about sending a message.
All IMHO
++++It is the craziest phenomenom.
Here is an even crazier phenomenom:
How can long term shareholders sit here year after year and just suck on this garbage without voting for a change.
Why would anyone in the world take King at his word? He has been talking partnership since 2003....yes 2003.
I'll use this analogy again...I bet on BAVI... an apparently awesome thoroughbred horse...and for many many years, my hard earned money along with many others here have as well. As more and more time passes we realize that we have a 350lb jockey (the bod) weighing down the horse.
After countless years of "contributing" to the advancement of the platform....selling at this stage would be moronic.
Voicing an opinion and backing opinions with facts about the shortcomings of the management team is fair game.
Ever since the India and Georgia trial results....these folks have made self serving decisions that have been disastrous.
How is the next generation Avastin trials going...they should be in phase 2 right now for every indication that Avastin treats had they partnered years ago. Now the whole subject just gets filed into the stuffed PPHM "let's just not talk about it folder"
All IMHO
+++the current bod is a major red flag for institutional ownership.
They take one close look at the composition and track record and flee the other direction like the family on the final scene of the Amityville Horror movie.
Sad but true.
When the share price declines……
each time after the CEO speaks on a conference call…..something is wrong.
Maybe…just maybe….we need someone new doing the talking.
A CEO that lost credibility with Wall Street is just that…lost…
The apathy related to the share price decline that permeates the majority of folks on this board is beyond perplexing. Hoping that our marquee trial will be stopped sometime in 2015 ….in reality, probably isn’t all that great. How often has King’s timeline projections come to fruition?
A realistic expectation of 2016 is most likely where it will pan out.
The number of up and running trial sites is encouraging. The fact that we are a one trick pony with BAVI is a management blunder….it just is.
I absolutely believe that King now suffers an acute case of “analysis paralysis” as it relates to partnering “anything”….so he just chooses to do nothing at the expense of shareholders and patients.
In the event of a real market selloff which looks probable, minus a partner, this stock is likely to get crushed.
All IMHO.
The management silent treatment ….
Let’s examine what we “know”:
The good:
Site enrollment ramping up nicely for the phase 3 lung trial…very encouraging
However…
1) The Breast Cancer Phase 3 enrollment should be coming along nicely ….it has been over a half decade since the phase 2 turned “signal seeking after Rob Garnick showed up” trial showed impressive results even though the naysayers shot down the data as being “cherry picked”.
2) The Hep C combo trial with Bavi cocktail replacing the toxic Interferon should be completing enrollment shortly…remember the previous trial wasn’t extended far enough to determine the effectiveness of Bavi….after all….viral trials render an outcome way faster than cancer trials….how did that come out????
3) Bavi for the treatment of prostate cancer is progressing nicely.
4) The “next generation Avastin” r84 phase 2 enrollment for numerous indications is going well…
Unfortunately…..none of the above has taken place.
The “go it alone” blunder has cost shareholders and potential cancer patients enormously as a result of squandered time that numerous trials should have been progressing while the dilution machine has gone into overdrive.
The R84 trial now resides in “Putinville”…go ahead and ask our IR dept how that phase 1 trial is going….I’m sure they will be glad to share any info on the progress in a respectful manner….just ask PPHMTOOLONG.
Maybe King-of-Talk-Pawn–of–Do can give Vladimir a call and ask for R84 back along with the phase 1 trial results. Have him explain to Vladimir that he can keep Crimea and “we” can call it even. I’ll bet Vladimir is feeling cordial nowadays…
As a result of the chosen management course…..the ultimate bet for this stock…whether everyone understands it or not…rests on 1 trial and 1 indication. While I absolutely like my odds of that trial turning out favorably…I find the choice not to partner and “spread the risk around” many different indications incredibly reckless and selfish as it relates to King and this management. Bavi needed the resources of a well funded partner years and years ago...
All IHMO….