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ann441j...Bless your heart! When you view the message list, directly above the black bolded Headings (Post, Subject, Posted By, Time), you'll see some bolded blue links. The first link located on the right half of the page is: Post New Message
Hope this helps...
Later,
W2P
Team...I saw that Orchid referenced a "robust" set of markers in their PR this AM. I remembered Tony, in some past publication, talking about the fact that we had to develop a robust set of markers due to the tendency of biological evidence to deteriorate. That's what I was looking for, and came up with something I didn't expect.
Later,
W2P
Team...University of Arizona...potentially the prime contractor on the NIJ project for which we received the sub? Just a speculation.
Later,
W2P
Wow, look at this. Maybe this explains Tony's presence on the biometrics council. Note, this is a link to a cached page. Just scroll down and look for the colored, highlighted DNAPrint. The rest of this is fascinating as well:
http://cp.yahoo.net/search/cache?p=robust+DNAPrint&ei=UTF-8&n=20&fl=0&url=MVrqacqjOs...
Later,
W2P
keiden...Is this part of that big bird???????
http://biz.yahoo.com/prnews/031125/phtu006_1.html
The informative Y-SNP panel could also potentially be used as a screening tool to derive broad physical characteristics based on information about a suspect's ancestral origin. These physical characteristics could be useful in so-called "no-suspect" crimes where investigators have DNA evidence but no other clues to identify possible perpetrators. Following the development of the Y-SNP panel, Orchid believes it would be the first private forensic lab to offer a gender-specific SNP-based panel as part of its services.
There's only one company in the world that can offer SNP based information on ancestral origins, and they are already an Orchid collaborator!
Later,
W2P
budddddylee...Excellent story. Thanks for bringing it to the attention of the board.
Later,
W2P
Website updated already:
http://www.dnaprint.com/2003/pressreleases/pr.html
Somebody's on the ball...
Later,
W2P
chig...IMO, we are witnessing the "imprint" of the new Senior Management. You know, I was getting a little frustrated, as I'm certain many were. Things just didn't seem to be happening fast enough. But a week or so ago I happened across the April 2003 PR that announced Richard Gabriel as the new CEO. In it, I found his first statement quite instructive:
"Our immediate goals are to make DNAPrint Genomics, Inc. profitable and strategically financed for its future expansion, research and product development..."
If we look back at the events of the past seven months (what the investors would call "the quiet period"), it seems apparent that they have been executing a strategy aimed precisely at achieving the goals outlined in that statement. They first secured limited short term placements to put cash in the bank, and simultaneously engaged an Investment Banker to execute a PP to gain longer term capital. We've seen commercial genotyping and AncestryByDNA revenue rise sharply from prior periods. Now they've lined up some great media exposure to expand those revenues even further. We have a way to go to profitability, but with additional products coming on line, break even is not that far down the road.
Along with the needed funding, they appear to have implemented measures to add discipline to the organization. They have added key management personnel, made several internal personnel moves, upgraded the company's auditor, and are now being reported on by at least two respected Research Firms geared towards Institutional Investors.
With these measures in place, the company appears ready to take the next step. We've seen some very promising announcements of late and I'm hoping to see it continue with announcements of new business collaborators, partners, or other revenue producing measures.
For the two plus years I've accumulated and held this stock, it has certainly had it's ups and downs. And I know that in a development stage company there are always too many things to be done, too few people to do them, and often too little in the way of resources to make it all happen. It is a tribute to the company that they have managed to survive, and appear to be on the verge of attaining some of their long sought goals.
So to anyone at DNAPrint that reads these boards. Congratulations. My hat's off to you. Now let's bring it on home!
Sincerely,
W2P
OT: Team...Must be why, all my life, I've felt middle aged! lol
Later,
W2P
Miss Scarlet...You have it correct, the December issue of Genetics. As a matter of fact, I discovered and posted the link on RB a day or two ago. The link takes you to the magazine's future table of contents for December 2003. Didn't copy it over here (sorry), and of course, with the static on that board, no one really paid much attention to it. Here is the link to that post:
http://ragingbull.lycos.com/mboard/boards.cgi?board=DNAP&read=282109
This is the article referenced in yesterday's PR.
Later,
W2P
Team/1USGrant/bag8ger...Once again, the east will scoop this story here on the boards. Where I am, the local affiliate airs it a half-hour later than the east coast.
Airs here in Wisconsin at 11:00 PM CST (9:00 Pacific). I'm certain we'll have a blow by blow preview before we see it ourselves.
Luck to all of us,
W2P
This went right over my head last night when I read that PR! DNAPrint introduced a "NEW" database system allowing investigators to query the database and to infer values for certain BGA traits. They're NOT talking about just Ancestry here folks. They're talking about other traits, thus, the "fuzzy photo" reference by Dr. Frudakis:
http://biz.yahoo.com/prnews/031120/flth020_1.html
DNAPrint(TM) introduced a novel database system and algorithms to allow investigators to make accurate and objective inferences about certain elements of physical appearance from a DNAWitness 2.0 BioGeographical Ancestry admixture profile. The system allows the customer to query the database with a BGA profile and visualize historically typed samples and to computationally infer values for certain anthropometric traits. For certain traits, and in certain BGA groups, BGA admixture can be used to make accurate predictions of trait value and the system was described as integral for allowing an empirical construction of partial physical profiles from crime scene DNA.
This is much more than I had thought.
Later,
W2P
Team..LOL Sorry, but when I made that last post last night (the one with ACTUAL content in it) it double posted. So I used the nifty little Edit Msg. feature here at iHub and deleted the text of the copy.
I'm certain there are some that think that's the most profound thing I've EVER posted! LOL
Later,
W2P
Probably just a coincidence, but DNAPrint just changed accountants. Now what was the name of that firm? Hmmmmm...
I know, it was:
Professional Service Relationships
Auditors: Pender Newkirk & Company, Certified Public Accountants
100 South Ashley Street, Suite 1650, Tampa, Florida 33602
Telephone: (813) 229-2321
Same one that Utek uses. Just scroll down:
http://www.utekcorp.com/PROCESS.CFM?PAGEID=35&TOPLEVEL=1
Later,
W2P
New MM TJAS on the ask at 0.044 - Headquartered in Austin, TX with office in FL. Website is under construction:
http://www.tejassec.com/
Tejas is the largest full-service brokerage firm based in the Central Texas region. And with plans to extend our network of offices, we're continuing to reach more and more satisfied customers across the nation.
Address: 2700 Via Fortuna, Suite 400, Austin, TX 78746
Phone: (512) 306-8222
Fax: (512) 306-1528
Toll-free: (800) 846-6803
Email: krechner@tejassec.com
Website http://www.tejassec.com
Later,
W2P
OK, one more then I've got to go:
As of December 31, 2002, UTEK's subsidiary companies are Ocular Technologies, Inc., UTEK Real Estate Holdings, Inc. and Advanced Sensor Technologies, Inc. Ocular Technologies, Inc. is a company that is seeking to acquire medical diagnostic technologies. It owns 100% of the common stock of Ocular Technologies, Inc., UTEK Real Estate Holdings, Inc. is a company that is to hold future real estate assets for the Company. It owns 100% of the common stock of UTEK Real Estate Holdings, Inc. Advanced Sensor Technologies, Inc. is a company that is seeking to acquire licenses to new nano science technologies. The Company owns 100% of the common stock of Advanced Sensor Technologies, Inc. In May 2002, UTEK acquired 100% of the outstanding common stock of Techex Acquisition Corporation in a stock-for-stock transaction. TechEx owned the TechEx.com Website, which is used by many technology transfer and research professionals to exchange licensing opportunities and innovations available for partnering.
In order to realize a return on its investments in its subsidiary companies, the Company must sell its subsidiary companies or the technology and development rights they hold. Its merger transactions to date have been with thinly traded public companies and private companies whose common stock is not publicly traded. As of December 31, 2002, it held shares in thinly traded public companies, including Lexon, Inc., Advanced Recycling Sciences, Inc., Clean Water Technologies, Inc., Sense Holdings, Inc., Stealth MediaLabs, Inc., Palladium Communications, Inc., Group Management Corporation, Circle Group Holdings, Inc., Voice and Wireless Corporation, FullCircle Registry, Inc., Innovative Medical Services, Inc. and Centrex Inc. As of December 31, 2002, all of securities it has received in exchange for its subsidiary companies are restricted securities. These securities may not be sold in the absence of registration under the Securities Act of 1933 or an exemption therefrom.
Now where have I heard the name Centrex before? Hmmmmm....
Later,
W2P
Now THIS is interesting:
UTEK Corporation is a non-diversified, closed-end management investment company that has elected to be treated as a business development company (BDC) under the Investment Company Act of 1940. As a BDC, the Company must be primarily engaged in the business of furnishing capital and making available managerial assistance to companies that generally do not have ready access to capital through conventional financial channels. Such companies are termed portfolio companies. UTEK's investments are concentrated in small or development-stage companies that license and develop new technologies for commercial applications.
Sounds like just what the doctor ordered.
Later,
W2P
This is a list of technologies licensed by UTEK:
New Technologies
The following new technologies have been licensed by UTEK. All of these technologies are under development.
Illuminating Lighted-Helmet - Potential Safety Applications for Construction Workers, Police, First Responders and Sport Related Products for Sports Fans of the National Football League, National Hockey League, NASCAR and Major League Baseball
Test for Potential Detection of Colon, Testicular and Ovarian Cancers
Technique for Converting MRI Images from Gray Scale to True Color
Technology to Produce Photo-Realistic Talking Heads for Internet Commerce Applications
Technology to Remove Arsenic From Water
Technology to Detect E.coli Bacteria in Food and Water
Technology to Identify Microorganisms in Water using Spectrophotometry
Technology for the Extraction of Cryptosporidium and Giardia from Drinking Water
Technology to Develop Commodity Chemicals from Recycled Tires
Technology for De-Icing Land Based Vehicles
Technology for Digital Watermarking of Stereo Audio Signals
Technology for Detection of Landmines and Other Explosives
Microsphere Technology for Encapsulating Drugs at Low Temperatures
Technology for Nitrone-based Antioxidant Compound for Skin Care Products
Technology for Enhancing MRI Digital Images
Technology for Enhancing the Visibility of Wheelchairs and Other Wheeled Vehicles
Technology for Saving Electrical Energy in Buildings
Technology for a Voice Controlled Internet Browser
AskPhysicians.com Permits Individuals to Access Board Certified Physicians with Confidential Health and Medical Questions
Technology for an All-Natural, High Fiber, Carbohydrate-Based Fat Replacement to Improve Human Nutrition
Safety and Security Technology for Chemical Detection on Surfaces
Safety Technology for Electroluminescent Lighted-Lines for Police, Fire and Other First Responders
Web-based System Designed to Empower Individuals to Select a Nutrient Rich Diet by Utilizing the USDA Nutrient Database
Later,
W2P
bag8ger...The page was a compilation of guest appearances on the Stern Show and date of appearance. I was merely pointing out that Zach was there in early September (Scroll down to September appearances), and then returned on 10/24/03.
When DNAP said they got a surge of orders (150 orders) from the show, was that after the September appearance? Or was it after the October appearance...or was it after both. That's my question and that's why I pointed out that they had actually made TWO appearances on that show.
BTW, I posted the "cached" page which highlights the search term in yellow. It makes it easy to scroll down and find what you're looking for.
Later,
W2P
ann...Yep: http://www.dnaprint.com/2003/pressreleases/pr_08_13_03.htm
Later,
W2P
Did you know...AncestryByDNA was featured "twice" on the Howard Stern show...once in September 2003 and again more recently on 10/24/03?
http://cp.yahoo.net/search/cache?p=ancestrybydna&ei=UTF-8&n=20&fl=0&url=fMhWVUDpGFQJ...
Later,
W2P
Looks like Tony was on the radio last week in Birmingham, AL promoting AncestryByDNA. Look under coming soon, Monday, November 10th, 2003:
http://cp.yahoo.net/search/cache?p=Tony+Frudakis&xargs=0&b=61&url=YbsVdi75lrwJ:www.960we...
Later,
W2P
I take that back, I'm certain mingwan0 was there first!
Dang, that guy's good! lol
Later,
W2P
What's new and exciting you ask? Don't remember seeing this before. If you go to the link, scroll down to Number 4.
http://www.1421.tv/pages/evidence/content.asp?EvidenceID=292
Tony Frudakis and colleagues: ‘SNP based Measurement of Biogeographical Ancestry Admixture Population’ Unpublished August 2003 – to be published shortly.
Frudakis and colleagues used the Human Genome project from which they selected Ancestry Information Markers specially chosen for denoting diversity (ie. taking Rosenberg and colleagues’ method a stage further). The results should give more accurate determination of ancestry than hitherto and should enable DNA to be dated using the percentage of linkage disequilibrium. They have built up a large database of N American Indian peoples. Their results corroborate Rosenberg’s. Relevance to Atlantic and Pacific voyages to the Americas.
Later,
W2P
Compare today's DNAP chart with today's Orchid chart...Hmmmmm:
http://finance.yahoo.com/q/bc?s=ORCH&t=1d
http://finance.yahoo.com/q/bc?s=DNAP.OB&t=1d
Price and volume of both seemed to pick up about the same time. Could mean nothing...but is interesting none-the-less.
Later,
W2P
stockboy...I believe I read somewhere that it takes 9 months to a year to achieve certification.
It requires a specific internal organization and set of procedures be established, followed by inspections and testing, followed by reviews, etc.
In other words, it is not a matter of sending in an application with the annual dues. It takes organization, testing and time. Hope this helps.
Later,
W2P
frogger...And with all due respect to my friend mingwan0, the text you cited was in relation to the company offering their new AncestryByDNA testing service. A first of it's own at the time, but not relevant to the subject of the current article.
The current article specifically addresses the use of DNAWitness (a product that was not even being marketed at that time) in forensic DNA profiling, in forensic identification, and with reference to the Louisiana Serial Killer case.
The fact that the company had contacts with Popular Science in 2002 is irrelevant to the time of origin of the current article.
Later,
W2P
frogger...This text is from the recently updated company website. Does this sound like they've abaondoned the test?
DNAWITNESSTM 3.0, will offer a dramatic improvement by adding a new predictive measure, eye color. We have developed and filed a patent application for RETINOME, a test for the inference of eye color from DNA. The SNP based method for testing eye color is the first of its kind. The method employs complex math and combines human pigmentation gene SNP combinations and ancestry informative markers to predict human eye color accurately and sensitively. DNAPrintTM has been working over the past year to update the RETINOME panel of SNPs in order to predict eye color shade and actual eye colors with greater accuracy. Validation experiments necessary to define the precise accuracy are currently ongoing. If test performance is satisfactory, DNAPrintTM will begin selling the test to the forensics community as an integrated component of DNAWITNESSTM 3.0.
Of the nearly 1.2 million reported incidents of violent crime in the U.S., only about 50% result in an arrest, and only a small percentage of those result in a criminal conviction. In violent crimes, DNA evidence is left at a crime scene or on a victim’s body in the vast majority of cases. DNAPrintTM can provide law enforcement with a potential suspect’s genetic heritage. Additionally, with the introduction of DNAWITNESSTM 3.0, DNAPrintTM expects to have the ability to provide law enforcement with a potential suspect’s eye color. It is our objective to add additional inherited traits in the future.
Doesn't look abandoned to me.....
Later,
W2P
frogger...The Popular Science article is a recently written piece. It refers specifically to the Lousiana Serial Killer case. So that means the quotes from Tony were made in June or July 2003 at the earliest. Did you READ the PS article? If you had it might help clarify your speculation.
Later,
W2P
Team...I understand some of this but not all. Would you mail me at:
work_to_play@hotmail.com
Thanks,
W2P
frogger...First, the tests are intended as investigative tools, not evidentiary tools. Even at 70%, most investigators would consider that a valuable piece of information. Conviction would still require a CODIS type of match from suspect and crime scene DNA, thus, your scenario is not going to happen, but that does not in any way diminish the value of the test to law enforcement.
But more importantly, Dr. Frudakis said in the Popular Science article that within a year they could produce an accurate commmercial test for hair color. I would suggest that that statement is based on this text from the published application:
[0500] Although the present analysis does not explain 100% of the variability in human hair color, and indeed, one would not expect a two gene solution to explain all of the variability in human hair color because there are 4-5 genes involved in melanin synthesis for which mutations have been identified to impact human pigmentation, the results obtained for the OCA2 8 locus haplotype+TYR.sub.--3 genotype plot explained all but 5/42 of the individuals, and 22/24 haplotype pair classes. The results indicate that human hair color is largely explainable through consideration of the diploid OCA2 haplotype and TYR-3 genotype combination present in any Caucasian individual.
Looks to me like they believe it WILL be possible to offer a useful test.
Later,
W2P
Cal...Since the DNAPrint Executive Summary was written last winter, and DNAPhenomics has only been in existence since July '03, it's not hard to figure the source of the text.
Secondly, the membership of this board long ago made DNAPrint aware of DNAPhenomics and their website. If the material were indeed plagiarized (and the MALD method as well), I think DNAPrint would have quickly pointed that out and it would have been changed by now.
Lastly, DNAPrint genomics...DNAPhenomics...Genomed...Phenomed And whois the central player in all of this...Senecio Software. Nuf said.
Later,
W2P
bag8ger/chig/66fan...I believe the quote was "We have no immediate affiliation with DNAPhenomics of Malaysia."
LOL
Later,
W2P
Have you ever looked at the similarities in the following language:
Until recently, to explain or solve the problem of differential drug response, for example, it has been necessary to perform pan-genome screening, but one cannot explain the genomic basis for these traits simply by screening genomes with randomly selected or publicly available markers. Our competitors do this - they select a small number of SNPs in a small number of genes (called a "Candidate gene" approach) in an attempt to study extreme responder and non-responder phenotypes. If they pick the wrong SNPs or genes, they do not find a solution - this is the problem with the traditional research approach used by most companies.
Another approach is to look at the entire genome. Genome based linkage analysis in large populations of unrelated individuals is not cost effective since it costs hundreds of thousands of dollars per patient to do this type of study properly. Other companies use "isolated populations" to bring the costs down, but this approach carries significant disadvantages because their results do not necessarily generalize to other populations.
And:
To solve these traits, it is necessary to perform pan-genome screening, but one cannot solve these traits simply by screening genomes with randomly selected or publicly available markers. Our competitors do this - they select a small number of SNPs in a small number of genes (called a "Candidate gene" approach) in an attempt to study extreme responder and non-responder phenotypes. If they pick the wrong SNPs or genes, they do not find a solution - this is the problem with the hypothesis-driven approach.
Genome based linkage analysis in large populations of unrelated individuals is not cost effective because it costs several hundreds of thousands of dollars per patient to do this type of study properly. Some companies use "isolated populations" to bring the costs down, but this approach carries significant disadvantages because their results do not always generalize to the world population.
One is from the DNAPhenomics "Methods of Discovery" page, the other from the DNAP Executive Summary in their investor packet.
Incredibly similar, don't you think?
Later,
W2P
mingwan0...It appears Tony is traveling in good company these days:
9:45 A.M. – 11:00 A.M.
Future Technology in Biometrics
John Woodward, director Biometrics Management Office, Department of Defense
Tony Frudakis, chief scientific officer and founder, DNAPrint Genomics
Barry Hodge, president, AcSys Biometrics Corporation
Andrew Kirby, Senior Physical Scientist, CIA
As nothing but a scam company though, he'd better be careful about hanging around with the CIA. Oh, and I'm certain the CIA and DOD are telling him the same thing, "There's no way you will be able to determine hair color from DNA, so stop making those outrageous and rediculous claims!" lol
Later,
W2P
eandjfla...We've always said Wisconsin is God's country...lol Now you know why!
Later,
W2P
stockzar...Popular Science article:
Popular Science, December 2003 Issue
"DNA and a New Kind of Racial Profiling: Police sketches from eyewitness accounts are notoriously unreliable. The question is, will "DNA Sketches" be any better?"
It's a three page article in the "Crime Seen" section by Jessica Snyder Sachs.
Cover is yellow. Focus of this issue is "Top 100 Tech Innovations. 2003 - Best of What's New."
Later,
W2P
From the Popular Science article:
Given the time and money, they will continue with the genomic sifting and sorting. Frudakis makes this bold prediction: "A few years from now, we're going to have figured out so many traits that a criminal might as well leave his driver's license at the scene of the crime."
Later,
W2P
mingwan0...Perhaps the election example was not the best choice. There actually IS great variation in voting methods across states...lol I know of at least three different types of machines used in my local area alone.
As regards the "Guidelines" though, some data is "required". Other information is "voluntary". But again, I have worked with the government in this country long enough to know that they take their "guidance" seriously. For instance, the DNR in Wisconsin has "guidance" concerning electrical design for explosive areas. You are free to submit a design that is in conflict with the "guidance", at which point they will send it back and "suggest" that you rethink your approach! lol
Secondly, the value of this guidance to DNAP is that it creates a regulatory path for them to present their data, either alone, or in conjunction with a research collaborator or pharmaceutical partner. In other words, a line of communication has been opened with the FDA, at the request of the FDA, that the company can now walk through to make their best case to the agency. And the document made the point that they expect this to be particularly relevant for certain oncological treatments and diagnostics.
I'm afraid we'll have to disagree as to the size of the step. I am very encouraged by this action. It will be interesting to view the comments as they are published.
Later my friend,
W2P