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Thank you Sir. I updated the AMBS pipeline sticky as well.
and down it continues
You are right. It will be Jaw Dropping!
Sorry Brick. The pipeline is so big i missed it! LOL
The pipeline is now starting to flow.
Dag Nabbit! Now we are going to need to change the AMBS Pipeline sticky i just posted yesterday from a collection of hard work from many posters. Seems to have gotten bigger today! I hate it when that happens. See you under .06. NOT!
Just call him SOL!
You know that's the same way I feel about AMBS. Have you seen that pipeline. WOW
Have a nice day. LOL
You just never know with penny stocks. LOL
I will buy more if it gets that low. The up list of AMBS will take care of the penny stock part.
I agree 100%
Every little bit of positive news, like the upgrade in numbers we got today in the 8k, means more cards in the game. AMBS is holding many cards and Gerald has brought on the correct players to the boards to show him the best way to play them.
If you need to pay rent with your trade account then sell and move on. Stop complaining with the ups and downs. One advantage to being long is I don't give a rats rear end if it goes back below .01! I will just load up like I did last time it did. This is a much better company than it was 18 months ago! Hard to argue with the science and the pipeline.
New to AMBS. Check out the sticky posts. Pipeline is now there. Thanks to all!
Thanks Gipper. Gerald is a class act and I like his approach to this subject. Long AMBS
That will only be a problem for AMBS or investors if no one is interested in buying shares. With the pipeline here i dont see a problem. I just added to the stickies. That should make things clear to new AMBS investors.
Something to consider if you are looking for value. MANF is on the move under the radar of most. The current stock price is a real steal at current prices, if just one of the many items on that amazing list put together by the board today becomes a success, better lives for people that Suffer and Investors that can afford to help others with good fortune. MANF is on that list of Holdings.
Tuesday, January 7, 2014
My goal in 2014, a small scale interventional study for Wolfram syndrome. My goal this year is to start a small scale interventional study for Wolfram syndrome. I believe that conducting a clinical trial in a small group of patients with Wolfram syndrome of homogeneous etiology could potentially lead to a breakthrough in treatments for other conditions associated with endoplasmic reticulum dysfunction, including type 1 diabetes and neurodegeneration. We all should be aware and appreciate the power of rare diseases, such as Wolfram syndrome. I was recently asked to write my view on type 1 diabetes and Wolfram syndrome by Nature, and this was just published. I hope... sincerely hope that this article will raise awareness of Wolfram syndrome."
Posted by Fumihiko Urano at 4:05 PM
******************************************************************
Here is the public text about the article.
I just love the references at the end. Many of them look like Dots.
I have not purchased the article.
******************************************************************
ArticleNature Reviews Endocrinology
Research Highlights
Development: Scope of DSD-linked conditions shown Next articleNature Reviews Endocrinology
Review Vitamin D and male reproduction
Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes
Fumihiko Urano
Journal name:
Nature Reviews Endocrinology
Year published:
(2014)DOI:
Published online 07 January 2014 Article
Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.
British Library Document Supply Centre You can also request this document from your local library through inter-library loan services.
References•
Author information
1.Wang, S. & Kaufman, R. J. The impact of the unfolded protein response on human disease. J. Cell Biol. 197, 857–867 (2012).
CASPubMedArticle
2.Fonseca, S. G., Gromada, J. & Urano, F. Endoplasmic reticulum stress and pancreatic ß-cell death. Trends Endocrinol. Metab. 22, 266–274 (2011).
CASPubMed
3.Engin, F. et al. Restoration of the unfolded protein response in pancreatic ß cells protects mice against type 1 diabetes. Sci. Transl. Med. 5, 211ra156 (2013).
PubMedArticle
4.Shang, L. et al. Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes
5.Fonseca, S. G. et al. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic ß-cells. J. Biol. Chem. 280, 39609–39615 (2005).
CASPubMedArticle
6.Barrett, T. G., Bundey, S. E. & Macleod, A. F. Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome. Lancet 346, 1458–1463 (1995).
CASISIPubMedArticle
7.Sandhu, M. S. et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat. Genet. 39, 951–953 (2007).
CASPubMedArticle
8.Bonnycastle, L. L. et al. Autosomal dominant diabetes arising from a wolfram syndrome 1 mutation. Diabetes 62, 3943–3950 (2013).
CASPubMedArticle
9.Fonseca, S. G., Urano, F., Weir, G. C., Gromada, J. & Burcin, M. Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat. Cell Biol 14, 1105–1112 (2012).
CASPubMedArticle
10.Fonseca, S. G. et al. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Invest. 120, 744–755 (2010).
CASPubMedArticle
Here are some recent posts about WOLFRAM SYNDROME
http://wolframsyndrome.blogspot.com/
I believe someone else posted this before but new investors should read.
http://wolframsyndrome.blogspot.com/2014/01/manf-wolfram-and-diabetes-what-is-manf.html
That sealed the deal for me too back in 2012.
Wow! Now that makes me feel even better than i did about AMBS!
Which is hard to do.
Thanks Warp. Do you have any thoughts on how you would like to see that whole warrent situation play out?
Very true. Can anyone remind me if there is a timeline to register the warrents and are we close to that time?
Thanks in advance
Very good point. I think funding will become a non issue soon. Many will want a part of our little miracle. How did Gerald put it," we have to many possible good products". I'm paraphrasing of course. The cat will be out of the bag soon enough. Wonder what that other orphan is?
On TDA i have bid .13 X ask .125
Hey Warp! I know good and well you have Permagrin today!
Wow! Volume has doubled in 15min!
You got it! Flippers will become chasers. Just a matter of time.
Sellers getting taken out at every turn. Nice action today.
Now Hear This! Calling all Warrent holders to the launch pad! LOL
Sorry for taking so long to respond Warp. Ambs is on the launch pad and we have a front row seat. Thanks for all you do here on the board. I also want to thank you for your service.
I was with the USS Orion in Sardinia, Italy form 1988-1990. Home port was Charleston Naval Shipyard. Then transferred to the USS Kanopus from 1990-1994 at King's Bay. I feel for you about the time in Charleston working on the sub. It was humid as $0%+**!
I was with the "Dry Dock" in King's bay while working out of the USS Kanopus, Both of my ships were sub tenders and provided every service needed for the SSBN Fleet. We were the pit crew for the subs. I was an Optical specialist (OM) and a Machinist (MR). Worked on many Periscopes. I did not order parts, I made them. Get'em in and get'em under! For everyone else out there, if you every watch "The hunt for Red October" the bridge on sub don't be lookin like dat!
AMBS has put together one hell of a "Pit Crew" and their team effort is about to shine. They are making all the right moves and calling them in advance on the Chairman's Blog. Pretty soon it's going to be 8 ball in the corner pocket, or 9 ball in the side. Whatever, it's going to be lights out for those sitting on the fence and chasing this up.
Have a great weekend and I'm looking forward to an exciting week ahead!
Very good stuff Zoom! That is very good information. Thank you
By the way. I have been enjoying the discussion today.
Thanks for the message JP. That means a great deal coming from you. I'm no share whale but I am a dolphin. Adding where I can and even got my wife to roll her entire Roth IRA into AMBS as soon as wolfram syndrome hit the radar. That sold it for her. I was sold long before.
Best to you Sir.
Thanks old Hillbilly. I put this on the sticky board. For all new investors to AMBS it is a must watch. This is not some num nut that can't find his rear end with both hands and a flashlight and pretends to know everything. This is the CEO of the company. Keep in mind this is just one of the many holdings for AMBS.
Amarantus BioScience Holdings, Inc
If you get the big picture and are long not a flipper, then big things are coming your way.
I know, I get it. Flipping makes money too, and lots of it (if your good at it), but I'm not going to be flipped out of this stock when it runs like the wind!
This is a future dividend stock. With a few Holdings buyouts or joint ventures likely along the way.
My best to all investors that are keeping it real and not playing games.
I'm hoping your right! I have been holding my breath all week waiting on funds to hit today. The drift down has helped me buy more. Just picked up another 56k at .0983
NOW you can release that BIG PR! LOL
I hope AMBS can JV with them or just buy the company.
http://gainesvillebizreport.com/banyan-biomarkers-revolutionizes-test-for-brain-injury/
This is for the new investors. And one of many reminders of why i'm invested here.
Amarantus BioSciences, Inc. and Banyan Biomarkers, Inc. Announce Positive Data from Traumatic Brain Injury Collaboration
Jun 7 12
Amarantus BioSciences, Inc. and Banyan Biomarkers, Inc. announced the successful completion of a collaboration agreement initiated in November 2011 to evaluate MANF's potential as a disease-modifying agent for the treatment of TBI. In in-vitro cell culture experiments, MANF was reproducibly shown to confer neuroprotective properties in various cell death-related pathways. The data raise the possibility that modulating MANF in patients immediately after suffering a TBI and in patients who have suffered multiple concussions over an extended period, could be a successful therapeutic approach to promote recovery after TBI.
You got it JP. Another great day for AMBS.
I took care of that! Gladly
Things are coming together for AMBS. Interesting time to be invested.
AMBS time to turn up the volume.
I trust everyone had a peaceful weekend.
Showtime https://www.regonline.com/builder/site/Default.aspx?EventID=1269518
Great day for AMBS. Going Long! Been trying to fight this with no help from upper MM.
We are going to do great. But those shares are now locked up in Roth IRA land! LOL
Nice close. Glad i got my fill at .081 early today.