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Can you imagine what would happen if the EMA approves Brilacidin before the FDA. It would make for some interesting articles....
Lets hope Brilacidin is what we think it is and does amazing in human trials.
This might turn out to be a great end to 2020 for IPIX and its shareholders!
Go Leo & IPIX!
I agree with your assessment that Europe looks like the site for the fastest human trial for Brilacidin.
Maybe when the pundits get a hold of the Brilacidin story they will ask how a drug developed in USA, tested at govt labs in USA, and that info was known by the govt agencies in charge of COVID/drug approval in early summer are still sitting on their collective asses while Europe was able to swoop in and get the ball moving on getting this potential/likely life saver (and economy saver for many countries) moving.
The above sounds good, but the power is in the hands of the people getting the BP payola so good luck on such an investigation ever seeing the light of day.
Damn shame even a pandemic can't get people to act properly.
Human trials soon and then Leo will be able to figure out Brilacidins future. Things might progress faster with the EMA and Brilacidin should be there soon... Then you will see the FDA get their sht together and the floodgates will open. Fingers crossed.
Go Leo & IPIX!
That makes Brilacidin worth its weight in gold. Gilead must be looking for a new cash cow.
In my opinion, if the FDA won't get it done the EMA will. There are now two shots on goal and if the FDA wants to claim discovery rights they will need to get a move on it. This plays well for Brilacidin and we will know shortly where Brilacidin fits in this covid-19 crisis.
Go Leo & IPIX!
Have you looked at the thinking process of Biden' picks for his covid task force. Dr Emanuel scares me. He devalues the lives of the elderly even though they are more susceptable to covid.
https://twitter.com/KarinCAtrades/status/1326764183707394048?s=20
Read the above thread. My post and what I responded to. My hope is that if Brilacidin works, those of us here have access to it.
We all age differently and I don't like the thought of him playing God. But, we are dealing with a global justice warrior in this man. A couple of quotes
Quote:
prioritizing seniors at higher risk would mean sending a disproportionate amount of vaccines to wealthier countries, where average life expectancies tend to be longer.
Quote:
Emanuel, 63, wrote that "by 75, creativity, originality and productivity are pretty much gone for the vast, vast majority of us"
Message in reply to:
Totally PO'd at all the attention these bogus vaccines get, not to mention the monies for study as well.
Treatments pushed to the gutter and here we have a drug with a near perfect answer to CV19 and it still sits waiting its turn to proceed to a human trial. I hope everyone realizes we are about the .001% of the population (or less) that has even heard about Brilacidin and yet by early summer we had evidence it was a POWERFUL looking prospect as a treatment gold-standard. Yet no money to date. No media coverage to date. No IND approval to date. Nothing but additional wait. None of this IPIX mgt fault, strictly systemic failure on the part of the government across the board to mainly include those agencies tasked with moving things forward at greatest speed possible. We all know who that is. Yet nearly unlimited funds channeled to BP and their lineup of continual failures to date regarding CV19. Who da thunk? Guess that lobbyist payola paid off in spades this year.
Tomorrow I go to a memorial service for my neighbor who died of CV19. He thought he had it as his visiting granddaughter had it. Nevertheless, though he felt bad for a week he wouldn't go to the doctor. Finally, he was so bad off he told his wife to take him to the hospital but he couldn't make it further than the kitchen so he told her to call an ambulance.
He had only a day or two and he was put on a ventilator. Very soon had a massive stroke and died within an hour or two. Has anyone ever heard of a good result from someone put on a ventilator for CV19 or is it a death warrant as seems to be the case?
Only close contact that has died of Covid that I know.
Makes me wonder if something as great as Brilacidin is buried this long, how many 'pretty good' drugs have been buried over the years? Too late at night to even want to go there.
Great post Pete, thanks,
Go Leo & IPIX!
Totally PO'd at all the attention these bogus vaccines get, not to mention the monies for study as well.
Treatments pushed to the gutter and here we have a drug with a near perfect answer to CV19 and it still sits waiting its turn to proceed to a human trial. I hope everyone realizes we are about the .001% of the population (or less) that has even heard about Brilacidin and yet by early summer we had evidence it was a POWERFUL looking prospect as a treatment gold-standard. Yet no money to date. No media coverage to date. No IND approval to date. Nothing but additional wait. None of this IPIX mgt fault, strictly systemic failure on the part of the government across the board to mainly include those agencies tasked with moving things forward at greatest speed possible. We all know who that is. Yet nearly unlimited funds channeled to BP and their lineup of continual failures to date regarding CV19. Who da thunk? Guess that lobbyist payola paid off in spades this year.
Tomorrow I go to a memorial service for my neighbor who died of CV19. He thought he had it as his visiting granddaughter had it. Nevertheless, though he felt bad for a week he wouldn't go to the doctor. Finally, he was so bad off he told his wife to take him to the hospital but he couldn't make it further than the kitchen so he told her to call an ambulance.
He had only a day or two and he was put on a ventilator. Very soon had a massive stroke and died within an hour or two. Has anyone ever heard of a good result from someone put on a ventilator for CV19 or is it a death warrant as seems to be the case?
Only close contact that has died of Covid that I know.
Makes me wonder if something as great as Brilacidin is buried this long, how many 'pretty good' drugs have been buried over the years? Too late at night to even want to go there.
Dr. Ahmed.
https://www.qantaahmed.com/bio/
https://video.foxnews.com/v/6196773763001#sp=show-clips
https://www.msn.com/en-us/news/watch/dr-qanta-ahmed-on-president-trumps-ongoing-covid-19-treatment/vp-BB19KQIB
https://finance.yahoo.com/video/nyu-pulmonologist-covid-19-virus-183507001.html
Go Leo & IPIX!
In this manuscript, we demonstrate brilacidin exhibits robust inhibition of SARS-CoV-2 in Vero cells and Calu-3 cells, supporting brilacidin as a promising novel drug candidate for the treatment of COVID-19. Functioning as a viral entry inhibitor, proposed mechanisms of action for brilacidin include affecting the integrity of the viral membrane and preventing viral binding to cells. More detailed mechanistic studies are planned. Destabilizing viral integrity is a desirable antiviral property, especially in relation to pan-coronavirus agents, as the viral membrane is highly conserved and similar in construct across different coronavirus strains. Moreover, drugs that can directly disrupt viral integrity would be less prone to resistance due to mutation, unlike many antivirals, antibody-based treatments and vaccines that are currently in use and in development. Brilacidin exhibits an excellent synergistic inhibitory profile against SARS-CoV-2 in combination with remdesivir. Experiments conducted in endemic human coronaviruses are ongoing, with additional testing planned in other lethal coronaviruses (MERS-CoV, SARS-CoV), toward assessing the potential of brilacidin as a broad spectrum inhibitor of coronaviruses.
http://www.ipharminc.com/new-blog/2020/10/30/preprint-brilacidin-a-covid-19-drug-candidate-exhibits-potent-in-vitro-antiviral-activity-against-sars-cov-2
Go Leo & IPIX!
Who is Dr. Ammads?
I honestly don't know but I am sure she is working on her plan of action. She likes the limelight and is well connected so I suspect she will bring this to the people who need to know.
To those interested in yesterday's meeting with my friend and Dr. Ahmed. See below on their update.
Go Leo & IPIX!
Dr. Ahmed, a highly respected and experienced NY Pulmonologist, and who was personally engaged treating Covid-19 patients in NYC hospitals during the height of the Covid-19 crisis, was not aware of Brilacidin and has received Pre-Print Peer Review Article from GMU and other documents supporting Brilacidin as a potentially highly effective therapeutic. She was surprised to hear of Remdesivir/Brilacidin combo 100% (99.85%) viral reduction and will review all materials received.
information received included contact information to pursue additional DD with other MD's, PhD's etc.
Appointment Scheduled
Appointment Information:
Department: WINTHROP PULMONARY ASSOCIATES
Department Address: 1300 FRANKLIN AVENUE
SUITE UL4A
GARDEN CITY NY 11530-0000
Provider: Qanta A Ahmed, MD
Date: 11/09/20
Time: 4:30 PM
It was just to snatch up stop losses and preparing for take off.
Go Leo & IPIX
Good luck with that. BTW - Thank you for the cheap share this morning...
Go Leo & IPIX!
Very nice post!
Go Leo & IPIX!
The "90% efficacy" claim is troubling. Based on what? This is a misleading claim. Because they are not releasing details, what seems to be able to be gleaned from what they are saying is that 90% of the cases of COVID-19 were in members of the control group. However, there are only 94 cases of COVID out of the 44,000 volunteers, and this, after only two months after vaccination.
Also, Pfizer's vaccine requires two doses, and the vaccine has to be stored and transported at extremely low temperatures. What are the chances that the vaccine will always be handled properly so that it is effective?
And, what are the chances that this vaccine is indeed safe and does not have longer-term side effects? Just as a recent example, the initial shingles vaccine was widely hailed as a safe and effective vaccine. Then, after a lot of people got dosed -- whoops, guess what, it is NOT safe and in some people TRIGGERED cases of shingles. (Please note: that vaccine has been withdrawn and the current one is safer -- supposedly.)
There have been many other cases of vaccines that appeared to be safe which turned out to have bad side effects over the longer term, when given to a very large population. Swine flu vaccine, anyone?
Also, they are saying that they will have enough vaccine to dose 15-20 million people in the next year. Even if this vaccine is safe and effective, and does not cause long-term side effects -- 15-20 million people vaccinated with even an optimistic 90% efficacy will NOT get the pandemic under control.
TREATMENTS will. And if you or a family member are among those who get COVID in the next year, you're going to be mighty grateful if there are good treatments available -- like, for instance, Brilacidin.
Shaking the tree boys? Cheap shares on tap!
Go Leo & IPIX!
Well said! I personally will never take a vaccine for something that mutates... in my opinion vaccines are money makers.
Go Leo & IPIX! Bring on the human trials...
There’s zero reason for people to get scared out of IPIX because of whatever vaccine might come along. As others have mentioned, vaccines aren’t 100% effective and not everyone will get one. I’d say less than 40% will voluntarily take a vaccine at this point, even assuming it’s ready by January, which I doubt can happen. That leaves a goodly portion of the world population who might have a need for a therapeutic remedy for Covid. If Farrell’s timeline for development holds then Brilicidin will be HUGE! If it takes two years then we’ll lose the Covid benefit but by that time B will have been developed and proven safe and effective against viruses in general.
There are problems with my two different accounts. I suspect it is to do with the markets. I don't know.
I will not take a vaccine and I wonder how many people won't. I would however take a therapeutic.
Go Leo & IPIX!
Doesn't. If Covid-19 is mutating like scientist think it is a vaccine will not stop it. A vaccine will also not reach poor countries unless it is affecting the rich and therefore the best cure (fingers crossed)is Brilacidin.
The world needs Brilacidin.
Go Leo & IPIX!
I love this timeline farrell90! I hope it comes true because the world will return to normal in the foreseeable future.
Go Leo & IPIX!
My bet is:
IND next week
First patient dosed the week of Nov16-20
Interim report week of Dec14
If interim report positive:
Barda application by Jan 1,
Completion of phase1 trial by 12/31
EUA with CTAP assistance by Jan 1
Phase 3 FDA trial thousands of patients multiple sites announced by Jan1
Multiple attractive partnership offers by Jan 1
Stage 3 FDA trial completed by 3/1/2021
New drug application approved by 3/8/2021
JMO {which has been pretty good so far}
GLTA,Farrell
I would be happy right now with 5000% gain = approximately $10. But, is it worth more if it shows to be a Covid-19 killer in human trials like I think. The market will tell us. We are not going to have to wait much longer for this to play out and we will have the answers.
DeGrado comeback to Brilacidin for a reason. I suspect that its self is a huge tell.
November 2, 2020
INNOVATION PHARMACEUTICALS RECEIVES PRE-IND RESPONSE FROM FDA ON COVID-19 TRIAL
October 30, 2020
INNOVATION PHARMACEUTICALS AND GEORGE MASON UNIVERSITY ANNOUNCE PUBLIC RELEASE OF LABORATORY TESTING RESULTS DEMONSTRATING BRILACIDIN’S COVID-19 TREATMENT POTENTIAL
October 2, 2020
INNOVATION PHARMACEUTICALS ANNOUNCES PRE-IND MEETING REQUEST GRANTED BY FDA FOR THE STUDY OF BRILACIDIN FOR THE TREATMENT OF COVID-19
September 15, 2020
LABORATORY TESTING OF BRILACIDIN FOR COVID-19 IN COMBINATION WITH REMDESIVIR REDUCES VIRAL LOAD BY NEARLY 100 PERCENT
September 8, 2020
INNOVATION PHARMACEUTICALS ANNOUNCES PUBLICATION OF INDEPENDENT RESEARCH ON KEVETRIN, THE COMPANY’S P53 DRUG CANDIDATE, IN ONCOLOGY REPORTS
August 26, 2020
DR. WILLIAM F. DEGRADO, A DISCOVERER OF BRILACIDIN, JOINS INNOVATION PHARMACEUTICALS AS SCIENTIFIC ADVISOR
http://www.ipharminc.com/press-release
Go Leo & IPIX!
If the human trials show even half of what the lab results were, and that information isn’t censored, then IPIX will be off the charts value wise, at least initially. Eventually it will be priced properly. I have no idea what it will be but certainly a 5000% gain is not out of the park. For starters.
Go Leo!
There has been some skepticism on this board from a select few about your post Pete and I wanted to add my thoughts.
Dr. Ahmed is a Pulmonologist (google definition) - A pulmonologist is a physician who specializes in the respiratory system. From the windpipe to the lungs, if your complaint involves the lungs or any part of the respiratory system, a pulmonologist is the doctor you want to solve the problem
September 15, 2020
Laboratory Testing of Brilacidin for COVID-19 in Combination with Remdesivir Reduces Viral Load by Nearly 100 Percent
Brilacidin
· Brilacidin and Remdesivir shown to act synergistically in vitro, increasing overall inhibition against the novel coronavirus to 99.85 percent in a human lung cell line
http://www.ipharminc.com/press-release/2020/9/15/laboratory-testing-of-brilacidin-for-covid-19-in-combination-with-remdesivir-reduces-viral-load-by-nearly-100-percent
I have been informed (and given permission to pass along)that a poster has an appointment next Monday with:
Dr Qanta Ahmed to review the attributes of Brilacidin vs Covid-19.
Links below will show why this should be quite helpful in spreading the Brilacidin story in both medicine and media:
https://www.qantaahmed.com/bio/
https://video.foxnews.com/v/6196773763001#sp=show-clips
https://www.msn.com/en-us/news/watch/dr-qanta-ahmed-on-president-trumps-ongoing-covid-19-treatment/vp-BB19KQIB
https://finance.yahoo.com/video/nyu-pulmonologist-covid-19-virus-183507001.html
We are lucky to have a few go far beyond in their drive to get the Brilacidin story out. Thanks to them for all they do!!!
You don't need permission to discuss public information that has been filed with the SEC.
Come on man! :)
Go Leo & IPIX!
Awesome Pete! She will be blown away...
I have been informed (and given permission to pass along)that a poster has an appointment next Monday with:
Dr Qanta Ahmed to review the attributes of Brilacidin vs Covid-19.
Links below will show why this should be quite helpful in spreading the Brilacidin story in both medicine and media:
https://www.qantaahmed.com/bio/
https://video.foxnews.com/v/6196773763001#sp=show-clips
https://www.msn.com/en-us/news/watch/dr-qanta-ahmed-on-president-trumps-ongoing-covid-19-treatment/vp-BB19KQIB
https://finance.yahoo.com/video/nyu-pulmonologist-covid-19-virus-183507001.html
We are lucky to have a few go far beyond in their drive to get the Brilacidin story out. Thanks to them for all they do!!!
Nice catch, big pharma's always get the accolades. We will eventually get ours.
Go Leo & IPIX!
They did make a mistake in the first sentence. They state that Brilacidin works better when used with Rem when it is quite the opposite. Despite FDA approval Rem has got a resounding thumbs down by medical professionals. Brilacidin makes it 99.85 % effective against CV.
BRILACIDIN will eventually be known as the catalyst that is the force behind a possible Brilacidin/REM combo therapy.
GO B GO *426* THE GOLD STANDARD
Morning Dr. It was posted on Daily Rounds for Doctors - Clinical Cases, News & Updates is on Facebook - and there isn't anything new. I just found it interesting that its on their Facebook account. There are 40 shares and comments. I am not on Facebook either and was brought to attention by my wife.
Good things are happening at IPIX! Great post.
Go Leo & IPIX!
The pre-peer review article, which has already been or will soon be, sent out to all the world's leading virology experts IS the empirical data per testing at a government sponsored lab that the world of medicine was waiting to see.
It is the document that takes Brilacidin from speculation among those that may have only heard of Brilacidin to actually seeing data so that they can compare Brilacidin to ALL current virus treatments and show them that it's uses should extend far, far beyond any other drug out there due to it's three properties of being antibacterial, antiviral, and having immuno/anti-inflammatory properties.
This is not a fringe drug the virologists are learning about, they will recognize that it is the swiss army-knife equivalent to solve the problems of their field.
We do need the human trial results to give proof of the ability of B to work as well in humans as in vitro and in vero test indicate as evidenced by the SI of 426. This will allow massive funds to be directed to further B testing and start BPs offering deals as to partnering for specific indications. Also the requirement for share price to actually start rising and not retreating a matter of days later.
The cat is out of the bag regarding Brilacidin in the area of its anti-viral properties and possible indications across the entire coronavirus spectrum.
The ABSSSI already showed its strength of being a great antibiotic.
The pulmonary results from the CV trial in being able to clear up severe lung problems should make it a star in the pulmonary field and other areas where an effective and safe anti-inflammatory is needed.
But we need publicity beyond just the medical world and I think that ball of wax gets taken care of as early as next week. Important people in politics and the media know about Brilacidin, I think the reins they have had put on them have been removed and they will make Brilacidin known to the general public in a big way very, very soon!!
https://m.facebook.com/story.php?story_fbid=3611341095599372&id=453584978041682&__tn__=%2As%2As-R
Daily Rounds for Doctors - Clinical Cases, News & Updates is on Facebook.
Interesting find!
Go Leo & IPIX!
WAKEFIELD, MA – November 2, 2020 (GLOBE NEWSWIRE) Innovation Pharmaceuticals (OTCQB:IPIX) (“the Company”), a clinical stage biopharmaceutical company, announced today receipt of written feedback from the U.S. Food and Drug Administration (FDA) that is in general agreement with the Company’s planned clinical trial for Brilacidin, a defensin-mimetic drug candidate, for the treatment of COVID-19. The FDA response completes the Pre-Investigational New Drug (Pre-IND) process.
http://www.ipharminc.com/press-release/2020/11/2/innovation-pharmaceuticals-receives-pre-ind-response-from-fda-on-covid-19-trial
Hopefully this helps.
Go Leo & IPIX!
Does anyone know if we have wait for approvals from anyone before beginning the clinical trials. I believe an assumed the sites were already chosen with the return response from the FDA on Pre-IND response.
Should response be construed as “acceptance “ that the clinical trial proceed without additional approvals?
Hoping for a quick results from the hospitals and doctors reviewing the identified patients.
Trying to accumulate more today.
GLTA.
Leo might be able to start Brilacidin human trials faster than some think if there are multiple sites for the trials. That would also mean that the results will be staggered. We won't have to wait for scientific confirmation for Brilacidin's effectiveness because (hopefully) covid-19 hospitalized patients will be released after a few days. Then, we are off to the races....
What is Brilacidin worth if it normalizes humanity? fingers crossed that the amazing initial results from the RBL's can continue into the human trials. Why wouldn't it given its already proven track record.
Go Leo & IPIX!
Greece locks down nation. Over 10,000 deaths across the planet as virus gains momentum. HELLO, medical community. BRILACIDIN can dramatically help those in need. It works and it is SAFE. You won't need a new liver or kidney after taking Brilacidin.
GO B GO *426* THE GOLD STANDARD
Great article!
Go Leo & IPIX!
Study shows brilacidin strongly inhibits SARS-CoV-2 in laboratory cell lines
A recent study by US researchers reveals that brilacidin, a small synthetic molecule with peptide-like properties, exerts potent in vitro antiviral activity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – both as a standalone treatment and in combination with FDA-approved remdesivir. The study is currently available on the bioRxiv* preprint server.
SARS-Cov-2, the pathogen and causative agent of coronavirus disease 19 (COVID-19), has been responsible for more than 1.2 million deaths worldwide since it emerged at the end of 2019. So far, there are no vaccines approved for preventing SARS-CoV-2 infection, and all presently available treatments are only modestly effective.
Therefore, while the quest for a vaccine is developing at an unprecedented pace, there is an urgent global need for therapeutic strategies to safely treat COVID-19 and reduce its substantial morbidity and mortality.
This is where natural and synthetic antimicrobial peptides come into play, also known as Host Defense Proteins/Peptides (HDPs), since they have confirmed inhibitory activity against multiple viruses. These compounds selectively and multifariously interact with different pathogens, increasing their vulnerability to proteolysis and degradation.
Within the broad context of the global COVID-19 pandemic and the possible therapeutic role of HDPs, a US-based research group - from George Mason University, the State University of New Jersey and Innovation Pharmaceuticals Inc. - evaluated de novo designed brilacidin in laboratory settings to appraise whether the drug might exhibit antiviral properties against SARS-CoV-2.
Brilacidin inhibits SARS-CoV-2 replication (Vero cells) (A) Vero cells were pretreated for 2h with 2 or 10µM brilacidin, infected with SARS-CoV-2 non-directly at MOI 0.1 for 1h, and post-treated with media containing brilacidin as described in Materials and Methods. At 16hpi, viral supernatants were evaluated by plaque assay as described in Materials and Methods. Figure 2B, 2C. Brilacidin appears to impact entry of SARS-CoV-2 (Vero cells) (B) Brilacidin was measured at 10 and 20µM for neutralization activity against a luciferase-expressing pseudotyped virus (rVSV) containing the SARS-CoV-2 spike protein using luciferase assay in Vero cells at 24hpt as described in Materials and Methods and compared to neutralization activity of hydroxychloroquine. (C) Vero cells were treated with 10 or 20µM brilacidin for neutralization activity against SARS-CoV-2 rVSV, and cells imaged and quantified using fluorescent microscopy and FITC surface intensity plots at 1 and 4hpt as described in Materials and Methods. Graphs are representative of one independent experiment performed in technical triplicates (n=3). Brl indicates brilacidin. **p<0.0021, ***p<0.0002, ****p<0.0001.
Brilacidin inhibits SARS-CoV-2 replication (Vero cells) (A) Vero cells were pretreated for 2h with 2 or 10µM brilacidin, infected with SARS-CoV-2 non-directly at MOI 0.1 for 1h, and post-treated with media containing brilacidin as described in Materials and Methods. At 16hpi, viral supernatants were evaluated by plaque assay as described in Materials and Methods. Figure 2B, 2C. Brilacidin appears to impact entry of SARS-CoV-2 (Vero cells) (B) Brilacidin was measured at 10 and 20µM for neutralization activity against a luciferase-expressing pseudotyped virus (rVSV) containing the SARS-CoV-2 spike protein using luciferase assay in Vero cells at 24hpt as described in Materials and Methods and compared to neutralization activity of hydroxychloroquine. (C) Vero cells were treated with 10 or 20µM brilacidin for neutralization activity against SARS-CoV-2 rVSV, and cells imaged and quantified using fluorescent microscopy and FITC surface intensity plots at 1 and 4hpt as described in Materials and Methods. Graphs are representative of one independent experiment performed in technical triplicates (n=3). Brl indicates brilacidin. **p<0.0021, ***p<0.0002, ****p<0.0001.
Cell lines and inhibition assays
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The potential antiviral activity of brilacidin against SARS-CoV-2 was initially assessed with the use of Vero cells as an infection model. Toxicity assessment of brilacidin in these cells was performed by incubating them with increasing concentrations of the compound for 24 hours, and the treatment effect was appraised by utilizing plaque assay.
Moreover, the potential of brilacidin for interfering with viral entry was also assessed in the Vero cell line by observing the angiotensin-converting enzyme 2 (ACE2) spike glycoprotein interaction. This was done using a recombinant vesicular stomatitis virus (rVSV)-pseudotyped SARS-CoV-2 expressing a luciferase reporter gene.
The aforementioned approach was supported with experiments conducted in the Calu-3 infection model to confirm that brilacidin can prompt anti-SARS-CoV-2 activity in an ACE2-positive human lung cell line.
To independently appraise the impact of brilacidin on viral particles and, hence, add support to the role of brilacidin as an inhibitor of viral entry, a direct virus inhibition assay was conducted alongside virus neutralization observed in the presence of antibodies.
Early-stage SARS-CoV-2 inhibition
“Our experiments in the Vero cell line model demonstrate brilacidin decreases viral load in a robust manner when the virus is pre-incubated with brilacidin, suggesting brilacidin impacts the virus directly,” say the study’s authors.
More specifically, after brilacidin treatment, a dose-dependent decrease in infectious viral titer was observed, with a maximum of 53% viral inhibition in the presence of the higher drug concentration (i.e., 10 micromoles). Likewise, the drug also achieved a high selectivity index.
The direct impact observation is supported by the inhibition observed in the context of a replication-incompetent pseudovirus, which additionally shows the propensity of brilacidin to exert inhibitory activity during the early stages of viral infection, but also to impede the interaction between SARS-CoV-2 spike glycoprotein and ACE2 receptor on the cells.
Furthermore, all experiments that were conducted in the aforementioned Vero and Calu-3 cell line models were supportive of an early inhibition exerted by brilacidin on the virus – indicating, in turn, the compound’s considerable impact on viral integrity.
A potential broad-spectrum coronavirus inhibitor
“Collectively, our data demonstrate that brilacidin exerts potent inhibition of SARS-CoV-2 and thus supports brilacidin as a promising COVID-19 drug candidate”, concludes study authors in this bioRxiv paper.
Their data suggest that SARS-CoV-2 inhibition in used cell culture models primarily arose as a result of the impact of brilacidin on viral entry and subsequent disruption of viral membrane viral integrity. Brilacidin has also demonstrated synergistic antiviral activity when combined with remdesivir, currently the only FDA-approved treatment for COVID-19.
In any case, more detailed mechanistic studies are planned, while experiments using endemic human coronaviruses are ongoing. On top of that, additional testing planned in other highly lethal coronaviruses (i.e., SARS-CoV and MERS-CoV) will fully gauge the potential of brilacidin as a broad-spectrum coronavirus inhibitor.
*Important Notice
bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
KarinCA, with all of this amazing news from IPIX in the past few days I cannot believe you are not posting more. People want to hear from you. You are our good luck charm!
Go Leo & IPIX!
Agreed! things are going to get crazy with winter rounding the corner which will bode well for Brilacidin.
Go Leo & IPIX!
Phase II or Phase III means nothing now. If it is successful EUA will be granted. If granted it will be a rolling review process. Gilead set the bar low, approval will be quick. All timelines are gone.
So do I, even if you are right we are still doing a lot better than we were 10 months ago before covid19. At least it will give Leo a chance to raise some real cash for further advancements with B and K.
Go Leo & IPIX!
"then I truly believe we will be at or past the $5.00 PPS figure. JMHO"
Hope you are right, really do, but my hunch is that we'll only see the $5 PPS range at the conclusion of a strong 2b, very strong. Not until, and maybe not even then. Of course a strong 3 would get us over that hurdle, and then some, probably a lot, IMHO.
Thanks for you thoughts farrell90.
Go Leo & IPIX!
Instead of a placebo the other arm will receive treatment either Remdesivir, Favipiravir or convalescent plasma. There is not likely to be a combination arm in this relatively small trial.
It will be interesting to see the dosing regimen approved by the FDA.
We know Brilacidin has a long half life with a short time to virolysis.It also is effective in vitro at low doses. Will the FDA opt for 1,2 or 3 infusions or 2 arms with different doses?
My guess is 2 different doses given 2 or 3 infusions 2-3 days apart.
Fortunately they have experienced researchers to work these matters out.
What will the end points be? The in patient study most likely will evaluate treatment in hospitalized patients on low levels of oxygen without signs of imminent pulmonary failure.
If you are really confident the first end point will be lower mortality[ which no antiviral drug has achieved]if not time to recovery second will be reduced percentage to pulmonary failure or shorten tim oxygen was required and the last will be time to virus neutralization in hospitalized patients .
We should have more details of the human clinical trials in 2-3 weeks. The trial will be short.
For comparison review the Remdesvir Adaptive Covid-19 Treatment Trial (ACTT-1)trial:
https://www.nejm.org/doi/full/10.1056/NEJMoa2007764
GLTA Farrell
I am with you HT! If this is the Covid-19 killer we think it is our SP will surpass $5 fast.
Go Leo & IPIX!
I will be as level-headed and evening keeled as possible with this assumption.
If and of course it’s always a Big If until proven in Human Clinical Trials, but If Brilacidin can succeed and get people cleared of the virus in under 3 - 5 days for the worst/most severe cases, then my friend, you need to add a couple of zeros to that $5.00 per share figure. Governments and countries around the world will be begging for Brilacidin’s use. That is a fact.
But once the trial actually is announced that it is starting and where, then I truly believe we will be at or past the $5.00 PPS figure. JMHO
I saw the email and the person it was sent to.
Go Leo & IPIX
Thanks cybermich, I have seen this email and it is legit.
Go Leo & IPIX!
This just in (shared by a respected long on this board.. and the party in which this email was exchanged)
I was given permission to post this:)...
feel free to use all or part of this post...John McLaughlin is a close associate of mine and DJT's private pollster...and is with him 24/7
John XXXX <johnxxxx@gmail.com>
10:20 AM (47 minutes ago)
to John McLaughlin
As a PS to our emails this weekend and AM...this would have been excellent news for DJT...and "finding a Therapeutic" that actually will work 100% against Covid-19...but the FDA held back until today...
If anyone wants to be brought up to speed...VP Pence's Key Scientific Advisor, Dr. Jeffry Howard, knows of Brilacidin. Dr. Howard is now at U. of Louisville, University Hospital.
Press Release this AM on the Brilacidin IND application response from the FDA.
You are right on, the possibilities are pretty wide ranging. The human trials for COVID19 will help narrow Brilacidins effectiveness.
Go Leo & IPIX!
I don’t think so. B will more than likely be the drug to give for multiple other viruses: MRSA, SARS, all strains of pneumonia maybe, equine encephalitis, West Nile, nasty ole Lyme disease which wreaks havoc in New England, Zica virus, herpes, HIV, the flu (if so then maybe they are the paranoid BP’s and their powerful connections are behind any road blocks placed in IPIX’s path), hepatitis, shingles, the flesh-eating Staph A. virus, Dengue, Ebola, norovirus, rotavirus, meningitis bacterial as well as viral, mononucleosis, and many more. There had even been suggestions ( and this one is a stretch but who knows) that multiple sclerosis could possibly have a viral connection as people have the disease without any known family history of it...that people get MS as a virus and then it gets triggered/activates years later. Brilacidin has a place in therapeutics and from what I have read very inexpensive compared to other drugs already available to treat some of the above conditions but at a much higher cost so those biopharmas do not wish B to be successful, but, thanks to CV-19, and it’s unfortunate with all the loss of loved ones, has created a spark to ignite B’s success.
I read it for the second time it was that good.
Go Leo & IPIX!
Thanks for the reminder.
I have a feeling a lot of conversations have been going on behind the scenes.
As requested an encore of a poem I wrote just for Infinity:)...
B for Absssi is phase 3 ready
B for Om is as well
B for UP is ready to go
B for UC was dosed in a pill
(and I assume your favorite still)
which brings us to B for C
now what do we know?
not only 3rd party validation
but the help of Dr. DeGrado..
and what do we gleam
from all those other Brilacidin trials?
for the purpose of B for C
there is an established safety profile...
when compared to Remdesivir
which inhibits viral reproduction
B will be better
and has a 3 in 1 antiviral
mechanism of action...
we can mention the high SI
which also supports
B against C in the fight
Now you speak of miracles?
said the lung test had no chance
and yet the Silico Molecular Screening Study
revealed it was not just happenstance...
you can flip that coin
over 11,500 times
or wait for each trial result
for one more sign..
or you can realize
B was developed over thousands of hours
(thats a lot of time:))
using supercomputers
and AI..
the evidence is there
in the science to see..
and no matter what you and I say
its not up to you and me..
Now you speak of miracles?
when this journey is through
we'll look back..
and see the miracle coming true.
(there's already proof of the miracle Infinity:)
p.s. the trial is coming:)