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This looks like we need to get on the stick and get some action going ...
Scientists are working on a nasal vaccine to try to reduce brain plaque seen in Alzheimer's disease.
So far, the vaccine has only been tested on mice, not people.
"It works in mice," researcher Howard Weiner, MD, tells WebMD. "I think the significance of the experiment is we've discovered a unique way of vaccination that may be of help for Alzheimer's.
"We think it's very exciting. The next step is to see whether it's safe in humans and then we can test to see how efficacious it is," says Weiner. He is the co-director of the Center for Neurologic Diseases at Boston's Brigham and Women's Hospital and Harvard Medical School, and the director of the Partners Multiple Sclerosis Center at Brigham and Women's Hospital.
Results of vaccine tests on mice appear in The Journal of Clinical Investigation.
Vaccine's Ingredients
The vaccine mixes an FDA-approved multiple sclerosis [MS] drug and an additional substance that helps the vaccine stimulate immunity. The nasal vaccination can be given as a spray or as drops. Drops were used on the mice in Weiner's study.
Read WebMD's "Memory Lapses: Are They Normal?"
Study's Results
The study focused on mice with an Alzheimer's-like brain disease. The mice got vaccine treatments and boosters for several weeks.
The vaccine is designed to activate brain cells called microglia. The microglia, in turn, are supposed to clean up a protein called beta-amyloid, which is found in brain plaques seen in Alzheimer's disease.
After the nasal vaccine treatments, total beta-amyloid levels dropped 73 perent, write the researchers.
Read WebMD's "New Thinking About Alzheimer's Treatment"
Surprise Discovery
Why did Weiner's team decide to make a nasal vaccine from those particular drugs?
They had been trying to figure out why another Alzheimer's vaccine hadn't worked. That vaccine had directly targeted beta-amyloid with antibodies, but side effects stopped trials of that vaccine in people.
"During that time, we made the unexpected discovery that if we gave the animals a type of disease that's like MS [multiple sclerosis], it cleared 80 perent of the beta [amyloid] from the brain. And when we made that discovery, the question was, how is this happening and can we take the discovery and find a way to use it to come up with a new vaccine for Alzheimer's," says Wiener.
The nasal vaccine doesn't stimulate the body to make antibodies. "In fact, in the animal models, it worked in mice that are genetically unable to make antibodies, so it's a totally unique type of vaccine from all the other vaccines that have been tried," says Weiner.
Beta-amyloid deposits are a bit different in mice and people, and the vaccine's long-term results aren't known yet, write the researchers.
Another researcher who worked on the study is an employee of and has shares in ID Biomedical Corporation of Quebec, the nasal treatment's maker, the journal notes.
Read WebMD's "Healthy Gums May Help Fight Alzheimer's"
By Miranda Hitti, reviewed by Brunilda Nazario, MD
SOURCES: Frenkel, D. The Journal of Clinical Investigation, Aug. 11, 2005; online edition. Howard Weiner, MD, co-director, Center for Neurologic Diseases, Brigham and Women's Hospital/Harvard Medical School; director, Partners Multiple Sclerosis Center, Brigham and Women's Hospital. News release, The Journal of Clinical Investigation.
Do these figures look familiar? Although the technology has really skyrocketed, the PPS seems to have been a little bit of a dud. Oh, and the total shares outstanding was in the 12 - 14 MM range. How does that compare to today?
Fiscal Year Ending December 31, 1998
Fourth Quarter Ending 12/31/98 .54 .51
Third Quarter Ending 09/30/98 .59 .56
Second Quarter Ending 06/30/98 .75 .63
First Quarter Ending 03/31/98 .35 .34
Fiscal Year Ending December 31, 1997
Fourth Quarter Ending 12/31/97 .48 .43
Third Quarter Ending 09/30/97 .20 .20
Second Quarter Ending 06/30/97 .30 .30
First Quarter Ending 03/31/97 .18 .18
http://www.sec.gov/Archives/edgar/data/1005302/0001005302-99-000002.txt
Now ain't this an interesting development? Read the article before starting to check out the various websites ... couple this with Yin's SSDNA and it could be the ultimate treatment and diagnostic aid ...
'Cheap' genome sequencing now possible
Friday, August 5, 2005; Posted: 10:50 a.m. EDT (14:50 GMT)
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WASHINGTON (Reuters) -- Want your own personal genome sequenced? Researchers said they had found a faster and cheaper way to do it that would cost only about $2.2 million.
George Church and colleagues at Harvard Medical School hope eventually to reduce the cost further to $1,000 per genome -- the entire DNA code of a person, plant or other organism.
Their new method, described in a report in the journal Science, bypasses the traditional gel-based technology for analyzing DNA and instead uses color-coded beads, a microscope and a camera. It is considerably cheaper than the current methods, which cost an estimated $20 million for a human genome.
"We are finding needles in a haystack very accurately," Church said in a telephone interview.
They said it costs about one-ninth the current cost of sequencing a genome, which involves using E.coli bacteria as an incubator to generate the genetic material, separating it out, breaking it apart and laying it onto a gel.
DNA, short for deoxyribonucleic acid, is made up of repeats of four nucleotide bases called A,C,T and G for short.
Each nucleotide carries a slightly different charge and thus can be filtered using a process called electrophoresis. Modern sequencing uses dyes to make it easy to pick out each one, but the process can take hours.
"Electrophoresis is slow. You can't really speed it up," Church said. "But with a digital camera, you can go as fast as electronics can go."
Church's team replicated thousands of DNA snippets at once, each snippet on its own tiny bead just one micron in diameter.
They packed 14 million of these beads into an area the size of a fingerprint.
"Each camera frame is filled with beads each of which has one of four colors corresponding one of the four bases of DNA (A,C,G,T)," Church said.
One of four fluorescent dyes corresponding to the four DNA bases attaches, depending on which base is present.
"As the computer controls the chemicals flowing in, the colors of the beads change to reveal which base (A,C,G, or T) is present at each sequential position of the DNA," Church said.
Right now the system must use an existing genome map as a reference -- it cannot sequence a new genome from scratch. But it worked to show the genetic differences between a new kind of E. coli bacterium and the existing E. coli genome map that has been published, Church said.
The idea is to produce a technology that could be used to compare one person's genome, for example, to the existing human genome map and find an individual's differences.
"There are needs for personal genomic data already," Church said.
"If you are a cancer patient there are quite a number of therapies which can only be used if you have a specific genetic component."
Harvard has licensed the technology to Agencourt Bioscience Corporation and Church and his colleagues would collect royalties on any commercial application.
It would be inexpensive to set up their system, the researchers said.
"Our integrated liquid-handling and microscopy setup can be replicated with off-the-shelf components at a cost of approximately $140,000," they wrote.
That is pretty much what I have thought. I know I considered selling off some common a while back and buying restricted stock in a PPO. Seems like a pretty good way to quickly and dramatically increase ones holdings ... and the PPO proceeds go directly to the corporation while buying on the open market gives money to other shareholders. Might be a quick painless way to finance the production facility.
Hope this bounce keeps up ... will make for a better weekend ... LOLOL
Arnold, here is a purely hypothetical question. If a major shareholder in a company "rolls over" a few million shares of common stock to participate in a PPO, are there any legal ramifications? I've heard both ways. If this is suggested by someone within a corporation, are there also legal ramifications to this?
Great to see the freefall stop. Looks like some of those saying that yesterday was indeed a buying opportunity were correct. Congratulations to those who bought in the low 40's and upper 30's. I should have listened to my gut feelings. Duuuuuuh
gdepc, finally you got something correct and caught me in a mistake. It was around fifty cents a share, and that is about $100K total. If it still had the same share price it had in 1999-2000, it would have been worth $600,000.00. Check that math for me ... LOL.
Point is that Malcolm took over in August or September of 1999.
Now are you going to address and answer these underlined questions from previous posts:
gdepc, we have had a far greater loss of equity value following the pathway that was used. Go back to the time of the Hemco deal. We had around 40MM (not sure) shares outstanding. That number has just about tripled and in so doing our equity interest has been reduced to about a third of what it was. That is roughly equal to giving away two thirds of the equity interest. Of course this has not hurt those very select few in management, has it?
Please show me your figures to show that the underpriced PPO's have been more beneficial to the shareholders and their equity interest.
As others have said, having debt is not in and of itself a bad thing. It depends on the structuring of that debt. If you end up with debt service, then you need to have a revenue flow. We could have had a revenue flow a long time ago. Unless you have data to support an opposing view, don't even tell me that we could have not been generating revenue.
Come on nc4s ... that is exactly what happened. It happened at the table located just to the left of the door to the meeting room. Malcolm was standing to the right of the table between it and the door with LW just inside the door. MS addressed me as I walked away and I returned the recoignition. The young lady explained that only shareholders of record could be admitted and apologized. Obviously you were inside the room and not at the door. I walked back out to the front parking lot while trying to contact my attorneys. You may have been there and not seen it just like you may have heard a lot of verbiage and not understood what was REALLY being said.
One person from raging bull board emailed me with his fantasy of owning 100's of 1000's of shares in his wife's name, and several children's name and being blocked from entering because h's or t's of shares he owned personally were bought to late and they demanded the proxies and BS and BS and BS. I was right there from the time they opened the conference room until the meeting started. NOTHING LIKE THAT HAPPENNED. Why do people create these little fantasies? Can somebody help me?
I held this stock when it was $3.00 a share back in 1999 - 2000. (I'll have to check the dates and amounts, so these are approx.) Back then I held over 60,000 shares that were worth well over $180,000.00. (It seems like there were 10 -12 MM shares outstanding when we got the first 60K.)As of the shareholders meeting, I held and controlled 200,000 shares worth a total of $50,000.00. After watching my total share value drop by well over 80%, I don't think any of the Johnny-come-lately gang are going to lecture me. Many of those shares that we held went back almost to the beginning of CYGS ... and then were converted over when it became CYGX.
As for LW's little dog and pony show, I've seen almost all of them over the years. If we have never considered other financing, then why in h&ll have we wasted all that money trying to get it.
All you are doing is posting some information that was put on the website years ago. I never denied it was there because ... well, it IS there.
Once more, here is my statement and query to you:
As for AVGI and PPO's, can you show us any proof of that having happened.
I doubt that AVGI was ever able to get that financing off the ground. For it to have happened, shares and participations would have had to be sold. For your statement to be correct, you will hve to offer proof that it ever happened. Otherwise, it is just like the plethora of 'just around the corner' financing deals that LW has been crowing about going back to the first dog & pony show in New York.
I thought we had a pretty good exchange of ideas yesterday, but if you are going to shift into Skoob&PNess mode, then you will get exactly the same response they get.
And unless you can offer proof otherwise, Dell was indeed lied to concerning the terms under which he left CYGX. They have been fortunate to avoid a lawsuit on that matter. Are you trying to push them into another suit? You had better be sure they want it.
First, you need to show where I have ever held any office at AVGI. You have posted an outright lie.
Second, you should check the dates on those bits of information on the AVGI board. Here your are trying to post misinformation.
Shame, shame on you.
gdepc, one of your problems is that you have never 'nailed' anyone with anything. You've simply been spewing out a stream of falsehoods, half truths and mis(dis)information. Your pathetic attempts at propoganda are exceeded only by Scoob and PaulNESS.
everytime you nail them with there bs they change and twist the topic
gdepc, you have failed to be accurate on even a single count. I have not been an officer at AVGI and I have made that abundantly clear to you. Do you have a problem understanding what you are told.
And again, neither Dell nor I were shown the door ... in Dell's case, he was simply lied to when he chose to leave CYGX. As for AVGI and PPO's, can you show us any proof of that having happened.
PPO's are a common manner of financing startups, and in the very beginning LW was sufficient at that task. You need to check and see who actually made those PPO's ... and what happened to those who were hard working and deserve far more credit than LW for 'keeping the doors open.' Here's a hint - it was not LW. Without some of the folks he has now betrayed, there would not be a CYGX. You better start getting your facts together and accurate.
Why are you clinging so tenaciously to the misrepresentation that I work for AVGI and/or PP?
That is a CYA answer ... note the use of the word "probably." I'd think that he would "KNOW."
The "difference" probably derives from the price difference between research grade DNA and cGMP (clinically pure and more expensive) DNA. MS
Oh, and I hadn't posted the date of those quotes ... it was in 2001. Kinda shoots down the crap about the price dropping in the past nine months.
Hey BigB, how pure is pure ... don't know?
a gram of the firm's plasmid DNA sells for $25,000 to $50,000. If that's a little beyond your budget, they'll sell you a milligram for as low as $250, a bargain for tailor-made materials certified as pure.
Also, it looks like you gotta get some approval from the FDA ... doesn't it?
Another milestone would be to get federal approval to supply plasmid DNA for clinical trials, which would open up a lucrative new market.
No argument there ... what hasn't he been late with? Was his lateness a factor in our getting delisted? Was that the reason for the Hemco deal? When have we had a need that was planned for and provided for? Has this constant lack of available funding been a factor in the progress of any (maybe all) of our projects?
In addition, LW is consistently late . . .
in getting the filings in: the company has had to file for an extension the last 7 quarters.
gdepc, we have had a far greater loss of equity value following the pathway that was used. Go back to the time of the Hemco deal. We had around 40MM (not sure) shares outstanding. That number has just about tripled and in so doing our equity interest has been reduced to about a third of what it was. That is roughly equal to giving away two thirds of the equity interest. Of course this has not hurt those very select few in management, has it?
Please show me your figures to show that the underpriced PPO's have been more beneficial to the shareholders and their equity interest.
As others have said, having debt is not in and of itself a bad thing. It depends on the structuring of that debt. If you end up with debt service, then you need to have a revenue flow. We could have had a revenue flow a long time ago. Unless you have data to support an opposing view, don't even tell me that we could have not been generating revenue.
You are on the button and that is the reason I posted this earlier. I watched all day to see if any of our rah-rah gang would comment. This kinda negates a lot of the hype about quarter of a million per gram info.
Whalen, now the leading researcher at Maxygen, a California biotech company, says Aldevron has become a leader in supplying research scientists all over the world with custom DNA materials at an affordable price - affordable, that is, in the world of biotech research: a gram of the firm's plasmid DNA sells for $25,000 to $50,000. If that's a little beyond your budget, they'll sell you a milligram for as low as $250, a bargain for tailor-made materials certified as pure. Forty percent of their sales are overseas.
http://www.ndsu.edu/ndsu/news/magazine/vol02_issue01/biotechnology.shtml
Gosh, what an interesting way to stir up new business ... (BTW, this is several years old, I think):
For a limited time, Aldevron is offering free plasmid DNA purification. As part of this service, we take care of all fermentation, downstream purification,
and QA/QC. The final plasmid prep is returned to the end user in the buffer of his or her choice. You our invited to send your plasmid to Aldevron for free
DNA purification. Our goal is to offer the highest quality of research-grade plasmid DNA at the lowest possible prices. We need your input to meet this goal.
Endotoxin-free (>0.1 EU per microgram) Plasmid DNA produced by Aldevron is excellent for all pre-clinical applications. The final product is also free of RNA,
genomic DN A, and protein contamination. For more information, please contact Aldevron or visit our web page at http://www.aldevron.com.
Thank you very much for your time.
Best regards,
Michael Chambers
Aldevron, LLC.
http://www.bioinfo.utmb.edu/~ovpr/mail_archive/msg00309.html
Here's some very interesting information about Aldevron.
Whalen, now the leading researcher at Maxygen, a California biotech company, says Aldevron has become a leader in supplying research scientists all over the world with custom DNA materials at an affordable price - affordable, that is, in the world of biotech research: a gram of the firm's plasmid DNA sells for $25,000 to $50,000. If that's a little beyond your budget, they'll sell you a milligram for as low as $250, a bargain for tailor-made materials certified as pure. Forty percent of their sales are overseas.
http://www.ndsu.edu/ndsu/news/magazine/vol02_issue01/biotechnology.shtml
gdepc, does duratech ring a bell for you?
With our highly experienced CFO, it is best that we have had no debt ... LOLOL. Remember how we lost 10% of our IP over a measley quarter million? Fortunately we got that back ... of course IMHO there is a lot more involved in that than we have been told.
I'm still waiting to hear what is happening with the Taiwanese deal that was in the bag and only needed a couple of signatures. ROFL
DEBT CAN BE GOOD.
Tell me ... do you think that the reason we have not progressed any of the earlier successes to the product stage is because there hasn't been enough funding to have multi-tasking for Yen and the back-shop gang?
Oh, and with the increase in shares outstanding to ten times what they were when I became involved, doesn't that add up to a 90% reduction in my equity value? AND DOESN'T THE 250% INCREASE IN SHARES OVER THE PAST COUPLE OF YEARS EQUAL A COMPARABLE REDUCTION IN SHAREHOLDERS EQUITY INTEREST?
gdpec, it's obvious that we will have to simply agree to disagree on the subject of LW. He was alright in the beginning, but the job outgrew him and he became a liability. Okay, let's go on to things where we may be able to agree.
Do you think that CYGX should have concentrated on getting a product to market when they discovered that they had something that worked, or do you approve of all this jumping from product to product? Do you think that this has been dictated by indecision or simply because there haven't been enough funds to tackle multiple projects?
As for my suing Bardwell and Boyd, I'll just say that I hope I don't have to do that? I'm not a litigeous person by nature, but I will do whatever it takes when I am wronged. There have been too many useless suits flying around for the past few years. Do you have any idea what the CYGX vs Waldroff suit cost both sides? We could have conducted testing on 40 - 50 horses and probably had the anti-inflamatory to market for what they both wasted.
gdepc, I hold no position with AVGI. I have never been an officer as I declined to hold an office after one of the current management people was involved. This was addressed in both my depositions and testimony in the CYGX vs Waldroff suit. Dell was not kicked out ... he threw up his hands and walked out.
I have posted repeatedly that I hold stock in both corporations. A disagreement concerning my AVGI holdings is currently in dispute ... however, I can assure you it will be settled.
AVGI could have been a great asset to CYGX. The reasons for the failure are legion and there is plenty of blame to pass around.
Now, do you feel that Lawrence has done a capable and creditable job over the past three to four years? Do you feel that the job could have been done better by someone with more experience and contacts? Why do you feel that way?
First of all, there is no think tank. Just a number of independent shareholders researching their investment.
Second, some are fairly new and some of us have been around since almost the beginning. As far as I know, I am the only one that even has any stock in both AVGI and CYGX. To my knowledge, there is not a single person who is affiliated with PP. That is not to say that nobody has open channels to all three corporations.
Third, nobody wants to see CYGX fail. We all have investments. I do not see any reason that I should withdraw my interest in CYGX. I not only have stock, but I have a lot of time, energy and effort invested. I have also been involved in experimentation with our product.
Now, what do you think of the CYGX scientists and why do you feel that way? What is your connection to CYGX? How long have you been involved?
There you go again, gdepc ... ignoring requests for information and asking a bunch of questions. Are you sure you're not Lawrence?
Let's understand how this little game is played. If you want answers, you have to provide answers and you will then get answers commensurate with the answers you have given.
If there anything about these rules you don't understand?
No gdepc, this is incorrect.
kind of like a anti cygx think tank
but yet this group will not release the DD they have found but they will post that they know something the rest of us do not
Is this correct
There is not a single person involved in the DD who is anti CYGX. If there were, you would have been able to read a lot of information that has not been posted.
None of us OWE anyone on these threads any information. And certainly none is owed to our group of resident rah-rah boys who post in vague unsubstantiated glowing praise of everything that is leaked or published by cygx management.
Be careful what you ask for. You might not like what you get. Always know the answers before you seek to have them made public. And remember, a lot of information is not released because of pending litigation.
If you want your questions to be answered, you need to start answering the questions you are asked. H&ll man, you can't even answer a simple question about what you think of the cygx back-shop. Why is that?
gdpec, years ago I was writing a story about the most brutal headstrummer in the history of the Texas Department of Corrections. I interviewed about 250 people ... frequently on back roads and in very shadowy places. Most of them told me things and then added, "If you ever let it out that I told you that, I'll kill you." (A lot of them wore badges - LOLOL) Of course nobody has told me anything about CYGX and threatened me, but many have either solicited a promise of confidentiality or at least a promise of their remaining anonymous.
Those promises are the reason for my not posting a ton of additional information.
my question is why not post it we may understand you a little better or even agree
I also know that the same applies to a couple of the others on this board. Some of us have discussed posting more info and all basically agree that it is not in the best interests of anyone at this time.
That said, I'm waiting for a few more responses from people who were involved and hope to be able to explain in much greater detail the facts surround my frequent statement that, "I KNOW our technology works in some applications." Stay tuned ... LOL
Now, the same questions could be posed to those who habitually post rah-rah crap but have nothing to back it up .... agree?
What is your opinion of Yen, Harilyn, XXT and the back-shop gang? Why do you feel that way?
BigWorld, this will no doubt get me really flamed, but I do believe that Malcolm should be in charge of IP. He is uniquely qualified to coordinate and translate backshop work into verbiage and get the protection afforded by the patent process.
Over that past couple of years I have reached the conclusion that we need a 'vacuum cleaner salesman type" as either Director of Marketing or even as CEO. I am frequently accussed of attacking Malcolm, but that is not actually the case. I was harder on Dell, for instance, but Dell reached the realization that the job had outgrown his ability and worked out a way to leave where he could still contribute. Unfortunately, that agreement was not honored or our stock would probably be at a much higher multiple.
The lack of meny has always been a major roadblock. In the earlier years Lawrence was able to move enough stock through a couple of helpers to keep the doors open. Unfortunately he was never able to swing the big deal to bring sufficient resources to allow a full fledged frontal assault on the market. Lawrence was outgrown by the job about four to five years ago. If you know the real story behind the Hemco fiasco you will probably agree that he was overwhelmed by the position by then. Of course, Malcolm must also shoulder some of the blame in that cluster flop.
You have no idea how many times Lawrence has told me about the big deal about to come down and then used his seemingly unending talent for shifting blame elsewhere when the deal didn't happen.
I haven't discussed anything with Kurt so I don't know what is happening in that arena.
gdepc, hogger doesn't want your or others info. I have served as intermediary for a substantial number of folks who wanted to get together but had reasons for not wanting to make that contact info public. My contact info has been posted so often that I get hundreds of ads to increase my length and staying power daily .... LOLOLOL.
In some of these instances the result has actually been a progressing of the technology ... uh, the vector, not the length and staying power ... ROFL. It is a shame you were not around while Thalio was very involved. Unfortunately he reached a point of disallusionment with certain aspect of the operation and although he still follows to a degree, he doesn't post. It would be most enligjhtening for him (and a couple of others) to post ALL of the results of their DD.
I have held this stock longer than the vast majority of the posters on this thread. I also just happen to KNOW that in some applications the technology works on humans, and thanks to happycamper, we now are reasonably sure we know why it has worked on some and been a dismal failure in other applications.
Unlike the majority of the posters on this thread, I actually know many, many of those who post here. I correspond on at least a periodic basis with many of those representing both views.
Just because a person may disagree with the actions (and lack thereof) taken by a person in management doesn't make them a basher. I believe more in Yen, Harilyn, XXT and the whole back-shop gang than I did when Mike and Charlie first came up with the whole concept.
You may not have seen CYGX management with anyone other than Malcolm. In HIS FIELD Malcolm is brilliant and one of the most capable people you will find. (Wish I could say the same for Lawrence.) Malcolm would far better serve the shareholders in a slightly different capacity and have a person in marketing and mergering that could bring some deals to fruition. And please, please don't ask if "there might be such deals just around the corner?" I have heard that for many, many years and am still waiting. The last one that I gave any credence to was the Taiwainese deal.
Sorry for the diatribe ... remember our new battle cry ... YEN, HARILYN and XXT for the NOBEL.
Easy there Happy ... maybe he knows exactly what those reasons are ... give him a chance ... just ask him to explain why it hasn't been done .... LOLOL
The reality is that there are two reasons that CYGX has not moved forward with filing an IND like previously promised, and unfortunately, you don't know what either of them is.
Congratulations to Yen, Harilyn, XXT and the whole back-shop gang for yet another bit of amazing scientific research and development.
Same to those who put the patent application together. Wouldn't it be great if we had the money to take advantage of these great scientific strides. Oh darned it, I forget that our CFO is working his fingers to the bone and needs another few million options on stock.
Wonder how far Yen, Harilyn, XXT and the others could go if they were not strapped down by monetary constraints.
Wouldn't it be nice to hear an announcement of a partnership that would give the back-shop gang all of the resources they could use to save us all?
I just hope this bit of good news does not drive the PPS into the 40's.
The DNA Vaccines have come a long way since the days of the Frankenfish. Thank you for the info. There have been many advancements since I last worked with it.
I have actually been thinking about adding PetroChina to my portfolio. God knows we added to their profit driving around that great nation. LOLOL I've acquired other interests in the Shanghai area over the past year. We're watching the RMB to see how floating it a little will effect our profit margins.
Thanks again ...
Bigworld, you make some great points ... and do so with a fabulous sense of humor.
Using our vector in shrimp and other crustacian farming still needs considerable research. The delivery method was always a great problem. That said, it probably would have been resolved by now. I think Yen, Harilyn and XXT have solved other far more difficull problems.
The main thrust for AVGI under Del was to get the anti-inflamatory into a product and get it to market. The anti-inflamatory concept using the anti-ICAM or Isis 2302 molecule was experiented with in human applications and worked great. It was never tested in equine applications. It was the subject of a lot of talk this week also. I think we finally figured out why it worked so well for herpes, arthritis and nasal congestion, but Lawrence still has a chrome dome ... like me.
As long as CYGX has Malcolm and Lawrence and AVGI has the two Charlies, neither is going to allow the problem to be worked out and there will be no co-operation.
Normally I just laugh at your psycobabble, but I'm going to answer a couple of your questions and then ask you a couple.
How about now, are they ready for business. I would like to call your friends and fax them something or send them an email. Can I do that now?? Please post the way we invest in them and we get a hold of them.
Well, you can ask Lawrence for their telephone numbers, or you can just send them an email at the addy on their website. You can look up their names in the telephone directory. As far as I know, you would not be eligible to inmvest in them, but that may have changed since I was involved with them.
"we could have had animal testing performed at no cost to CYGX"
Oh sure, they were going to do it to help mankind, right.
You act like CYGX missed out on this great opportunity, how do you know they were going to do it. Did you read a signed agreement, where you there. Did they have a legal document that says they were ready and Yin just had to engage them??
CYGX indeed missed out on a great opportunity. Testing was to be performed at universities and clinics. It would have been proof of concept and could have resulted in the immediate marketing of products for the equine market ... a cure for their number one concern, just for starters.
Yes, I was there. I spoke with Scientists and Professors who would have done the work. One of the posters on this board offered additional animals at a great discount for use by BOTH AVGI and CYGX. I also had discussions with officers of both AVGI and CYGX.
Scooby, you are simply a chauvenist ... your last two posts make very little sense and you attempt to apply phrases to totally nonconnected verbiage.
Now, try to tell me why the Tawainese deal fell apart? What happened to the many, many financing deals that were supposed to take place? What is the significance of the alternate backbone?'
gdepc, I really wish you could have been with me for the past two days. It is a little ironic that over supper a couple of us brought up the subject of those great days when CYGX had no office, no lab and all of the other things you now seem to think are necessary. H&ll man, the only scientific equipment was Del's cold brewed coffee machine.
The closest thing to an office was an area in one of the officers living room with some card tables. None of the research was performed BY cygx. NONE. Yes CYGX has grown and become more sophisticated ... well, if some areas. (It remains neanderthalian in some, as well.)
AVGI actually has had testing and research facilities available at major universities and clinics for years. Previous attempts to work together with cygx and co-ordinate the research at these universities was met by a most contemptuous attitude on the part of a couple of the officers at CYGX. There was absolutely no effort to attempt to work together. Had CYGX been willing to have Yin sit down with Lawrence Scow (Texas A&M) we could have had animal testing performed at no cost to CYGX. There are many additional examples of their cavalier attitude.
As I have shouted on these threads, CYGX has a brilliant back-shop gang, and someday they will get their nobel prizes. It is the front-shop that harbors the failures. Malcolm does not know how (and apparently really doesn't want) to market a product. Can you show me where Lawrence has had the funding in place when it was needed? Yen and company deserve far better treatment than they have received. Remember how we got Yen in the first place and who brought him down here.
BTW, who is telling you that the appeals judge will have even the slightest understanding of the technology? The win by AVGI in court was not the juries fault. It was because Waldroff had a valid license ... like it or not. CYGX breached that agreement. I KNOW that there were many opportunities to have prevented the loss in court, but they were not pursued.
How would I know ... do you remember when the same could (and was) said about CYGX. Maybe you should address that question to Bardwell.
why does avgi work out of a PO box and have no phone number
Paul-NESS, I am apologizing for comparing you to Jane Fonda and any implication anyone may incorrectly infer concerning your patriotism. For all I know you may have the right to wear a 'pukin' buzzard' on both shoulders and have three PH's and a DSC on your left breast.
Speaking of parties, downreg, remember this and the great predictions from the rah=rah gang:
CytoGenix Engages Jesup & Lamont as Financial Advisor and Placement Agent
Houston, TX, (June 29, 2004) Cytogenix, Inc. (OTCBB: CYGX)
CytoGenix, Inc. (OTCBB: CYGX) announced today that it has engaged the services of Jesup & Lamont Securities Corp., New York, New York, as exclusive financial advisor and placement agent for the purpose of raising equity capital to support the Company's on-going product development efforts.
CytoGenix is conducting pre-clinical product development studies preliminary to filing for Investigational New Drug Applications before the Food and Drug Administration for the Company's lead compounds against bacterial infections, sepsis and herpes.
The Company also expects to use a portion of funds to build a DNA manufacturing facility. Frank Vazquez, Chief Operations Officer of CytoGenix explained, "As we approach clinical trials for our products, our need for clinical grade DNA will expand. It will be more cost effective for us to produce the necessary quantities ourselves rather than purchase needed supplies in the market. We also expect to utilize excess capacity to service the growing DNA market."
Malcolm Skolnick, President and CEO of CytoGenix stated, "We are pleased that our Company's progress has enabled us to secure the assistance of an investment banking firm with Jesup & Lamont's experience and expertise. These funds will be used to accelerate product development and clinical trials required by the FDA so that we may market our DNA therapeutic compounds."
Established in 1877 and headquartered in New York City, Jesup & Lamont is a full service brokerage and investment banking firm providing institutional sales and trading services, equity research, and financial advisory services in connection with a broad range of corporate finance matters.
CytoGenix, Inc. is a biopharmaceutical company that develops and markets innovative products and services based on its proprietary DNA expression technology. CytoGenix has products in pre-clinical development including, anti-herpes, anti-psoriasis and anti-inflammatory topical creams. The company owns a US patent for its core DNA expression technology and has 40 international or US pending patent applications.
SAFE HARBOR: Except for statements of historical fact, the statements in this press release are forward-looking. Such statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from the statements made. These factors include, but are not limited to, general economic conditions, risks associated with the acceptance of new products, competition, and other factors more fully detailed in the company's filings with the Securities and Exchange Commission. Additional information about CytoGenix and its technology can be found on the website at www.cytogenix.com.
Contact: Communications Director — Juan Ferreira, (407) 774-9949
Scooby, don't try dodging the question. Bobbing and weaving is only acceptable in the squared circle. Now, let's try this again. This time just drop the psycobabble and answer the question.
Scoob, did you actually read all of the documents for yourself ... or did you just decide to take Lawrence's word for it? And if you're correct, can you explain why CYGX just wasted all that money to try to get something back that wasn't worth anything?
Scoob, did you actually read all of the documents for yourself ... or did you just decide to take Lawrence's word for it? And if you're correct, can you explain why CYGX just wasted all that money to try to get something back that wasn't worth anything?
Oh, by the way, this "court victory" for AVGI is based on the 1998/1999 technology. When the new management came in late 99' they implemented a new technology and drastically improved it & went away from that OLD technology. AVGI now has to fend for itself with the old technology & CYGX no longer has to lend them any new support. AVGI'S scientists (HA HA HA, oh I am sorry for the laugh), will have to take care of themselves & find a good way of delivering the technology to the target.
Neo, they were offered that opportunity before it deteriorated into a legal action ... they were offered that option as it was deteriorating ... they were offered that option almost up until it went to trial. They declined. Of course, the AVGI group were little if any different. The only one agreeable to mediation and looking for that win-win situation was Waldroff. How would you like to be caught between Bardwell/Boyd and Wunderlich/Skolnick??
With regard to the latter, has anyone at CYGX ever heard of finding solutions that are a 'win-win' for all parties?