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Brilacidin monkey pox...AI
Innovation Pharmaceuticals has announced that NIH/NIAID-affiliated researchers will evaluate Brilacidin, the company's defensin-mimetic drug candidate, for its potential to treat monkeypox. This evaluation comes as the world faces a new viral outbreak in monkeypox following the COVID-19 pandemic.
Evaluation Process
The initial testing will be conducted in vitro using orthopoxviruses related to monkeypox, such as vaccinia and cowpox. This builds on previous NIH/NIAID-affiliated research of Brilacidin in other acutely infectious virus families, including coronaviruses, alphaviruses, flaviviruses, and filoviruses.
Potential of Brilacidin
Brilacidin has shown antiviral activity in multiple virus families, which makes its potential effectiveness against poxviruses promising. Academic literature supports this potential, as similar natural antimicrobial peptides like LL-37 and CRAMP have demonstrated antiviral activity against the poxvirus vaccinia both in vitro and in vivo.
Current Monkeypox Situation
As of August 2022, over 26,500 monkeypox cases have been reported in 92 countries. The World Health Organization has declared the global monkeypox outbreak a Public Health Emergency of International Concern, and the U.S. Department of Health and Human Services has declared it a national public health emergency.
Galp has an excellent track record for new discoveries for example the Mopane discovery in Namibia's PEL 83. The Mopane oil field is estimated to be10 billion barrels. Currently several deep pocketed oil company including XOM, CXR, Shell and TOT are reviewing the drilling results to bid on Galp's offer to partner with 40% of the Mopane field and the PEL 83 block which contains several unexplored structures.
https://www.upstreamonline.com/exploration/namibia-showdown-looms-in-battle-for-stake-in-galp-s-crazy-mopane-discovery/2-1-1659797
In addition, they have been very active off the coast of Brazil.
IMO the biggest "problem" Galp has with EEZ block 6 is the energy and expense of the Mopane field. Hopefully when they sign a partner {estimates are as high as 20 billion dollars for 40% of the block} they will focus on EEZ block 6..
Farrell
Upstream update:
https://www.upstreamonline.com/exploration/partner-waiting-for-word-from-woodside-on-promising-namibia-exploration-block/2-1-1682292
"Partner waiting for word from Woodside on promising Namibia exploration block
Shareholders in Pancontinental remain in limbo on major's Orange basin intentions, despite progress on seismic studies
Woodside Energy chief executive Meg O’Neill.
Woodside continues to keep Australian junior Pancontinental Energy guessing about its intentions surrounding a promising exploration block in Namibia’s red-hot Orange basin, no less than 16 months after securing an option to operate the acreage.
Since the Australian major unveiled its farm-in option in March 2023, Petroleum Exploration Licence (PEL) 87 has arguably become even more attractive because it lies right next door to the block housing Galp Energia’s stunning Mopane oil and gas discovery, which holds an in-place resource of 10 billion barrels of oil equivalent.
Woodside has an option to acquire a 56% stake in the licence after paying for a 6593-square kilometre 3D survey and giving Pancontinental $1.5 million in cash.
This option can be exercised at least 180 days after delivery of the seismic survey data.
In late April, Pancontinental said the long-stop date by which Woodside has to exercise its farm-in option — by committing to drill an exploration well — would be 180 days from the date that the PEL 87 partners give Woodside a licence to hold ongoing rights to the 3D seismic data.
Pancontinental said on Wednesday it is “working to finalise” the seismic licence with the Namibian authorities so the long stop date “can be established as soon as possible”.
However, the company stressed that Woodside could still exercise its option at any time prior to the long stop date.
As things stand, both the current operator and Woodside are undertaking separate technical analyses of the 3D data.
Pancontinental said its primary focus is on Cretaceous play concepts that range in age from Barremian channelised fans to Cenomanian channels, within which it has identified the full array of trapping styles.
The operator noted that seismic bright spots and amplitude-versus-offset (AVO) anomalies — all potential indicators of the presence of hydrocarbons — are “evident” within some exploration leads identified within the greater Saturn complex.
Pancontinental said its in-house technical team is focused on maturing interpretation of key sequences within the Cretaceous petroleum systems that host on-trend discoveries, such as TotalEnergies’ Venus find.
Earlier this month, a specialist consultancy started to undertake an AVO study.
Pancontinental said the bright spots “clearly indicate” the presence of deepwater feeder channels running west into what are interpreted to be deepwater turbidite fan systems, one of which appears to be detached from the feeder system.
These bright spots are located north of the structural high around the legacy Moosehead-1X exploration well, and east of a regional high.
“These features,” argued Pancontinental, “are thought likely to host high quality reservoir sands, of comparable age to those that host TotalEnergies' giant Venus discovery.”
The operator will soon start work on a basin modelling study to fully define the hydrocarbon source kitchen and hydrocarbon charge mechanism and its timing.
Once the AVO and basin modelling work are complete, the Aussie junior can then begin to better define individual prospects.
Even so, Pancontinental said it “remains encouraged by the high quality of the data and is increasingly confident in the hydrocarbon potential of PEL 87”.
Pancontinental holds a 75% stake in PEL 87 and is partnered by local player Custos Energy on 15%, while state-owned Namcor has a 10% interest."
Hopefully Woodside will commit to exploring the oil field or let an operator with proven experience in Namibia such as neighboring Galp or Total get on with it.
Rick Rule recommends Africa Oil on Bloomberg 7/19/2024
-Valuation less than half of what its worth
-Increased dividend
-Namibian holdings a plus
-cash flow can fund dividend and growth
-All 8 analysts have buy rating... up to $3.65 Cdn
https://www.bnnbloomberg.ca/investing/2024/07/19/rick-rules-top-picks-for-july-192024/
Good luck,Farrell
Thanks
Farrell
Shell has not PR'ed the Sao Tome Principe EEZ block 4 agreement to date.
Why ?
Looks like ERHC and Peter were no shows at the energy chamber meeting.
https://energychamber.org/panel-highlights-africas-oil-gas-investment-hotspots-at-invest-in-african-energy-reception-in-london/
Did the Erhc web page get a new background?
https://www.erhc.com/
The erhc text is unchanged as far s I can tell
Farrell
Thanks for posting.
I could not find any other source confirming this report. Even though Tele Non has been reliable in the past.
Total has not PR'ed it yet
May be some small hope for news favorable to ERHC
https://totalenergies.com/news
Good luck,Farrell
Thanks for posting. I appreciate your efforts.
Farrell
Galp review of Namibia PEL 38; 4/30/2024 1st qtr transcript
I re read Galps best review of PEL 38 to date.
All share holders should read first quarter transcript completely.
https://www.galp.com/corp/Portals/0/Recursos/...deo_QA.pdf
High lights:
Galp confident of 10 billion barrel or higher light oil estimate
AVO 1 and AVO3 have extensions;only a part of Mopane has been drilled
Quick development planned with 4 additional Mopane wells,"keepers"
Drilling may begin as soon as 4th quarter 2024
Oil has no substantial impurities; not a gas discovery
Galp describes a project as too big for its resources alone to develop; a multiple FSPO project
Seekiing partner to pay for rest of capital expenses and perhaps over see development ASAP
Galp to use proceeds from sale directly into PEL83 project
Ideal well conditions; low viscosity,,good porosity ,high pressures and permeabilities should lower pre drill estimated expenses
Namibia cooperation is first rate
More seismic for northern PEL83 to outline additional potential drill sites
Potential large multiple world class oil fields in north PEL 83
Most upbeat review of an oil field development I have ever read. Guyanna parallels are well deserved in my opinion
Farrell
" The offshore field in Sao Tomé has recently become a hotspot for oil companies eagerly awaiting the results of drilling on block 6. If drilling is successful, negotiations over block 4, contested by ERHC, Kosmos and TotalEnergies, may resume.
Published 2022.
The results of the drilling of the Jaca well on block 6, offshore Sao Tomé and Principe, should be made public in the next few days. If the news is good, operator Shell and partner Galp will be able to reduce geological risks throughout this commercially untouched archipelago and exclusive economic zone. Block 4 may also profit from Shell's drilling. Kosmos Energy and TotalEnergies have had their eye on this block run by American junior ERHC for years.
As we revealed, in 2017, ERHC signed sales agreements for similar parts of this block, including the operatorship, first with Kosmos then with TotalEnergies (AI, 03/03/20). Both buyers took ERHC to court; Kosmos in the US and TotalEnergies in London. Both courts confirmed each company's rights on the block, but neither company has taken any steps to claim them. In 2020, Kosmos asked to suspend the confirmation procedure on the US sentence after partially pulling out of Sao Tomé - it sold blocks 6, 10, 11 and 13 and all of its assets in Namibia to Shell for $200m.
This move, a strategy also adopted by TotalEnergies, made their intentions unclear. As a result, the local regulatory authority, Agência Nacional do Petróleo de São Tomé e Príncipe (ANP-STP), run for the last three months by Luiz Manuel Gamboa da Silva, has no visibility on work that might be done on block 4. ERHC still owns the permit but does not have the means to drill, and neither TotalEnergies nor Kosmos Energy have produced their court ruling to negotiate with ANP-STP. If there is a major discovery on block 6, ANP-STP may require the three oil companies to come to the table and start working on the block straight away.
Good climate for lesser-known areas
Crude oil prices have been on the rise since the beginning of the year, allowing oil companies to increase their exploration budgets in lesser-known areas, such as Sao Tomé and Principe. For some 20 years, the country has also shared a development zone with Nigeria. Despite the presence of majors since as Chevron and TotalEnergies, there have been no discoveries there."
The above describes the situation in 2022 and little has changed for STP and da Silva. In fact the prospect for another exploration well in the EEZ is probably worse now than it was in 2022.
Below is all conjecture on my part. Since we know so ittle factual information it frees us to imagine.
In 2022 Galp and Shell operators of EEZ 6 found a working petroleum system but no oil field, at least not an economically viable investment.
https://geoexpro.com/promising-results-in-the-new-sao-tome-principe-frontier/
da Silva is in a situation where EEZ block 4 may be a better bet for a successful exploration than a second effort in block 6. The main players, Galp,Shell and Total all are planning to invest huge sums to develop their Namibian oil discoveries, and may feel the Namibian investment may make more financial sense than risking another drilling effort in the EEZ.
Kosmos may still have an interest in EEZ 4. Its financial situation may not allow it to make a large investment. Kosmos currently has more debt than market cap, a relatively high PE and PS for an oil co and stagnant net income. https://www.tradingview.com/symbols/NYSE-KOS/financials-overview/
The inaction in the EEZ by the majors may be the reason Sao Tome and Principa has allowed ERHC to remain in the game.
2 years post drilling EEZ block 6 with no action may have led daSilva to realize unless he attracts another major to drill an exploration well in Block 4 EEZ it may be a number of years before more drilling occurs .
Thus attracting another major such as the current Aramco rumor suggests is at least tenable in the absence of an official announcement. If I was in daSilva's place I would be trying to attract another major to drill the block.
Just my opinion only
Good luck to all,
Farrell
Alvaro Silva linkedin page
Picture of Alvaro with an arab would not copy and paste. Below is the caption:
More activity of Álvaro
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Álvaro Silva liked it
https://st.linkedin.com/in/%C3%A1lvaro-silva-91449b1a
I agree.
Latest from Upstream ???who is the minority partner who may be interested in selling?
Namibia showdown looms in battle for stake in Galp’s ‘crazy’ Mopane discovery
"The battle to buy a big part of Galp Energia’s mighty Mopane oil and gas discovery offshore Namibia is hotting up, with all the big beasts of the Western upstream world said to be assessing options. At stake is entry into a discovery that Upstream has been told recently may hold substantially more in-place resources than even the 10 billion barrels of oil equivalent revealed by the operator in April. Adding to the intrigue is speculation that a minority partner in Galp’s sought-after acreage may also be open to offers.
Mopane was discovered in January in Petroleum Exploration Licence 83, located just west of BW Energy’s Kudu gas discovery. An appraisal well was drilled quickly, before Galp returned to Mopane-1X to carry out a production test that flowed at an impressive rate of 14,000 barrels of oil equivalent per day. Good news about the reservoir characteristics came thick and fast, with the operator reporting good porosities, high pressures, high permeabilities and large hydrocarbon columns, with fluid samples indicating very low oil viscosity with minimal impurities.
As a result, when Galp said it was open to offloading half of its 80% stake in PEL 83, it lit the touchpaper for what is set to be one of the most competitive farm-in opportunities of recent years. Last month, Bloomberg reported that offers are due to be submitted in mid-June, with ExxonMobil, Shell, TotalEnergies and Equinor among the potential bidders for a discovery valued at about $20 billion. However, in recent weeks, some other serious contenders are believed to have shown their colours, including Chevron, Azule Energy, Woodside Energy — all existing Orange basin players — as well as Brazil’s Petrobras."
"Woodside is also said to be interested, because Galp’s acreage is located directly south of PEL 87 over which the Australian player has still not exercised a farm-in option. Exploration sources spoken to by Upstream said that some companies wanting to visit Galp’s data rooms are unlikely to submit bids because they are more interested in gleaning geological and geophysical information on Mopane that could inform their own exploration initiatives in the Orange basin."
"Galp’s two Mopane probes, 1X and 2X, intercepted three distinct reservoirs, only one of which was tested, with the Lisbon-based player reluctant to say whether the 10 billion boe resource figure applies to all the reservoirs or not. However, Upstream was advised recently by a source with knowledge of the drilling programme that the resource estimate applies only to the main AVO 1 reservoir found at both well locations. The AVO 2 and AVO 3 reservoirs are said to be “independent discoveries that will require further appraisal to establish their size”. AVO 1 is believed to extend “far beyond” the Mopane 1X and 2X locations, with some of Galp’s exploration team understood to be talking about resources of 12 billion boe for this reservoir. The informed source said the operator was, until recently, carrying internal resource estimates for AVO 2 and AVO 3 of at least 1 billion boe each.
“It’s crazy stuff,” remarked the well-watcher, who added that the “most exciting part is Galp clearly has the amplitude variations absolutely nailed on in calibration”. Another exploration source cautioned that Mopane may have more gas than originally thought which could complicate any development and potentially jeopardise plans for a fast-track project. Asked about the PEL 83 farm-out process, a Galp spokesperson declined to comment, while Custos could not be reached for comment. Chevron, Eni, Petrobras, Shell and TotalEnergies also declined to comment. Azule, Equinor, ExxonMobil and Woodside had not responded to Upstream inquiries by the time of publisLatest from Upstream ???who is the minority partner who may be interested in selling?
Namibia showdown looms in battle for stake in Galp’s ‘crazy’ Mopane discovery
"The battle to buy a big part of Galp Energia’s mighty Mopane oil and gas discovery offshore Namibia is hotting up, with all the big beasts of the Western upstream world said to be assessing options. At stake is entry into a discovery that Upstream has been told recently may hold substantially more in-place resources than even the 10 billion barrels of oil equivalent revealed by the operator in April. Adding to the intrigue is speculation that a minority partner in Galp’s sought-after acreage may also be open to offers.
Mopane was discovered in January in Petroleum Exploration Licence 83, located just west of BW Energy’s Kudu gas discovery. An appraisal well was drilled quickly, before Galp returned to Mopane-1X to carry out a production test that flowed at an impressive rate of 14,000 barrels of oil equivalent per day. Good news about the reservoir characteristics came thick and fast, with the operator reporting good porosities, high pressures, high permeabilities and large hydrocarbon columns, with fluid samples indicating very low oil viscosity with minimal impurities.
As a result, when Galp said it was open to offloading half of its 80% stake in PEL 83, it lit the touchpaper for what is set to be one of the most competitive farm-in opportunities of recent years. Last month, Bloomberg reported that offers are due to be submitted in mid-June, with ExxonMobil, Shell, TotalEnergies and Equinor among the potential bidders for a discovery valued at about $20 billion. However, in recent weeks, some other serious contenders are believed to have shown their colours, including Chevron, Azule Energy, Woodside Energy — all existing Orange basin players — as well as Brazil’s Petrobras."
"Woodside is also said to be interested, because Galp’s acreage is located directly south of PEL 87 over which the Australian player has still not exercised a farm-in option. Exploration sources spoken to by Upstream said that some companies wanting to visit Galp’s data rooms are unlikely to submit bids because they are more interested in gleaning geological and geophysical information on Mopane that could inform their own exploration initiatives in the Orange basin."
"Galp’s two Mopane probes, 1X and 2X, intercepted three distinct reservoirs, only one of which was tested, with the Lisbon-based player reluctant to say whether the 10 billion boe resource figure applies to all the reservoirs or not. However, Upstream was advised recently by a source with knowledge of the drilling programme that the resource estimate applies only to the main AVO 1 reservoir found at both well locations. The AVO 2 and AVO 3 reservoirs are said to be “independent discoveries that will require further appraisal to establish their size”. AVO 1 is believed to extend “far beyond” the Mopane 1X and 2X locations, with some of Galp’s exploration team understood to be talking about resources of 12 billion boe for this reservoir. The informed source said the operator was, until recently, carrying internal resource estimates for AVO 2 and AVO 3 of at least 1 billion boe each.
“It’s crazy stuff,” remarked the well-watcher, who added that the “most exciting part is Galp clearly has the amplitude variations absolutely nailed on in calibration”. Another exploration source cautioned that Mopane may have more gas than originally thought which could complicate any development and potentially jeopardise plans for a fast-track project. Asked about the PEL 83 farm-out process, a Galp spokesperson declined to comment, while Custos could not be reached for comment. Chevron, Eni, Petrobras, Shell and TotalEnergies also declined to comment. Azule, Equinor, ExxonMobil and Woodside had not responded to Upstream inquiries by thhing."
Exxon,Shell,as well as total interested in buying into PEL 83
https://finance.yahoo.com/news/exxonmobil-shell-considering-bids-stake-102243971.html
Woodside 2024 first quarter report and 2023 annual report ... no mention of PEL 87. Is the project too big for Woodside? Even after its recent merger with BHP petroleum?
I would not be surprised if Woodside entices a major oil company to partner with exploration and development of PEL 87 either before option expiration or after the first well.
Namibia is such a hot exploration area and the Saturn turbide complex seems to be generally viewed as a sign of oil prospectively I am shocked at the lack of Woodside corporate enthusiasm.
We should receive the final seismic report soon which should clarify the issues.
https://www.woodside.com/docs/default-source/about-us-documents/first-quarter-2024-report.pdf?sfvrsn=e7d32afc_1
https://www.woodside.com/docs/default-source/investor-documents/major-reports-(static-pdfs)/2023-annual-report/011.-full-year-2023-results-and-briefing.pdf?sfvrsn=4af86e05_5
No updates I can find since 3/2023 announcement:
https://www.offshore-energy.biz/woodside-eyes-offshore-acreage-close-to-shell-and-totalenergies-discoveries-in-namibia/
https://announcements.asx.com.au/asxpdf/20230302/pdf/45m868tbj7xfhg.pdf
GLTA,Farrell
Jan 24,2024 note from PCOGF updating developments:extention of lease in PEL 87 for 2 additional years; suggests final seismic review would be completed in mid March{ have not found that update}; and Woodside would be required to drill the first well 180 days after receiving final seismic data.
Perhaps we can expect drilling late this year.
https://announcements.asx.com.au/asxpdf/20240119/pdf/05zknbm4frn7fk.pdf
2023 yearly report released last week. https://pancon.com.au/wp-content/uploads/2024/05/Pancontinental-Energy-Annual-Report-2023.pdf
Nice review of Namibian efforts and a reminder of what a small, under financed company with almost a billion shares and options out PCOGF represents.
That being said real progress is being made. Hopefully Woodside will get mobilized and get it done.
GLTA Farrell
New Sintana comprehensive summary:
https://sintanaenergy.com/wp-content/uploads/2024/05/sintana_web_presentation_may-12-24.pdf
Sintana releases more good news.
Custos Energy (Pty) Ltd. (“Custos” or the “Company”) is pleased to announce that Chevron Namibia Exploration Limited (“CNEL”), an affiliate of Chevron Corp. (“CVX”) has executed an agreement that provides for their entry in Petroleum Exploration License 82 (“PEL 82) with the assumption of an 80% working interest and operatorship. NAMCOR, the National PetroleumCorporation of Namibia, and Custos will each maintain a 10% carried interest in PEL 82.PEL 82 governs blocks 2112B AND 2212A located in the Walvis Basin, offshore Namibia. PEL 82 is one of the Walvis Basin’smost attractive opportunities.
Sintana owns 49% of Custos
https://finance.yahoo.com/news/pel-82-chevron-farm-154633336.html
OT Not directly but the successful drilling by Total.Shell and now Galp will raise the value of all the Namibian and South African blocks.
I am still optimistic about AOIFF. The Egina projects are all doing well and the rest of the South west African blocks all look promising.
GLTA Farrell
Galp seeks to sell 50% of its share in PEL 38 to a large international oil company to assist in development of what is estimated to be a 10 billion barrell field.
https://www.reuters.com/markets/deals/galp-seeks-sell-stake-namibia-oilfield-after-discovery-sources-say-2024-04-22/
Farrell
Galp seeking a large international oil company to partner with 50% of its holdings in PEL83,field may contain 10 billion barrels of light, low sulfur oil.
LONDON, April 22 (Reuters) - Portuguese oil company Galp Energia has launched the sale of half of its stake in an exploration block offshore Namibia where it has made a major oil discovery, three industry sources familiar with the matter told Reuters.
Galp's Mopane field discovery appears to be one of the largest made in the nascent oil basin which could help kickstart the southern African country's oil industry even as governments around the world seek to reduce fossil fuel consumption.
Galp has an 80% stake in Petroleum Exploration Licence 83 (PEL 83), which covers almost 10,000 square kilometres (3,860 square miles) in the Orange Basin, with Namibia's national oil company NAMCOR and independent exploration group Custos each holding another 10%.
Lisbon-based Galp is offering to sell half of its stake in the block, said the sources, who could not be named because they are not authorised to speak to the media.
It is also offering to cede control of the development of the project to the potential buyer, expected to be a major international rival with a strong track record in project management, the sources said.
Galp declined to comment. It has previously indicated it could launch a process to raise capital for the development of its projects in Namibia, as they could reach a large scale.
It has hired Bank of America to run the sale process, which could raise several billion dollars for Galp, although the exact value is unclear, the sources said. Bank of America declined to comment.
Galp shares were up almost 20% at 1506 GMT following Galp's update on the Mopane field and Reuters reporting the sale process.
The discovery followed successful exploration campaigns in the same area by rivals TotalEnergies and Shell in recent years.
Namibia has attracted huge interest from international oil companies seeking to increase production as demand is forecast to remain strong for years.
Redburn analysts said Galp's update on the discovery implied the field had a resource three time larger than previously estimated.
The United Nations has said that by 2050 global oil use must drop by 60% and gas use by 45% if the world is to avoid temperatures increasing above 1.5 degrees Celsius - the threshold beyond which climate change would unleash more disastrous and irreversible impacts.
Global oil demand has yet to peak and is forecast to grow to around 103 million barrels per day in 2024 by the West's energy watchdog the International Energy Agency.
Oil companies say they need to continue to develop new fields to meet rising demand and to compensate for falling production from older fields.
Galp itself aims to reduce its carbon emissions to net zero by 2050 and in 2021 committed to allocate half of its spending towards low-carbon energy by 2025.
Namibia could become a new source of revenue for Galp, which currently has strong investments off the coast of Brazil and is also present in a natural gas project in Mozambique's Rovuma basin. (Reporting by Ron Bousso; Editing by Emelia Sithole-Matarise and Mark Potter)
https://www.msn.com/en-gb/money/other/portugals-galp-says-field-off-namibia-could-contain-10-billion-barrels-of-oil/ar-AA1noW7o
https://www.upstreamonline.com/exploration/10-billion-barrels-galp-stock-price-hits-all-time-high-as-it-confirms-vast-scale-of-namibia-discovery/2-1-1630753
link seems broken
Farrell
Galp up 19% today.This field may have the potential of Shell's and Total's fields in their Namibian blocks.
Company making news for Sintana.
IMO Sintana still cheap
JMO Farrell
Like: PEL 83... multi-billion light oil discovery
Pete I do not believe the Kevetrin story is over. Below is a study of a Kevetrin modification which reportedly increase its effectiveness 100X.Obvoiously more studies need to be done. Based of the results below I expect a whole series of studies based on these results.
In the present study, we designed and synthesized a novel analog (compound 900) of Kevetrin and its cytotoxicity was assessed using four different ovarian cancer cell lines viz. OVCAR-3, OVCAR-10, ES2, drug-resistant HeyA8 cells, and normal fibroblast cells (FHC). Compared to the control and Kevetrin, compound 900 inhibited the ovarian cancer cell viability in a dose- and time-dependent manner. The IC50 value of compound 900 was 0.8 µM, 0.7 µM, 0.8 µM, and 0.9 µM for OVCAR-3, HeyA8, OVCAR-10, and ES2 cells, respectively, while for Kevetrin the IC50 value was >100 µM for 48 h treatment. Compound 900 was thus found to be >100 times more potent than standard Kevetrin. To further acquaint the effect of 48 h treatment on cell proliferation, we performed trypan blue cell viability assay, trypan blue dye exclusion assay, Annexin V/7-AAD, Caspase 3/7 apoptosis assays, and Western blotting of apoptotic proteins involved in apoptosis. Compound 900 significantly induced apoptosis in OVCAR-3 and HeyA8 cells in a dose-dependent manner. Upregulation of several apoptotic proteins, as evident by Western blot, suggested that 900 causes the induction of apoptotic pathways efficiently. Further, the cell cycle analysis showed a significant arrest of OVCAR-3 and HeyA8 cells in the S-phase, which was further confirmed by the analysis of cyclin A2, cyclin-E1, p21, and p27 protein expression. Additionally, compound 900 caused a significant increase in the expression of the cell cycle inhibitory genes p21 and p27 in a p53-independent manner, compared to Kevetrin. Kevetrin has shown promise in preliminary clinical studies in solid tumor patients. The new analog 900 is >100 fold more potent than Kevetrin and holds great promise to be developed further for ovarian and other mechanistically relevant cancers.
Citation Format: Asif Raza, Jacek Krzeminski, Shantu Amin, Arun Sharma. Discovery of a novel Kevetrin analog as a potential therapeutic for ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1650.
The news in PEL 83 just gets better and better.
Farrell
New England Journal of Medicine study of Paxlovid shows no conclusive benefit in high risk patients.
"Conclusions
The time to sustained alleviation of all signs and symptoms of Covid-19 did not differ significantly between participants who received nirmatrelvir–ritonavir and those who received placebo. (Supported by Pfizer; EPIC-SR ClinicalTrials.gov number, NCT05011513.)"
"In this trial, we assessed the safety and efficacy of nirmatrelvir–ritonavir as an antiviral agent against SARS-CoV-2 in symptomatic, nonhospitalized, vaccinated or unvaccinated adults. Nirmatrelvir–ritonavir was not associated with a significantly shorter time to sustained alleviation of Covid-19 symptoms than placebo, and the usefulness of nirmatrelvir–ritonavir in patients who are not at high risk for severe Covid-19 has not been established."
Is it time for a Paxlovid vs Brilacidin clinical trial?
Farrell
It was Kevetrin not Brilacidin. It is a shame Kevetrin never made the cut for a clinical trial for retinoblastoma.
https://www.fdanews.com/articles/174349-cellceutixs-kevetrin-wins-rare-pediatric-disease-designation
Farrell
The last published report on STP's EEZ block 4 I could find were from March 2023. The report claims ERHC still controls EEZ block 4.The report acknowledges that ERHC lost its arbitration cases in London and Texas, but STP never forced ERHC to relinquish the block. Kosmos and Total are reported to pay ERHC for "most" of the block, but how much does ERHC now hold and how or how much was it paid?
This report helps understand the confusion regarding the development or the lack there of EEZ block 4. The ambiguity in losing the arbitration but allegedly still controlling at least part of EEZ block 4 certainly should spark speculation about the current situation. Evidently Kosmos's interest in the block is diminished. Total evidently has standing awarded by the STP, but the silence regarding ERHC's position is interesting to say the least; especially in view of the findings in EEZ block 6.
I welcome any updated information anyone can post.
Good luck, Farrell
Sao Tome and Principe
Block 4, eyed by TotalEnergies and Kosmos, still held by US junior ERHC
Published on 15.03.2023 at 04:40 GMT
The Sao Tomé & Principe government formed last November by Prime Minister Patrice Trovoada is looking for a solution to the problem posed by Block 4. Positive results from drilling by Shell and Galp on Block 6 further south last August in turn sparked enthusiasm for Block 4, which is being eyed by TotalEnergies and Kosmos Energy (AI, 09/09/22).
The US junior ERHC, the block's operator, owes significant tax arrears to the state, but the Agência Nacional do Petróleo de São Tomé e Príncipe (ANP-STP) has not decided to withdraw the licence despite having formally notified the firm of its delay. Several arbitrations have been made in the case in favour of Kosmos and TotalEnergies, which had both successively made a deal to purchase most of the ERHC shares on Block 4.
Shell is expected to decide shortly whether to re-drill Block 6 to ascertain its potential. Failure to do so would be bad news for the entire offshore basin where, to date, no commercial discovery has been made. A joint development zone with Nigeria has also not brought any hope, despite interest from TotalEnergies and Chevron.
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Agencia Nacional do Petroleo de Sao Tome e Principe
Chevron
ERHC
Galp
Kosmos Energy
Patrice Trovoada
Shell
TotalEnergies
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Stock up 20% last month with higher oil prices and continued good news ...crossed 50 day moving average. Nice move
GLTA Farrell
Thanks to you and guard dog
Great news with world class partners and world class discoveries on trend with unusually good terms.
$10 million in staged compensation with a 2 well carry plus 17% of a potentially large oil field
AOIFF now at a almost 2 year low in share price.
Now awaiting development plans.
GLTA Farrell
Terrific news! Great deal, excellent terms.
"A large opportunity set of exploration prospects has been identified in deepwater Block 3B/4B and the ability
to stack targets in early wells on the license combined with an extensive data acquisition campaign will help
to significantly understand the prospectivity and presents opportunities for ‘cluster’ developments to
optimize value from any possible developments.
Recent exploration in South Africa has opened a new deepwater play. TotalEnergies made the Brulpadda
gas-condensate discovery on Block 11B/12B in 2019. Prior to this discovery, South Africa's deepwater plays
had seen minimal exploration. Only four deepwater exploration wells had been drilled, in the late 1980s and
early 1990s, in the Southwest coastal basin. TotalEnergies followed the Brulpadda discovery with the Luiperd
discovery in 2020.
Shell Exploration & Production’s (“Shell”) recent Graff well discovery and TotalEnergies Venus well discovery
in deep water Namibia contain seismic amplitude anomalies and are on trend with AOC’s South African
3B/4B license. The discoveries prove the existence of a working petroleum system for light oil, gas
condensate and gas in the geological play fairway. The proven reservoirs in Graff and Venus discoveries are
similar to Cretaceous reservoirs and geological plays that would be targeted in the AOC 3B/4B Exploration
Right.
Block 3B/4B is in water depths ranging between 500 m and 2,500 m with the majority of the prospects lying
in approximately 1,500 m of water. AOC has approximately 14,000 km2 of 2D seismic and 10,800 km2 of 3D
seismic over Block 3B/4B. RISC has reviewed 10,210 km2 of 3D seismic..."
https://africaoilcorp.com/operations/block-3b-4b/
I have picked up more shares I am surprised with the collapse of the share price. I still think AOIFF is the safest way to play the Namibian oil boom. It is obvious it will take years to monetize their holdings, but the demand for oil goes up every year and we seem to be at the crest of peak oil. EV's seemed to have hit the wall; although China's success bears watching.
IMO the patient will be rewarded.We will see,
GLTA, Farrell
Thanks for posting. One can spin this how one likes,but it is definitely another achievement before the full approval.
"estimating up to 10 billion barrels of original oil in place." Video included in link
https://finance.yahoo.com/news/sintana-energy-ceo-confirms-2nd-151232381.html
Sintana Energy CEO Robert Bose shared significant developments regarding the Mopane-1X well during an interview with Steve Darling from Proactive.
According to Bose, Sintana Energy, in partnership with Galp through the AVO-2 consortium, has successfully and safely drilled, cored, and logged a deeper target in the Mopane-1X well, located on block 2813 governed by PEL83 in Namibia.
Bose also revealed that Galp has made another noteworthy discovery within the Mopane-1X well. A second substantial column of light oil has been identified in reservoir-bearing sands of high quality. Following these discoveries, the drilling rig is expected to be relocated to the Mopane-2X well location to further evaluate the extent of the Mopane discoveries. Subsequently, a Drill Stem Test will be conducted in Mopane-1X to assess commercial viability.
Bose highlighted the strategic importance of the Multani 1x location, emphasizing its position as the first well drilled beyond Shell and Total's concentrated efforts. The discoveries, announced on January 10th and 26th, showcased the basin's extensive resources, estimating up to 10 billion barrels of original oil in place.
Sintana Energy maintains an indirect 49% interest in Custos Energy, which holds a 10% working interest in PEL 83. The National Petroleum Company of Namibia (NAMCOR) also maintains a 10% working interest in the project. The consortium partners, including Sintana Energy and Galp, will continue to analyze the acquired data to determine the commercial potential of these discoveries.
Contact Details
Proactive Canada
GLTA Farrell
Great due diligence...once again
Seems to be a serious dude.
JMO but some things up...unfortunately we have to wait again to find out.
GLTA Farrell
From Aoiff web page an extensive review of the entire block 3b-4b
https://africaoilcorp.com/operations/block-3b-4b/
Should be we hit more crude...JMHO
Farrell