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hi loanranger. RE: QLGN. Have you taken a look at the 5 year chart of that stock? During 2017 it was trading at over $900!!! They must've had reverse splits "Up the old wazoo." And people complain about Leo???
Another one bites the dust.
Lilly antibody drug fails in a COVID-19 study; others go on
By MARILYNN MARCHIONE, AP Chief Medical Writer
U.S. government officials are putting an early end to a study testing an Eli Lilly antibody drug for people hospitalized with COVID-19 because it doesn’t seem to be helping them.
https://www.msn.com/en-us/health/medical/lilly-antibody-drug-fails-in-a-covid-2019-study-others-go-on/ar-BB1apGYj?ocid=msedgntp
Dane; The below chart appears to firm up your post.
Sorry that I am not skilled enough to get the number columns to line up properly.
SOURCE
https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-age.html
Assuming a total current deaths number of 210.000, the below chart shows what the actual deaths by age is in current numbers.
CDC Web site uses + or – multiplier of what each age group is using ages 18 to 29 as a basis.
Age Group.......... Deaths
0 – 4............... 22
5 – 17.............. 13
18 – 29..............213
30 - 39..............654
40 – 49............1,913
50 – 64............6,408
65 – 74...........19,224
75 – 84...........46,992
85+...........134,568
TOTAL............210,207
Negative results are required to be disseminated
Sounds like that's the way it should be. Please provide a link.
Thank you.
Why have a placebo group when this condition has never had a history of curing itself without the patient having to endure dreadful pain?
petemantx:
Thanks for the reply. You raise good question (above). But doesn't the FDA require a "control" group in all Phase 2 and Phase 3 trials? My experience may be limited, but in all P2 and P3 trials that I have followed, the drug under trial was put up against either a placebo or the existing Standard of Care, if one exists. The "dropout" issue must be a concern to the Pharmas holding Brilacidin CDAs for BOM.
Sachets will also be less expensive to ship while also taking less storage space in trial sites, pharmacies and hospitals.
KarinCA: What about the issue of BOM placebo patients dropping out (because it is so painful for them to "Swish & Spit")? Sachets will do nothing to reduce dropouts. I have not seen a word about IPIX doing anything to fix that problem. Must admit that I have a dozen or so on IGNORE here, so if there has been info posted about this issue, I would certainly appreciate a link.
Hi "justfactsmam". RE your trip as a "merchant marine" on a Moore-McCormak ship to the Baltic Sea area 49 years ago. That is about the same time I made several relief trips as 2nd Mate on the MOOREMAC ALTAIR containrship running between New York and Amsterdam. Trouble with those containerships is that we tie up to the dock at 8PM and they would have us unloaded and repacked by lunchtime the next day.
Have to say, today was a great day - set in motion by some real news.
Its been a drag these last few years, but I doubled my stake with cheapies during 2018 and hope the "science" will prove correct. I have also enjoyed your other posts as well as those of other true (non-pumper) longs.
Thanks also to Karen, Kahuna, sox, Petmantx, and others.
Windansea
It's such a relief to see you posting here again KarinCA. Sorry to hear about your sister.
PIX
I have the feeling, that independent of all the positive developments a large holder is selling.
"time and tide wait for no man"
I was one of sellers last Dec. between the 18th and 21st while acting as Trustee of my father's much younger brother. Back in 2012 I told him about CTIX and he bought some in the range of $0.75 and kept buying during 2013 in the $1.75 to $2.00 range. 2014 was a great year, but I did not have the skill or sense to advise him to sell out in the $4 range, and then came the big drop. He was involved in serious auto accident in March of 2016. I think that a combination of accident injuries and his age resulted in his death in January of 2017. His Trust had a clause stating that all assets of the Trust had to be liquidated for the purposed of distribution to his Beneficiaries by one year from the date of the death of the Grantor.
I was hoping that the spike during the 1st week of Dec. on the BOM data would continue, but I was disappointed again. I was forced to liquidate his 135,000 shares the week before Christmas, 2017.
So it is not just shorts, hedge funds, and market makers who are selling.
Sometimes "true longs" also have to sell because of uncontrollable events in their lives (or deaths). I am soooo glad that I never told any other family member or friend about CTIX / IPIX. I am still hanging onto my own sizeable holding, but can't say it has been a happy experience - yet. My thanks to those posters who have provided the facts about the science behind the drugs of IPIX.
I had actually had the same thought. What if it could be used as a daily mouth wash for treatment/prevention of periodontal conditions since bacteria/inflammation are drivers of that disease process.
When Brilacidin was first obtained by CTIX, the talk was how it had to be saved as a precious last resort drug for the terrible afflictions like ABSSI and perhaps those other flesh eating organisms. CTIX had to be careful not to overexpose our precious molecule, lest it fall prey to "resistance" development by the organism(s) being treated. Based on those assumptions I was under the impression that even "swish and spit" would not be into a sink, but into a special container so that the contents could later be boiled to eliminate any possible remaining organisms surviving and coming back later and resistant.
I recently watched the PBS documentary THE FORGOTTEN PLAGUE which was about fighting tuberculosis in the U.S. from 1910 to 1950. When Penicillin first came out in early 1940s it was found to be very effective in "curing" TB. But within 4 years, it became useless against TB because of resistance developed.
I hope IPIX management is keeping this issue in mind.
Salamat sa imbitasyon. But please be careful not to the let the work get out that your guests "made a lot of money in drugs"! President Duterte might be listening. Good luck to all true longs.
When time comes all LONGS are invited to join my party in my home country - The Philippine Islands.
RE: Brilacidin
rapid clearing of bacteria is also a factor in lowering risk of resistance
I have no medical background, but to me,the above statement refers to the development resistance that would happen within the body of he person being treated. What happens to the oral rinses and enema solutions that being used in B-OM and B-UP? Are the rinses being spit into sinks and the enemas flushed down toilets? If this is the case, isn't our precious Brilacidin being introduced into public sewage systems to mingle with the gazillion badass bacteria that thrive in such places? I hope that CTIX has created a protocol which is part of our trials to carefully dispose of Brilacidin carrying waste in a manner that does not promote the development of resistance.
http://consumersunion.org/news/the-overuse-of-antibiotics-in-food-animals-threatens-public-health-2/
Can Brilacidin foam be used as shaving creme?
The whole idea of having a new anti-bacterial drug of "last resort" is carefully restrict its use for the really bad bugs. If it goes it into everyday use for things like shaving cream and hand soap, the quicker some bacteria will develop a resistance to it. It will end up in the "useless" basket like so many other former wonder drubs. Just my opinion.
feels like we're getting close to something positive coming
Green: I was under the impression that based on past history, nothing positive happens until after the obligatory option awards are handed out to the BOD. (Or perhaps that would be the something positive.) Only then would the ATM be shut down and the PS be allowed to run. We may not be "close", but it will happen "soon".
Good luck to all.
fool: Great post. I am in the same age group, financial position, and state of mind as you have expressed so well in your post. Bavi is either the most carefully contrived scam in the history of biotech or the real deal. Thankfully, within 6 months we should know the truth. GLTA
I firmly believe the success of m pesa
The 60 Minutes piece emphasized that m pesa has, so far, only been a success in Kenya. It has not caught on in other African countries. This could be because those nasty banks are cut out of the action completely. Lets hope that since MYEC's system is done using the banks, it will do well in those places where m pesa has failed. GLTA
Where does this $.25 per transaction number come from? I could see this applying in the USA where incomes are pretty high, but in AFRICA??? Many people there work for a few $ a day. The last IHUb outfit I saw that was going to make a fortune in Africa (Ghana) was Ewaste Systems. Last price 0.0002. I'd be happy with 2.5 cents per transaction in Africa. GLTA - we'll need it.
BHE: I do not know what version of Chase QuickPay you are referring to.
Several of my tenants pay their rent every month via Chase QuickPay and there is absolutely no fee or charge collected by the bank. The only requirements are that both the payer and the payee have current Chase bank accounts and sign up to use Chase QuickPay. There is a $2000 limit to any single payment, so my tenants with a higher than $2000 rent, just makes a 2nd Chase QuickPay for the remaining amount. Signing up for Chase QuickPay can be daunting. I have Kaspersky internet protection, which opens a special protected browser whenever the web site of a financial entity is used. It does not like Chase's several levels of security and there was also a issue with the "cookies" settings of my computer. But now that I have that is all cleared up, Chase QuickPay is working great. There is an instant deposit to my account when I "ACCEPT" the e-mail notification that funds have been sent to me. I do not know if there is a lag on the sending end.
Echo; my understanding is that in order to prevent bacteria from developing resistance to B, the medical establishment will have to carefully control its use. If B is added to consumer products, its useful life may be shortened drastically. IMO.
hi nerby: best laugh I have had in quite a while. Going thru a rough patch in my private life, and your post just reminded me what it felt like to enjoy something again. This is a great board, with a wonderful debate format discussion tonight. GLTA and go CTIX.
Maybe the final mos beats soc by 4 to 8 weeks. That would be amazing.
md1225: To my (non-expert) understanding, Bavi beating the current SOC (Docetoxil) by 8 weeks would yield a Median OS of 8 months for Docetoxil/Bavi. Per Pharmboy21's post 210878, Bristol-Myers' Opdivo just finished a Phase 3 among patients with NSCLC with a 9.2 months median OS.
Doesn't this mean that Doxetoxil/Bavi does NOT become the SOC? Would PPHM would have to do another Phase 3 with Opdivo? Or would the outcome that Bavi greatly improved the performance of Docetoxil (with safety) allow granting an FDA Approval of Bavi, with the assumption that it would probably improve the performance of Opdivo as well? All IMO.
daydreaming: the "rocket scientist" is still here - lurking, reading, and adding regularly. Because of my past life's work and knowledge base, I know that I cannot contribute much in the way of DD to the discussions here. (I am especially in awe of newcomer slcimmuno's posts.) My contribution to the CTIX story will be the steady accumulation of shares each month until the price gets to $6. Then I hope to be able to sit back and enjoy the fireworks. GLTA
reply to:
daydreaming2 Wednesday, 02/25/15 07:44:04 AM
Re: TimetoRetire post# 92595
Post # of 92875
Blindly follow someone that's been on the board for less than a month....Not real sound advice. Nothing against the person at all, but I have seen people come and go... doctors, rocket scientist, I think even Buffet was here for a bit lol
Dane: along with other differences provided by Fanfoiz and cabel, can I add they are all listed on the NASDAQ exchange? CTIX is not only on the OTC, but in the peanut gallery PINK sheets section. Has any Pharma done a deal with a PINK in the past?
greater for CTIX then anti-biotics
familyman: (hope this is not considered off-topic) It is said that language is a constantly evolving medium, and it appears IHub is a good example of that. There are many people on IHub who post confusing the use of the word "then" for "than". But I am shocked to see that Leo does it as well. (if those were his words and not a retyping error of the email by the person who received it) Leo's response certainly added to my understanding of the time-consuming process required to move drug testing along. Go CTIX.
Drano: looks like some other people agree with you and already took that name.
http://www.corporationwiki.com/California/Palo-Alto/nanobiotics-technologies-inc/44508291.aspx
epcjmc: Nicely put about both holiday sentiment and understanding how to sort through the postings on this board. Hope 2015 will be the year many of us have been waiting for.
don't know how that number looks after the transfer of shares to Aruda.
tduggan: per the Form 10-Q of Nov. 10, 2014 in the Risk Factors, page 41:
*******************************************************
The dual class structure of our common stock can have the effect of concentrating voting control with Dr. Menon and/ or Mr. Ehrlich, which will limit or preclude your ability to influence corporate matters.
Our Class B common stock entitles holders to ten votes per share on all matters submitted to a vote of our stockholders and our Class A Common Stock entitles holders to one vote per share on all matters submitted to a vote of our stockholders. Dr. Menon and Mr. Ehrlich each have vested options that they can exercise and convert into 18,000,000 shares of Class B common stock. That alone could result in the equivalent of 360,000,000 votes of Class A Common Stock. As of October 24, 2014 we had 114,237,129 shares of Class A Common Stock outstanding and no shares of Class B common stock outstanding. Because of the ten-to-one voting ratio between our Class B common stock and Class A Common Stock, upon exercise and conversion of such options into shares of Class B common stock, the Class B common stock holders can collectively control a majority of the combined voting power of our common stock (i.e., approximately 48.1%) and therefore be able to control all matters submitted to our stockholders for approval. This concentrated control will limit or preclude your ability to influence corporate matters for the foreseeable future.
***********************************************************
Hope this helps. Seems to me Leo and Dr. Mennon are still in control.
LOOf:I would like to submit my application for the job you just posted as your assistant in helping the PPHM rocket go into orbit. I spent 14 years at General Dynamics/Lockeed Martin- first assisting in the conversion of the old military Atlas I design into the commercial Atlas II, and ATLAS IIAS, then finishing up as a test engineer running some critical components through cryogenic acceptance tests using liquid hydrogen (-420 deg F) and liquid nitrogen to simulate liquid oxygen (-220 deg f). KORN LICKER can use atmospheric oxygen while PPHM's rocket is still at lower altitudes, but if you want to escape earth's gravity and the influence of day traders and shorters, etc., nothing beats liquid hydrogen for a power-packed energy punch. Since there is no oxidizer in space we'll have to carry a supply of liquid oxygen along to burn it. Not easy to build and operate such a system, but it is probably easier than curing cancer. During my time on Atlas, we had 37 successful launches and two failures. I have not been able to contribute much to this board because I have no background in things medical, but I was able to recognize that some very knowledgeable people are posting on this board and believe that Bavi will be vindicated in the Sunrise trial.
P.S. The current (huge) Atlas V uses Russian-built RD-180 rocket motors which burn 249 gallons of kerosene per second each. That would be a huge waste of good KORN LICKER, so I suggest you keep your rocket size to the minimum. (it takes 94 seconds to get an ATLAS V off the launch pad to the edge of space)
REF http://en.wikipedia.org/wiki/Atlas_V
Some news that may be of interest to those who are agreeable to the idea of Kevetrin combined with existing cancer drugs:
*************************************************************
Dr Reddy's Laboratories launches Docetaxel injection in US
Nov 24, 2014
HYDERABAD: Dr Reddy's Laboratories has launched Docetaxel injection USP 20 mg/mL and 80 mg/4 mL, a generic version of Taxotere (docetaxel injection) in the US market.
Dr Reddy's Abbreviated New Drug Application (ANDA) is approved by the United States Food & Drug Administration ( USFDA), DRL said in a statement today.
http://articles.economictimes.indiatimes.com/2014-11-24/news/56420833_1_states-food-drug-administration-dr-reddy-ims-health-data
*******************************************************************
The idea here being - combine Kevetrin with a proven generic to keep costs down for patients, and add Kevetrin to improve outcomes and reduce side effects. Leo and Dr. Menon would probably feel at home working with Dr. Reddy's in such a relationship. IMO
maybe it's just me
oddone: its not just you. Very reasonable post--you not only commented on a very important issue, but did it in a courteous way. GLTA
Wook: I read in an earlier post that biopsies were taken only from patients who were willing to "volunteer" for the procedure. It was described as being quite "painful" which is why there were only 6 of the 34 who responded.
Rocky: since you seem to be a market historian, can you tell the Board how many shares of MYEC were outstanding on 04-18-2008? That would give us the ability to calculate the Market Cap, of the stock which is the really important number. Thanks.
There is a reason why this was trading over $100 bucks
GM Tech: maybe the reason is that there was not 4,117,470,000 shares outstanding then like there is today.
. the poster (F Frazzano) is the biggest evangelist over there.
slcimmuno: just to correct Mr. Frazzano - CTIX is not a "PINK" but trades on the OTCQB.
Someone needs to call Cramer
Tundra: Jim Cramer doesn't do penny stocks, especially one that is still a stinky Pinky. MYEC will have to wait for uplist to NASDAQ before CNBC will consider mentioning it. GLTA
Penny: My apologies. Just looked at the copy of the patent in the Ibox. It appears to NOT be assigned. We may have a problem here. On my patents, the assignment is typed in right after my name as "inventor". I have read this issue being discussed months ago and there were posts by some very knowledgeable posters that Ed has used some means to make the patent as asset of MYEC. This would have been a great issue to bring up at the AGM.
Penny: When I was an engineer at Whittaker Survival Systems, I developed 2 patents while working for that company. The patents are in MY NAME but "assigned to Whittaker Corporation". Therefore, they do not belong to me, but to Whittaker. Same deal here with MYEC. My understanding is that the E-Check Patent reads "assigned to..." the entity that we are holding stock in.
GLTY
tduggan: when you talk to Fidelity, be specific in your questions.
My experience with Fidelity has been that funds are instantly available only for NASDAQ, NYSE, and AMEX stocks. OTC still has a 3 day wait. (That may be for "penny" stocks only though. Since CTIX is now trading above $2, Fidelity may no longer have it lumped in with all the trash that trades in the Pinks and other OTC levels.) GLTA and go CTIX.