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Created: 09/27/2009 04:11:41 PM - Followers: 123 - Board type: Free - Posts Today: 0

For filings:

Investment by Nostrum Pharmaceuticals LLC:

On August 2, 2021, the Audit Committee approved the appointment of RAM Associates, LLP (“RAM Associates”) as our new independent registered public accounting firm, effective immediately, to perform independent audit services for the fiscal years ending December 31, 2021 and 2020. RAM Associates has served as the auditor for Nostrum Laboratories, Inc. and its affiliates, which are subsidiaries of Nostrum Pharmaceuticals LLC, our largest shareholder, since 2008. update:

Understanding refractory angina and the AFFIRM study:

Taxus Cardium Announces Name Change To Gene Biotherapeutics

January 10, 2018PR-M01-18-NI-021

SAN DIEGO, Jan. 8, 2018 /PRNewswire/— Taxus Cardium Pharmaceuticals Group (Trading Symbol: CRXM) today announced plans to affect a name change from Taxus Cardium Pharmaceuticals Group Inc. to Gene Biotherapeutics Inc. 

The name change reflects the Company's plan to exclusively focus on the late-stage clinical research and commercialization of gene-based biotherapeutics for niche markets in the oncology and cardiology spaces for patients with unmet medical needs.  Gene Biotherapeutics is actively pursuing the acquisition of clinical development and commercialization rights to new and innovative, late-stage, DNA-based product opportunities focused on multiple forms of cancer to leverage the company's established and validated adenovector-based technology platform and deep experience in the clinical advancement and commercialization of gene therapy product candidates.

Previously, the Company established Angionetics Inc., an 85% majority-owned subsidiary, to lead Gene Biotherapeutics' cardiovascular clinical research and commercialization activities.  Angionetics is currently focused on independent financings to support advancement of the FDA-cleared, Generx AFFIRM Phase 3 clinical study of patients with refractory angina (myocardial ischemia) due to advanced coronary artery disease. There are an estimated 1.0 million patients with refractory angina in the United States. Gene Biotherapeutics' plan to advance forward to establish Angionetics as an independent company remains unchanged.  As previously reported, Gene Biotherapeutics expects to retain a substantial long-term equity investment in Angionetics following completion of the planned external financings. For more information about the Generx AFFIRM Phase 3 clinical study visit

Angionetics is also considering the initiation of multiple Phase 2 clinical studies to evaluate the Generx angiogenic gene therapy product candidate as a treatment for patients with Cardiac Syndrome X (microvascular dysfunction) and certain forms of congestive heart failure, including ischemic cardiomyopathy.

Angionetics' Generx [Ad5FGF-4] is a first in class, disease altering, one-time administered, late-stage, angiogenic gene therapy product candidate which has been biologically engineered to enhance blood flow (perfusion) in ischemic regions of the heart by leveraging cardiac plasticity to promote the natural formation and growth of microvascular coronary structures (collateral vessels). This is achieved by stimulating and augmenting the heart's innate natural capacity to modulate the enlargement of pre-existing collateral arterioles (arteriogenesis), and to form new capillary vessels (angiogenesis) in select ischemic regions downstream from large coronary arteries.

Angionetics is being uniquely positioned to become a leading molecular interventional cardiology company, and is seeking to develop a portfolio of new and innovative, single-treatment, gene-based, catheter-administered therapeutic products focused on the biologic modulation of cardiac conductivity, contraction and angiogenic revascularization to address the global unmet medical needs of millions of patients with multiple forms of heart disease. Consistent with Angionetics' business strategy, the company is currently considering the acquisition of several early-stage gene therapy product candidates.  To learn more about Angionetics visit

As previously reported, Gene Biotherapeutics further plans to monetize its FDA-cleared, U.S.-patented, Excellagen, a highly-purified, aseptically-manufactured, fibrillar bovine collagen [2.6%] flowable dermal matrix for the treatment of diabetic neuropathic lower extremity ulcers, pressure and venous ulcers as well as other wound healing applications.  Excellagen has demonstrated its medical utility as a delivery platform for stem cells, and also carries the potential as a topical dermal delivery vehicle for small molecule drugs, peptides, proteins, and exosomes.   Excellagen® has been designated as a skin substitute (bearing a unique product Q Code), in accordance with the standards established by the U.S. Centers for Medicare and Medicaid Services (CMS). For more information about Excellagen, visit

As of December 31, 2017, approximately 14.3 million shares of Gene Biotherapeutics Common Stock were issued and outstanding, and approximately 4.6 million additional shares of Common Stock have been reserved for future issuance upon the conversion of the Series A Convertible Preferred Stock.

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He is. My acquaintance talked to him on _fatty_ 06/22/2022 06:30:05 PM
I agree. Doesn't mean I like the way docj 06/22/2022 06:50:45 AM
IMO This will fly once current with or JJ24 06/21/2022 07:55:35 PM
Not suggesting they don't intend to get current. docj 06/21/2022 07:33:51 PM
Well they have never said they not going JJ24 06/21/2022 07:08:34 PM
Is C. Reinhard even still alive?! BlueChip$ 06/21/2022 06:50:49 PM
I'm sure you are not alone. docj 06/21/2022 05:40:09 PM
In my top 5 worst investment ever here, vinsterr 06/16/2022 01:35:49 PM
docj.....I Believe We Will See A Flurry Of bentleyt 06/15/2022 10:40:04 AM
Due for news or at least another filing. docj 06/15/2022 06:54:48 AM
Yup, new cost basis. campe 06/10/2022 01:34:35 PM
Anyone knows what happens if you do total _fatty_ 06/10/2022 11:56:58 AM
There are certainly reasons for this lack of marketmanallm 06/02/2022 02:16:26 PM
No doubt! The point that this stalling as BlackSnake1 05/27/2022 08:48:02 PM
On the bright side the domain seems to _fatty_ 05/27/2022 08:23:22 AM
Problem is at the rate they are completing docj 05/27/2022 06:50:06 AM
I’m always surprised to see new posts on crazyflavor 05/26/2022 10:08:19 PM
Altitrade.....Any Thoughts.....Ideas.....Updates....We Respect Your Knowledge An bentleyt 05/26/2022 04:53:17 PM
marketmanallm.....I Can Understand Your Logic....I Still Expect That bentleyt 05/26/2022 12:09:49 PM
Anyone remembers the days our 2 heroes here _fatty_ 05/25/2022 04:35:31 PM
We can only go up from here! Lol! JJ24 05/25/2022 12:03:34 PM
I believe Metformin is a large portion of marketmanallm 05/25/2022 11:54:47 AM
Nostrum was not alone in the Metformin recall......Apotex,Amneal,Lupins,Marksans bentleyt 05/25/2022 11:26:01 AM
If you do some digging you will find marketmanallm 05/25/2022 09:57:38 AM
Good to hear (if true), but....filings not current BlueChip$ 05/25/2022 08:34:27 AM
There are shareholders who are in communication with docj 05/25/2022 08:20:18 AM
Faith is a God thing, not a stock BlueChip$ 05/24/2022 08:26:42 PM
Bluechip.....I Expect The Completed Filings.....A P.R. Regarding OTCQB bentleyt 05/24/2022 06:51:48 PM
Are they even still in business? Seems like BlueChip$ 05/24/2022 05:09:32 PM
When are these people running the show going BlackSnake1 05/24/2022 03:44:28 PM
Look at what happened to Andrew Cuomo.....In this bentleyt 05/24/2022 11:00:00 AM
Sounds like this guy would be a great campe 05/20/2022 12:53:38 PM
Been cutting down on beer to save the _fatty_ 05/20/2022 10:05:16 AM
I would not hold my breath. They have lakes 05/20/2022 06:14:52 AM
Super pathetic that a company that has assets BlackSnake1 05/19/2022 03:21:56 PM
When not trading and zero real news, I BlackSnake1 05/06/2022 05:10:24 PM
docj.....For Sure We Need To See The Complete Picture bentleyt 05/06/2022 11:55:53 AM
Seems to me the subsequent quarter filings from docj 05/06/2022 07:52:53 AM
My sense is they may have the quarters marketmanallm 05/06/2022 07:49:06 AM
Totally inexcusable not to have this ticker trading BlackSnake1 05/05/2022 04:24:42 PM
docj.....All in the works....IMHO SOON bentleyt 05/03/2022 11:38:20 PM
It would be nice to get notice a docj 05/02/2022 07:03:37 PM
One good thing about this ticker is its _fatty_ 04/29/2022 03:45:09 PM
How is this relevant in 2022? Tia, campe 04/27/2022 02:42:19 PM
$CRXM: This is now ANGIONETICS ???? makinezmoney 04/27/2022 11:22:06 AM
docj....thanks! bentleyt 04/19/2022 04:06:43 PM
EXPLANATORY NOTE TO 10-K/A docj 04/19/2022 10:37:32 AM
docj.....What was the 10-K amendment about? bentleyt 04/19/2022 10:10:50 AM
"We intend to become current" ..I believe marketmanallm 04/15/2022 04:05:49 PM
One of my biggest loser here, I still vinsterr 04/14/2022 11:36:32 AM
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