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Yield 10 Bioscience (YTEN)

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Last Post: 11/12/2018 8:50:15 AM - Followers: 31 - Board type: Free - Posts Today: 1


Yield10 Bioscience is an agricultural bioscience company focusing on the development of disruptive technologies to produce step-change improvements in crop yield for food and feed crops to enhance global food security. Experts forecast that food production must be increased by over 70% in the next 35 years to feed the growing global population, which is expected to increase from 7 billion to more than 9.6 billion by 2050. Yield10 is focused on new agricultural biotechnology approaches to improve fundamental elements of plant metabolism through enhanced photosynthetic efficiency and directed carbon utilization. Yield10 is working to develop, validate and commercialize new traits and identify gene editing targets in several key crops including canola, soybean and corn. Yield10 was launched by Metabolix, Inc. in 2015 and is traded on Nasdaq (YTEN). Yield10 is headquartered in Woburn, MA and has an additional agricultural science facility with greenhouses in Saskatoon, Saskatchewan, Canada.


Metabolix was founded in 1992 and focused on engineering microbes to make proprietary bioplastics and bio-based chemicals. In 2002, Metabolix started a crop science research program with the intent to harness the renewable nature of plants to produce renewable bioplastics, chemicals and bioenergy from agricultural crops. Historically, Metabolix put most of its crop technology efforts on developing proprietary systems to produce PHB, the simplest member of the PHA family of biopolymers, in high concentration in the seeds of oilseed crops or in the leaves of biomass crops for these applications.

With development advancing in our agricultural biotechnology approach and with our progress producing PHB in plants, we learned that producing PHB in increasing levels in the biomass of switchgrass resulted in impaired plant growth. This result is not unexpected, as we were diverting a significant fraction of the carbon fixed by the plants into PHB, which represented a new carbon sink. Given these observations and our longer-term goal at the time to develop commercially viable ways to produce PHB biopolymer in switchgrass and the industrial oilseed camelina, we began developing new genetic and informatics tools and began capturing intellectual propertyaround strategies to enhance the photosynthetic capacity of plants.

In 2015, we set a new mission and redeployed our crop science program, launching with the name “Yield10 Bioscience.” It is now developing proprietary, breakthrough plant biotechnologies to improve crop productivity and seed yield based on our “Smart Carbon Grid for Crops” and our metabolic engineering platform called the “T3” Platform. We are now focusing on advanced crop technologies to boost the CO2 fixation efficiency through photosynthesis as well as its direction to and conversion into plant matter. Our team has demonstrated yield improvements inswitchgrass biomass and camelina oilseed, and we are developing innovative agricultural biotechnology approaches in significant row crops to provide novel solutions for global food security.


                                                                                                                                                                                    2016 Update

Metabolix, Inc. is implementing a strategic plan under which the Company has wound down its legacy PHA biopolymer business and Yield10 Bioscience will become its core business with a focus on developing disruptive technologies for step-change improvements in crop yield. Yield10 is leveraging Metabolixs extensive track record of innovation based around optimizing the flow of carbon intermediates in living systems. Yield10 is working on new approaches to improve fundamental elements of plant metabolism through enhanced photosynthetic efficiency and directed carbon utilization. Yield10 is advancing several yield traits in development in crops such as camelina, canola, soybean and corn. The Company is based in Woburn, MA



Yield10 Bioscience is a planned spinout that will commercialize crop science innovations that Metabolix and its partners have developed over the last 10+ years. “Yield10” will focus on step changes in crop yield to enhance global food security. This will be achieved through enhanced carbon capture (photosynthesis) and targeted carbon deposition through advanced transcriptome targeted metabolic engineering. Target crops will include key row crops (corn, soybean, canola, sugarcane, sorghum, alfalfa) as well as industrial and energy crops (e.g. Camelina and switchgrass). The increased fixed carbon will be directed to products of interest through Yield10’s advanced metabolic engineering capabilities.

  • Oilseed crops – increase carbon flow to seed and oil
    Corn – increase carbon flow to seed and starch biosynthesis
    Biomass crops – increase carbon flow to sucrose (cane) or biomass
    Industrial and energy crops (e.g. Camelina, switchgrass, sugarcane) – increase carbon flow to industrial products (e.g. bioplastics)

Yield10 Bioscience: The Innovation Opportunity

A complex trait such as increased crop yield depends on many metabolic pathways enabling multiple processes, starting with photosynthetic carbon fixation and finishing with carbon conversion to end product. Because these processes involve multiple genes and pathways, traditional plant breeding or single transgene approaches are limited and provide only incremental gains in yield. Yield10 Bioscience will focus on identifying key combinations of genes to deliver step changes in crop yield. This will be achieved using the foundation “T3 Platform” technology developed at Metabolix that utilizes advanced transcriptome network analysis to identify key global regulatory genes, and the broad set of metabolic genes they control, with the potential to massively up-regulate key pathways. We have demonstrated the T3 Platform technology in switchgrass in gene discovery efforts focused on increasing photosynthesis and primary plant metabolism and have identified key global transcription factors that increase photosynthesis, biomass yield, and starch accumulation. This T3 Platform technology can be used to query gene data sets to discover methods to increase carbon flow to other metabolic pathways by changing the input information. In collaborations with leading academic groups, Metabolix has accessed additional novel traits each also targeting step changes in crop yield through metabolic engineering. The combination of in-house and licensed technologies combined with metabolic modeling, systems biology, and bioinformatics fully integrated through the T3 platform forms the technical foundation for the next generation of crop metabolic engineering to achieve step changes in yield. 

The company was founded in 1992, is based in Cambridge Massachusetts


Yield10 Reports 2016 Camelina Field Test Results for C3003 Yield Trait Gene 

Yield10 announced preliminary field test results in its model Camelina system showing that the novel yield trait gene C3003 produces significant improvements in seed yield. Specifically, C3003 produced an increase in seed yield in Camelina of up to 23% in the best line as measured by average seed weight (kg/hectare), which was statistically significant as compared to control plants. The field trials, which were started in May 2016, were primarily designed to establish Yield10’s Fast Field Testing platform and accelerate the generation of field data for crop trait discovery and improvement in addition to evaluating changes in seed yield and composition generated by specific trait leads in Camelina.

Read more about the Camelina results here.

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#477   MONSANTO getting into MJ FairviewInvestor 11/12/18 08:50:15 AM
#476   The Meteoric Rise of Genomics BMGS 11/08/18 12:58:57 PM
#475   Some great news would be nice for sure. BMGS 10/24/18 02:27:27 PM
#474   Range Bound until next News FairviewInvestor 10/17/18 06:02:32 AM
#473   2018 Field Tests for C3003 and C3008 Traits BMGS 10/03/18 03:35:27 PM
#472   Recent news releases underline the big potential of BMGS 10/03/18 02:09:39 PM
#471   Agree. A debt-free too. ash111 10/02/18 08:48:50 AM
#470   $14M Valuation crazy low considering progress. FairviewInvestor 10/02/18 08:36:54 AM
#469   CRISPR Non-Regulated Status approved FairviewInvestor 10/02/18 08:36:04 AM
#468   What’s up here? Eagle1 09/21/18 07:50:45 PM
#467   Today's news release is very promising imo. Land BMGS 09/21/18 01:43:55 PM
#466   Yield10 Bioscience Grants Research License to Forage Genetics BMGS 09/21/18 09:13:21 AM
#465   WOW- Here is how Crispr/Cas9 will change ash111 09/18/18 10:34:27 AM
#464   Would be Nice and looking forward to some news FairviewInvestor 09/16/18 08:54:47 PM
#463   . ash111 09/12/18 02:19:04 PM
#462   An interedting information by eximiuscapitalgroup StockTwits. I'm connecting ash111 09/11/18 04:26:16 PM
#461   Company just mentioned many opportunities : partnership... Page ash111 09/11/18 03:41:06 PM
#460   SSR SEC restriction on. = shorts were artificially FairviewInvestor 09/10/18 04:46:49 PM
#459   I hope everyone read through data that was FairviewInvestor 09/07/18 02:04:24 PM
#458   This is a High Risk / High Reward FairviewInvestor 09/07/18 01:30:31 PM
#457   picked up a bunch @ $1.42 today.. who FairviewInvestor 09/07/18 01:28:42 PM
#456   The next 14 days I expect to be FairviewInvestor 09/06/18 06:33:42 PM
#455   Sold some for $1.64 average when I saw FairviewInvestor 09/06/18 04:16:41 PM
#454   September 05, 2018 08:00 ET - Yield10 Bioscience BMGS 09/06/18 05:23:58 AM
#453   CT order just filed. They have something interesting ash111 09/05/18 01:36:48 PM
#452   Accumulation seems to be going on over past week FairviewInvestor 08/28/18 11:44:29 AM
#451   Trump administration farm bailout to provide $6 billion ash111 08/27/18 04:40:08 PM
#450   https://twitter.com/tgtxdough/status/1028974897203236865?s=19 ash111 08/21/18 05:37:29 PM
#449   I haven't thought something else. "C3003 planned ash111 08/21/18 05:12:32 PM
#448   I had the date wrong.. it's 1 month FairviewInvestor 08/21/18 04:02:42 PM
#447   Tic toc.The future is here. Check O/S and ash111 08/21/18 02:33:51 PM
#446   What did I say about today? FairviewInvestor 08/21/18 11:27:45 AM
#445   Someone accumulating a big Short Position. FairviewInvestor 08/21/18 09:33:29 AM
#444   Today is a big date. maybe it FairviewInvestor 08/21/18 08:59:11 AM
#443   I hope your feeling is correct... BMGS 08/18/18 06:52:05 AM
#442   Gut feel is we are waiting days now FairviewInvestor 08/16/18 12:47:17 PM
#441   Int’l Red Cross warns of food crisis in ash111 08/13/18 07:43:46 AM
#440   10Q, the balance sheet remains solid, total assets/ ash111 08/09/18 04:49:49 PM
#439   Warren buffett ash111 08/08/18 12:40:36 PM
#438   We need Partner news next. today is just FairviewInvestor 08/08/18 09:24:56 AM
#437   Yield10 Bioscience Signs Research License Agreement Covering CRISPR-Cas9 ash111 08/08/18 08:35:30 AM
#436   Bitcoin Prices Drop After SEC Postpones ETF Decision https://www.forbes.com/site ash111 08/08/18 06:14:23 AM
#435   Warren knows the potential https://www.theatlantic.com/amp/article/476385/ ash111 08/07/18 12:17:00 PM
#434   agriculture Tesla on the works ? ash111 08/07/18 03:25:23 AM
#433   Lot of eyes on this stock. If we FairviewInvestor 08/06/18 04:06:07 PM
#432   Agree, but 1st step is to announce a FairviewInvestor 08/06/18 02:11:53 PM
#431   https://modernag.org/innovation/future-of-food-farming-2050/ A very interesti ash111 08/06/18 01:49:05 PM
#430   Tick, Tock. My clock says that there's FairviewInvestor 08/06/18 01:07:36 PM
#429   We need some good news to get this BMGS 07/31/18 04:22:45 PM
#428   YTEN the relationship with Monsanto is another solid ash111 07/31/18 01:40:16 PM