Bacterin International Holdings, Inc. develops, manufactures, and markets biologics products in the United States and internationally. The company's products are used in various applications, including enhancing fusion in spine surgery, relief of back pain with a facet joint stabilization, promotion of bone growth in foot and ankle surgery, promotion of cranial healing following neurosurgery, and subcondral bone defect repair in knee and other joint surgeries. Its biologics products include OsteoSponge, a form of demineralized bone matrix made of human bone that is used as natural scaffold for cellular in-growth and exposes bone-forming proteins to the healing environment; OsteoSponge SC, a subchondral bone void filler and cartilage re-generation scaffold; and OsteoWrap, which wraps around non-union fractures to assist with fusion, as well as is used in conjunction with a hardware plate system, and acts as a biologic plate. The biologics products also comprise OsteoLock and BacFast facet stabilization dowels that are used to augment spinal procedures; and hMatrix dermal scaffold that promotes cellular ingrowth, tissue vascularization, and regeneration, as well as sports, milled, and traditional allografts. The company also researches, tests, and develops coatings for medical devices, primarily antimicrobial-based coatings; and produces and distributes OsteoSelect DBM putty, an osteoinductive product used by surgeons as a bone void filler in the extremities and pelvis. In addition, it develops custom surgical instrument kits for use with allografts; and wound drain products. The company sells its products through various channels comprising independent distributors and joint development projects, as well as its direct sales network. Bacterin International Holdings, Inc. is headquartered in Belgrade, Montana.