Viking Therapeutics Inc (VKTX)

[BrazenBull]

Thanks brother, I am glad we are churning out more volume here. It's good tonchuelrn all these shares.

[Lynx7]

Nice! I respect that!

[BrazenBull]

I hold only a few positions. Cash, metals and VKTX. So I guess you could say 33%.

[Lynx7]

In my defense I'm 33 so I have time to play lol

[Lynx7]

Question time, what percentage of your portfolio does VKTX take up?

I will answer first: 30%

It used to be 50% lol

[ZeWaffleBaron]

Very relevant post greens. Positive phase 2's can be significant catalysts. Especially given lack of available similar treatments on market for our product/class, esp w unique indication they are seeking initial approval for, further differentiating the product from other companies. Things hopefully get interesting over next two weeks. Being close to a month out is quickly becoming crunch time

[greens12]

churning today, need to break 1.26. Hey buddy, Check out another San Diego biotech stock going nuts today up MRTX over 158 % gain on some phase 2 data.

VKTX is next !!!!!!!!!!

[BrazenBull]

steady march towards it!!!

[greens12]

7.00

[BrazenBull]

Viking sword found = massive monster catalyst!

[BrazenBull]

THanks brother! looking forward to it. Expected a slight pull back today, looking for some good follow through on this. happy we had some great churning and some good volume the last few days. There will be a time when no market makers can keep this down.

[Lynx7]

Historic gains let's do it!!!

[Lynx7]

I'm back

[greens12]

Viking Therapeutics (VKTX) Presents At Rodman & Renshaw 19th Annual Global Investment Conference - Slideshow
https://seekingalpha.com/article/4106580-viking-therapeutics-vktx-presents-rodman-and-renshaw-19th-annual-global-investment-conference

[greens12]

new profile pic ? Frank Frazetta has some bada--Viking Paintings.
http://frankfrazetta.org/viewimage.php?loc=snow_.jpg

[greens12]

Brother Brazen, when VKTX breaks thru 1.26 on solid vol...VKTX will rocket higher.

getting a little resistance at 1.25 200 mda , but it will fly when it breaks it. glta
http://stockcharts.com/h-sc/ui?s=VKTX

[greens12]

Yes Historic gains , lol, that Viking leaving his sword on a Mountain top is a
strong buy signal.

[ZeWaffleBaron]

historic gains coming? lol greens!!!

[greens12]

got your message on S.T., you should have 15 free posts a day here without a subscription.

VKTX

[greens12]

I would like to use that sword on the MM's trying to hold us back. VKTX is worth a 7.00 valuation according to Zacks research..

[BrazenBull]

freaking love this man! 1000 year old viking sword!! awesome find!

[greens12]

1000-Year-Old Viking Sword Discovered In Norwegian Mountain is a good luck sign for VKTX , breaking news today.
https://www.msn.com/en-us/news/other/1000-year-old-viking-sword-discovered-in-norwegian-mountains/ar-AArPbsc?OCID=ansmsnnews11

GLTA..... VKTX

[greens12]

Zacks research thinks VKTX worth 7.00 valuation http://s1.q4cdn.com/460208960/files/News/2017/June-19-2017_VKTX_Bautz.pdf

[greens12]

Looks like the MM crooks are getting a little short squeezed today.lets Hope they get squeezed for days...forcing them to cover. They shorted the trading float heavy on friday with 300,000 + shares and alot yesterday.... lets burn these bastards.

VKTX

[greens12]

vktx had a nice presentation today, but the crook' Market Makers are hard at work shorting it again today. bang it down when it ticks up ...MM's don't want it to close over 1.20..suppressing it as much as they can.
VKTX MM's are Crooks , and management are slackers...just wonderful.

[greens12]

Market Makers cockroaches shorting this everytime it ticks up...they just are a bunch of crooks....sad to watch this manipulation continue all summer long and even now they hit it with all they can to prevent it from moving up..55% short friday and 45% today...just fing ridiculous. This stock is rigged by MM to smash retail investors every chance possible.The crook MM's just refuse to let this run. Trading 8x lower valuation than MDGL its easy to see we are in a manipulated stock. ...just sad management let this happen with all the delays they did.
http://www.volumebot.com/?s=vktx

Maybe when Management gets off their ass and does something about it things might change. They as are much to blame as the Market Maker crook shorts at this point.

[greens12]

Statistically Significant Changes Observed in Multiple NASH-Associated Genes Following Eight Weeks of VK2809 Treatment

Gene Expression Changes Align with Histologic Data Showing Significant Reductions in Fibrosis, Steatosis and NAS

SAN DIEGO, Sept. 11, 2017 /PRNewswire/ -- Viking Therapeutics, Inc. ("Viking") (VKTX), a clinical-stage biopharmaceutical company focused on the development of novel therapies for metabolic and endocrine disorders, today announced positive results from a gene expression analysis conducted as part of its recently completed study of VK2809 in an in vivo model of diet-induced non-alcoholic steatohepatitis (NASH). The analysis, which evaluated more than 20,000 genes, demonstrated that eight weeks of treatment with VK2809 led to statistically significant changes in the expression of multiple genes associated with the development and progression of NASH. These findings align with recently reported histologic results from this study, which demonstrated statistically significant improvements in non-alcoholic fatty liver disease activity score (NAS), liver fibrosis, and liver and plasma lipid levels in animals treated with VK2809 relative to vehicle-treated controls.

Top-line data from the analysis include the following changes in the expression of key genes associated with NASH development and progression:

43.7% decrease in SREBF1 expression (p < 0.001), suggesting reduced SREBP1 expression, reduced de novo lipogenesis
64.2% increase in PPARD expression, (p < 0.01), suggesting improved PPARd expression, improved lipid metabolism
336.8% increase in FGF21 expression (p < 0.001), suggesting improved insulin sensitivity
36.3% decrease in COL1A1 expression (p < 0.05), suggesting reduced collagen I production
Significant improvements were also observed in other NASH-related genes of interest, including CYP7A1 (cholesterol metabolism), MAP3K5 (ASK1, oxidative stress), ANXA2 (inflammation), KRT18 (CK-18, cell apoptosis), ACTA2 (aSMA, fibrosis) and LGALS1 (Galectin 1, fibrosis). Detailed results from this study will be presented at the 68th annual meeting of the American Association for the Study of Liver Diseases (AASLD), October 20-24, 2017 in Washington, D.C.

"The changes in gene expression observed following treatment with VK2809 provide further evidence of its potential benefit in the setting of NASH and related diseases," said Brian Lian, Ph.D., chief executive officer of Viking. "As we reported earlier this year, VK2809 demonstrated potent reductions in liver fat, fibrosis, and the NAFLD Activity Score in this model of diet-induced NASH. The genetic analysis results corroborate the histologic data and suggest that VK2809 achieves this activity by modulating the expression of genes associated with lipid metabolism, insulin sensitivity, and fibrosis, all of which are important in the setting of NASH. This breadth of activity highlights VK2809's differentiated mechanism of action and exciting potential therapeutic profile."

The study was designed to evaluate VK2809 dosed orally (10 mg/kg/day) for eight weeks in a mouse model of diet-induced NASH.1 Control cohorts received either vehicle or active control. Animals were biopsied prior to treatment to ensure disease characteristics consistent with the human form of disease, including the presence of fibrosis. Changes in gene expression were evaluated by assessing changes in RNA expression at the conclusion of the experiment, compared with vehicle-treated controls.

[greens12]

The perfect time to load up is right now. Enjoy the ride up.

[Cbdpotential]

Thanks man!
Will do

[BrazenBull]

Cheers brother much love to you. Hop on a call soon and chat.

[Lynx7]

Good news to wake up to!

[Cbdpotential]

Nice
Maybe I should have had a little more patience here oops!
GL everyone

[greens12]

Thanks for reply, it seems like the data was good . Really Looking forward to the next few weeks, I would like to see it trading near 52 week high around 1.70 before they release the data later next month. GLTA

[ZeWaffleBaron]

The additional data is from mouse testing. It's always possible that anima data may not translate into results for humans, but we have some human phase data that correlates already with a lot of what they are seeing. Without digging too deep into what if's, the data is great. I guess the question always in the back of my mind, is what are the downstream effects of these huge lipid reductions this accomplishes... like are their possible unforeseeable downstream effects. Will this be the holy grail of lipid lowering agents, or a drug that is used in small doses at periodic intervals to decompress the effects in people with serious glycogen storage diseases. That's the real question. And I don't think we may actually know the answer to that until phase 3 or later. The longer we go without unexpected weird side effects divulged, the higher the chances get that it may be closer to being a great all around lipid lowering agent, that could be a miracle drug in a different dose range for those poor individuals suffering from GSD. Time will tell. 5 weeks until possible sarm data... things should starting heating up over the next 2 weeks... let's hope.

[greens12]

Volume has been way up this week almost 1 mil shares traded yesterday tells me that many are starting to get in before the vk5211 Phase 2 results in mid to late October. The next few weeks we push to 1.50 range...very exciting time we are about to enter.


any thoughts you have on the vk2809 tidbits the company gave us in the PR last week would be welcome ?

GLTA Vikings

[alx8967]

Thank you I have waited three years for something like this to happen luckily I've prepared that whole time with the majority of what I've needed I am prepared as I can get Godspeed

[greens12]

Technical breakout above 1.20, knocking on the door now $$$$$$$$$$$$$$$

VKTX

[greens12]

Hang in there buddy, it looks like a strong one.

Go VKTX

[ZeWaffleBaron]

Thoughts and prayers buddy, take care

[BrazenBull]

very best wishes and blessings to you and your family!

[alx8967]

Feel free to check In with me after Sunday. I pray this city is intact and we are still on the grid.

[alx8967]

Thank you sir very kind of you. We are in sarasota Florida 3 miles from beach

[greens12]

Done buddy alx , what city are you in ? http://images.christianpost.com/ipost/full/547/sandy.jpg?w=500&h=375

[alx8967]

I don't know if you guys are they praying type but if you could throw one up for us here in south FLORIDA .. it's going to be a long weekend.

[greens12]

The MM's in this stock are crooks.

[alx8967]

It's moving like it should. Get ready guys those mms can kick rocks

[greens12]

Ok now we are moving knocking on 1.16 door , lets get to 1.20 today and I will be happy.

VKTX

[greens12]

Yes nice news on 2809, but the stock is hardly moving. The corrupt Market Makers have scared off all the buyers with their crooked Manipulation the last few months. Very disappointing.

[ZeWaffleBaron]

Timing seems good on this PR. Don't think it will do much right now for price, but will likely make others more comfortable putting some money in during the run up to trial results coming up

[ZeWaffleBaron]

Good PR out this morning. Really impressed with the magnitude of effect in the trial. Looks like things keep moving along. Nice to see this data out in a timely fashion! Hopefully you will sleep easier tonight greens (pardon my Thursday morning humor, but it is nice to see them stick to a timeline for a change lol) Have a good day all

http://ir.vikingtherapeutics.com/2017-09-07-Viking-Therapeutics-Announces-Presentation-of-Data-from-In-Vivo-Proof-of-Concept-Study-of-VK2809-in-Glycogen-Storage-Disease-Ia-GSD-Ia-at-the-13th-International-Congress-of-Inborn-Errors-of-Metabolism-ICIEM