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Sunshine Biopharma Inc. (SBFM)

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Last Post: 3/22/2019 9:43:46 PM - Followers: 381 - Board type: Free - Posts Today: 0










 



 



 


"The Future Of Medicine"


 

http://sunshinebiopharma.com





 
Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 





 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

 

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options

 
 
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.







Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 







 
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).



January 29, 2014 S-4
https://www.sec.gov/Archives/edgar/data/1402328/000135448814000422/sbfm_s4.htm

followed again by another withdrawel
https://www.sec.gov/Archives/edgar/data/1402328/000135448814002116/sbfm_rw.htm

RCMP Canada.
http://www.rcmp.gc.ca/en
http://www.antifraudcentre-centreantifraude.ca/reportincident-signalerincident/index-eng.htm

SEC Complaint process
https://denebleo.sec.gov/TCRExternal/index.xhtml
================================================================== 



 



http://sunshinebiopharma.com/investor/press-releases/
 
 
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
 
Chairman and CEO Dr. Steve N. Slilaty Interview 

FDA links:

http://clinicaltrials.gov/ct2/seac/index

 
 

 
We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

 
Intellectual Property

 
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
 
 
 
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com





 

 



 


 

 












































































 
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SBFM News: Current Report Filing (8-k) 03/12/2019 08:39:42 AM
SBFM News: Information Statement - All Other (definitive) (def 14c) 01/31/2019 02:34:30 PM
SBFM News: Proxy Statement - Other Information (preliminary) (pre 14c) 11/28/2018 02:38:18 PM
SBFM News: Quarterly Report (10-q) 11/16/2018 05:03:07 PM
SBFM News: Notification That Quarterly Report Will Be Submitted Late (nt 10-q) 11/14/2018 01:30:48 PM
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PostSubject
#41938  Sticky Note FDA of CANADA ?? https://www.canada.ca/en/health-canada.html PENNIEStoSTACKS 12/18/18 10:57:02 AM
#41532  Sticky Note ALL: 1/20 RS HAS BEEN AUTHORIZED BY THE Learjetter 11/29/18 01:03:41 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Dan (Retired) 10/09/13 10:52:01 AM
#44089   Anyone have the insight on any or that Learjetter 03/22/19 09:43:46 PM
#44088   Volume is picking up.Handshake happy hour deals starting Ex-brokerBry 03/22/19 03:14:12 PM
#44087   All that money could have gone towards drug Learjetter 03/15/19 08:47:40 PM
#44086   And this, from their filing. Note 11 – Learjetter 03/15/19 08:41:01 PM
#44085   I suggest you do your own DD. Google Learjetter 03/15/19 08:32:26 PM
#44084   Why have you been following this for so josh08 03/15/19 06:17:10 PM
#44083   Are there any other catalysts for this stock? josh08 03/15/19 05:22:39 PM
#44082   JUST CALLED CAMILLE THE RAT SEBAALY, NEWS WILL Angel21stCentury 03/15/19 11:45:01 AM
#44081   Anything is possible. Anything. But don't expect it Learjetter 03/14/19 06:00:42 PM
#44080   Do you see this going over .02? Why josh08 03/14/19 04:40:46 PM
#44079   PnD seemed to fail with the ridiculous waste Learjetter 03/14/19 03:41:02 PM
#44078   ANSWER THE PHONE CAMILLE YOU DIRTY ROTTEN SCUMBAG, Angel21stCentury 03/14/19 12:42:41 PM
#44077   Wow! Haven't been exposed to pee-pee kah-kah conversations gooferball 03/14/19 12:04:15 PM
#44076   CAMILLE THAT DIRTY RAT!!!! 10 years and he mamushki 03/14/19 11:37:50 AM
#44075   Camille could only wish to be referenced to Lavaliotis 03/14/19 11:34:15 AM
#44074   THE CAMILLE SEBALLY SCREWED US ALL YOU DIRTY Angel21stCentury 03/14/19 10:54:51 AM
#44073   Respectfully, can a mod please require this person gooferball 03/14/19 10:50:10 AM
#44072   TAKE OUT THE NEWS CAMILLE YOU DIRTY ROTTEN SCUMBAG$$$$ Angel21stCentury 03/13/19 04:13:33 PM
#44071   JUST CALLED CAMILLE, HE SAID BIG NEWS IS Angel21stCentury 03/13/19 04:12:04 PM
#44070   NEWS TOMORROW MORNING$$ HOLD ON TO YOUR DIRTY Angel21stCentury 03/13/19 04:09:23 PM
#44069   Really?!?! How did you come to that conclusion?? Learjetter 03/13/19 03:09:43 PM
#44068   I suspect that something is happening with the Col317 03/13/19 02:47:23 PM
#44067   Happy hour handshake deals taking hold now.Go hang Ex-brokerBry 03/13/19 01:51:40 PM
#44066   I wish there was a way to see Learjetter 03/13/19 12:58:23 PM
#44065   the buying will start right back after lunch!! vinc1712 03/13/19 12:40:38 PM
#44064   CAMILLE IS DROPPING THE POTATOES WHILE ITS HOT$$$$ Angel21stCentury 03/13/19 12:34:34 PM
#44063   I guess that means the MM shorts with stockstalk09 03/13/19 12:32:03 PM
#44062   SEE YOU IN POTATOE LAND$$$$$ Angel21stCentury 03/13/19 12:28:50 PM
#44061   agreed! over 0,02, it might reach 0,04-5 easily imo! vinc1712 03/13/19 12:28:42 PM
#44060   Something is up, their not buying for their stockstalk09 03/13/19 12:26:58 PM
#44059   BIG NEWS TOMORROW MORNING$$$$ Angel21stCentury 03/13/19 12:26:57 PM
#44058   GO CAMILLE GO$$ DUMP ALL YOUR POTATOES$$$$ Angel21stCentury 03/13/19 12:25:45 PM
#44057   BANG THE POTATOES AND CALL HER CAMILLE Angel21stCentury 03/13/19 12:24:16 PM
#44056   something is up with this P O S.....BUY/SELL dirtydozen911 03/13/19 12:21:01 PM
#44055   yup! now that revenus are pourring in (atlas vinc1712 03/13/19 12:12:30 PM
#44054   You know it. Col317 03/13/19 12:09:52 PM
#44053   wow! mms are really pushing it up! big vinc1712 03/13/19 12:05:13 PM
#44052   yesterday 8-k is just the beginning imo, too vinc1712 03/13/19 11:54:28 AM
#44051   Quarterly pump n d. Enjoy!! Happens every quarter. Wait Learjetter 03/13/19 11:45:03 AM
#44050   Exactly. I think I will visit my local cfoofme 03/13/19 11:39:56 AM
#44049   MM are pushing it up with nice «hidden» vinc1712 03/13/19 11:36:44 AM
#44048   Curious if the volume is nothing more than Learjetter 03/13/19 11:26:05 AM
#44047   some good action this morning, might have a run vinc1712 03/13/19 11:17:49 AM
#44046   Place is a joke. It is a personal Learjetter 03/12/19 10:02:58 PM
#44045   Looks like they are trying to suck in cfoofme 03/12/19 09:16:35 PM
#44044   JUST SPOKE TO CAMILLE, HE SAID ITS TIME Angel21stCentury 03/12/19 06:14:21 PM
#44043   ITS TIME TO PUMP THE POTATOES FROM PEI$$$$ Angel21stCentury 03/12/19 05:25:19 PM
#44042   its about that time again. Unfortunately they already Learjetter 03/12/19 04:46:33 PM
#44040   BANG THE POTATOES$$$ NEWS IS COMING$$$$ Angel21stCentury 03/12/19 03:29:52 PM
#44039   GET READY FOR NEWS TOMORROW MORNING$$$$$ Angel21stCentury 03/12/19 03:27:59 PM
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