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Sunshine Biopharma Inc. (SBFM)

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Last Post: 5/25/2022 9:16:08 AM - Followers: 798 - Board type: Free - Posts Today: 6






"The Future Of Medicine"



Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.

Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 

Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

January 29, 2014 S-4

followed again by another withdrawel

RCMP Canada.

SEC Complaint process

Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
Chairman and CEO Dr. Steve N. Slilaty Interview 

FDA links:



We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.
Intellectual Property
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f


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SBFM News: Notice of Effectiveness (effect) 05/23/2022 02:04:23 AM
SBFM News: Prospectus Filed Pursuant to Rule 424(b)(3) (424b3) 05/20/2022 01:00:33 PM
SBFM News: Quarterly Report (10-q) 05/06/2022 10:48:22 AM
SBFM News: Small Company Offering and Sale of Securities Without Registration (d) 04/29/2022 10:13:56 AM
SBFM News: Notice of Effectiveness (effect) 04/11/2022 02:04:41 AM
#107206  Sticky Note This is and always will be a scam Big Eli 02/26/22 11:13:28 AM
#110953   Short interest completely disappeared yesterday. There was FeMike 05/25/22 09:16:08 AM
#110952   Level 2 looks great! ttottip 05/25/22 08:18:48 AM
#110951   Nice time to buy now Byronbud 05/25/22 07:17:37 AM
#110950   Good morning all! This is going to rebound ttottip 05/25/22 07:17:27 AM
#110949   Yea I’m not waiting until 1 dollar I’m maryj55555 05/25/22 07:11:27 AM
#110948   I’ll wait for it to go back to maryj55555 05/25/22 07:10:01 AM
#110947   Let us know if they get back to hssbwwmp 05/24/22 11:46:33 PM
#110946   I left them voicemail haven’t heard back Stockgamer2020 05/24/22 09:36:32 PM
#110945   2021 this was my best stock....2022 the worst....only hockeypond 05/24/22 09:29:50 PM
#110944   Believe the science lol. Smoothie 1 05/24/22 07:49:00 PM
#110943   Almost. It's been 10 years so hssbwwmp 05/24/22 07:33:35 PM
#110942   Has this Stinky-Pinky vitamin re-seller cured cancer yet? Homebrew 05/24/22 07:29:29 PM
#110941   SBFM's IR/PR firm (TraDigital) needs to get busy hssbwwmp 05/24/22 07:28:37 PM
#110940   Somebody wanted 10 million shares and got them. JoeLahr 05/24/22 07:20:35 PM
#110939   Okay so a pump and obviously everyone took posterschild 05/24/22 07:15:27 PM
#110938   Today was one bad joke, wasn't it Jean Naymar 05/24/22 06:41:33 PM
#110937   $1.37 = .00685 for a Nasdaq listed stock. radly 05/24/22 06:14:56 PM
#110936   tomorrow! JoeLahr 05/24/22 06:00:42 PM
#110935   When will the Nasdaq give notice of delisting Money Management 05/24/22 05:56:43 PM
#110934   It sure was bbartgen 05/24/22 05:11:09 PM
#110933   So either you own a lot of this JoeLahr 05/24/22 05:00:29 PM
#110932   Manipulated garbage. Acehole 05/24/22 04:52:26 PM
#110931   What the hell was that? FeMike 05/24/22 04:49:21 PM
#110930   For every seller there's a buyer, people are JoeLahr 05/24/22 04:10:22 PM
#110929   SMh Stockgamer2020 05/24/22 04:04:05 PM
#110928   WTF was that...a flood of volume to pump BlazingStocks 05/24/22 03:42:24 PM
#110927   Right on! bme 05/24/22 03:35:43 PM
#110926   Surprised by the new 52 week low followed BlazingStocks 05/24/22 03:16:46 PM
#110925   Right on! bme 05/24/22 03:11:11 PM
#110924   Nice 50c jump so far BlazingStocks 05/24/22 03:10:42 PM
#110923   Yes and a big one. ttottip 05/24/22 03:02:26 PM
#110922   im just waiting on monkeypox vac. then im rooscogburn 05/24/22 12:25:24 PM
#110921   Reversal today? ttottip 05/24/22 08:31:04 AM
#110917   I’m pretty sure they abused the US stock posterschild 05/23/22 05:56:09 PM
#110916   http://stocktwits.com/joelahr/message/461573027 JoeLahr 05/23/22 05:13:00 PM
#110915   Yeah and I'm dying of thirst here. radly 05/23/22 04:58:37 PM
#110914   Does it include vodka with Dr Pepper? Aka posterschild 05/23/22 04:58:36 PM
#110913   The Dr Pepper will be tough to get bbartgen 05/23/22 03:37:55 PM
#110912   Ummm there are already institutions in it. How bbartgen 05/23/22 03:37:31 PM
#110911   Aren’t they all elderly and entitled to retire? posterschild 05/23/22 03:12:38 PM
#110910   .0079 Great job Sunshine radly 05/23/22 02:58:52 PM
#110909   This is going higher. ttottip 05/23/22 02:43:48 PM
#110908   Let's make some money here! ttottip 05/23/22 01:36:28 PM
#110907   Here's the 1.50's. So predictable. Major BooDog 05/23/22 12:44:50 PM
#110906   Glad we can disagree to agree. Makes perfect bbartgen 05/23/22 10:31:11 AM
#110905   ok, moving on...none of that makes sense. JoeLahr 05/23/22 10:27:22 AM
#110904   My failure to believe? Lmao belief went out bbartgen 05/23/22 10:24:47 AM
#110902   Ya but now I don’t even want to bbartgen 05/23/22 10:10:11 AM
#110900   Almost to my $1.50 FeMike 05/23/22 10:01:33 AM
#110899   Post it. FeMike 05/23/22 10:01:01 AM
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