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Sunshine Biopharma Inc. (SBFM)

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Last Post: 10/17/2019 12:44:31 AM - Followers: 367 - Board type: Free - Posts Today: 1




"The Future Of Medicine"



Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 


Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697


Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options

Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.

Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 

Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

January 29, 2014 S-4

followed again by another withdrawel

RCMP Canada.

SEC Complaint process


Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
Chairman and CEO Dr. Steve N. Slilaty Interview 

FDA links:



We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

Intellectual Property

We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f







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SBFM News: Statement of Changes in Beneficial Ownership (4) 10/07/2019 09:20:22 AM
SBFM News: Amended Statement of Changes in Beneficial Ownership (4/a) 10/07/2019 09:05:05 AM
SBFM News: Amended Statement of Changes in Beneficial Ownership (4/a) 10/07/2019 08:56:20 AM
SBFM News: Amended Statement of Changes in Beneficial Ownership (4/a) 10/04/2019 07:11:06 PM
SBFM News: Amended Statement of Changes in Beneficial Ownership (4/a) 10/04/2019 07:04:34 PM
#44479  Sticky Note You Gotta follow what’s been happening with this Col317 10/15/19 09:23:30 AM
#41532  Sticky Note ALL: 1/20 RS HAS BEEN AUTHORIZED BY THE Learjetter 11/29/18 01:03:41 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Dan (Retired) 10/09/13 10:52:01 AM
#44510   Thy sky is blu. Le bleu. 355m OS Stock__Hawk 10/17/19 12:44:31 AM
#44509   Thought .002s were long gone? Maybe you meant Learjetter 10/16/19 10:52:07 PM
#44508   002+ coming Selling drying up. CDEL just needs Stock__Hawk 10/16/19 10:25:37 PM
#44507   Yes.....they are just gonna make it for free.....sounds Learjetter 10/16/19 08:01:36 PM
#44506   Anyone that’s been paying attention can se that Col317 10/16/19 03:24:09 PM
#44505   Volume GONE! Trips coming! SBFM is now selling tshirts. Learjetter 10/16/19 11:01:08 AM
#44503   The time is NOW. It Looks like Crocus Col317 10/16/19 08:10:12 AM
#44498   “2011“ Seriously... complaining about the development years? Col317 10/15/19 05:39:06 PM
#44497  Restored It always amazes me to see those with Col317 10/15/19 05:30:58 PM
#44496  Restored Prior scammers notifying us of their trials, via Learjetter 10/15/19 05:09:12 PM
#44495   Thanks mate. Cheerio! Why did they give away Learjetter 10/15/19 05:02:39 PM
#44494   Nicely articulated and well stated. Col317 10/15/19 04:40:49 PM
#44492   Things have changed in an aggressive way. Col317 10/15/19 02:25:07 PM
#44491   Every share they have diluted has a value roytoy6969 10/15/19 01:22:15 PM
#44490   When they announce clinical trials has begun this Col317 10/15/19 01:00:20 PM
#44489   I asked why the new website is .org. Col317 10/15/19 12:17:15 PM
#44488   Anyone know why they didnt dilute this to Learjetter 10/15/19 11:57:36 AM
#44486   Wow that’s a smart opinion of SBFM. Col317 10/15/19 11:28:55 AM
#44485   Reality check....Clinical trials that support FDA approvals of Learjetter 10/15/19 10:46:06 AM
#44484   They PRd vegan approval..which was useless....why wouldnt they Learjetter 10/15/19 10:23:27 AM
#44483   wow Such a show of wisdom haha Col317 10/15/19 10:13:41 AM
#44482   They didn’t PR it. Actually they don’t put Col317 10/15/19 10:04:37 AM
#44481   CEO looks as sleazy as he acts. Who Learjetter 10/15/19 09:56:40 AM
#44480   Howd you find that website?? Seems odd. Gonna buy Learjetter 10/15/19 09:38:05 AM
#44479   You Gotta follow what’s been happening with this Col317 10/15/19 09:23:30 AM
#44478   Like any new drug. These things take a Col317 10/15/19 09:02:53 AM
#44477   Holy Cow.... brand new website today. Col317 10/15/19 08:34:32 AM
#44476   What’s gonna happen to SBFM stock price when Col317 10/14/19 10:17:43 PM
#44475   Regardless I think we have great things coming here!!!! Col317 10/14/19 11:23:38 AM
#44474   Thanks I couldn’t remember, but WOW that’s a Col317 10/14/19 10:12:31 AM
#44473   They RS to 85.5 Mil...so they have diluted roytoy6969 10/14/19 09:57:17 AM
#44472   What happened? You were on board 5 days ago. Stock__Hawk 10/14/19 09:29:49 AM
#44471   Anyone Looking at the chart post RS can Col317 10/14/19 09:23:25 AM
#44470   Yup looking forward to it!! 355m OS near Stock__Hawk 10/13/19 10:24:46 AM
#44469   Good close, next week! The Dutchess 10/11/19 04:22:20 PM
#44468   $SBFM exactly, Buying the blood and fear.. PennyMaster 10/11/19 03:30:39 PM
#44467   Yup!! Buy when low sell when high!! Stock__Hawk 10/11/19 03:29:50 PM
#44466   $SBFM .00128 Cross trade in, adding 52 week PennyMaster 10/11/19 03:10:45 PM
#44465   52wk low! .0012 x .0013 The Dutchess 10/11/19 12:16:59 PM
#44464   That's really, really bad advice! Each is unique. All IMO. Learjetter 10/10/19 06:53:02 PM
#44463   We are indeed. Below 400m will see a Stock__Hawk 10/10/19 05:33:02 PM
#44462   Bottom is in!! SBFM get some or Stock__Hawk 10/10/19 05:31:34 PM
#44461   Its being diluted. When they were done, that Learjetter 10/10/19 03:15:09 PM
#44460   $SBFM .0013 looks like a bottom forming last PennyMaster 10/10/19 02:54:35 PM
#44459   If this patent had the potential to cure Learjetter 10/10/19 09:02:28 AM
#44458   Possible. Or they can do what car makers Learjetter 10/10/19 08:43:57 AM
#44457   Exactly. Adva-27a is basically the cure for cancer Col317 10/10/19 04:55:55 AM
#44456   the answer to your question may be big bamaj 10/09/19 10:05:38 PM
#44455   Yay, validation! Year in, hopefully they can update Learjetter 10/09/19 02:07:45 PM
#44454   Of coarse it is and it’s exciting!!!! Col317 10/09/19 01:19:08 PM