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Sunshine Biopharma Inc. (SBFM)

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Last Post: 5/21/2019 9:42:29 PM - Followers: 372 - Board type: Free - Posts Today: 0




"The Future Of Medicine"



Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 


Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697


Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options

Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.

Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 

Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).

January 29, 2014 S-4

followed again by another withdrawel

RCMP Canada.

SEC Complaint process


Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
Chairman and CEO Dr. Steve N. Slilaty Interview 

FDA links:



We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

Intellectual Property

We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f







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SBFM News: Quarterly Report (10-q) 05/20/2019 01:15:45 PM
SBFM News: Notification That Quarterly Report Will Be Submitted Late (nt 10-q) 05/14/2019 11:35:58 AM
SBFM News: Annual Report (10-k) 04/12/2019 05:10:19 PM
SBFM News: Notification That Annual Report Will Be Submitted Late (nt 10-k) 03/29/2019 01:53:26 PM
SBFM News: Current Report Filing (8-k) 03/12/2019 08:39:42 AM
PlusOneCoin Top Posts
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#41532  Sticky Note ALL: 1/20 RS HAS BEEN AUTHORIZED BY THE Learjetter 11/29/18 01:03:41 AM
#11692  Sticky Note Please stay on topic. The only topic to IH Dan (Retired) 10/09/13 10:52:01 AM
#44159   Ah yes, another wonderful filing by the scammers. Learjetter 05/21/19 09:42:29 PM
#44158   Who runs this company? Col317 05/21/19 10:34:38 AM
#44157   Assist dilution IMO. All that nonsense did. Learjetter 05/16/19 12:09:17 PM
#44156   Because anyway you want to look at it, stockstalk09 05/16/19 11:04:00 AM
#44155   Can someone answer me why selling something on Learjetter 05/16/19 10:53:36 AM
#44154   Next news flash as I predict....they will announce Learjetter 05/15/19 07:20:39 AM
#44153   Well look at that. All kinda of 4 Learjetter 05/14/19 02:22:45 PM
#44152   Weeeeeeeelllll, I guessed .0080, .0071 works too! Scams like Learjetter 05/13/19 08:28:51 PM
#44151   YOU ALSO SCREWED YOUR MOM CAMILLE,YOU DIRTY ROTTEN Angel21stCentury 05/13/19 04:47:06 PM
#44150   Yep....this is a scam here todd1975 05/13/19 03:10:53 PM
#44149   CAMILLE,JAIL IS WHERE YOU BELONG IN HELL Angel21stCentury 05/13/19 11:30:17 AM
#44148   ANSWER THE PHONE CAMILLE YOU DIRTY ROTTEN SCUMBAG, Angel21stCentury 05/13/19 11:25:44 AM
#44147   4/14: you made the same prediction. Learjetter 05/12/19 10:27:13 PM
#44146   Mirage deals already agreed on.Get in Monday if Ex-brokerBry 05/11/19 10:41:43 PM
#44145   No paperwork,no fillings,no jibber jabber with the media.Smart,very Ex-brokerBry 05/11/19 03:58:23 PM
#44144   Wow, did some happy hour handshakes take place cfoofme 05/10/19 10:45:19 PM
#44143   It's probably the same BS like a month stockstalk09 05/10/19 04:49:29 PM
#44142   Sure thing. It's the post baiting those uninformed, Learjetter 05/10/19 03:10:12 PM
#44141   My statement was posted well after the fact stockstalk09 05/10/19 02:58:19 PM
#44140   Your statement is exactly why someone bought a Learjetter 05/10/19 11:09:40 AM
#44139   Looks like something is going on, some big stockstalk09 05/10/19 11:05:03 AM
#44138   Yea happy hour handshakes with each other, but Learjetter 05/10/19 12:31:50 AM
#44137   But, but, but, how about all those happy cfoofme 05/09/19 10:27:44 PM
#44136   SBFM is nothing more than a mechanism to Learjetter 05/09/19 04:34:14 PM
#44135   I can believe it......this company is garbage todd1975 05/09/19 02:41:08 PM
#44134   Notes coming due. expect massive dilution/pump. This will Learjetter 05/09/19 12:45:12 PM
#44133   Complete scam! Their filings confirm it's a scam! Learjetter 05/07/19 10:12:27 AM
#44132   Not a SCAM. Col317 05/05/19 04:25:44 PM
#44130   S todd1975 05/05/19 12:40:30 AM
#44129   C todd1975 05/05/19 12:40:20 AM
#44128   A todd1975 05/05/19 12:40:09 AM
#44127   M todd1975 05/05/19 12:39:58 AM
#44126   The nasty locusts should be returning soon to cfoofme 05/03/19 09:43:30 PM
#44124   He said Monday, didnt say which Monday, LOL. SBFM Learjetter 04/30/19 10:01:23 PM
#44123   LOL PENNIEStoSTACKS 04/30/19 08:19:00 PM
#44122   We're still waiting. How about you? Heard from cfoofme 04/25/19 10:01:09 PM
#44121   Good luck finding an OTC company that doesn't roytoy6969 04/24/19 10:58:01 PM
#44120   If anyone is still here, someone really needs iluvcanada 04/24/19 09:58:32 PM
#44119   Anyways, to those that believes SBFM, with no iluvcanada 04/24/19 09:52:52 PM
#44117   Happy hour handshake deals done..get ready for the astonishing. Ex-brokerBry 04/14/19 07:12:02 PM
#44116   Starting Monday it’s up .. up and away..GUARANTEED... Ex-brokerBry 04/14/19 07:06:22 PM
#44115   Love this one... In December 2016, we received monies Learjetter 04/13/19 05:55:09 PM
#44114  Restored LOL, SCAM!!! For the period ended December 31, 2018, Learjetter 04/12/19 07:06:30 PM
#44113   So it appears sbfm made it look like Learjetter 04/04/19 10:31:41 AM
#44111   ADVA27A does NOT exist. They gave the worthless Learjetter 04/03/19 06:40:14 PM
#44110   Lol, talking about trials?!?!? Really? Based on what? Learjetter 04/03/19 06:05:01 PM
#44107   Let them scam away, all the way to stockstalk09 04/03/19 04:10:11 PM
#44106   Lol, theres camilles shell company manipulating the PPS.. Learjetter 04/03/19 04:03:00 PM
#44105   Looks somebody really wanted in today, buying with stockstalk09 04/03/19 03:56:50 PM
#44104   nt 10-K filing (again) Get ready for the pump!!! Learjetter 03/30/19 11:38:34 AM