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Sunshine Biopharma Inc. (SBFM)

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Last Post: 3/27/2020 9:46:06 PM - Followers: 363 - Board type: Free - Posts Today: 0










 



 



 


"The Future Of Medicine"


 

http://sunshinebiopharma.com

https://mobile.twitter.com/sunshinepharma_


 
Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 





 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 
 


Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

 

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.


Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options

 
 
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.







Check out SBFM's drug Adva-27a (27a) vs the leading chem drug Etoposide (2) - results are better in every category except two. And in the multi drug resistance breast cancer category (MCF7R) it's over 3x more effective. 







 
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).
 

January 29, 2014 S-4
https://www.sec.gov/Archives/edgar/data/1402328/000135448814000422/sbfm_s4.htm

followed again by another withdrawel
https://www.sec.gov/Archives/edgar/data/1402328/000135448814002116/sbfm_rw.htm

RCMP Canada.
http://www.rcmp.gc.ca/en
http://www.antifraudcentre-centreantifraude.ca/reportincident-signalerincident/index-eng.htm

SEC Complaint process
https://denebleo.sec.gov/TCRExternal/index.xhtml
================================================================== 



 



http://sunshinebiopharma.com/investor/press-releases/
 
 
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 

SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals
 
Chairman and CEO Dr. Steve N. Slilaty Interview 

FDA links:

http://clinicaltrials.gov/ct2/seac/index

 
 

 
We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.

 
Intellectual Property

 
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
 
 
 
 
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464, Camille.sebaaly@sunshinebiopharma.com
 

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

http://corporatestock.com





 

 



 


 

 







































































https://www.sunshinebiopharma.org/



 
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SBFM News: Proxy Statement - Other Information (preliminary) (pre 14c) 01/06/2020 06:02:56 AM
SBFM News: Quarterly Report (10-q) 11/13/2019 02:56:07 PM
SBFM News: ALYI Rated BULLISH - Momentum Pushing $0.01 Breakthrough and 1000% ROI Potential 11/07/2019 09:03:56 AM
SBFM News: Statement of Changes in Beneficial Ownership (4) 10/07/2019 09:20:22 AM
SBFM News: Amended Statement of Changes in Beneficial Ownership (4/a) 10/07/2019 09:05:05 AM
PostSubject
#45147  Sticky Note PENDING: 2ND RS IN 2YRS. COMPANY REFUSES Learjetter 03/07/20 07:00:53 PM
#45022  Sticky Note 1. They already tested on Humans and found out otced 02/25/20 12:19:30 PM
#11692  Sticky Note Please stay on topic. The only topic to IH Dan (Retired) 10/09/13 10:52:01 AM
#45340   THEY TESTED THIS DRUG ON POTATOES FROM PEI Angel21stCentury 03/27/20 09:46:06 PM
#45339   ITS ALREADY BANKRUPT,THEY SCREWED ALL Angel21stCentury 03/27/20 09:38:07 PM
#45338   WOW YOUR SO SMART Angel21stCentury 03/27/20 09:36:59 PM
#45337   VERY SMART DD WHAT ELSE DO YOU KNOW Angel21stCentury 03/27/20 09:35:19 PM
#45336   THESE CLOWNS NEVER MATERIALIZED AN EVENT ALL THERE CAREERS Angel21stCentury 03/27/20 09:28:27 PM
#45335   *****SBFM reverse split coming ? 1vman 03/27/20 08:53:34 PM
#45334   *****What happened to the clinical trials SBFM was 1vman 03/27/20 08:52:30 PM
#45333   *****SBFM Going bankrupt soon ? 1vman 03/27/20 08:51:23 PM
#45332   *****SBFM .0001 with news ! 1vman 03/27/20 08:49:17 PM
#45331   $sbfm Share Structure Taurus69 03/27/20 08:06:21 PM
#45330   $sbfm http://www.sunshinebiopharma.com/ Taurus69 03/27/20 08:04:42 PM
#45329   $sbfm Sunshine Biopharma is a fully integrated pharmaceutical Taurus69 03/27/20 08:03:56 PM
#45328   $sbfm $.0002 Taurus69 03/27/20 08:01:54 PM
#45327   HOW CAN U TEST THIS TRASH IF ALL Angel21stCentury 03/27/20 02:04:57 PM
#45326   THE XENOGRAPH RESULTS IS JUST LIKE ALL THE Angel21stCentury 03/27/20 02:02:21 PM
#45325   Hey MKAT, Col317 03/27/20 01:54:22 PM
#45324   They Are doing a RS with 2.1bil shares Col317 03/27/20 01:07:56 PM
#45323   THEY NEVER MATERIALIZED AN EVENT, THE ONLY MATERIAL Angel21stCentury 03/27/20 01:05:56 PM
#45322   They haven’t done everything yet... MKAT 03/27/20 01:01:22 PM
#45321   ALL COMPANIES MANUFACTURING ADVA-27A ARE BANKRUPT, ADVA-27A DOESNT Angel21stCentury 03/27/20 12:26:31 PM
#45320   Is it going to happen after the rs? Col317 03/27/20 12:10:49 PM
#45319   No they haven’t, but I showed you the timeline. Col317 03/27/20 11:23:57 AM
#45318   THEY DID NOT ENTER CLINICAL TRIALS CAUSE THEY Angel21stCentury 03/27/20 10:00:34 AM
#45317   Back in stock on amazon US Col317 03/27/20 09:49:44 AM
#45316   This is our last chance ... MKAT 03/27/20 07:18:22 AM
#45315   CALL CAMILLE 514-814-0464 HE SCREWED US ALL. Angel21stCentury 03/27/20 06:12:32 AM
#45314   Rs tomorrow...... morning??? Col317 03/26/20 07:10:45 PM
#45313   WE ARE ALL READY FOR SLILATY TO PULL Angel21stCentury 03/26/20 03:19:20 PM
#45311   “The question is: are we now prepared?“ Col317 03/25/20 05:53:30 AM
#45309   Seriously.... it’s on every financial information site... even Col317 03/24/20 07:00:34 PM
#45308   If you are using the app, click news, Learjetter 03/24/20 04:48:40 PM
#45307   Please show filing that shows another RS otherwise pennyman247 03/24/20 04:45:01 PM
#45306   On this board under the SP... 14c Col317 03/24/20 04:38:15 PM
#45305   Please share where you found this info pennyman247 03/24/20 04:32:46 PM
#45304   1/20 R/S final March 27/20 Col317 03/24/20 04:21:51 PM
#45303   HERE COMES THE NEWS$$$$$$ Angel21stCentury 03/24/20 11:33:48 AM
#45302   Dang, I did!! Someone needs to bet me Learjetter 03/23/20 05:49:23 PM
#45301   You lost lol Joep77 03/23/20 05:47:54 PM
#45300   Anyone else wanna bet this jumps back to Learjetter 03/23/20 03:08:43 PM
#45299   google adva-27a... clinical human trials next.... Col317 03/23/20 12:30:40 PM
#45298   Lol, I'm sure. Learjetter 03/23/20 11:58:08 AM
#45297   Thanks LJ.... but my broker won’t take the Col317 03/23/20 11:55:42 AM
#45295   Price of .0001 is all that needs to Learjetter 03/23/20 10:12:17 AM
#45294   Ya... like I just said Col317 03/23/20 09:47:30 AM
#45293   Dont forget to mention how many times they Learjetter 03/23/20 09:20:43 AM
#45292   Lack of understanding is the enemy. Col317 03/23/20 08:35:39 AM
#45291   NOX pharma!! Get ready for it! Learjetter 03/20/20 08:50:22 PM
#45290   THESE DIRTY SCUMBAGS NEVER MATERIALIZED AN EVENT ALL Angel21stCentury 03/20/20 12:36:23 PM
#45289   THE ONLY THING IS COMING IS BANKRUPTCY,FILLED UP Angel21stCentury 03/20/20 12:26:27 PM
#45288   Soooooo close to .0001 again!!!! Will the morons Learjetter 03/20/20 10:31:52 AM
PostSubject