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Created: 10/27/2008 02:24:11 PM - Followers: 782 - Board type: Free - Posts Today: 1






"The Future Of Medicine"

Topoisomerase II is an enzyme that aggressive cancer cells make too much of. When the cell is able to make a lot of the Topoisomerase II 
enzyme, it becomes able to proliferate and metastasize; so, if you can inhibit or destroy the activity of Topoisomerase II, you would then be 
able to prevent cancer cells from spreading. 

Our  Proprietary Technology

Our licensor, Advanomics Corporation, has developed a way to replace the diester bond with a Carbon-Difluoride bond which acts as a perfect diester isostere.  This technology allows us to create a large variety of therapeutic compounds that are completely stable and often more active than the original drugs.  This unique capability allowed us to create our Lead Compound, Adva-27a, an effective and highly specific Topoisomerase II (Top2) Inhibitor. 

Our Carbon-Difluoride Technology is covered by issued and pending patents filed under PCT/FR2003/002330 and PCT/FR2007/000697

Adva-27a is 16-times more effective at killing multidrug resistant  breast cancer cells than Etoposide, the drug currently in use.

Adva-27a is unaffected by P-Glycoprotein, the enzyme responsible for making cancer cells resistant to anti-tumor drugs.

Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies.

Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.

Adva-27a is an excellent inhibitor of Topoisomerase ll with an IC50 of only 13.7 micromolar.

Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats

Adva-27a's initial indication will be multidrug resistant breast cancer for which there are little or no treatment options
Our Published Data show that Adva-27a is a true Topoisomerase ll Inhibitor and is significantly more effevtive at killing aggressive cancer cells than Etoposide, the current drug of choice.
Unique Features of Adva-27a  

* Adva-27a can be taken orally.
* Adva-27a is not a so-called me-too drug; our technology is unique. Adva-27a will be the only Topoisomerase ll Inhibitor on the Market.
* Adva-27a's initial indication will be multi-drug resistant breast cancer. Adva-27a can be used to treat other Top2 Positive Cancer Types (Prostate, Colon, Lung, Stomach, Ovarian).
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464,
SBFM SEC Filings

Avastin Ousted By FDA For Breast Cancer, Sunshine Biopharma Gears-Up For Clinicals

We were incorporated in the State of Colorado on August 31, 2006 under the name “Mountain West Business Solutions, Inc.”  During our fiscal year ended July 31, 2009 our business was to provide management consulting with regard to accounting, computer and general business issues for small and home-office based companies.  Effective October 15, 2009, we executed an agreement to acquire Sunshine Biopharma, Inc., a Colorado corporation (“SBI”), in exchange for the issuance of 21,962,000 shares of our Common Stock and 850,000 shares of Convertible Preferred Stock, each convertible into twenty (20) shares of our Common Stock (the “Agreement”).  As a result of this transaction our officers and directors resigned their positions with us and were replaced by our current management.  Following completion of this transaction we changed our name to “Sunshine Biopharma, Inc.”.  On December 21, 2011, Advanomics Corporation, a privately held Canadian company (“Advanomics”), and our licensor, exercised its right to convert the 850,000 shares of Series “A” Preferred Stock it held in our Company into 17,000,000 shares of Common Stock.
Intellectual Property
We are the exclusive licensee for the U.S. territory of Advanomics Corporation’s Adva-27a which is covered by international patent applications filed on April 27, 2007 (PCT/FR2007/000697).  These patent applications, which are now issued in Europe and the United States (US 8,236,935) and are still pending elsewhere around the world, were originally owned by Institut National des Sciences Appliquées de Rouen (France) and have recently been purchased by Advanomics Corporation.  On January 14, 2013, Advanomics Corporation filed a new patent application covering Adva-27a manufacturing processes as well as new Adva-27a derivatives and compositions.
Sunshine Biopharma Inc. Contacts:
Camille Sebaaly, CFO, Tel.: 514-814-0464,

SBFM Transfer Agent
Corporate Stock Transfer
3200 Cherry Creek Dr. South
Suite 430
Denver, CO 80209
(303) 282 - 4800 p
(303) 282 -  5800 f

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Agreed. They can only hope for a HoldWhatDoor 09/12/2022 07:29:06 PM
This is and always will be a scam Big Eli 02/26/2022 04:13:28 PM
iluvcanada sniffed out this company 4-5 years ago. mrpennystocks 09/29/2022 01:02:07 PM
May the retirement happen by making History not Stockgamer2020 09/27/2022 04:29:53 PM
Yes, and 4-6 months from now the answer hssbwwmp 09/27/2022 04:08:04 PM
Today will be day 10 VikingSkol 09/27/2022 02:15:35 PM
If you go here, look at the recent mrpennystocks 09/27/2022 12:53:50 PM
Don’t worry nothing has changed joe! Other than bbartgen 09/27/2022 09:24:30 AM
Exactly! people wanna be provocative and say it’s JoeLahr 09/27/2022 07:44:51 AM
Wild. Not surprising, Benzinga is a group JoeLahr 09/27/2022 07:42:39 AM
Have to start considering a delist notification. What mrpennystocks 09/27/2022 05:39:32 AM
In 4-6 months it will be at pennies. HoldWhatDoor 09/27/2022 12:37:01 AM
Well I think we'll know a lot more hssbwwmp 09/27/2022 12:17:05 AM
This is the link to the 2012 Benzinga hssbwwmp 09/27/2022 12:08:13 AM
I’ve gone blind. posterschild 09/26/2022 10:01:00 PM
They'd go to jail... Simple JoeLahr 09/26/2022 08:34:14 PM
I’d imagine having a Fidelity Nasdaq Index Fund mrpennystocks 09/26/2022 07:08:28 PM
This fintel image is easier to read. mrpennystocks 09/26/2022 05:09:52 PM
Indeed. If I was Bridgeway Investments with over mrpennystocks 09/26/2022 03:42:10 PM
So where’d the $40Million in funding from them GMJDubbs 09/26/2022 03:35:55 PM
Any institutional hedge with -100% has left mrpennystocks 09/26/2022 03:28:50 PM
Latest fintel data mrpennystocks 09/26/2022 03:19:37 PM
Uplisted, went as high as $8-12, and made mrpennystocks 09/26/2022 01:01:30 PM
Yeah. About the general sentiment summed up. 2012 article mrpennystocks 09/26/2022 12:29:53 PM
Smh Stockgamer2020 09/26/2022 09:35:43 AM
The point is it doesn't really matter because HoldWhatDoor 09/26/2022 09:16:45 AM
thx .. just catching up Stockgamer2020 09/26/2022 07:58:51 AM
#111968’s not the date on the PowerPoint, which JoeLahr 09/26/2022 07:58:04 AM
Why Sep 21 2022 ? Is that officially Stockgamer2020 09/26/2022 07:55:48 AM
Which link is from 2012 ?? I JoeLahr 09/26/2022 07:35:40 AM
I agree, but I think sadly the new JoeLahr 09/26/2022 07:31:58 AM
I don’t understand from which date are they Stockgamer2020 09/26/2022 07:02:45 AM
He likely put it up to show that HoldWhatDoor 09/25/2022 11:23:19 PM
Wow, I missed that year and read 2022! hssbwwmp 09/25/2022 10:22:49 PM
Ha, it showed up as the most recent. mrpennystocks 09/25/2022 04:13:08 PM
Whoops, that article was from 2012! penny11 09/25/2022 03:50:27 PM
Very interesting development. If SBFM publishes updated cancer hssbwwmp 09/25/2022 03:47:55 PM
Make or break: Biotech Stock Breaking News; Sunshine Biopharma's penny11 09/25/2022 02:56:58 PM
Neither are very well distributed PR's since they mrpennystocks 09/25/2022 02:49:22 PM
Some news came out today and 09/23/2022 / mrpennystocks 09/25/2022 02:45:48 PM
What do you think it means? Green hssbwwmp 09/25/2022 12:24:54 AM
0.065 interesting TRUSTUNITS1000000 09/24/2022 01:49:52 PM
#111952 Jean Naymar 09/23/2022 09:06:58 PM
A material adverse effect usually signals a severe mrpennystocks 09/23/2022 03:01:22 PM
Advanomics corp is Dr Slilaty, where he acquired mrpennystocks 09/23/2022 02:03:11 PM
All the other institutional investment funds are junk, mrpennystocks 09/23/2022 01:48:29 PM
Latest fintel. At least two insiders are at mrpennystocks 09/23/2022 01:36:58 PM
Quiet board TRUSTUNITS1000000 09/23/2022 09:16:11 AM
What is that??? Vaison 09/22/2022 05:31:36 PM
$4M evaporated from the market cap this week. mrpennystocks 09/22/2022 03:46:22 PM
These institutional investors are of interest to me. mrpennystocks 09/22/2022 03:16:00 PM
US8677814035 Institutional Ownership and Shareholders - Sunshine Biopharma In mrpennystocks 09/22/2022 03:10:59 PM
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