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Stemline Therapeutics (STML)

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Last Post: 5/9/2020 5:53:09 PM - Followers: 15 - Board type: Free - Posts Today: 0

Stemline Therapeutics, Inc. is a clinical stage biopharmaceutical company developing novel oncology therapeutics that target both cancer stem cells (CSCs) as well as the tumor bulk. Among Stemline's drug candidates are SL-401 and SL-701, both of which have demonstrated single agent clinical activity in Phase 1/2 studies of advanced cancer patients.

In a multicenter Phase 1/2 trial in patients with advanced hematologic cancer, SL-401 demonstrated single agent activity in multiple indications, including durable complete responses (CRs) in relapsed or refractory acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN), and an overall survival (OS) improvement relative to historical data in the most heavily pre-treated patients. In addition, SL-401 was well-tolerated and was not toxic to the bone marrow. SL-401 is being advanced into a pivotal Phase 2b trial in patients with BPDCN and a registration-directed Phase 2b study in patients with advanced AML. In Phase 1/2 trials, Stemline's second clinical stage therapeutic, SL-701, has demonstrated single agent activity including durable CRs and partial responses (PRs) in adult patients with refractory or recurrent glioblastoma and pediatric patients with malignant glioma, as well as an OS benefit in adult patients with refractory or recurrent glioblastoma compared with historical data. SL-701 is now poised for later stage trials in pediatric and adult patients with advanced brain cancer.

Stemline is also developing a broad portfolio of preclinical small molecules and antibodies for a variety of solid and hematological cancer types. Many of these compounds have derived from the Company's proprietary discovery platform, StemScreen®. Stemline also possesses a landmark portfolio of intellectual property that includes the earliest filings in the CSC field covering CSC-directed therapeutics, diagnostics, and drug discovery.



Stemline Therapeutics has developed a Discovery Platform called StemScreen® to identify novel compounds that target and kill CSCs.

StemScreen®-1 is a 3-step platform which involves:

1. CSC isolation and target identification.

2. Proprietary in silico screen which identifies compound classes that interact with CSC targets.

3. Battery of anti-CSC functional assays that test compounds for activity against CSCs both in vitro and in vivo. In some cases the Company has employed medicinal chemistry to optimize lead compounds. Stemline currently has 6 active oncology programs — three of which have yielded lead compounds to date.

StemScreen®-2 is a proprietary high throughput screen currently in development. StemScreen®-2 takes advantage of a landmark discovery that cancer cell lines harbor CSCs. This technology enables the development of high throughput screens for compounds that target CSCs.


Pre-Clinical Programs



Clinical Programs

 
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STML News: Termination of Registration of a Class of Security Under Section 12(b) (15-12b) 06/22/2020 09:52:59 AM
STML News: Notice of Effectiveness (effect) 06/17/2020 06:02:06 AM
STML News: Notice of Effectiveness (effect) 06/17/2020 06:01:24 AM
STML News: Notice of Effectiveness (effect) 06/17/2020 06:00:54 AM
STML News: Post-effective Amendment to an S-8 Filing (s-8 Pos) 06/10/2020 12:23:08 PM
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#81   Seems to me like the deal isn't set zc182 05/09/20 05:53:09 PM
#80   Short squeeze in progress. TonyJoe1957 05/04/20 08:05:35 AM
#79   CONGRAT$ STML Stemline Therapeutics to be Acquired [SMART MONEY] 05/04/20 07:38:44 AM
#78   Filing: another 7% owner in Stemline: https://ir.stemline.com/static-files/8d9 biotech_researcher 02/14/20 12:13:17 PM
#77   BlackRock discloses 7.4% stake in Stemline: https://ir.stemline.com/sec-filing biotech_researcher 02/06/20 09:46:03 AM
#76   Eventide claims a 8.3% ownership https://ir.stemline.com/static-files/e641d603 biotech_researcher 02/04/20 03:45:31 PM
#75   Added this one to my watch list. trustbutverifyit 12/24/19 08:07:05 AM
#74   Stemline Therapeutics: Post-ASH Update For This Leader In biotech_researcher 12/12/19 05:39:05 AM
#73   ASH clinical trial results https://ir.stemline.com/news-releases/news-release- biotech_researcher 12/10/19 08:24:03 AM
#72   Tagraxofusp has been a welcome new addition and biotech_researcher 12/06/19 08:15:48 AM
#71   Stemline’s three presentations at ASH in Orlando next biotech_researcher 12/05/19 03:04:30 PM
#70   News: $STML Stemline Therapeutics to Present at Piper whytestocks 11/29/19 03:15:18 PM
#69   Stem line reports Q3 results -$13 million in sales https://ir.stemline.com/ne biotech_researcher 11/07/19 05:14:57 PM
#68   STML- Stemline Therapeutics Announces Three ELZONRIS Presentations, Including biotech_researcher 11/06/19 10:45:57 AM
#67   https://ir.stemline.com/news-releases/news-release-details/stemline-therapeutics biotech_researcher 10/08/19 07:36:57 AM
#66   SL-801 Poster from 2019 ESMO http://stemline.com/wp-content/uploads/2019/09/SL- biotech_researcher 09/29/19 09:51:20 AM
#65   News: $STML Stemline Therapeutics Announces Felezonexor (SL-801) Clinical whytestocks 09/27/19 03:00:28 PM
#64   News: $STML Stemline Therapeutics to Present at the whytestocks 09/18/19 11:30:21 AM
#63   Ivan’s presentation at the biotech conference in NY biotech_researcher 09/10/19 10:25:18 AM
#62   Great granular presentation on Stemline’s pipeline.. http://wsw.com/webcast/wed biotech_researcher 08/17/19 04:19:24 PM
#61   STML- • Stemline Therapeutics (NASDAQ:STML) prices its public biotech_researcher 08/09/19 08:03:00 AM
#60   STML up 18% on twice average volume. My biotech_researcher 08/06/19 03:28:09 PM
#59   News: $STML Stemline Therapeutics Announces that CMS Grants whytestocks 08/06/19 02:30:27 PM
#58   * * $STML Video Chart 08-02-2019 * * ClayTrader 08/02/19 05:40:03 PM
#57   Webbush upgrades and raises target to $20 due biotech_researcher 08/02/19 03:12:20 PM
#56   Stemline Theraputics STML Stemline Therapeutics (NASDAQ:STML): Q2 GAAP biotech_researcher 08/02/19 03:08:47 PM
#55   News: $STML Stemline Therapeutics Reports Second Quarter 2019 whytestocks 08/02/19 10:50:22 AM
#54   <div style="width:700px;height:420px;"><iframe src="https://riskvar.com/wp-admin biotech_researcher 07/22/19 10:45:11 AM
#53   STML: Stemline Therapeutics highlights recent clinical and biotech_researcher 07/08/19 09:08:14 PM
#52   https://twitter.com/caesarbiotech/status/773124984914976768?s=21 biotech_researcher 07/07/19 07:37:37 AM
#51   https://www.mdanderson.org/publications/cancerwise/new-blastic-plasmacytoid-dend biotech_researcher 06/23/19 10:58:34 AM
#50   Stemline Therapeutics Announces Presentation of ELZONRIS (tagraxofusp) Preclinic biotech_researcher 06/19/19 09:29:03 AM
#49   This is my pick for one of the biotech_researcher 06/17/19 02:03:23 PM
#48   Three upcoming poster presentations at EHA: http://www.globenewswire.com/news-r biotech_researcher 05/20/19 08:00:40 AM
#47   STML reports Q1 2019 results. First quarter since biotech_researcher 05/11/19 07:03:45 AM
#46   STML has never looked back through all this biotech_researcher 05/09/19 02:44:58 PM
#45   Stemline Therapeutics Announces New England Journal of Medicine biotech_researcher 04/27/19 09:08:23 AM
#44   Ripping...... biotech_researcher 04/23/19 10:11:31 PM
#43   Approved by FDA for BPDCN, rare blood cancer biotech_researcher 04/23/19 02:48:30 PM
#42   CD123 makes a great target for many indications.. biotech_researcher 03/30/19 08:38:43 AM
#41   Sold last week at $9.47 and then bought Lazarus 01/15/19 10:58:36 AM
#40   Unmet medical need. Should strengthen.... biotech_researcher 12/30/18 07:54:30 PM
#39   Now that the stock is in the toilet Lazarus 12/21/18 11:08:47 AM
#38   http://petroglobalnews24.com/2017-03-22-ladenburg-thalmann-financial-services-an cashcow3 03/23/17 08:03:14 AM
#37   Perceptive Advisors LLC bought a new position in cashcow3 03/23/17 08:02:57 AM
#36   Stemline Therapeutics Inc (NASDAQ:STML) has been given a cashcow3 03/23/17 08:01:36 AM
#35   http://www.globenewswire.com/news-release/2017/03/23/943431/0/en/Stemline-Therap cashcow3 03/23/17 08:00:53 AM
#34   HUGE NEWS cashcow3 03/23/17 08:00:36 AM
#33   Stemline Therapeutics Inc (NASDAQ:STML): What’s The Other Side trendmkr 02/03/17 09:12:24 PM
#32   Stemline says patient died during Phase 2 BPDCN trial guchu 02/03/17 09:05:51 AM
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