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Sophiris Bio Inc. (SPHS)

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Last Post: 7/15/2020 12:44:03 AM - Followers: 103 - Board type: Free - Posts Today: 0

Sophiris Bio Inc.



Sophiris Bio Inc. is a Canadian urology company with operations based in San Diego developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH or enlarged prostate), a large unsatisfied market. PRX302, the company’s lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is planning to begin a pivotal trial by the end of 2012.

The pivotal trial is supported by a randomized, controlled Phase IIb study that met the objective and subjective endpoints used as the basis for current BPH drug approvals. Sophiris is advised by world-leading urologists, is backed by experienced investors, and is led by an experienced drug development team that has achieved more than twenty drug approvals including several blockbusters.




 





Ongoing Clinical Development
 
Study Phase Trial Design
PLUS-1
PRX302-3-01 BPH

 

 III On-going/Enrollment Completed (479 patients) Prospective, randomized, double-blind, placebo-controlled, transrectal treatment of PRX302, which will utilize the IPSS outcome measure evaluated at 12 months as the primary endpoint
PRX302-2-7 PCa

 

 IIa Enrolling (approximately 20 patients) Open label, Phase 2a study, evaluating the safety and tolerability of targeted intraprostatic administration of PRX302 to treat men with histologically proven, clinically significant, localized, low to intermediate risk prostate cancer


Completed Clinical Development
 

Study Phase
(pts treated with PRX302		 Trial Design
TRIUMPH
PRX302-2-03 BPH		 IIb (61 pts) Randomized, double-blind, placebo-controlled, transperineal treatment of PRX302
PRX302-2-06 BPH I/II (32 pts) Randomized dose escalation, multicenter trial of a single transrectal intraprostatic treatment of PRX302
PRX302-2-02
Phase 2a BPH		 IIa (18 pts) Open-label, safety, volume escalation clinical trial of a single transperineal treatment of PRX302
PRX302-2-01
BPH		 I (15 pts) Open-label, safety, dose escalation clinical trial of a signal transperineal intraprostatic treatment of PRX302
PRX302 PCa I (24 pts) Open-label, safety and tolerability, dose escalation trial of PRX302 in patients with biopsy-proven, locally-recurrent prostate cancer
PRX302 PCa II (6 pts) Open-label clinical trial in locally-recurrent prostate cancer


$SPHS was $40.00 in 2011 We will be back there soon enough.
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PostSubject
#2953   Why we paying SPHS any attention here..? 5/18/20 Aarons 07/15/20 12:44:03 AM
#2952   WHITTENHALLJR good to see you here, room is KILLERMIKE 06/22/20 09:22:30 AM
#2951   Yep...there's a dropdown on IHUB's quote where you Eli's Gone 06/20/20 12:49:56 PM
#2950   Ahhh thanks .0117 I see on my TD Ameritrade WHITTENHALLJR 06/20/20 12:29:56 PM
#2949   SPHS was delisted from the NASDAQ on March Eli's Gone 06/20/20 12:13:24 PM
#2948   Why is this stuck at $.23? Is it WHITTENHALLJR 06/20/20 12:05:54 PM
#2947   The rose bush is in full bloom, how KILLERMIKE 06/16/20 09:29:21 AM
#2946   WOW, no one is paying attention here KILLERMIKE 06/15/20 12:43:23 PM
#2945   SPHS...007...Reversal Hammer...added here on the Oversold Pincher...Open Gap...0 georgie18 06/05/20 05:42:01 AM
#2944   Pay attention here, something is up with this one. KILLERMIKE 06/05/20 12:16:44 AM
#2943   Oversold. Should bounce nicely from here on WARHAMMER 05/27/20 12:12:56 PM
#2942   Needs more kaboom WARHAMMER 05/27/20 10:50:41 AM
#2941   SPHS huge gap above .10. Volume means WARHAMMER 05/27/20 10:47:34 AM
#2940   Needs a lot more volume... retireat40 05/27/20 10:36:13 AM
#2939   Hey bro sorry I didn't get back with marknet 05/27/20 12:06:03 AM
#2937   Kaboom day here abazaba375 05/26/20 05:40:14 PM
#2936   Solid close. .02 break and hold tomorrow. marknet 05/26/20 05:28:31 PM
#2935   Let's close above .02 today. Break .05 tomorrow. marknet 05/26/20 01:22:30 PM
#2934   Weee. More in store me thinks. Much more. WARHAMMER 05/26/20 12:34:33 PM
#2933   Weeeeee cashes it for a friend abazaba375 05/26/20 12:30:44 PM
#2932   L2 looks very thin for a bounce back ShaneO19 05/26/20 11:40:27 AM
#2931   Welp.... lol Awl416 05/26/20 11:26:55 AM
#2930   Break through those .02s and it's game on. marknet 05/26/20 10:57:07 AM
#2929   Let’s do this! WARHAMMER 05/26/20 10:50:28 AM
#2928   Big wall at .018. retireat40 05/26/20 10:49:09 AM
#2927   Small amounts on the ask. Won't take much marknet 05/26/20 10:43:35 AM
#2926   Nice one for Bottom fishers Awl416 05/26/20 10:41:17 AM
#2925   Agreed. Slow and steady. Nice accumulation and building marknet 05/26/20 10:40:51 AM
#2924   Just the first leg imo hb90 05/26/20 10:35:02 AM
#2923   Bids creeping up. Very solid trading here. marknet 05/26/20 10:34:16 AM
#2922   Almost broke out...nice move though. retireat40 05/26/20 10:30:59 AM
#2921   Already almost passed Friday's volume with majority traded marknet 05/26/20 10:29:14 AM
#2920   .10+ maybe this week. marknet 05/26/20 10:26:13 AM
#2919   Think they know where this is going! Likely marknet 05/26/20 10:24:59 AM
#2918   Definitely can see that today. Really solid here. marknet 05/26/20 10:23:31 AM
#2917   SPHS buying some for the real move WARHAMMER 05/26/20 10:23:25 AM
#2916   1 mil bid at 0125 hb90 05/26/20 10:21:34 AM
#2915   Good amount of shares exchanged 015+ next leg hb90 05/26/20 10:19:51 AM
#2914   Let's get through .06s then there's nothing til .7056. marknet 05/26/20 10:05:39 AM
#2913   Awesome volume! Lets take out those .03s. marknet 05/26/20 09:55:54 AM
#2912   Huge volume! .04s in sight. marknet 05/26/20 09:54:21 AM
#2911   Break through .016 and and whole lot of marknet 05/26/20 09:53:14 AM
#2910   Indeed hb90 05/26/20 09:49:19 AM
#2909   .01 break and hold should send this. marknet 05/26/20 09:48:17 AM
#2908   Nice volume first few minutes. Crazy thin stock! hb90 05/26/20 09:34:45 AM
#2907   Huge accumulation on Friday on 1.8 million volume. marknet 05/25/20 08:33:04 PM
#2906   #1 small cap performer on Friday. marknet 05/25/20 08:14:56 PM
#2905   1000% coming here. Gonna be a nice gap marknet 05/25/20 08:05:37 PM
#2904   SPHS no pullback at all on Friday. Closed marknet 05/25/20 07:18:34 PM
#2903   Will likely open at .009 and hit .015 marknet 05/25/20 06:22:58 PM
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