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Sophiris Bio, Inc. (SPHS)

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Last Post: 2/21/2018 7:51:01 PM - Followers: 124 - Board type: Free - Posts Today: 0

Sophiris Bio Inc.

Sophiris Bio Inc. is a Canadian urology company with operations based in San Diego developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH or enlarged prostate), a large unsatisfied market. PRX302, the company’s lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is planning to begin a pivotal trial by the end of 2012.

The pivotal trial is supported by a randomized, controlled Phase IIb study that met the objective and subjective endpoints used as the basis for current BPH drug approvals. Sophiris is advised by world-leading urologists, is backed by experienced investors, and is led by an experienced drug development team that has achieved more than twenty drug approvals including several blockbusters.


Ongoing Clinical Development
Study Phase Trial Design
PRX302-3-01 BPH


III On-going/Enrollment Completed (479 patients) Prospective, randomized, double-blind, placebo-controlled, transrectal treatment of PRX302, which will utilize the IPSS outcome measure evaluated at 12 months as the primary endpoint
PRX302-2-7 PCa


IIa Enrolling (approximately 20 patients) Open label, Phase 2a study, evaluating the safety and tolerability of targeted intraprostatic administration of PRX302 to treat men with histologically proven, clinically significant, localized, low to intermediate risk prostate cancer

Completed Clinical Development

Study Phase
(pts treated with PRX302
Trial Design
PRX302-2-03 BPH
IIb (61 pts) Randomized, double-blind, placebo-controlled, transperineal treatment of PRX302
PRX302-2-06 BPH I/II (32 pts) Randomized dose escalation, multicenter trial of a single transrectal intraprostatic treatment of PRX302
Phase 2a BPH
IIa (18 pts) Open-label, safety, volume escalation clinical trial of a single transperineal treatment of PRX302
I (15 pts) Open-label, safety, dose escalation clinical trial of a signal transperineal intraprostatic treatment of PRX302
PRX302 PCa I (24 pts) Open-label, safety and tolerability, dose escalation trial of PRX302 in patients with biopsy-proven, locally-recurrent prostate cancer
PRX302 PCa II (6 pts) Open-label clinical trial in locally-recurrent prostate cancer

$SPHS was $40.00 in 2011 We will be back there soon enough.
Current Price
Bid Ask Day's Range
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SPHS News: Annual Report (10-k) 03/21/2018 04:44:32 PM
SPHS News: Current Report Filing (8-k) 03/21/2018 04:14:27 PM
SPHS News: Sophiris Bio Reports Fourth Quarter and Full Year 2017 Financial Results and Key Corporate Highlights 03/21/2018 04:05:00 PM
SPHS News: Sophiris Bio to Present at 17th Annual Needham Healthcare Conference 03/15/2018 04:05:00 PM
SPHS News: Sophiris Bio to Participate in the 10th Annual Biotech Showcase Conference 12/27/2017 09:00:00 AM
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#2833   Breakout maybe in March month. nymostwanted 02/21/18 07:51:01 PM
#2832   Soon as this market settle we start to nymostwanted 02/11/18 05:09:20 PM
#2831   May be higher in March BurntNAlive 02/08/18 02:31:04 AM
#2830   $3 plus by March 2018 nymostwanted 02/07/18 03:54:16 PM
#2829   $SPHS 2’s panic will set in along with MazelTov 01/26/18 07:24:09 PM
#2828   $SPHS take your ego out of this, you MazelTov 01/26/18 07:23:17 PM
#2827   We are ready to blast off. News to BurntNAlive 12/31/17 12:06:31 AM
#2826   2018 Boom buyout coming shorties ... nymostwanted 12/28/17 10:21:48 PM
#2825   $SPHS Overbought Garbage Back to $1 MazelTov 11/29/17 12:36:52 PM
#2824   Dream man Dream! BurntNAlive 11/19/17 08:45:35 PM
#2823   $SPHS .25 coming. Timmmmmmmmmmber MazelTov 11/15/17 08:50:15 PM
#2822   Patience bud nymostwanted 11/02/17 12:18:26 AM
#2821   Well, was it good news? eazolan 11/01/17 04:56:41 PM
#2820   Full enrollment news due before end of month nymostwanted 10/18/17 08:47:30 PM
#2819   Next week looking good. nymostwanted 09/22/17 08:44:47 PM
#2818   Agree! BurntNAlive 09/17/17 06:42:03 PM
#2817   BurntNAlive, Thanks for the information, and definitely it is Maple tree 09/17/17 04:43:10 PM
#2816   Expecting this to fly during 1 qtr of BurntNAlive 09/16/17 06:05:02 PM
#2815   I bought sphs when it was less than Maple tree 09/16/17 12:25:28 PM
#2814   Love this company soon will save people lives. nymostwanted 08/15/17 06:59:19 PM
#2813   Nice earnings! nymostwanted 08/10/17 07:04:50 PM
#2811   August 8th -15th not confirmed. nymostwanted 07/28/17 05:19:47 PM
#2810   When do we expect it? BurntNAlive 07/28/17 12:14:23 PM
#2809   Should expect news soon coming into earnings report. nymostwanted 07/27/17 05:13:53 PM
#2808 nymostwanted 07/25/17 05:56:19 PM
#2807   Excellent article. Just wish it put Sophiris' name Boolsyet 07/24/17 08:20:45 PM
#2806 nymostwanted 07/23/17 03:43:10 PM
#2805   Yes far more active! Lnp30 07/11/17 05:14:09 PM
#2804   Thanks for introducing me to stock twits it's nymostwanted 07/11/17 04:10:06 PM
#2803   What a let down this week.. nymostwanted 07/07/17 05:56:44 PM
#2802   Dude get stock twits... Lnp30 07/06/17 04:42:26 AM
#2801   Sphs CEO article click June 27th nymostwanted 07/05/17 11:26:36 PM
#2800 nymostwanted 07/05/17 11:25:05 PM
#2799   Hoping for some merger news this year. nymostwanted 07/05/17 11:09:15 PM
#2798   Happy 4th of July everyone hope for some nymostwanted 07/04/17 03:10:28 PM
#2797   Lol very funny you wish to get 1.40s.. nymostwanted 07/03/17 02:47:16 PM
#2796   Extremely Bearish Wicked_600hp_67_vette 07/02/17 10:24:32 PM
#2795   Waiting on the 1.40's to cover and go long. Wicked_600hp_67_vette 07/02/17 10:22:02 PM
#2794   Let's continue this uptrend all week show some nymostwanted 06/27/17 07:10:38 PM
#2793   Very soon! BurntNAlive 06/26/17 07:59:54 PM
#2792   Bring me some good news today $ph $ nymostwanted 06/26/17 09:22:28 AM
#2791   the company interested would not need to wait BurntNAlive 06/25/17 05:07:44 PM
#2790   I believe partnership will be done before a Gremlins 06/25/17 01:12:48 PM
#2789   But you know this can go $4 plus nymostwanted 06/25/17 11:13:09 AM
#2788   Is there any chance $sphs will announce dilution flm09 06/25/17 09:56:39 AM
#2787   Thank You! I am waiting for the institutions BurntNAlive 06/24/17 02:42:48 AM
#2786   I certainly hope so. I believe in SPHS Boolsyet 06/24/17 01:36:00 AM
#2785   Small caps usually perform better on the Russell. nymostwanted 06/23/17 07:34:24 PM
#2784   How this would help? I have lot of BurntNAlive 06/23/17 06:50:21 PM
#2783   From next week a different sphs. Russell nymostwanted 06/23/17 04:25:37 PM