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Sophiris Bio, Inc. (SPHS)

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Last Post: 6/13/2017 8:18:55 PM - Followers: 127 - Board type: Free - Posts Today: 0

Sophiris Bio Inc.

Sophiris Bio Inc. is a Canadian urology company with operations based in San Diego developing a late-stage, highly targeted treatment for benign prostatic hyperplasia (BPH or enlarged prostate), a large unsatisfied market. PRX302, the company’s lead candidate for BPH, is designed to be as efficacious as pharmaceuticals, less invasive than the surgical interventions, and without the sexual side effects seen with existing treatments. Sophiris is planning to begin a pivotal trial by the end of 2012.

The pivotal trial is supported by a randomized, controlled Phase IIb study that met the objective and subjective endpoints used as the basis for current BPH drug approvals. Sophiris is advised by world-leading urologists, is backed by experienced investors, and is led by an experienced drug development team that has achieved more than twenty drug approvals including several blockbusters.


Ongoing Clinical Development
Study Phase Trial Design
PRX302-3-01 BPH


III On-going/Enrollment Completed (479 patients) Prospective, randomized, double-blind, placebo-controlled, transrectal treatment of PRX302, which will utilize the IPSS outcome measure evaluated at 12 months as the primary endpoint
PRX302-2-7 PCa


IIa Enrolling (approximately 20 patients) Open label, Phase 2a study, evaluating the safety and tolerability of targeted intraprostatic administration of PRX302 to treat men with histologically proven, clinically significant, localized, low to intermediate risk prostate cancer

Completed Clinical Development

Study Phase
(pts treated with PRX302
Trial Design
PRX302-2-03 BPH
IIb (61 pts) Randomized, double-blind, placebo-controlled, transperineal treatment of PRX302
PRX302-2-06 BPH I/II (32 pts) Randomized dose escalation, multicenter trial of a single transrectal intraprostatic treatment of PRX302
Phase 2a BPH
IIa (18 pts) Open-label, safety, volume escalation clinical trial of a single transperineal treatment of PRX302
I (15 pts) Open-label, safety, dose escalation clinical trial of a signal transperineal intraprostatic treatment of PRX302
PRX302 PCa I (24 pts) Open-label, safety and tolerability, dose escalation trial of PRX302 in patients with biopsy-proven, locally-recurrent prostate cancer
PRX302 PCa II (6 pts) Open-label clinical trial in locally-recurrent prostate cancer

$SPHS was $40.00 in 2011 We will be back there soon enough.
Current Price
Bid Ask Day's Range
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SPHS News: Sophiris Bio Announces that the First Patient Has Been Dosed in Phase 2b Study of Topsalysin in Patients with Clinically Sign... 06/08/2017 08:00:00 AM
SPHS News: Current Report Filing (8-k) 06/02/2017 04:08:16 PM
SPHS News: Statement of Changes in Beneficial Ownership (4) 06/01/2017 04:36:45 PM
SPHS News: Statement of Changes in Beneficial Ownership (4) 06/01/2017 04:35:54 PM
SPHS News: Statement of Changes in Beneficial Ownership (4) 06/01/2017 04:35:28 PM
#2782   Keep pushing shorts just keep loading up shorts please.. nymostwanted 06/13/17 08:18:55 PM
#2781   Let's hope. Holding 15.5 k shares here still Lnp30 06/12/17 01:49:43 PM
#2780   Yes yes of course, I believe sphs nymostwanted 06/12/17 01:21:06 PM
#2779   You were holding the line during the roughest Lnp30 06/12/17 09:40:21 AM
#2778   I am coming back soon don't mind buying nymostwanted 06/12/17 08:53:18 AM
#2777   I just can't believe you abandoned xxii. Xxii Lnp30 06/12/17 08:37:48 AM
#2776   Wake up SPHS.. nymostwanted 06/07/17 05:07:21 PM
#2775   Thank you good luck to you as well, hwpbnj 06/05/17 07:40:42 PM
#2774   No problem good luck hope you take profits nymostwanted 06/05/17 07:28:40 PM
#2773   Or it's at .30 easy ;). I'm not hwpbnj 06/05/17 07:18:26 PM
#2772   But you know how these bio works right? nymostwanted 06/05/17 07:17:30 PM
#2771   Absolutely. I have plenty of wiggle room. Been hwpbnj 06/05/17 06:51:56 PM
#2770   $PH $ healthy long term.. nymostwanted 06/05/17 06:51:33 PM
#2769   But hey more of you better for me nymostwanted 06/05/17 06:50:38 PM
#2768   I feel sorry for you did you. You nymostwanted 06/05/17 06:49:51 PM
#2767   Goodnight :) hwpbnj 06/04/17 10:45:48 PM
#2766   Good Night and dream that price if you BurntNAlive 06/04/17 10:45:06 PM
#2765   80,000 shares right to buy stock options filed.. nymostwanted 06/01/17 05:39:08 PM
#2764   Still short. Will cover at 1.25. Goodnight hwpbnj 05/31/17 10:42:07 PM
#2763   Yes this is great news now we should nymostwanted 05/23/17 04:48:45 PM
#2762   AH NEWS Awl416 05/23/17 04:21:06 PM
#2761   Where is the partnership announce it already let's nymostwanted 05/16/17 11:33:43 AM
#2760   .06 jump after hours to return to 2.65 AprilFool 05/15/17 05:25:16 PM
#2759   Important updated info: melaurian 05/12/17 09:05:53 AM
#2758   Waiting on the next good thing .. nymostwanted 05/07/17 03:59:38 PM
#2757   We are in both, currently very + with each. north40000 04/04/17 09:00:57 PM
#2756   I let you know when I buy back nymostwanted 04/03/17 07:11:25 PM
#2755   Lots more risk in this one IMO. But Lnp30 04/03/17 06:19:06 PM
#2754   Too much positive data here and lots of nymostwanted 04/03/17 05:45:43 PM
#2753   Not too too late to turn back! Lnp30 04/01/17 09:09:47 PM
#2752   We just need some good volume and we nymostwanted 04/01/17 01:14:02 PM
#2751   SPHS bullish 2.7800 stocktrademan 03/28/17 04:18:57 PM
#2750   Updated PRX302 PC Ph2a Results Abstract Poster djpope 03/27/17 01:02:53 AM
#2749   They said they won't be using cash from nymostwanted 03/26/17 05:25:56 PM
#2748   don't they need to raise cash soon? Any StocksInvestor 03/26/17 05:21:59 PM
#2747   Need to break $3.25 to confirm a higher nymostwanted 03/25/17 05:53:55 PM
#2746   Topsalysin Data from Successful Phase 2a Localized Prostate AprilFool 03/23/17 05:04:54 PM
#2745   Great news, let's go mike007 03/23/17 04:29:15 PM
#2744   Where is our 10Q !!! Let's go .. Gremlins 03/21/17 05:11:19 PM
#2743   Be careful today shorts;) nymostwanted 03/16/17 09:34:57 AM
#2742   check AVIR it went up on Friday from pad72m 03/13/17 01:15:44 PM
#2741   SPHS News Views and Commentary updated: melaurian 02/25/17 06:42:31 PM
#2740   38 Mil shares fully diluted. Bullish Betz 02/20/17 06:42:14 AM
#2739   It went to 8 on news. What news K-Pax 02/16/17 09:47:06 AM
#2738   He's not far off. What do we have Lnp30 02/15/17 11:59:42 AM
#2737   I dunno why it went to $8 before? nymostwanted 02/15/17 09:46:02 AM
#2736   $10-15 based on what? K-Pax 02/15/17 08:26:02 AM
#2735   Thanks & you are very Welcome djpope 02/14/17 08:23:05 PM
#2734   You on top of your game, I never nymostwanted 02/14/17 08:07:07 PM
#2733   Yes share price held steady for 6 months djpope 02/14/17 07:46:54 PM