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Hi Steve some quick notes ..hope they help.
I use Twitter a lot to stay current with Shockwave Medical , IVL etc and the conferences they present at .
I suggest you look into Vascepa for your PAD , diabetes etc
https://www.healio.com/news/cardiology/20211117/icosapent-ethyl-provides-consistent-benefit-in-patients-with-without-prior-pad
I'm prescribed Vascepa .
I want indépendant confirming trials of the risk reduction seen in the REDUCE -IT trial ( and thus are not welcomed much on the AMRN board ) ......but I'm willing to take Vascepa for CV risk reduction as I believe there is some benefit, but maybe not as much as claimed.
If you don't have a history of Afib or bleeding risks ...I'd definitely talk to your MD about it and review the research .
I'm not an MD so best you do your own DD
Good luck
Kiwi
Thanks, Kiwi
You seem to be able to gain information from many sources that I am not even aware of! I never received anything from Shockwave from their "blog" even though I signed up for it...disappointing!
I worry about my symptoms: cold feet (both), pain, especially left big toe, and diagnosed with PAD. & diabetic neuropathy..hope this does not develop into something worse...my vascular surgeon sees me again in Sept for IB's and follow up.
I need to wear my bregg fusion oa knee brace until late June; this other doctor (ortho doc) said I should not go for walks for my meniscus tears to heal, along with my osteo-arthritis...it's bad getting old...he suggested NO planned walking just pretty much hanging around the house...it's driving me nuts.....regards, Steve
New data has dropped! Amazing #SCAI2023 presentation from the @SCAI Early Career Research Grant Winner Dr. @nmbutala, concluding that, since its release 2 years ago, #ShockwaveIVL has transformed the calcium modification landscape. See the data:
ISI http://bit.ly/3iEq7fC
Image
Image
Image
2:44 PM · May 19, 2023
New data has dropped! Amazing #SCAI2023 presentation from the @SCAI Early Career Research Grant Winner Dr. @nmbutala, concluding that, since its release 2 years ago, #ShockwaveIVL has transformed the calcium modification landscape. See the data:
— Shockwave Medical (@ShockwaveIVL) May 19, 2023
ISI https://t.co/sZ0NdzYl2t pic.twitter.com/ohAFXtcH91
Kiwi:
I take 20mg atorvastatin (Lipitor) my chol is 199, but my hdl is low and ldl hi, 500 mg Metformin, diabetes is under good control, A1c below 6.6, and 20/25 Lisinopril/Hydro...live in Wash DC metro area,..seems like SWAV IR does not want to answer simple question about docs in this area using Shockwave IVL or hospitals...like John Hopkins, etc....she never answered about OCT imaging...lol
Best, Steve
Hi Sab. I'm in Nth Ca . Originally from New Zealand ( thus the Kiwi ). Came to the US on a grad student visa that lead to a green card etc .
Great to hear U don't have CLI
I've been on max dose Statins since 1987 due to inherited HeFH ( high LD cholesterol ).
One concern with long term Statin use is the build up of calcified plaques in ones coronaries ..The last angiogram I had in 2016 identified the extent of my coronary plaques which were deemed not large enough at that time ( thankfully ) to require stents ...just max medical therapy ...hello Repatha .
So I've followed the Cardiovascular space a lot over the past 10 yrs
Some major SWAV presentations at EuroPCR...including a live case . Should be on the Shockwave website in the coming days ...including one on the importance of using of OCT imaging to optimize vessel prep and stent deployment .
Kiwi
Wow! Kiwi
You are so informed that it blows my mind on this....appreciate the information which I will try to keep track of....I assume you are in Australia? Don't know where you get this information, but I really appreciate it.
BTW, I thought I had every indication for CLI, but was told by my vascular surgeon that I don't have it! My left big toe is always terribly sore along with the tingling, pain, numbness, etc, in my lower extremities and with my current knee problem another source of discomfort. I was told to wear this Bregg Brace for at least another 5-6 weeks to see if it heals....since Feb, but now getting better...
Please keep me up on things, please! I didn't get too much from the blog from yesterday, but hoping that Thursday will be helpful....best
CHAPTER 12
Intracoronary Imaging-I: Step-by-Step Technique for Intravascular Ultrasound (IVUS)
Poonam Velagapudi, MD, MS, 1 J. Dawn Abbott MD2 1University of Nebraska Medical Center, Omaha, NE 2Brown University, Providence, RI
Introduction
Intravascular ultrasound (IVUS) imaging has evolved as an adjunct to coronary angiography for
understanding coronary pathology. This technique has enhanced the ability to characterize intracoronary plaque morphology and guide intervention.
When compared with two – dimensional coronary angiography, IVUS has the advantage of providing three – dimensional information about the coronary arteries, including lesion quantification (vessel dimensions, lesion size, severity and volume) and anatomical architecture (arterial remodeling, thrombus, and dissection).
It can also be used to assess atherosclerotic plaque composition, such as extent of calcification, which can help guide an interventional strategy and optimize results after drug eluting stent (DES) deployment. IVUS provides information about stent expansion and apposition, which may help decrease occurrence of stent thrombosis (ST) and in-stent restenosis (ISR) down the line. In this chapter, we discuss the indications for IVUS, various types of IVUS catheters, and procedural technique including challenges.
my emphasis
Kiwi
Sab. this is what I posted to Dew recently
ce post# 246963
Monday, May 15, 2023 7:38:53 PM
Post# of 247029
Dew the trend is increasingly " if you can cross then you should shock "
This refers to crossing the blockage with an IVL catheter . If the calcified plaque is blocking so much of the coronary that they can't cross with the IVL catheter then they use the atherectomy device to create an opening .
What is the disadvantage of intravascular lithotripsy?
However, the main disadvantage of IVL is the low crossability of the balloon. 2 In balloon-uncrossable lesions, atherectomy or excimer laser remains the initial option.Sep 23, 2022
Atherectomy devices have always had a risk of distal embolisms . That has never occurred with Shockwaves IVL that I'm aware of.
The imaging techniques now available ( IVUS etc ) allow the interventionist to better see the amount of calcified plaque in the artery ...so as to better evaluate wether they can cross the blockage or not.
The new imaging technology available has helped increase the use of IVL.
Coronary angiography often underestimates calcium.[16] In our experience, optical coherence tomography (OCT) is the preferred imaging modality due to its high spatial resolution and ability to measure calcification thickness.
Intravascular ultrasound imaging (IVUS) is a valid alternative. In an in vivo sensitivity assessment of 440 lesions, OCT detected calcium in 76.8% and IVUS in 82.7% of lesions, whereas angiography identified calcium in only 40.2% of lesions.[17]
. ( my emphasis )
What has also changed recently is that reimbursement for the cost of the IVL procedure has significantly increased in both the US and Germany .
Re PAD vs CAD . SWAV probably breaks that down in their qtly reports .
I know IVL for PAD is getting a lot of interest from those that treat diabetic foot ulcers ...CLI ( critical limb ischemia ) ...below the knee applications .
In Japan they use IVUS or OCT in all coronary procedure .
SWAV ( IVL ) is expected to do well there
Just my thoughts . I'm an investor ..not an MD .
Kiwi
Kiwi:
I wrote to IR (Debbie) Kaster about IVUS or COT for imagining and she replied that they do NOT track this..why do you think this is important and relates to Shockwave IVL?
Further I asked for information on vascular docs who use this procedure and are trained in this area in the Wash DC metro area (Maryland and Virginia)...I was thinking John Hopkins might be doing this.
Best
Yes, I guess Gotshall is recruiting people from $BSX where he also was employed, hence the earlier speculation that a potential acquirer was $BSX....maybe some truth to that? $275 seems to be too cheap...
Interesting addition to the BOD
Thx re VKTX. Dew's board helped a lot there .
Let me know how the blog goes if you watch / listen.
I think they are presenting at the big Cardio conference in the EU now , plus a training day on the new catheter in Paris
By the way ..if you ever have an IVL procedure ...be sure to get it done where the facility also uses IVUS or OCT for imaging
Kiwi
Now that I'm flat on this position, Kiwi.....I've observed that the low was at a prior recent low and held up...it's roughly trading where I sold (279)....maybe Thursday's Blog will change the perception on the price.....you have a great low cost entry, mine was not as low, so I just wanted to lock in a gain...golden cross today....btw, congrats on the binary result on $VKTX
Kiwi:
I had seen that and you're right when the CFO sells it's not received well although he has a lot of shares...over $500k is quite a lot!
I sold out today around the lows and had I not been biased and greedy would have taken in more, but my profit was appx $29 per share....
I'm most interested in when the CMS sees the advantage in using this technology rather than the more aggressive and inferior Atherectomy....hopefully, as you might be thinking in August or September.
I am now on their mailing list and receive all of the sec filings, blog info, etc.
Hi Sab. I think the reaction is to the CFO's open market sale ( not pre planned ) of around 2,000 shares ....which he would probably not be doing if he felt a BO was imminent .
Just my quick take
Sorry I don't have time rt now to link the Form 4
Kiwi
Surprised with the reaction, I think I will take a small profit here and approach again....as you know my purpose on Shockwave IVL is for my own personal medical reasons...I realize we have another blog on Thursday and I am signed up for it...
Better to have a small profit than trying to figure out a good price level to take another entry..
Kiwi
That was a very timely 23 min with Dr. Jonathan Hill on C+2, thanks for giving me a heads up on it!
Kiwi:
I was able to listen to this presentation in between my tasks today & thanks again! I actually signed up for this blog (which I was unaware of)...so hopefully I will get update notices....I did see that another one comes on this coming Thursday!
I will try to listen to this 23 min presentation after Mother's Day when our whole family comes over to visit us and honor their Mom.....Shockwave C+2 is something new and points to good things, I hope!
Kiwi
I pretty much agree with this, except for the golden cross (50 day above the 200 day); sometimes it works like magic and often it does not...let's hope it works this time....the set up for it is nice....I mostly use the RSI and OBV, too....with MACD as confirming the trend. A negative was the RSI dropping as we tapped into a new high print...that's a negative divergence.
Best of luck...stock and (for me) eventual use of Shockwave...
Thanks for that, will read when my service is up again on my laptop hard to handle with this small device
Thanks, our internet is out so I am answering via my iPhone, should be working by tomorrow
Hi Sab A technical analysis today for you from Real Money
Kiwi
Looks like something is up! potential target I have (minimum) is $359....I think it could go over $400....you are probably on West Coast, so hopefully pre-market of $306 will confirm the breakout!
Thanks, Kiwi.......hopefully Matson was really impressed now!
IBD's take
SWAV Stock Tops An Early Entry
Shockwave shares are within striking distance of a buy point at 300.10 out of a cup-with-handle base, according to MarketSmith.com. The base is deeper than normal, but the handle has good form.
SWAV stock is also 8% above its 21-day moving average, clearing an early entry near 293. Investors could buy now around the early entry and add shares if Shockwave moves above the 300.10 buy point.
Shockwave stock is benefiting from the company's bullish growth. In the first quarter, sales rocketed 72% to $161.1 million, easily beating Wall Street's call for $147.3 million. Earnings more than doubled on a year-over-year basis, hitting $1.03 a share. That soundly beat estimates for 79 cents.
Coronary sales surged 62% after Shockwave launched its new device, dubbed C2 Plus, outside the U.S.
"Management noted that early feedback has been very positive and that they have seen C2 Plus used in long calcified segments with complex lesions," Matson said.
Matson notes C2 Plus can use a maximum of 80 electrical pulses to break apart calcifications. More than 70% of C2 Plus cases to date have hit that maximum. This indicates physicians are taking advantage of the enhanced capabilities of C2 Plus vs. the original C2, he said.
This could be a promising indicator for demand when Shockwave launches the new system in the U.S. in the fourth quarter.
Peripheral sales rocketed almost 98% in the U.S. and more than 133% abroad.
SWAV stock investors are now watching for how the launch of the new L6 system in the U.S. in April will impact second-quarter sales. Shockwave designed the L6 system for larger vessels, giving it "a more uniform, high energy profile for large vessel lesions," Matson said.
--------------------------
Kiwi
Thanks much, Kiwi...
I've been busy today adapting to my costly Breg Fusion OA Plus Brace this morning...it's hard getting used to it, but at least the doctor's PA said that I might get better within 4-6 weeks!
She said I had a preliminary fracture which I did not read correctly on the MRI report....so AO, 2 meniscus tears and now fracture...how in the heck did I get that? ....lol
Let's get a buyout at $350 to $400 !!!
Sab. More buyout spec this am .
Medtronic and JNJ appear interested.
SWAV apparently may consider offers in the mid $300's
BSX's offer was reported to be $275 and a mix of cash and stock
Kiwi
Congrats on 58 yrs of marriage . Yes I'm also too old to live thru another patent challenge . The risk is that Boston Sci is working on their own version of IVL and used the recent negotiations to get a better insight into what SWAV was doing .
Kiwi
Thanks, Kiwi.....hope you have improving good health and quality of life! My current struggles are related to my lower extremities with PAD and calcium build up; and recently meniscus tears and osteoarthritis in my left knee (over 2 months now). just received a medical knee brace finally; no surgery. But I have cancer (NHL) which is incurable but in remission since 2017, diabetes under good control , high blood pressure treated with Lipitor...so I have my problems, too! I've been married for about 58 years & my wife has NO medical issues and is the same weight as when we married (110 lbs)...I was 155 lbs and now 180 lbs....ha ha
Competition is a problem especially since $BSX was/is a great possibility for a takeout; too bad if they walked away and maybe working in this area. I had quite some experience with litigation stocks and I'm too old to wait for legal outcomes on a long and tiring result.
Here's my earlier post
Sab. I had an angiogram in 2016 that identified the extent of my coronary plaques ( family history and I'd failed an echo stress test ) .
At the time they decided not to stent ( much to my relief ) but put me on max medical therapy ( Repatha , max dose Crestor and Vascepa ) . I was already on Crestor and Vascepa , so it was just the Repatha that was added later .
Anyway long story short ...a friend that follows new biotechs in the Bay Area told me about SWAV ...using IVL to better prepare coronaries for stent deployment .
So I bt some right after their IPO .
I sold half after the initial ramp when I became aware of the challenge to their patents .
Added back at $186 ...think I posted that on this board.
My take at present .
This Co has a lot further to go. Japan is just starting . The Japanese hate stents ...foreign metal in their bodies . They will IMHO become big user's of IVL to increase blood flow ...and forgo the stents
China ...very early days . Almost no revenue in Jan due to Covid lock down ...but now opening up.
Germany ..under used to date but will change as SWAV doubles their sales force there this year and the German Health Dept more fully appreciates the value of IVL instead of atherectomy for treating coronary calcium deposits.
For sure I'd like to wake up one day with an accepted buy out over $350 ....but if not, I'm ok with a slow steady PPS appreciation based on increasing revenue .
Risks ...competition . They seem so far ahead ( first mover advantage ) its hard to imagine any successful competition at this point in time
Kiwi
Actually, I almost sold today but decided to hold with this nice growth rate....that, btw, would not have affected my personal interest in what they do....when I saw the price last week, I thought we might pop today, but the denial of a deal with $BSX hit the stock...my cost is around $250...and I think you said your cost was around $40 or so (I am jealous...ha ha)
Sab. I liked their guidance
2023 Financial Guidance
Shockwave Medical projects revenue for the full year 2023 to range from $700 million to $720 million, which represents 43% to 47% growth over the Company’s prior year revenue. This compares to previous revenue guidance for the full year of 2023 of $660 million to $680 million.
Re the takeover ...always thought Boston Sci would not pay the price SWAV wanted .
No way they would sell this Co for $275 a share
JMO
Kiwi
yes, probably get the pr & 8k at 4 pm ahead of the 4:30 pm CC
Thx
Earnings after the close Monday ?
Kiwi
Whatalane:
Kiwi...I found it! "ROCE
https://finance.yahoo.com/news/shockwave-medicals-nasdaq-swav-returns-130101958.html
Kiwi:
I saw somewhere an analysis of comparable statistical return of some sort called "rocc" or something that I have never seen before that $SWAV is WAY ABOVE it's competition on return, something like 21% as compared to 9.8%. & I have seen ROC analysis..but could not find it and I am not familiar with whatever that analysis pointed to other than it's exceptional....also noted that an insider at $BSX sold appx $4Mil in stock with the assumption that $BSX would make an offer for $SWAV (I have no way to know what his motivation might be, but I assume if it's a stock offering for shares, it would hit $BSX)...since maybe just you and I are following, I thought I would pass this on to you....no guarantee that any part of this is worthwhile.
Earns on 5/8....normally scheduled end of April......fireside chat: 5/10
note: $BSX.... ASM today and an exec sold $4m in stock on 5/2
Dear Boston Scientific Stockholder: You are cordially invited to attend the Annual Meeting of Stockholders (Annual Meeting) of Boston Scientific Corporation (the Company or Boston Scientific) to be held on May 4, 2023, at 8:00 a.m. Eastern Time. The Annual Meeting will be held in a virtual format only, via live webcast over the internet. You will be able to join the Annual Meeting and vote and submit your questions online by visiting www.virtualshareholdermeeting.com/BSX2023. We have designed the virtual Annual Meeting to ensure that stockholders are afforded the same opportunity to participate as they would have at an in-person meeting, including the right to vote and ask questions through the virtual meeting platform. Reference to “in person” attendance or voting in our proxy materials refers, therefore, to attending or voting at the Annual Meeting virtually
https://finviz.com/quote.ashx?t=BSX&ty=c&ta=1&p=d
You're right about that as long as the trustee sticks to the written plan, don't know if that continues or is somehow altered, but with those profits and low strikes, it is most likely going to continue...ha ha.....
as far as RSUs, as you know, that happens on a yearly basis and hits them each and every year. so that is something they have to accept..luckily the stock ownership in their company has a stock to option grant policy....
hope it does NOT go below my cost basis of apprx $250 with the market in turmoil and guys like Carl Icahn getting slammed by Hidenburg Research (pretty smart group) who short then publish negative hit pieces after discovering bad accounting, etc., which is apparently allowed by regulators!
I've noticed that many potential acquisitions seem to occur after earnings releases...but as I stated I do have a personal interest in using this for my problems in lower extremities, just like the ESWL which I used when I had kidney stones blasted away!
Well 10b -5 sales correct ? Did you chk the options or RSU's available to mgt ?
Earnings on May 8th .
A Boston Sci deal may not go thru due to concerns over monopoly and not willing to pay the price SWAV would want .
I'll add on any significant correction
Kiwi
Well couldn't link but try SWAV presentation by Nicolas Mouawad MD , MBA chief of Vascular surgery at a hospital in Michigan ...on Twitter
Kiwi
Boston Scientific lifts annual profit forecast on heart devices strength
BY Reuters
— 8:19 AM ET 04/26/2023
April 26 (Reuters) - Boston Scientific Corp (BSX) raised its full-year profit forecast on Wednesday, after strong sales in its cardiovascular devices unit helped the company beat first-quarter estimates.
As the pandemic-induced staffing shortages ease, hospital operators have begun to see a much-awaited recovery in elective surgeries, boosting the demand for medical devices, such as the pacemakers, stents and catheters the company makes.
While analysts were expecting good results stemming from a recovery in medical procedures and product momentum, "this result well exceeded our expectations", J.P.Morgan analyst Robbie Marcus wrote in a note.
------------------------------
Highlighted area relevant to SWAV wether or not buy out occurs
Kiwi
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