SIGA Technologies Inc. (SIGA)

[axelvento]

news: U.S. Clinical Trial Evaluating Antiviral for Monkeypox Begins
NIH Trial Gathering Data on Tecovirimat (TPOXX)
September 9, 2022

https://www.niaid.nih.gov/news-events/us-clinical-trial-evaluating-antiviral-monkeypox-begins

[Sunshine90]

https://finance.yahoo.com/news/united-kingdom-monkeypox-therapeutics-market-110000831.html?clientlang=1

[axelvento]

The Lancet: Human monkeypox virus infection in an immunocompromised man: trial with tecovirimat: He reported no significant adverse effects and the skin lesions healed rapidly.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01528-8/fulltext


$SIGA

[axelvento]

In addition to a blistering rash and flu-like symptoms, the monkeypox virus could wreak havoc on your brain, new research reveals.


https://m.jpost.com/health-and-wellness/article-716738/amp

[Ecomike]

So do we call it Dog Pox, Greyhound Pox or monkey-dog Omega Pox now?

https://www.iflscience.com/monkeypox-confirmed-in-pet-dog-for-first-time-64868

[axelvento]

Monkeypox update: FDA focuses on testing as cases continue to rise

https://healthexec.com/topics/healthcare-management/healthcare-policy/fda-issues-new-guidance-monkeypox-testing

[axelvento]

US: Concerns Are Mounting Due to Escalating Monkeypox Outbreak

https://www.telesurenglish.net/news/US-Concerns-Are-Mounting-Due-to-Escalating-Monkeypox-Outbreak-20220908-0005.html



$SIGA alert... is manipulated!

[Ecomike]

Are they finally realizing what dawned on me in May yet, that all contact sports are going to have an even worse time with Monkey pox sports skin on skin contact infections spreading Monkey Pox, in the asymptomatic stages than Covid19?
Or are they still D'ing(LOL) around about funding who dropped the ball?

$SIGA and prior administrations ages ago are why we are already dosing people... with $SIGA antiviral. So there is that.

[axelvento]

this is big!!! I've been waiting for this.........

https://sports.yahoo.com/us-lawmakers-set-quiz-health-182454743.html

[axelvento]

Thank you Oregon !!!

"We're also encouraging providers to consider treatment with the TPOXX antiviral for people infected with monkeypox when they're first diagnosed to prevent complications, lessen symptoms and potentially decrease risk for transmission, regardless of disease severity (or risk of)."

— OR Health Authority (@OHAOregon) September 7, 2022

[Ecomike]

$SIGA a highly profitable, dividend paying stock, in the right place at the right time:

Patient With New Strain of Monkeypox Hospitalized in U.K.

BY JESS THOMSON ON 9/2/22 AT 5:33 AM EDT
00:32

New Strain Of Monkeypox Discovered In U.K.:

Health
HEALTH AND MEDICINE
MONKEYPOX
INFECTIOUS DISEASES
U.K.

Health officials in the U.K. have announced that they have found a new strain of monkeypox.

According to the UK Health Security Agency (UKHSA), it was discovered in an individual who has recently traveled to West Africa, from where monkeypox originated. The person's strain is genetically distinct from the one being spread across the world.

"Preliminary genomic sequencing conducted by UKHSA indicates that this case does not have the current outbreak strain circulating in the UK," said UKHSA in a statement.

Endemic to areas in West Africa, monkeypox has been spreading across the world rapidly during 2022. According to the CDC, 52,090 cases have now been reported worldwide, of which 19,465 have been found in the U.S.

monkeypox
Stock images of a man with a monkeypox rash and a test. A new strain has been found in an individual who recently travelled to West Africa.
ISTOCK / GETTY IMAGES PLUS
This discovery reveals a third category of monkeypox. Previously, monkeypox was known to have two variants, Clade I and Clade II, which were respectively known as the Congo Basin and West African clades.

Clade II has two-sub strains, Clade IIa and Clade IIb, with the latter being responsible for the worldwide outbreak of the infection throughout 2022.

According to The Telegraph, a British newspaper, while Clade II has a low mortality rate of one in 100, Clade I is more deadly, with a rate of one in 10. Whether this new case is a sub-clade of I or II, or a third distinct clade, is unknown.

"Given that the person caught the infection in West Africa, it is likely that it is the less- virulent Clade II West African variant, though I don't know for certain," Paul Hunter, a Professor in Medicine at the Norwich School of Medicine, University of East Anglia, told Newsweek.

Dr Sophia Maki, incident director at the UKHSA, said in a statement: "We are working to contact the individuals who have had close contact with the case prior to confirmation of their infection, to assess them as necessary and provide advice.

"UKHSA and the NHS have well established and robust infection-control procedures for dealing with cases of imported infectious disease, and these will be strictly followed and the risk to the general public is very low."

TECH & SCIENCE
Patient With New Strain of Monkeypox Hospitalized in U.K.
BY JESS THOMSON ON 9/2/22 AT 5:33 AM EDT
00:32New Strain Of Monkeypox Discovered In U.K.: Health

MONKEYPOX
INFECTIOUS DISEASES
U.K.

Health officials in the U.K. have announced that they have found a new strain of monkeypox.

According to the UK Health Security Agency (UKHSA), it was discovered in an individual who has recently traveled to West Africa, from where monkeypox originated. The person's strain is genetically distinct from the one being spread across the world.

"Preliminary genomic sequencing conducted by UKHSA indicates that this case does not have the current outbreak strain circulating in the UK," said UKHSA in a statement.

Endemic to areas in West Africa, monkeypox has been spreading across the world rapidly during 2022. According to the CDC, 52,090 cases have now been reported worldwide, of which 19,465 have been found in the U.S.

NEWSWEEK NEWSLETTER SIGN-UP >
monkeypox
Stock images of a man with a monkeypox rash and a test. A new strain has been found in an individual who recently travelled to West Africa.
ISTOCK / GETTY IMAGES PLUS
This discovery reveals a third category of monkeypox. Previously, monkeypox was known to have two variants, Clade I and Clade II, which were respectively known as the Congo Basin and West African clades.

Clade II has two-sub strains, Clade IIa and Clade IIb, with the latter being responsible for the worldwide outbreak of the infection throughout 2022.

According to The Telegraph, a British newspaper, while Clade II has a low mortality rate of one in 100, Clade I is more deadly, with a rate of one in 10. Whether this new case is a sub-clade of I or II, or a third distinct clade, is unknown.

NEWSWEEK SUBSCRIPTION OFFERS >
"Given that the person caught the infection in West Africa, it is likely that it is the less- virulent Clade II West African variant, though I don't know for certain," Paul Hunter, a Professor in Medicine at the Norwich School of Medicine, University of East Anglia, told Newsweek.

Dr Sophia Maki, incident director at the UKHSA, said in a statement: "We are working to contact the individuals who have had close contact with the case prior to confirmation of their infection, to assess them as necessary and provide advice.

"UKHSA and the NHS have well established and robust infection-control procedures for dealing with cases of imported infectious disease, and these will be strictly followed and the risk to the general public is very low."

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Monkeypox is a viral infection spread by close skin-to-skin contact, as well as skin-to-material contact. This includes, but is not limited to, sexual contact. The majority of infections so far have been contracted by men who have sex with men.

According to the WHO, symptoms include fever, headache, muscle aches, back pain, low energy and swollen lymph nodes. Monkeypox is characterized by the skin rash that occurs around three days after fever begins, and is usually concentrated on the face and extremities.

Vaccines for monkeypox have been prioritized for the most at-risk communities across the U.S., but there is still not enough to vaccinate everyone who needs it.

In August, the U.S. Food and Drug Administration issued an emergency-use authorization, allowing the injection of the vaccine intradermally, between the layers of the skin, rather than beneath the skin.

According to Robert Fenton, the White House monkeypox response coordinator, this method requires only one-fifth of the dosage, meaning that five times more vaccine doses will be available for use.

The U.K. individual with the new monkeypox strain has been admitted to the High Consequence Infectious Disease (HCID) unit at the Royal Liverpool University Hospital.

"We remind everyone who is planning to travel to West and Central Africa to be alert for the symptoms of monkeypox," said Dr. Maki.

[Ecomike]

Deaths have started to be reported, and a new strain in the UK found...

[Ecomike]

Global Monkeypox Treatment Market to Surpass US$ 258.6 Million by 2030 - Coherent Market Insights

https://www.prnewswire.co.uk/news-releases/global-monkeypox-treatment-market-to-surpass-us-258-6-million-by-2030-coherent-market-insights-802985410.html

$SIGA

[axelvento]

Institutional Shares 29,023,148 - 39.74%
Insider Shares 28,016,560 - 38.37%

[buckysherm]

I think that would be the worst possible news. It nearly confirms a repeat of Covid strategy of NO TREATMENTS !

[buckysherm]

That would interfere with their strategy of vax vax vax vax vax vax vax vax vax vax vax vax Vax as a treatment vax vax vax vax vax vax vax vax

[Sunshine90]

"Tutes not selling" Can you show the link or screen shot of it? Thanks!

[axelvento]

the value of being the only approved MP drug with multiple global clinical trials on deck, is much higher than where this is. There is zero reason for this share price EXCEPT manipulation. Why? Tutes not selling. What's the play? Something is up.

It's written on the wall over here- winner!!!!!!

There's an unexploded bomb in the next street.........

$SIGA

[axelvento]

Global Monkeypox Treatment Market to Surpass US$ 258.6 Million by 2030 - Coherent Market Insights

https://www.prnewswire.co.uk/news-releases/global-monkeypox-treatment-market-to-surpass-us-258-6-million-by-2030-coherent-market-insights-802985410.html

[axelvento]

TPOXX, a therapeutic originally approved for smallpox that is believed to be effective against monkeypox, will also be distributed under the $20 million contract.




https://www.foxnews.com/us/biden-administration-expanding-monkeypox-vaccine-distribution-20-million-amerisourcebergen-contract

[powerwalker]

U.S. to expand monkeypox vaccine, drug distribution through AmerisourceBergen contract
BY Reuters
— 2:50 PM ET 09/06/2022
By Michael Erman

NEW YORK, Sept 6 (Reuters) - The U.S. Department of Health and Human Services (HHS) on Tuesday said it will significantly expand the number of distribution locations for monkeypox vaccines and treatments through a new $20 million contract with AmerisourceBergen Corp. (ABC)

Under the new contract, HHS said it will be able to make up to 2,500 shipments per week of frozen doses of Bavarian Nordic's (BVNKF) Jynneos vaccine from the Strategic National Stockpile (SNS), as well as shipments of SIGA Technologies' (SIGA) drug TPOXX to up to 2,500 locations.

The national stockpile had been shipping to only about 5 locations per state and other jurisdictions.

"This new commercial contract will help deliver vaccines and treatments to communities and at-risk individuals more quickly and bring us a step closer to ending the current outbreak," HHS Assistant Secretary Dawn O'Connell said in a statement.

Since late May, when a large multi-nation outbreak began in countries where the virus is not endemic, nearly 20,000 cases of monkeypox have been reported in the United States, according to government data.

The vaccine and TPOXX doses - as well as the distribution - are being provided to states and other jurisdictions for free.

As of Sept. 2, the SNS has shipped more than 800,000 vials of Jynneos and more than 37,000 courses of TPOXX nationwide.

By the end of August, more than 350,000 doses of Jynneos had been administered in 30 jurisdictions that are reporting data on the shots to the U.S. Centers for Disease Control and Prevention (CDC).

The U.S. Food and Drug Administration approved TPOXX in 2018 to treat smallpox, but the drug may be used for monkeypox under a special "compassionate use" protocol from the CDC.

(Reporting by Michael Erman Editing by Bill Berkrot)

Copyright © Reuters 2008. All rights reserved. Republication or redistribution of Reuters content, including by caching, framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

[Ecomike]

Great $SIGA DD. Thanks and keep it coming. I share it in other places from your posts...

[axelvento]

Don't miss the White house update on Thursday 9/2 regards to the funding for monkeypox!

[axelvento]

New strain of monkeypox detected in the UK as officials urgently testing whether it’s a deadlier version

The strain which has just been discovered is thought to be the former more deadly version of the disease


https://www.thescottishsun.co.uk/health/9397167/new-monkeypox-detected-uk/

$SIGA

[axelvento]

Baby hospitalized after testing positive for monkeypox
Officials said the infant in Washington State was exposed to the virus by an infected family member and is now being treated with an authorized anti-viral called TPOXX in a Seattle hospital.

https://www.avnblogfeed.com/2022/09/03/baby-hospitalized-after-testing-positive-for-monkeypox/

[axelvento]

FDA Should Expand Access of Tecovirimat for Monkeypox Now
Unfortunately, access to tecovirimat is severely restricted due to bureaucracy.


https://www.stateofthevirus.com/blog/fda-should-expand-access-of-tecovirimat-for-monkeypox-now


stay tuned!!!!!!

$SIGA

[axelvento]

"to read" My main reason is that I think TPOXX can help stop the spread of MPX in this country. If it shortens the duration of illness, and illness duration is similar to contagiousness duration, that alone is worth it
We need expanded TPOXX access now. We need an emergency use authorization.



https://typefully.com/grahamwalker/PtkV0yV

[axelvento]

HHS Expanding Monkeypox Testing Capacity to Five Commercial Laboratory Companies
This week, the Department of Health and Human Services (HHS), through the Centers for Disease Control and Prevention (CDC), began shipping orthopoxvirus tests to five commercial laboratory companies, including the nation’s largest reference laboratories, to quickly increase monkeypox testing capacity and access in every community during the ongoing monkeypox outbreak. The companies include Aegis Science, Labcorp, Mayo Clinic Laboratories, Quest Diagnostics and Sonic Healthcare

[Ecomike]

Not to mention the anti-vaxer movement... They need the antiviral in massive supplies world wide now. And they need testing.

Has anyone looked at the testing method(s) and who is cashing in on it?

[Ecomike]

$SIGA only approved Monkey Pox antiviral

https://arstechnica.com/science/2022/08/monkeypox-encephalitis-deaths-probed-as-global-cases-top-25000/
Ars Technica
Monkeypox: 25K cases, a batch of new deaths, and 3 state emergencies
WHO says it's seeing a broad range of illnesses as more people are infected.

[Ecomike]

$SIGA has started its bounce:

[Ecomike]

Medicines against monkeypox (copied from EU website)
Tecovirimat $SIGA approved anti viral

There is one antiviral treatment against monkeypox authorised in the EU, Tecovirimat.

Tecovirimat is also authorised to treat smallpox and cowpox.
Imvanex

There is one vaccine authorised for use against monkeypox disease in the EU, Imvanex.

Imvanex has been authorised to protect adults from monkeypox disease in the EU since 22 July 2022. It is also authorised to protect people against diseases caused by the vaccinia virus.

These new indications were added to Imvanex's existing authorisation against smallpox, which has been in place in the EU since 2013.

EMA's Committee for Medicinal Products for Human Use (CHMP) began evaluating extending Imvanex's authorisation for use against monkeypox on 27 June 2022.

For more information on the vaccine and its assessment by the CHMP, see Imvanex.

[axelvento]

My take on the Press Briefing and all information other sources, including a Danish Study into the Bavarian Nordic Vaccine. The EU prefers TPOXX as the defence against Monkey Pox, and are going to imminently order much larger orders for all EU Countries. There are very many doubts over the Bavarian Nordic
Vaccine effectiveness

SIGA winners

[Ecomike]

The $SIGA Tigger bounce has started says Poo...

[Zorro]

Might be. Looked like they wanted to dip it under $14 the other day though.

[axelvento]

https://www.ema.europa.eu/en/events/ema-regular-press-briefing-covid-19-monkeypox

EMA -Antiviral Tecovirimat.......

[axelvento]

EMA Says Antiviral Tecovirimat For Monkeypox Should Be Available Shortly In EU In Larger Quantities, After A Joint Procurement Procedure

https://www.benzinga.com/general/biotech/22/09/28732512/ema-says-antiviral-tecovirimat-for-monkeypox-should-be-available-shortly-in-eu-in-larger-quantiti


$SIGA

[axelvento]

The authors recommended new mRNA vaccines be developed before monkeypox is declared a pandemic

Paving the way for mRNA MP vaccines BIG Pharma

Read between the lines but here it is!

Those fuckers are getting in the race and before you know it


that's what you want F:D:A

A new monkeypox vaccine is needed to prevent global transmission

https://www.news-medical.net/news/20220901/A-new-monkeypox-vaccine-is-needed-to-prevent-global-transmission.aspx

[axelvento]

I agree 100%

[Ecomike]

$SIGA may not be oversold much longer now.

With new problems arriving like MonkeyPox bad news and now this:

https://www.telegraph.co.uk/global-health/science-and-disease/mystery-pneumonia-kills-two-infects-six-argentina/

UNKNOWN PNEUMONIA—Very worrisome—3 people have died, 9 people infected, of which 8 medical workers, are in hospital after developing a “pneumonia of unknown origin”—Argentinian authorities announced. Not COVID or flu.

⚠️UNKNOWN PNEUMONIA—Very worrisome—3 people have died, 9 people infected, of which 8 medical workers, are in hospital after developing a “pneumonia of unknown origin”—Argentinian authorities announced. Not COVID or flu. #ArgentinaPneumonia

By @sneweyy https://t.co/UVBnbrbOZA pic.twitter.com/tYH10wTcs0

— Eric Feigl-Ding (@DrEricDing) September 1, 2022

He added that the six patients have had a series of tests for “Covid, cold, influenza of both types A + and B +, Hantavirus and 25 other germs” but no virus has yet been identified.

5) He added that the six patients have had a series of tests for “Covid, cold, influenza of both types A + and B +, Hantavirus and 25 other germs” but no virus has yet been identified. ⚠️

— Eric Feigl-Ding (@DrEricDing) September 1, 2022

The 8 medical workers is really bad news "3 people have died, 9 people infected, of which 8 medical workers" which is scary infectious....

If the medical workers got it that easy that is massively bad news....

And the monkeyPox just got a lot worse:

People of dying of it now. So much the CDC play it down like they did early on with Whuan Covid19 BS...

https://arstechnica.com/science/2022/08/monkeypox-encephalitis-deaths-probed-as-global-cases-top-25000/

Texas reports what may be the first U.S. death from monkeypox

https://www.cnbc.com/2022/08/30/texas-reports-what-may-be-the-first-us-death-from-monkeypox.html

Asymptomatic MonkeyPox is the clue the CDC and WHO missed, just like with Covid19 in 2020.

https://www.news-medical.net/news/20220817/Study-detects-asymptomatic-monkeypox-virus-infection.aspx

[axelvento]

Texas reports what may be the first U.S. death from monkeypox


https://www.cnbc.com/2022/08/30/texas-reports-what-may-be-the-first-us-death-from-monkeypox.html

[chrispy2468]

Bottom may be in. I just got out of some of mine. this is usually an indication that we go up.

[Carjockey2]

Geez I hope he's okay!!!!

[Ecomike]

Same here.

[Carjockey2]

I just saw this I hope you're okay?????..

Health always has to come first.

[Golden Cross]

Yep, missed that one... heart problms prob gonna quit trading... GLTA

[Ecomike]

Nice bounce after the morning dip here today. Bottom may be in...

[axelvento]

“Brazil receives first batch of tecovirimat to treat monkeypox”


https://olhardigital.com.br/2022/08/29/medicina-e-saude/brasil-recebe-primeiro-lote-de-tecovirimat-para-tratamento-da-variola-dos-macacos/

[axelvento]

Baby hospitalized after testing positive for monkeypox
Officials said the infant in Washington State was exposed to the virus by an infected family member and is now being treated with an authorized anti-viral called TPOXX in a Seattle hospital.

If an INFANT is receiving TPOXX therapy in a hospital in Washington, that tells you ALL YOU NEED TO KNOW about risk/ benefit. TPOXX DESERVES IMMEDIATE EUA.


https://abcnews.go.com/WNT/video/baby-hospitalized-testing-positive-monkeypox-88948234

[axelvento]

The Palm Springs hospital received both oral and IV forms of the medication on Aug. 22, explained Dr. Claudia Fortiche, manager of the research program at Desert Regional. The oral medication, typically three tablets taken twice a day, is the preferred treatment method, Foriche said, but an IV is available for patients who are experiencing painful mouth lesions that make it difficult to swallow. Once a patient is able to swallow, the CDC recommends that they switch to the oral form, Foriche said.

https://eu.desertsun.com/story/news/health/2022/08/26/desert-regional-medical-center-now-providing-tpoxx-medication-monkeypox-infections/7905491001/

$SIGA