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Rick.. one could argue that Mike may have hired the wrong outfit to conduct the trial. He may have been trying to safe $$. This is exactly what RLFTF did. They hired an outfit that bungled everything up on the end-points.
Only an idiot with no experience tries to run a phase 3 trial. He could have hired someone but instead was too arrogant thinking he could do it.
Mike didnt "RUN" anything jester......it was Pharn Olam that was hired to conduct and oversee all aspects of the trial.
This info is so basic and yet ye still got it all wrong, therefore the only complete idiot was the joker that posted this garbage, and that would be...........................................
My previous post were questions posed to demonstrate how silly the complaining about mike thats being done here is but ye obviously missed the context, as usual!
I don't consider myself a "talking head", but I will own what I say and what I believe.
With regards to the FDA being corrupt, they are a government run entity. They have already had to admit to taking short cuts, and/or plain and simply not doing their jobs what was one of the most significant things to come through their office in the past 3 years.
With that, I have not said they are "never" going to give RVV the approval. But, I did say that they are going to look out for Big Pharm. You know...the ones who can grease their pockets the most?! If that means moving the goal line, changing the game, etc...
When BP went to them and said, "we have this...", they jumped and said, "Okay! Go ahead and give it out". There was no thorough testing, etc...
But when RVV went to them and said, "We have this...30+ year old remedy" the FDA said, "Wait! Did you test this condition? Did you shake the tree just the way we told you?" When Revive said, "Yes! Here is the proof." They said, "Okay! Let's set up a meeting 3-4 months from now to review." When the 3-4 months passed (2 or 3 times), they said "Oh! The virus has changed, and we're looking for your stuff to do ZYX, not the XYZ that you wanted to show us. Can you show us ZYX?!"
In the meantime, I see those Paxlovid commercials LEFT AND RIGHT!
It`s far from over lets hope something can still get $RVVTF a win..............For the past several months, Omicron subvariants BA.4 and BA.5 have dominated COVID-19 cases in the U.S. But now, there’s a class of new COVID subvariants on the rise and one in particular is getting plenty of attention. It’s called XBB—or Gryphon—and there’s a chance it could overtake everything else out there.
If Bucillamine is as good as we hope maybe it can help with this too........CEO of Carolina Blood and Cancer Care Associates, Dr. Kashyap Patel, believes that the COVID-19 virus not only affected cancer treatment in recent years, but may have also affected the development of “cancer itself.”.....In recent years, Patel has treated several patients in his Rock Hill, South Carolina, clinic who suffer from a rare cancer called cholangiocarcinoma. A number of the patients began developing the cancer 20 to 30 years earlier than the standard age.
Cholangiocarcinoma normally begins forming within the human body around 65 years or older. In the past year alone, Patel’s clinic had seen seven patients diagnosed with the cancer at much younger ages.
Govprs - Did you sign the request for a presentation from Revive Therapeutics? If you have, it would be a good opportunity to address your concerns directly to MF.
But the talking heads, bmt, tix etc all state FDA is corrupt and never gonna give a tiny rvv the approval.
Most ceos would do what’s in the best interests of stockholders. I snoop and others believe MF could do more for shareholders by licensing to BP and monetize this asset. Most bag holders here many proclaimed to be here 2-3 yrs are growing tired and want to monetize the shares they hold. I don’t MF dragging this out longer for a bigger return is what investors want.
What BMTs letter to MF? Bet he ignores it or says no thank you to an investor call
All this makes it more doubtful we have a drug that works. My opinion only
More importantly does MF have a position in rvvtf? How many shares does he own? Did he participate in the offering at .15/share just 8 weeks ago?
How in the F are you trying to still compare a tiny no revenue biotech penny stock firm to the Duponts and Apples of the world?!
How does this:
That may be one thing MF has been waiting for:
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
These results propose that BUC can be a potential drug candidate against the COVID-19 disease progression.
$RVVTF BOOM up 10% today
Published ( online ) for the first time 3 days ago , not yet in paper print
This is not the place to ask that question the Canadian filings are, but one that knows how to do real DD would have done the DD in the filings not here.
I still can’t figure out if the drug was so good why he wouldn’t license to a BP?
Dow, DuPont, Amazon, Apple, ... none of their CEOs hold shareholders hands 365/year. So you are saying they are not professional? All people get from them is a 4 filings a year and after the fact 8-K event notices.
I too have worked for public companies, going back 48+ years, and when there is Major deal brewing with a mega billion dollar firm even the flies and blinded and silenced and the CEOs are gagged.... until the NDA and deals allow a deal/news release, and even then I have seen international law firms dag shit out so long the stock got clobbered by the silence. In one case the silence was worth it.. They were closing a world wide deal with a 14 Billion dollar firm 10 years ago. Not even light leaked out on that deal for 9 months.
It was very painful. But it was what Alstom Power (Later bought part of by GE).
Disagree it is professional. Addressing shareholder sentiment and sharing the strategy/ action plan moving forward is not illegal. I have worked for public companies. IMO mf is an amateur.
LMAbsoluteFAO @ “I think we should thank the CEO for trying” !!!!!!!!
WTF……………
I think shareholders are looking for more than just a CEO trying. Thanks may be appropriate if RVVTF achieves its goals, gets FDA approvals, provides a positive ROI to shareholders, etc.
“If any thing we should be thanking the CEO for trying”
In answer to your $RVVTF question:
"Please elaborate and include how shareholders may have benefited. Thank you
“What MF has pulled off so far the last 3 years, is historical in nature.”
Interesting. How does this help RVVTF shareholders?
Please elaborate and include how shareholders may have benefited. Thank you
“What MF has pulled off so far the last 3 years, is historical in nature.”
And potentially a fraud. I still can’t figure out if the drug was so good why he wouldn’t license to a BP?
Does MF actually own shares in rvvtf?
Good to know. I'd like to see exactly what the plan is as Revive moves forward. All I know is I paid a lot of money to see the trial unblinded by now and I still wait.
There trying to get last digit pump and dump. MF was just pumping and dumping and this article came out what a joke! MF should be though in jail pumping and dumbing the stock. But SE C don't care. Wait till they start being charged with crypto. LOL
Disagree it is professional. Addressing shareholder sentiment and sharing the strategy/ action plan moving forward is not illegal. I have worked for public companies. IMO mf is an amateur.
Did you notice that the article was "received" back in August 2022? It was accepted 8 months after it was received. Even then it was published nearly 3 weeks after being accepted.
This is definitely great information. But it is either so insignificant to someone that it didn't merit being published a whole 8 months after it was written, or it was significant enough that someone didn't want it published.
Am I missing something? Feel free to correct me if my deduction is wrong.
It’s franks greed that got in the way of this company being successful. Only an idiot with no experience tries to run a phase 3 trial. He could have hired someone but instead was too arrogant thinking he could do it. The fact people still can’t see that after the last 3 years is ridiculous. Open your eyes.
.....a little knowledge is a dangerous thing. It's very naive to think you know what is going on behind closed doors in any company. It's all conjecture so do whatever research you can to make yourself comfortable with your investment. It's simple, if you aren't sell and find another company you feel safe with....good luck!
You're a poet and you didn't even know it.
Dark Chocolate is bitter
White should be sweet
RVVTF ain't over yet
Say "NO" to de feet.
So in a nutshell......its Mike's fault that through amateurish GREED, many shareholders consciously and irresponsibly decided to go all in for the huge score, as opposed to simply trading the continuous swings for 2+ years which would have resulted in them recouping their total $$ investment, in addition to amassing a huge cache of "free" shares???
That Mike designed a trial that chose parameters which were practicable back in 2020-21, back when literally NO ONE, even the so called pandemic experts, had foreseen the direction the pandemic would take that made the current trial ep's moot yrs later???
That Mike is responsible for not being able to meet the ever evolving requirements set by the clowns at the fda.....the very same fda clowns who literally approved a covid booster for mass public use that was ""thoroughly"" tested on 8 mice???
Im by no means whatsoever a sycophant of MF and several of my previous posts clearly attest to that fact but the level of projection and entitlement on display here is simply amazing.
Watch and learn grasshopper.
$RVVTF has many options.
Those companies share prices are a little higher than $0.05 no? Are you putting the blame on those CEO’s? If so, you better realize it is mf’s fault for where this company is now. You realize he is going to keep this trial blinded as his job security and not for shareholder value? He knows he isn’t finishing the trial so why keep it blinded?
BS, DuPont and 3M are being sued for trillions of dollars now for lying about and selling fire fighting chemistry that is now causing sterility in Humans and Salmon and so on.
$RVVTF ? no lawsuits
Exxon lied about climate change it knew it was causing and knew was real 40 years ago. Cost? Trillions, also in courts
Dow and GE lied about agent orange, PCBs, dioxins and has lost 100s of Billions of dollars that will cost them trillions in today's dollars for next 100 years
That may be one thing MF has been waiting for:
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
These results propose that BUC can be a potential drug candidate against the COVID-19 disease progression.
$RVVTF BOOM up 10% today
Published ( online ) for the first time 3 days ago , not yet in paper print
More on the super highly contagious new strain in India
https://kathmandupost.com/health/2023/04/03/nepal-confirms-spread-of-omicron-s-xbb-1-16-sub-variant
Proof +ve of sheer ignorance of the easily verifiable fact that the trial has an extremely rigid health inclusion/exclusion criteria as opposed to having random patients simply agreeing to participate, ie, recruitment was designed to only source patients that fit the required criteria.
A simple perusing of the rvv trial on the clinical.gov site would have alerted one to this fact and as such one wouldnt make an utter fool of themselves for the world to marvel at. lololsss
Inclusion Criteria:
-- Is within 72 hours from onset of symptoms consistent with COVID 19 at time of study enrollment
-- Has at least 2 of the following: fever (oral temperature =38°C), cough, shortness of breath, chest x ray changes consistent with COVID-19 at time of screening
-- Has peripheral capillary oxygen saturation (SpO2) =94 by pulse oximetry at time of screening
-- Has either a laboratory-confirmed SARS-CoV-2 infection as determined by FDA-approved rapid diagnostic (e.g., PCR) assay
-- Has a score of = 2 on the 8-category NIAID ordinal scale at time of screening
-- Agrees to the collection of blood and urine samples, nasopharyngeal (NP) swabs, and non-invasive oxygen monitoring (via pulse oximeter) per protocol
-- Patient (or their legally authorized representative) is willing and able to provide written informed consent prior to performing study procedures
-- Understands and agrees to comply with planned study procedures
-- Women of childbearing potential must agree to either abstinence or use at least 1 primary form of contraception not including hormonal contraception from the time of screening through -- Day 29 following randomization. All subjects of childbearing potential, including males with partners of childbearing potential, must use highly effective methods of birth control defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1 percent per year) when used consistently and correctly. Abstinence is NOT an acceptable method of contraception UNLESS it is the subject's normal practice.
Exclusion Criteria:
-- Prior history of, or considered to be at risk for, agranulocytosis, nephropathy, liver disease, or interstitial pneumonia
-- Serious hepatic disorder (Child-Pugh scores B or C) or alanine transaminase (ALT) or aspartate transaminase (AST) > 5 times the upper limit of normal (ULN) at screening
-- Chronic kidney disease (CKD) National Kidney Foundation (NKF) stages 3B - 5 chronic renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min/1.73m2 according to -- ------- Cockcroft Gault formula)
-- Proteinuria = 1+ or = 30 mg on dipstick urinalysis that is confirmed on repeat assessment within 24 hours
-- Serum BUN = 2 × ULN or Cr = 2 × ULN
-- Leukopenia with absolute granulocyte count < 1500/µL
-- History of positive Human Immunodeficiency virus (HIV) test or organ transplant
-- Receipt of cancer chemotherapy or immunomodulatory drugs including (but not limited to) biologics such as anti-CD20, anti-TNF, anti-IL6; alkylating agents (e.g., cyclophosphamide); antimetabolites (e.g., azathioprine); or chronic corticosteroid use equivalent to prednisone >10 gm/day, during preceding 2 months
-- Confirmed positive for influenza at screening
-- Confirmed positive for respiratory syncytial virus (RSV) at screening
-- Pregnant or breastfeeding
-- Current use of, or known allergy to bucillamine or penicillamine (e.g., for Wilson's disease, rheumatoid arthritis)
-- Current participation in any other clinical trial of an experimental treatment
-- Receipt of any experimental treatment for COVID-19 (herbal/homeopathic, off-label, compassionate use, or trial related) within the 30 days prior to screening
Now back to my drink...............................
Two things:
1) let’s not compare revives ceo to Dow or DuPont or Exxon. Those ceos know how to run a company and what they don’t know they hire the right people to do.
2) the only thing historic in nature was the historic failure of being fast tracked to a phase 3 and still only getting to 710 patients in the worst pandemic in 100 years with literally over a million cases a day.
Actually it is very professional, not armature.
We have been told what the lawyers let him say, that is how real pubic stock disclosure works with CEO's that are not Pump-it scum bags.
They a rare bread, and attract a lot of flack and haters.
Check out how much bank stocks, Exxon, GE, Dow, DuPont tell shareholders. It is 99.9% said in 4 time a year fillings.
It is what it is.
What MF has pulled off so far the last 3 years, is historical in nature.
I blame retail more that CEO, and MM/hedge fund short profiteer pirates. That too, is what it is.
I'd rather have a company that is diversified than one that has all their eggs in one basket. I'm happy for this development.
Investigation of Bucillamine as anti-COVID-19 drug: DFT study, molecular docking, molecular dynamic simulation and ADMET analysis
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
True.
ps. I got nothing these days.
pps. Saw the MF letter. He likely will tell shareholders to read the PR again.
ppps. Does the study continue for hospitalization or can Revive go back and contact the patients and use that as part of a long hauler study?
India sees 114% rise in Covid-19 deaths, 437% rise in cases in 28 days, Omicron variant XBB.1.16 behind the surge, warns WHO
https://www.businesstoday.in/coronavirus/story/india-sees-114-rise-in-covid-19-deaths-437-rise-in-cases-in-28-days-omicron-variant-xbb116-behind-the-surge-warns-who-375623-2023-03-31
ps. It's to bad Bucillamine is still Not approved yet, could be helping This situation probably....
So they’re using the capital raised to purchase MDMA stock and push that pipe dream forward. It should be 100% all Bucci focus right now
News: Revive Therapeutics Advances MDMA Transdermal Patch Development with Purchase of MDMA Supply from PharmAla Biotech
https://www.stocktitan.net/news/RVVTF/revive-therapeutics-advances-mdma-transdermal-patch-development-with-ohg1cm9pkwbb.html
It’s not a scam like so many in the otc it’s greed and incompetence. But he takes liberties like golf vacations in the Bahamas
Don’t worry eco gio gator cw will save the day
If it turns out CEO Michael Frank has ‘scammed’ us, a lawyer will offer little defense to the pound-of-flesh peeling that I sense he will experience having ruined so many families’ lives.
Just a hypothetical sense of course.
His silence is certainly deafening.
Where is his course of action follow-up to shareholders?
Amateur..
No, not necessarily. His first reply to me seemed to have a mildly defensive tone to it. I sorta expected it considering my tone in the first email i had sent him. The other replies i received felt more cordial.
(Only his first reply to me was CC'ed to Jay Vieira, a lawyer. The other replies weren't.)
So in other words, he said eff off.
So in other words, he said eff off.
hope not, counting on either a buyout or a quick turn.
Here is this..at this point only one of the few I listen to. Bmt reply.
The FDA gave Revive guidance on how to submit an SAP and they just announced they weren’t going to do that, despite all the promises. If they have a better idea, fine.
If this is purely a failure to deliver, then we’ll need leadership I can work with to get an SAP submitted per the FDA’s recommendations on March 7th.
https://www.reddit.com/r/RVVTF/comments/121xidv/comment/jdoo4g8/?utm_source=share&utm_medium=web2x&context=3
Ps. Im good at sensing things, but truely wanted leadership to prove This wrong....
pps. 6 shots is my limit lol :)
Just in case if you still read ihub lol..thanks for dd bmt. signed the N64 thing ;)
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Scientific Rationale of Bucillamine
Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to restore antioxidant and to reduce the activity of cellular glutathione 2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via restoration of glutathione activity and other anti-inflammatory activity, to lessen the negative consequences of SARS-CoV2 infection in the lungs.
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