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BS, DuPont and 3M are being sued for trillions of dollars now for lying about and selling fire fighting chemistry that is now causing sterility in Humans and Salmon and so on.
$RVVTF ? no lawsuits
Exxon lied about climate change it knew it was causing and knew was real 40 years ago. Cost? Trillions, also in courts
Dow and GE lied about agent orange, PCBs, dioxins and has lost 100s of Billions of dollars that will cost them trillions in today's dollars for next 100 years
That may be one thing MF has been waiting for:
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
These results propose that BUC can be a potential drug candidate against the COVID-19 disease progression.
$RVVTF BOOM up 10% today
Published ( online ) for the first time 3 days ago , not yet in paper print
More on the super highly contagious new strain in India
https://kathmandupost.com/health/2023/04/03/nepal-confirms-spread-of-omicron-s-xbb-1-16-sub-variant
Proof +ve of sheer ignorance of the easily verifiable fact that the trial has an extremely rigid health inclusion/exclusion criteria as opposed to having random patients simply agreeing to participate, ie, recruitment was designed to only source patients that fit the required criteria.
A simple perusing of the rvv trial on the clinical.gov site would have alerted one to this fact and as such one wouldnt make an utter fool of themselves for the world to marvel at. lololsss
Inclusion Criteria:
-- Is within 72 hours from onset of symptoms consistent with COVID 19 at time of study enrollment
-- Has at least 2 of the following: fever (oral temperature =38°C), cough, shortness of breath, chest x ray changes consistent with COVID-19 at time of screening
-- Has peripheral capillary oxygen saturation (SpO2) =94 by pulse oximetry at time of screening
-- Has either a laboratory-confirmed SARS-CoV-2 infection as determined by FDA-approved rapid diagnostic (e.g., PCR) assay
-- Has a score of = 2 on the 8-category NIAID ordinal scale at time of screening
-- Agrees to the collection of blood and urine samples, nasopharyngeal (NP) swabs, and non-invasive oxygen monitoring (via pulse oximeter) per protocol
-- Patient (or their legally authorized representative) is willing and able to provide written informed consent prior to performing study procedures
-- Understands and agrees to comply with planned study procedures
-- Women of childbearing potential must agree to either abstinence or use at least 1 primary form of contraception not including hormonal contraception from the time of screening through -- Day 29 following randomization. All subjects of childbearing potential, including males with partners of childbearing potential, must use highly effective methods of birth control defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1 percent per year) when used consistently and correctly. Abstinence is NOT an acceptable method of contraception UNLESS it is the subject's normal practice.
Exclusion Criteria:
-- Prior history of, or considered to be at risk for, agranulocytosis, nephropathy, liver disease, or interstitial pneumonia
-- Serious hepatic disorder (Child-Pugh scores B or C) or alanine transaminase (ALT) or aspartate transaminase (AST) > 5 times the upper limit of normal (ULN) at screening
-- Chronic kidney disease (CKD) National Kidney Foundation (NKF) stages 3B - 5 chronic renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min/1.73m2 according to -- ------- Cockcroft Gault formula)
-- Proteinuria = 1+ or = 30 mg on dipstick urinalysis that is confirmed on repeat assessment within 24 hours
-- Serum BUN = 2 × ULN or Cr = 2 × ULN
-- Leukopenia with absolute granulocyte count < 1500/µL
-- History of positive Human Immunodeficiency virus (HIV) test or organ transplant
-- Receipt of cancer chemotherapy or immunomodulatory drugs including (but not limited to) biologics such as anti-CD20, anti-TNF, anti-IL6; alkylating agents (e.g., cyclophosphamide); antimetabolites (e.g., azathioprine); or chronic corticosteroid use equivalent to prednisone >10 gm/day, during preceding 2 months
-- Confirmed positive for influenza at screening
-- Confirmed positive for respiratory syncytial virus (RSV) at screening
-- Pregnant or breastfeeding
-- Current use of, or known allergy to bucillamine or penicillamine (e.g., for Wilson's disease, rheumatoid arthritis)
-- Current participation in any other clinical trial of an experimental treatment
-- Receipt of any experimental treatment for COVID-19 (herbal/homeopathic, off-label, compassionate use, or trial related) within the 30 days prior to screening
Now back to my drink...............................
Two things:
1) let’s not compare revives ceo to Dow or DuPont or Exxon. Those ceos know how to run a company and what they don’t know they hire the right people to do.
2) the only thing historic in nature was the historic failure of being fast tracked to a phase 3 and still only getting to 710 patients in the worst pandemic in 100 years with literally over a million cases a day.
Actually it is very professional, not armature.
We have been told what the lawyers let him say, that is how real pubic stock disclosure works with CEO's that are not Pump-it scum bags.
They a rare bread, and attract a lot of flack and haters.
Check out how much bank stocks, Exxon, GE, Dow, DuPont tell shareholders. It is 99.9% said in 4 time a year fillings.
It is what it is.
What MF has pulled off so far the last 3 years, is historical in nature.
I blame retail more that CEO, and MM/hedge fund short profiteer pirates. That too, is what it is.
I'd rather have a company that is diversified than one that has all their eggs in one basket. I'm happy for this development.
Investigation of Bucillamine as anti-COVID-19 drug: DFT study, molecular docking, molecular dynamic simulation and ADMET analysis
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
True.
ps. I got nothing these days.
pps. Saw the MF letter. He likely will tell shareholders to read the PR again.
ppps. Does the study continue for hospitalization or can Revive go back and contact the patients and use that as part of a long hauler study?
India sees 114% rise in Covid-19 deaths, 437% rise in cases in 28 days, Omicron variant XBB.1.16 behind the surge, warns WHO
https://www.businesstoday.in/coronavirus/story/india-sees-114-rise-in-covid-19-deaths-437-rise-in-cases-in-28-days-omicron-variant-xbb116-behind-the-surge-warns-who-375623-2023-03-31
ps. It's to bad Bucillamine is still Not approved yet, could be helping This situation probably....
So they’re using the capital raised to purchase MDMA stock and push that pipe dream forward. It should be 100% all Bucci focus right now
News: Revive Therapeutics Advances MDMA Transdermal Patch Development with Purchase of MDMA Supply from PharmAla Biotech
https://www.stocktitan.net/news/RVVTF/revive-therapeutics-advances-mdma-transdermal-patch-development-with-ohg1cm9pkwbb.html
It’s not a scam like so many in the otc it’s greed and incompetence. But he takes liberties like golf vacations in the Bahamas
Don’t worry eco gio gator cw will save the day
If it turns out CEO Michael Frank has ‘scammed’ us, a lawyer will offer little defense to the pound-of-flesh peeling that I sense he will experience having ruined so many families’ lives.
Just a hypothetical sense of course.
His silence is certainly deafening.
Where is his course of action follow-up to shareholders?
Amateur..
No, not necessarily. His first reply to me seemed to have a mildly defensive tone to it. I sorta expected it considering my tone in the first email i had sent him. The other replies i received felt more cordial.
(Only his first reply to me was CC'ed to Jay Vieira, a lawyer. The other replies weren't.)
So in other words, he said eff off.
hope not, counting on either a buyout or a quick turn.
Here is this..at this point only one of the few I listen to. Bmt reply.
The FDA gave Revive guidance on how to submit an SAP and they just announced they weren’t going to do that, despite all the promises. If they have a better idea, fine.
If this is purely a failure to deliver, then we’ll need leadership I can work with to get an SAP submitted per the FDA’s recommendations on March 7th.
https://www.reddit.com/r/RVVTF/comments/121xidv/comment/jdoo4g8/?utm_source=share&utm_medium=web2x&context=3
Ps. Im good at sensing things, but truely wanted leadership to prove This wrong....
pps. 6 shots is my limit lol :)
Just in case if you still read ihub lol..thanks for dd bmt. signed the N64 thing ;)
Yeah it's a total scam with the FDA. When they didn't approve RVVTFs drug and you kept seeing things in the MSM about how bad ANYTHING was for you besides the Big Pharma approved vaccines?
I got the hell out.
This has been my contention on how the trial and data review has gone.
I certainly acknowledge that Revive has to own a bit of the process. But it is clear that the FDA gets to play king maker. They can control the tempo of the trial, move the target just enough so that the little guys struggle to change course, add a little more to what is required in testing, etc...
Throughout Revive's course we would receive the occasional update that the FDA was going to hand hold them to and through the next phase. But the timelines that we would be given was something crazy like 3-4 months at a time. When that time would lapse, the landscape would have changed just enough that we could see relevancy slipping.
We may never know all of what was truly behind it. Very likely some dropped balls on Revive's part. But in the meantime, the big's were basically being fast tracked left and right, only months or years later to learn that corners were cut in testing, or in some cases data was falsified (bad or damning data was intentionally left out), and they floated through unchecked.
Maybe there is hope yet. But I think most of us now understand that the FDA doesn't truly have the publics best interest at hand.
I didn't come back to gloat. I was mainly responding to the bowling part. IMO what the FDA is doing to smaller companies such as RVVTF is criminal. I said it back then and I say it now. The FDA fast tracked mRNA vaccines in 6 months when they hadn't worked or been approved for 25 years. And yet a drug such as what RVVTF has,...that has been around forever and proven safe takes years and multiple back and forths to get approval?
It is all a big scam....just like covid was.
And then they have to start a new 3 year trial for the next virus?
Yes, many egos to be satisfied.
Correct. Plus Bucillamine has many uses. That other poster your responded to just came back to gloat btw. Not worth your time.
I should have sold then too Threeflight but if Bucillimine works to degrade the effects of viruses of this type there will be a use for it down the line again even though BP seems to have all the advantages. Rest assured we will have a virus outbreak like covid 19 again.
I actually use 16 pound bowling balls lol. Have around 35 or 40 of them. All brands and types from reactive to urethane. Big fan right now of the Reality and the Venom. Average around 225 in many leagues and tourney's. Am also a PBA pro although not an elite one. Most of the pro's these days use 15 pounds. I like the extra power that extra pound gives me.
As for RVVTF.....I got out a year and a half ago when the covid craze started to die down and I could tell that the FDA was only giving BIG pharma the approval for covid treatments and vaccines. Smaller companies like RVVTF were being shut out from anything. IE.....it's all a scam.
The stock will probably hang around these levels for a while.
According to one of MF's emails, the trial was designed for hospitalization not for symptoms.
So, according to the latest Press Release, "Although the Study was originally designed for a ‘hospitalization or death’ primary endpoint, and it completed enrollment of almost three-quarters of the Study’s recruitment goal and recorded specific clinical symptoms (i.e. cough, fever, heart rate, and oxygen saturation), the Study was not designed to take into account all of the symptom assessments and supporting data outlined in the FDA guidelines to warrant a primary symptom-based endpoint for COVID-19 studies."
Which is why they're unable to pivot to the FDA's recommended primary endpoint. Even though the design was for hospitalization they should have assigned it in order to take in all data points to be more thorough.
I don’t know one way or the other. But could it be experience or lack of that determines success or failure? A BP has the expertise and staff. Or is it fact that small guys don’t have a chance
Sounds like the later is the case here
"He gave examples of other companies that had difficulties trying to get through to the FDA."
The companies he gave as examples were Atea Pharmaceuticals, Appili Therapeutics, CytoDyn, and Humanigen, etc.
Thanks. Interesting how he’s blaming the fda. Plenty folks here had both sides of that coin. They said fda is corrupt while saying also the fda was working with rvv on steps toward approval
I would think if they couldn’t get it done as MF stated then why waste time and money and simply partner or license to a BP?? If they don’t then all hope is lost and the drug isn’t what it seems
Sure this is now option 4 in the PR so maybe one day folks will wake up to a pps above 1.00 with news of some arrangement
Gltu
Since you asked to keep you posted i've had a few email exchanges with Revive (MF). I'm paraphrasing because i never asked for permission to post the entirety of his emails.
From my original email posted here in which i voiced my disappointment with Revive management...
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171514727
His reply was that i should speak to and argue with the FDA because they're the governing body. He gave examples of other companies that had difficulties trying to get through to the FDA. And, shareholders knew the risks.
I responded with "A poorly designed clinical trial is not the FDA’s fault, the fault falls on Revive’s management."
In reply MF stated that the trial was designed with hospitalization and the environment changed.
In response i stated that for shareholder's sake i hope Revive has a good plan for moving forward.
His reply was for me to read the Press Releases.
The long haul is over and gone.
Interesting comments in the reddit post Cw..
https://www.reddit.com/r/RVVTF/comments/124lnn4/revive_therapeutics_provides_update_on_psilocybin/?utm_source=share&utm_medium=android_app&utm_name=androidcss&utm_term=1&utm_content=share_button
Ps.still holding to see what happens with Bucillamine of course...
Pps. Rio even commented in there...
Nobody knows the trouble I've seen nobody knows my sorrow........CW thanks for the link,wonder if this will
help share price at all.
Remember this one? How you said it’s no surprise sheep pay a premium to the market
https://seekingalpha.com/news/3924063-revive-therapeutics-close-private-placement
Rug pull
News out on the other side: First patient enrolled.
https://revivethera.com/2023/03/revive-therapeutics-provides-update-on-psilocybin-clinical-study-for-methamphetamine-use-disorder/
Thanks Eco, I'm in for the long haul.
I'm right there with you Classic. Having owned this stock for 2 years I've put more in than I normally do with penny stocks but I guess this has turned into a long term investment rather than a short term one. No reason to dig your own ditch yet, hang in there.....
Yes but there are buy the dippers and some publicly here state so
The non-stop screeching about INVESTORS investing in rvv at these bargain prices is priceless. lololsss
Nobody believes these fake expressions of concern for shareholders are sincere so the act can come to an end.
Too bad, for some, the rabid attempts to create "chaos" has generally failed and likely backfired to some extent.
I wonder what our $25M benefactor Canaccord, and their cohorts have been up to lately!?!?!.............................
Yes but there are buy the dippers and some publicly here state so.
I want the stock to got up to .17 and get me back onto even on 10k shares!
Otherwise there’s a lot of pumping going on and sheep need to be aware.
Put me down for wanting the stock to go up. If this continues, my next ditch to dig may be my own.
ps. Not looking at the stock 50 times a day anymore; I only check it about 15 hoping for a buyout miracle or something to cheer about.
Hedge fund backed MMs prefer that stocks like $RVVTF go to zero, because they sell fake shares, pocket the cash, and if the stock goes to zero they never have to buy back the fake shares (illegal/unreported naked shorts, and short interest). It is also a tool for big business, bug pharma to kill young, limited funding start ups so BF can steal the tech...at fire sales
Flippers world only wants volume and a spread and chaos and mayhem as they drive the share price lower, because they buy more shares for less and drive the stock down to over sold status. The trade mark is "sell as the sky is falling" giberish, typically followed by deliberate bid whacks.
They only win if retail longs let them win.
Everyone wants to be correct but ultimately don't we all just want the stock to go up?
The daily inane posts CONsistently exposes how much an utter fraud ye are.
The motives arent altruistic one bit but rather has an obvious intent, that being to CONvince major retail holders to stampede for the door.
The reason for these efforts?.......time will tell!!!
Sorry plank, while dullard tactics may influence others, screeching non stop outside this window is futile.
Were now witnessing the separation, per say, of the revive Sheep and the Goats..........ie Investors vs Traders.
Eco
Well someone was buying.Hmmmmmmm!
https://www.reddit.com/r/RVVTF/comments/121xidv/request_for_presentation/
If you care to simply put aside at what's being requested, BMT does have some good thoughts on how to proceed forward.
Provide links. I want to hear the crying first hand
Everyone should check out reddit or Facebook revive pages and look at the recent post about getting 5% of the shareholders to ask MF Q & A to clarify our path forward. The reddit it by nick Nintendo and BMT. The Facebook Nick. They are trying to have everyone sign up by this upcoming Thursday.
What fake news? Only fake news I recall is MF telling us he’s moving to NJ back in Sept 2022
Heard a rumor he’s still playing golf in the Bahamas. Dude is screwing shareholder ever day.
Don’t believe put me on ignore.
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Scientific Rationale of Bucillamine
Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to restore antioxidant and to reduce the activity of cellular glutathione 2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via restoration of glutathione activity and other anti-inflammatory activity, to lessen the negative consequences of SARS-CoV2 infection in the lungs.
| Psilocin Pharma Corp. has developed production solutions for the active compound Psilocybin. Our process encompassed with our intellectual property cover methods of production of Psilocybin based formulations. Psilocin Pharma Corp’s range of products have been engineered to work synergistically with the body's own natural pathways of absorption while offering a contemporary approach to consumption. Psilocin Pharma also has strong relationships with specific lab partners in certain areas like Brazil, where these formulations are legally approved and plan to sell products in these jurisdictions. | |
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