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Rubber.....It would be great to have a product that really works. My sister is still dealing with some of the long covid stuff...fatigue,smell,tingling. Lets hope this can cross the finish line.
What I have is more of an annoyance than anything. A significant decline in fitness level from one year to the next that begs the question of "is this more than just aging"?
Doc tells me many of her patients have experienced similar since covid, with chest x-rays showing lung scarring that looks like "crushed glass".
There's a few of us hoping to make some cash out of our RVVTF investment, but there are countless more people out there whose health may have a shot at improving if Bucillamine proves to be a winner
Good luck to all!
Rubber....Sorry you have to deal with all that,hope they get "B" out to the public as I would like to try it for RA. We are going to see alot of other things pop up with the long covid.
Sorry to hear that Rubber. I trust, if we can get thing this to market, your problems will be lessened.
ps. I don't know if Bucy can help with your mother in law, though.
GLTA.
ps. Someday, somewhere, something soon will happen.
That's bizarre. It's well over a year since my infection. I still have constant rushing in my ears, reduced lung function/energy, and difficulty grabbing bits of information from my brain at times. Blood tests from my last two Annual medicals indicate my liver shows signs of damage that is inconsistent with my lifestyle.
This new study would explain why the mother in law slaps me every Friday night.
A odd long covid symptom - It's not clear how many people have developed face blindness after having COVID-19. But the woman, whom researchers identified only as "Annie" to protect her privacy, was one of more than 50 long COVID patients who reported to Dartmouth College researchers in a new study they were having trouble identifying faces after their infection.
I also saw that claim being made re the placebo group but I chose to verify whether it was true or not, found it wasnt, instead of pointlessly ranting about it.
My confidence in rvv isnt based on claims made by random anonymous posters online....but you do you!
Eco
Well I'll tell you what. The folks that got shingles would really wished that they got the vaccine! And probably the level of the shingles virus in the vaccine was to prep the immune system to produce antibodies to fight the bitch. I know folks that got it on their bodies and it is completely debilitating to the max!!
100% go Buci@
From a discussion on Reddit...
From Revive's patent from March 16th, 2021: "Preliminary indications are that none of the patients receiving Bucillamine in the trial have to date been hospitalised for COVID-19 or have died from COVID-19."
https://www.reddit.com/r/RVVTF/comments/r9ug7u/from_revives_patent_from_march_16th_2021/
However, there's no mention about the 1 placebo death or placebo hospital admissions.
The so called news media is not so much corrupt, as it is devoid of science journalists, in part because the so called watchers of the news media click bait news, 99+% have no real educations in science fields, and would not understand any of it. kind of like like the day day trading flip it market place, cesspool these stocks trade in...
The so called Shingles Vaccine is know to actually cause shingles. Google it,
I 100% agree "We have a winner here." $RVVTF
LOL, well I'll be a suck egg Mule, there it is, or part of it. I was going to charge $$$ for it, oh well.., at least it was fun letting the battle drag on claiming I made it up, while it lasted, so now they need to find other BS mud to toss to try and push the stock price down.
"'final thoughts' where it says 'since we had 140 patients taking bucillamine and none of them were hospitalized or died of COVID'.
https://www.reddit.com/r/RVVTF/comments/ritbjd/where_we_stand_on_the_trial/"
LOL, Zelle me the first 1/2, $250 and I will post it.
Hint, the 210 person DSMB review/data was allowed to opened by special request to the FDA, last year, to enable submitting of a request for a possible end points change, and possible ending of adding new people to the trial, which is in the RVVTF public reporting, filings, PRs. tweets in compliance will all Canadian and US regulator rules. So it was unmasked because the FDA approved the RVVTF request for permission.
Rather that waiting for me to reply, I suggest reading and search the known DD already here and in company filings and discussions, on reddit, here and CEO tweets... etc.
I do my own DD - anyone that relies on info posted on a board isn't being real smart. I do pay attention to what folks are saying here, but don't use it as gospel for my decisions.
Even the reddit post I provided to you is only a post. Do with it what you want. Folks that have truly been around for a couple years already know where I stand - no need to either trash talk or thump my chest here.
I have looked at all dd. I have been around here longer than most and never once read anything about the death or icu admissions. We all know about what was in the patent. If you are an actual investor I would think you would also want to see this information and not just believe what some pumper says.
A few weeks ago you were cheering potential results on, only to lambaste the stock when the latest update came out. Even to the point of calling for .05, trying to put words in others’ posts, and calling people out to try and bet against them. What is the purpose?
We can wait patiently and encourage each other on without the help you’ve given to this point.
Ok, Michael Frank. The ball has been passed back to your hands. Take your time to cross your t's and dot your i's. Give the FDA exactly what they want, and put a bow on it. The FDA is not keeping us around because they are nice guys. Clearly, the data is amazing and the unblinding of the next 500 at higher doses will be even better. At this point, all resources and efforts need to be put into this venture. When the new endpoints are submitted, then you may play golf. Until that time, ten hour days with thirty minutes for lunch is all I can give you. Let's make this happen.
This isn't official data / link you're looking for, but it as analysis frorm BMT - I could try to go back farther, but I'm not in the habit of spoon feeding folks - maybe spend a bit of time andd you'll find the data you're looking for, take a look at the last line of the paragraph before 'final thoughts' where it says 'since we had 140 patients taking bucillamine and none of them were hospitalized or died of COVID'.
https://www.reddit.com/r/RVVTF/comments/ritbjd/where_we_stand_on_the_trial/
With the new eyes coming in here I’m sure they would benefit from seeing the data showing one death and multiple icu hospitalizations in the placebo arm. You should find that and post it. You said in the one post it was from the dsmb reviews but that can’t be true because that data is blinded and whoever releases it is going to get fired. What you are saying isn’t adding up. The fact you charge $500 for dd is concerning if you can’t even provide proof to back up your claims.
Eco
Your last paragraph is imo.probably the most important to all the shot and booster recipients who will without a doubt be candidates for minor and major blood clotting. This has already killed too many for the corrupt media to acknowledge.
And PLEASE stop referring to the experimental shot(jab)as a vaccine. PLEASE!
IF YOU RECEIVE THE POLIO VACCINE IT PREVENTS POLIO. IF YOU GET A FLU VACCINE IT PREVENTS YOU FROM.GETTING THE FLU. IT YOU GET THE SHINGLE VACCINE IT PREVENTS YOU FROM GETTING SHINGLES. THANK GOD!
We have a winner here. Thats why I have xxx,xxx shares and am buying more.
Seems like you have to play the "No lowballs, I know what I got" card with these people.
Great job today folks, RVVTF is now luucky #7 on the break out boards, New eyes coming here the rest of the day and evening, lets keep posting facts and DD and explaining all about the gem we have here that is about to Go To $$s/share once the FDA approves the RVVTF antiviral Bucillamine...
Not the first time, and the common trick is to try and knee cap retail by paying a hedge fund to short the stock and at the same time hire a social media fake news squad to spread false information about the CEO, the tech, the chances of approval, the value, all to try and force a sell out cheap.
All we need to do is rally retail and explain the facts. Buy has not been this cheap in ages, and we are 2.5 years closer to FDA approval of potential Multi-billion dollar antiviral drug
I am an investor in many stocks, in new technology, start ups and in RVVTF.
Pressure on shorts and illegal naked shorts to cover will not go away, as the stock continues to rally. Time to cover and buy.
Time for shorts to pucker up, and go long.
Time to review what we know. For starters:
" Revive Therapeutics Announces Publication of Research Data with Bucillamine in COVID-19
TORONTO, Canada -- April 18, 2022 -- InvestorsHub NewsWire -- Revive Therapeutics Ltd. ("Revive" or the "Company") (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, today announced the publication of a scientific article evaluating the impact of medication, including Bucillamine, on antibody response to SARS-CoV-2 mRNA vaccines in Japanese patients with rheumatic diseases. The article titled, "Antibody Response to SARS-CoV-2 mRNA Vaccines in Patients with Rheumatic Diseases in Japan: Interim Analysis of a Multicenter Cohort Study", is published in Modern Rheumatology and can be found here.
The article described that antibody levels were significantly lower in the groups treated with TNF inhibitor (TNFi) with methotrexate (MTX), abatacept, mycophenolate mofetil (MMF), MMF or mizoribine (MMF/MZR) combined with calcineurin inhibitor (CNI), and rituximab or cyclophosphamide (RTX/CPA) compared with those treated with sulfasalazine and/or bucillamine or CNI (p<0.01). The newly published study further validates the potential of Bucillamine in the treatment course for COVID-19.
Bucillamine, an oral drug with anti-inflammatory and antiviral properties, is currently being evaluated in a Phase 3 clinical trial (the "Study") (NCT04504734) in patients with mild to moderate COVID-19. The Company intends to seek U.S. Food & Drug Administration ("FDA") Emergency Use Authorization.
"The potential of Bucillamine for COVID-19 is evident with its anti-inflammatory and antiviral properties and its potential use in patients who have taken SARS-CoV-2 mRNA vaccines," said Michael Frank, CEO of Revive....
Fun Fact nearly 300 Billion dollar Novartis drug firm started out targeting the same Market $RVVTF is targeting "a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders"
$RVVTF had Bucillamine already and jumped into the EUA-FDA trials for Covid19.
They are just about the only really promising new Covid19 drug left in FDA Trials and the FDA is acting happy to work with and modify and adjust plans and end points, because the FDA is now desperate for a win themselves....
https://ih.advfn.com/stock-market/USOTC/revive-therapeutics-qb-RVVTF/stock-news/87845219/revive-therapeutics-announces-publication-of-resea
Would be a win for investors if they sold out to bp in my opinion
Safely used for 32 years for RA, repurposed drug for Covid19 and soon for Long Haul Covid19 and other respiratory viruses and Liver transplants. Now in the late stages of an FDA EUA phase Trial, where 710 people were already tested.
No better risk vs reward, over sold, massive upside drug stock in the sector right now, this close to approval... $RVVTF
Massive DD shared and debated here for 2.5 years for new folks to catch up on.... Enjoy
Yes, I was right, again, and they raised 4.3 mil dollars. they raised millions at .10 and .40 and .50 during the 2.5 year Covid19 trial of a safely used for 32 years RA drug, being repurposed for Covid19, that IMO, based on know as of today research, will be proved to be a perfect drug for Long Haul Covid, and not just covid19.
They also have been approved by the FDA to suse the same drug for Liver transplants in an orphan drug trial approval.
That means the FDA like this drug for many applications!!!
Looks to me like a rug pull of RVVTF shorts has panicked RVVTF shorts. Best to cover now before the next news route pushes the stock back to .70/share
It is now clear to me that a Big Pharma operation has hired a hedge fund that shorts stocks and uses short and distort miss information to push stock prices down with fake news claims to scare retail on $RVVTF.
One of the best signs that Big Pharma must be talking to MF and hard bargain pushing him to sell.
That means we need to protect our investment and push the retail backup now.
WE start with all the reasons it is undervalued now. Including
"They just raised 4.3 mil based on 1 share at .15 and I think a warrant at .20 and .72/share
I have been an investor here for years. Big pharma and their FDA are roadblocking RVVTF's Bucci to pressure RVVTF to sell out Bucci.
Put yourself in the investor shoes. You supposedly paid .15 for a reason?? What was shared or stated that compelled that person to pay the premium
It’s very possible things were said that could have been misleading
I guess time will tell
Meanwhile pressure on who became instant bag holders will not go away near term
Keep in mind the virus also forces the body to produce virus cells with lots of spike proteins.
Not just the vaccine. The difference is that vaccine spikes to not attack and enslave human cells turning the infected cells into WMD's that mass produce the virus.
Both wake up the immune system to make antibodies.
Some antibodies mass produce WMD's, the most deadly ones on the planet, known as Super Oxide Anion. It is the most powerful oxidant known to man. It damages genes and DNA and that damage can lead to cancer...
One of the regenerable, mother of all antioxidants is Glutathione, which Bucillamine regenerates, and it is 16 times more active than "NAC" and it neutralizes excess Super Oxide Anion.
It also is a safe blood clot buster, that we know will work for most all autoimmune diesease thanks to recent discoveries we shared here several months ago. And it helps block Covid19 cell infection... Safely!!!
no--just a bet about the "lawsuits" that you published here that you say will happen--
I’ll take a bet we see .04 before .12.
The stock could 4cents in either direction
Wanna bet that?
No connection rvvtf closed up Friday. But the trend is down as people get tired having there $$$ sit
BS, Friday a major US Silicon Valley bank died, 169 Billion dollar bank died in days, and the US stock market took a massive hit, and yet RVVTF closed green Friday, already rising back up now because people now understand the news was all good news.
One could make more money flipping that kind of volatile garbage daily than trying to scare longs in RVTTF in a failed routine of lets just make some shit up and scare retail on RVVTF..
Time for RVVTF shorts to cover RVVTF shorts before they end up like the Silicon Valley bank, broke, begging for crumbs on street corner IMO
want to bet on whether there are any lawsuits that you feel will happen?
Sheep will be sheep
I admit I was surprised that investors were willing to pay a premium. Those same investors can’t be happy with todays pps.
Watch for the lawsuits from those down 50% in a matter of weeks
I’m not the only one on here calling for nickel pps. I’m not necessarily buying at nickel like others. Nothing going to change the short term outlook folks will get bored or move cash to real runners instead of keeping money here
Not a single cataylst here over the next 120 days
I found it here in posts linked to the Official $RVVTF updates on the DSMB periodic safety reviews that were DSMB safety gateways to the second round of 500 people tested and and the approval by the FDA to up the daily dose (100?) and it was discussed and debated here for weeks and weeks and periodically since then. We all saw, read and know that the first 210 people, that none of the RVVTF Bucillamine dosed people at the low doses (The next 500 people got the higher doses) died, non even ended up on ventilator, and if IIRC none of the RVVTF Dosed patients in the low dose 210 person group, even had to go to an ER.
One of the Placebo (Please google the definition of "Placebo"), it is not the RVVTF Bucillamine dosed people group, Placebo is the people that go a fake, no drug pill instead).
So one placebo death was good news for the RVVTF drug, bad news for the person that did not get the real RVVTF Bucillamine.
I suggest you read the last 3 years of posts here, and the articles and discussion, and do real DD. I charge $500/hour to do DD research, etc, for customers.. WE all saw it and know it is posted and debated here already.
Is Eco overly bullish; probably. Is Govprs full of ishit in every post absolutely. I guess the guy has a set; to claim for weeks that there is “no possible way that Revive can get their funding”.and still come on after the funding was completed and make more ridiculous comments every day. No one is listening to his garbage.
Bottom line is there is still a need and there is currently the fewest drugs available to treat iCovid since the first drugs were given an EUA. Add in the fact that no one wants the vaccines anymore and there is still a big opportunity for Revive. We have an extremely safe drug with strong science that shows it should work and work extremely well. We unfortunately also have an extremely small company with three actual employees that have made many mistakes along the way as they try to compete on the big stage. Revive is squarely still in the game and there are certainly still hurdles left to cross over but the risk reward here is as good as it gets especially at these prices. The FDA has given the go ahead for the EP change, Revive just needs to send in the protocol as the FDA stated and we will be looking at symptoms as an endpoint. The DSMB will be shortly after where we will finally see the data. If you believe in the science and opportunity shut out the noise and maybe avg down. If you don’t believe in the science sell your position, take the L and go buy some crypto; it’s still cheap!
That "So it appears that a specific trial is going to have to be done to determine if Bucillamine works for long haulers. It's not enough to just go back and ask each person about symptoms now, It has to be in the design"
Is not clear, and will not be clear until the data is un-blinded and the case histories since the trial started are collected and examined for clues, "oh my god" Holy smokes" "Wowser" insights are found and analyzed. It is obvious to me the FDA is ready and willing to let that take place, and based on what we know, what I know, I expect that they wild enough evidence inside and out side of the trial support approval of $RVVTF use for Covid19, enabling doctors to use Bucillamine on patients with Long haul Covid when they get repeat infections, if they have RA and Long haul covid for instance.
The hardest part of all of this is behind us, that is getting ones foot in the door.
The FDA has already seen the data from the first 210 people, and the FDA and DCMB both allowed the trial to continue with higher does rates for last 500 (whose data has not yet been seen), that is huge folks!!!!
Most drug trials with the FDA take 100s of Millions of dollars and 10 years to get to where $RVVTF is already today with Bucillamine EUA for Covid19.
People still get Covid19 infections and reinfections daily, and about 300 people in the USA die daily because of Covid19. That does not include people dying from the protein spike remnants that trigger the micro blood clots, that trigger all manner of Autoimmune symptoms common to ME-CFS, MS, Lupus, Lyme, RA, that we now know $RVVTF can address (Call Bucillamine a safe blot buster? One of its many advantages, and benefits).
That "With fewer people getting Covid, patients are going to be hard to find." is not true.
What is true is that fewer that are getting it, end up in ICU's dying.
What we need is approval based on the existing door, that opens its use for people that have long haul covid19, and RA, when they get reinfected with Covid19, and then let the new data show it also reduces long haul covid19 symptoms just like it does RA symptoms.
We already know the damn stuff is safe and has been used for 32 years safely for RA, and autoimmune disease just like the others listed above.
The only real difference between all the autoimmune diseases is a key part of the body the autoimmune diseases attacks first, that knee caps the body, leaving it open to a myriad of other failures and infections...
I agree:
"Cheers to unblinded the final 500 and show the world that this drug is boss for many infectious diseases including covid"
"Unblinding and a buyout will still be a nice return." Or a JV licensing and marking deal with a major partner.
IMO, Bucillamine has many applications that have huge world wide market potential for life time daily use of the drug...
They just raised 4.3 mil based on 1 share at .15 and I think a free trading warren at .20.
Looks to me like a rug pull with MF seen playing golf in the Bahamas.
Good luck to you
Nice, to have you Ben
New here. Just glance at FINs. Zero revenue last four years, is that right?
What is the excitement here
Selectively quoting is a 100 times out of 100 sign of total failure........no, we are definitely not in the same camp!
So barchart.com is now part of the fda decision making inner circle??? lololsss
Try again................
Apparently "some" still havent yet grasped the concept that the pps of a stock doesnt always mesh with its Intrinsic Value, which IMO applies to revive at this point.
Sorry but Im not falling for the ongoing game of "cat and mouse" being played between revive and the fda, along with the accompanying market shenanigans thats been a trading feature.......oh and mindless agitator(s) who have no clue about anything and a patently obvious agenda!
It's getting rather clear that theres ever an intensifying effort by a team of clods trying everything possible to convince holders to dump rvv.....problem is the efforts are simply incoherent and daft.
Giovanni
Also all the fing terrible side effects of the spike proteins!!
Giovanni
Also all the fing terrible side effects of the spike proteins!!
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Scientific Rationale of Bucillamine
Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to restore antioxidant and to reduce the activity of cellular glutathione 2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via restoration of glutathione activity and other anti-inflammatory activity, to lessen the negative consequences of SARS-CoV2 infection in the lungs.
| Psilocin Pharma Corp. has developed production solutions for the active compound Psilocybin. Our process encompassed with our intellectual property cover methods of production of Psilocybin based formulations. Psilocin Pharma Corp’s range of products have been engineered to work synergistically with the body's own natural pathways of absorption while offering a contemporary approach to consumption. Psilocin Pharma also has strong relationships with specific lab partners in certain areas like Brazil, where these formulations are legally approved and plan to sell products in these jurisdictions. | |
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