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White Choc.... I agree. At least 2 years ago multiple leading scientists announced that 'historically' viruses become weaker and weaker as they mutate over time. Hence, all of the talk about how the delta virus will eventually mutate and be treated as a common winter flu. This is exactly what happened.
And.... over that period of time standard of care (SOC) continued to improve. So biotech therapies during their FDA studies were constantly competing against improving SOC. IMO it was improving SOC is what took the legs out of most biotech FDA covid studies. As far as I could tell, most FDA studies for covid did not 100% decouple their primary endpoints from SOC. Investors who made a lot of $$ on the covid biotech sector did so by selling 'on the hype'. Those that lost $$ typically were those that held their shares down to the end (FDA trial completions).
Now RVVTF must dump/dilute more shares to keep paying their high compensation packages. The O/S and float will continue to grow. I now only see one undesirable outcome for this when MF and other officers realize that they need to re-energize this cash cow machine while they continue to pursue the DREAM of actually generating sales from a real product. Shroom sales just won't cut it IMO.
I suggest ye go back to the narrative at that time and youll see what you claim is 100% false bullshite!!!
Seems ye absolutely cant read but instead choose to use snippets that support yer arguments.....the fact is a "positive trend" @ 210 means nothing as it could NEVER be extrapolated into meaning a positive outcome @ 1000 so your inference is totally asinine!
"Put in place???"......keep telling yourself that jester. lololsss
Just proved my point......ye muppets are too easy. lololsss
#uselessagitators
Didn’t take a rocket scientist to know the virus would mutate to a less serious strain over time. We weren’t going to be with delta forever. And no one would know how the results would have been if they recruited all 1000 before omicron but based on the first 210, which were before omicron, the trend was looking positive. So keep making useless arguments every time I put you in your place if that makes you feel better about yourself.
You talked about the virus changing and I said that’s a bs excuse cause they had more than enough time to get 1000 people in the trial before the virus went to omicron.
Apparently only you, a chocolaty board scammer, amid all the lying and misinfo put out by the medical establishment, only you knew how the virus would progress over time. lololsss
In addition, you literally have zero idea what the results would have been even if the 1000 were recruited before omicron so as with everything else you post........BULLSHITE!
#arseclowns
Where did I talk about their criteria for patients to get into the trial? No where. No one is arguing anything about criteria. You talked about the virus changing and I said that’s a bs excuse cause they had more than enough time to get 1000 people in the trial before the virus went to omicron. Ye need to work on your reading comprehension.
Hurting???
Played the volat since the original run in 2020 and still do to this day ye numpt.....obvious ye havent read anything bcuz yer too busy posting asinine quips and acting like the board jester.
The benefit of having free shares is that the garbage spewed by you lot is wholly meaningless and why pray tell would I pay any attention to some knob who literally knows nothing.
Seems now ye magically transformed into a Clinical Trials expert innit. lololsss
Get a life and a real job joker.........................
Its a known FACT that the trial only selected individuals that met their stringent criteria because it was geared specifically to investigate the effects against mild/moderate disease and as such me citing that FACT was most pertinent.
That ye cant grasp this just proves my point that yer illiterate and lack basic comprehension skills.
Just one of many scammers that invade the board daily to post garbage......how truly pathetic!
Zero deaths and only 3 hospitalizations in the placebo group. There is nothing to read between the lines. Bucillamine did not outperform the placebo in any way, shape, or form. Look I know you’re hurting but when you compare bucillamine to the placebo you have nothing….zero. If all you have is O2 sat it is weak. A lot of things affect O2 sat including patient position. Were the patients in the trial self-proning? If some were and some were not that would skew the O2 sat results. How many of these patients were fluid overloaded? Did any of these patients get diuretics in a timely manner? All of these things affect oxygen saturation and have nothing to do with bucillamine or placebo.
No shit Sherlock. I never once mentioned it being for high risk. You brought that up in your original reply to me. I said in my reply to you that I never mentioned high risk. Maybe you need to learn to read peoples posts instead of flying off the handle right aways and insulting people. Makes you look like a tool.
"...there were no deaths and four hospitalizations, of which three were from the placebo arm and one from the Bucillamine low dose group (300mg/day)."
Talk about self owing oneself. lololsss
Its yet another clear demonstration of the lack of basic knowledge among "agitators".
It was the DSMB that recommended eliminating the low dosage ye cited, opting instead for the 600mg/day dosage where there were ZERO deaths and hospitalizations ye numpt.
Keep exposing yerself as a complete fraud with an agenda.
Wont even grace the other buffoonish "ice pack" post with an answer since it deserves none and only serves to expose the silliness of you lot.
Ice packs will reduce fever too. Pack 'em under the arms. They're cheaper than bucillamine too.
"...there were no deaths and four hospitalizations, of which three were from the placebo arm and one from the Bucillamine low dose group (300mg/day)."
Nobody died in the placebo arm either.
Nice try
The trial was never intended for HIGH RISK patients but rather those with MILD TO MODERATE disease....good grief!
The level of pure ignorance displayed by that silly comment truly astounding.
I cant say Im surprised one bit.
For one who literally does nothing except whine ad naseum and cite nothing of remote relevance, you so do pretend to know a lot about whats going on......BULLSHITE!!!
ZERO in the high dose group......learn to read, but then again the omission of pertinent info is likely on purpose.....what a numpt!
Do you know that reducing fever with ibuprofen will improve oxygen saturation?
Cite a study akin to the trial results presented in the buccy trial......you cant because there are none in comparison.
As a supposed ""professional"" you would obviously know that ibuprof was and still is NOT recommended as a widespread treatment for many covid patients due to its interactions and myriad short and long term side effects, as opposed to the tried and now tested Buccy.
What a joke....................
Nothing was talked about regarding high risk patients. I said the excuse of a changing virus was garbage because he had more than enough time to enrol during delta and earlier variants. You said as the trial dragged on they had less chance because of the virus getting weaker. Well no way. That was the most profound statement I have ever heard. He shouldn’t have taken that long in enrolling to begin with. That’s why I said the excuse of a changing virus is stupid. The virus was always going to change. The speed at which they enrolled was the problem.
And how does RVVTF monetize that?! They can’t short of a buyout. They do not have three years and millions of dollars to start fresh for a new study on said symptoms for a virus the majority of the world has moved on from. Hence BP buyout is their only out. And regardless of said symptom relief which comes with time regardless, propping their value up on the heels of a failed trial will not fetch a significant price
Three hospitalizations from placebo and one hospitalization from bucillamine. Maybe MF should trial the placebo. What do you think?
I'm a bedside healthcare professional. Do you know that reducing fever with ibuprofen will improve oxygen saturation?
The unbridled ignorance is palpable.................
75% of the hospitalizations were in the Placebo group based on low dose for Bucillamine and 100% of the hospitalizations were from Placebo in the High dose Bucillamine trials.
data demonstrated that for patients with oxygen saturation <96% at baseline, Bucillamine had a 29.1% improvement over placebo in time to normal oxygen saturation (SpO2)"
Additional analyses of the Study data are ongoing, which could support certain strategic decisions on pursuing the development and commercialization of Bucillamine
Whether the latter analyses bears any fruit remains to be seen but do stop with this nonsensical diatribe.
While you may be able to CONvince some here, there are those who actually "read between the lines" and extract the not so obvious nuggets of info.
I dont have any PROOF, but, the EVIDENCE discerned from past investing experiences, suggests that its primarily agenda driven, as opposed to simply being people with no life goals that revel in the misery of others.
What is behind all of the happiness behind the demise of this stock? Why do some of you enjoy beating people up and seeing others lose money? Everyone is entitled to their opinion whether it's bearish or bullish. This stock will either go back up, be bought by another pharmaceutical or it will tank. Those are the options. Thus is the nature of investing in penny stocks. Email and social media has made it so easy to be nasty to others without suffering the concequences.
"There was no significant overall improvement trend between the Bucillamine and placebo arms for observed clinical symptoms and viral load data."
Enough of your retaliatory BS you insolent little peasant.
I understand how difficult it may be to grasp, hence I will ""dumb"" it down so even you can understand.
Wild Strain/Delta were more VIRULENT as opposed to Omicron and as such the longer the trial dragged on the less likely statsig could ever be achieved because as the data proves, death and hospitalization rates plummeted after the Delta surge and even more into Omicron.
Also, I repeat the point which you CONveniently ignored, the trial cohort EXCLUDED participants who were most likely to die or become hospitalized because of the stringent medicals that those chosen had to undergo.
I was and still am no fan of MF (the critical posts are there) so any reference to his stewardship of Revive is wholly irrelevant, ie your entire post, because I invested because of Buccy, NOT MF.
Exactly, and as such theres EVIDENCE, based on the data and posted studies, that Buccy is effective re symptom relief.
Reading and Comprehension 101 as opposed to the ad naseum windbaggery on display from certain persons with an agenda and/or nothing better to do than post about a stock they dont,or have never owned.
Honestly speaking, how utterly pathetic is that........................
Statistical significance had nothing to do with a changing virus. They had plenty of time to enrol enough patients before omicron came into the picture. The changing virus argument can stop anytime cause it’s not even relevant.
FACT: Medical professionals are driven by evidence based medicine.
You have nothing. If you can’t handle that fact I suggest a GI Joe and a sippy cup.
If you cant handle FACTS I suggest crayons, a picture book and a quiet "safe space".
Obviously this adults only area isnt for you.
Funny how ye never seem to address the cast of losers who come here daily solely to gloat and mock (shite) all over those who "lost big" but yer problem is with my post about self accountability.......what a joke!
#whiners
Agree with the first half of your post. A pity because for the remainder, you come across as a gloating bell-end.
#wanker
The results show no such thing and that very statement literally proves one cant read and, most importantly, COMPREHEND!
The data did not show statsig for the trial objectives ie hospitalizations and death, but did show effectiveness re symptoms, which is why they tried to modify the ep's to symptom relief.
Anyone with two functioning brain cells and a basic understanding of the process saw that the reason for the lack of statsig was due to the evolution of the virus over time to less virulent forms and the fact that virtually all deaths were VERY OLD and VERY SICK people.
The composition of the persons recruited for the Buccy trial were only healthy people so in hindsight the ""death ep"", and to a lesser extent the hospitalization ep, of the trial was dead on arrival from the onset.
The comments here from a bunch of whiners says it all about the utter stupidity on display.....no one is to blame for any losses other than the investor who greedily went all in rather than playing the volatility since 2020.
Problem for the agitators is that those of us who did now own loads of FREE SHARES and as such cant be swayed by the yarn being spun by the ""army"" of planks here......keep posting in vain! lololsss
#bloviatingwindbags
And I’m sure some Greeks still believe in Zeus.
What is to still believe? The data shows its ineffectiveness. It took years to get to that. There’s nowhere else to go save a buyout for a few pennies for a BP pet project who thinks they can roll the dice on another indication years down the road
Gray area hypotheticals are his forte. As I said before he can milk his six figure salary for awhile longer dangling the carrot in front of investors who are in hefty denial until the checks dry up and he has no choice but bankruptcy. Pocketed a few million and can play the “ho hum I tried” card.
Yeah I agree but once again the wording of the PR is strange. It said something like working with interested partners for potential approvals. I take that to mean they have nobody from BP knocking on the door, but who knows with the history of MF's vague PRs.
Our only hope is for Revive to be bought out by BP. MF did make mention of partnering so I have to figure that maybe just maybe we will all get lucky. Why sell now, I lost most of what I invested.
Here’s a post from another message board that lays it out pretty clearly.
“It’s apparent with the recent developments of the bucillamine trial, it is proven that bucillamine is a powerful drug for luring people into the idea that it might be effective against anything to do with breathing. Clinical trials have proven that if you say “it looks as if bucillamine ”or “there might be evidence that bucillamine…” it is a powerful tool for market manipulation. The ability of Bucillamine (alias name of a poster) to put out countless Press Releases, indicates that bucillamine is a powerful tool in the epidemic of ‘pump and dump’ stocks. Bucillamine has proven to be a powerful IP for its CEO and board members to create unlimited hopium for investors. And when 2.0 is added to bucillamine it appears bucillamine can be 2.0 times as effective for bringing in new investors and will extend the life of bucillamine for another year. Who would have thought? Oh… yeah… MF.”
It’s pretty hard to be outraged when you enable and promote the scam.
It’s pretty hard to be outraged when you enable and promote the scam.
LOL. Wrong again. Historically, my charter was to respond to those posters who blatantly bashed / chastised this company and stock without backing it up / quantifying their statements. I am all for negative posts if they are backed up. Dignity doesn't feature here.
I see you are on my blocked list which means I have thought you were a twat for some time now. This has not changed.
#bucillamine
To clarify, I believe in Bucillamine not CEO Michael Frank. You have confused me with another poster when you claim that I have "defended" him (in fact I have done quite the opposite and yes, I am outraged by how he has played his role as CEO). In my last response to your onslaught of bitterness, I meant refrain from such statements as "this goose is cooked" among others of yours - again, some of us Longs still believe in Bucillamine.
You want dignity now after blindly defending this buffoon of a CEO who took your money and the incessant pumpers on here? You should be outraged. You. I. Everyone here are bagholders and need to face reality. MF is now milking a hefty salary on us. Denial
Were you showing dignity when you castrated those who correctly pointed out all the red flags over the years?
Yes I'm 100% calling them out. They have absolutely no criteria that would say it's over because most of them have been practicing nothing but blind faith for 3 years now. They will continue with this delusional behavior because they know nothing else. I'll wait till the grass stops growing and the rivers stop flowing for an answer.
How bitter are you fella? We Longs are all mortified but show some dignity by giving it a rest.
Target all your hatred and despair directly at CEO Michael Frank vs here. His response will be telling after all.
Apparently Michael Franks office chair being auctioned by the bank
Okay…so tell us what objective criteria is required to say the fat lady is singing?
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Scientific Rationale of Bucillamine
Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to restore antioxidant and to reduce the activity of cellular glutathione 2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via restoration of glutathione activity and other anti-inflammatory activity, to lessen the negative consequences of SARS-CoV2 infection in the lungs.
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