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Hang in there, buddy. I've seen horses finish first without a jockey.
ps. I just realized they are disqualified, but you see my point. lol.
pps. As cash depletes, a partnership is growing more and more likely and more and more imminent.
Personally I now think of MF as the big letdown. Until he proves otherwise.
It is no good owning the best thoroughbred race horse if the Jockey is crap.
gator why not Buc for glutathione?
Glycine and NAC pair to increase Glutathione, Increased Glutathione increases have some dramatic effects on increasing life expectancy and health.
This reference cites a number of YouTube videos on the subject. Dr. Brad Stanfield is an interesting addition to the regular Youtube channels as all his videos are based souly on printed medical studies, and he has no horse in the race.
insert-text-here
Agree. This is the first time we heard it from the big cheese.
The fact that MF mentions partnership more than once in the PR is a positive sign, GLTA!
it's easy to play with percentages - but keep in mind thata 17.5% increase comes after a 66.7% decrease (just speaking roughly of the .15 to .5 drop I could site worse.
agreed I was referring to the letter. A shareholders mtg (scheduled and publicized) wouldn't be a bad idea.
Frank screwed every shareholder due to his incompetence. That’s why people are upset. And now the dsmb will likely tell them to continue which will not help anyone cause we have no money or patients, or they halt due to futility. Either way we get screwed. Not a chance they halt due to efficacy.
Maybe. But I think it is only reasonable that the shareholders can request to have a shareholders/investors call. I don't think that would have created any questionable scenarios, if the call is publicized for all to be able to join.
Just as well, they could have transcribed question & discussions, and made it available to the public. I think if they (RVV) try to use that as an out or way to possibly avoid taking questions from the "angry mob" that is just cherry picking to avoid the tough situations, which then seems to indicate a very disheartening pattern.
Did u see mice and men. We are George.
Single-Dose Psilocybin Promising for Resistant Depression
Liam Davenport
April 06, 2023
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PARIS — A single 25-mg dose of a synthetic formulation of psilocybin appears to improve the core symptoms of treatment-resistant depression (TRD), a new analysis of phase 2 trial data suggests.
Known as COMP360, the synthetic agent, a proprietary, purified form of psilocybin, improved symptoms related to mood and anhedonia while leaving aspects such as appetite and weight changes unaffected, report investigators led by Guy Goodwin, PhD, emeritus professor of psychiatry, University of Oxford, UK, and chief medical officer, COMPASS Pathways.
The study was presented here at the European Psychiatric Association (EPA) 2023 Congress.
100 Million Affected
Affecting up to 100 million people globally, TRD is "not an official diagnosis," although it is often defined as the failure to elicit a response with at least two antidepressant treatments, said Goodwin.
Compared to their counterparts with non-TRD, those with TRD experience higher relapse rates, higher rates of suicidal behavior, and more residual symptoms even when they do respond to treatment.
Previous results from the study known as P-TRD indicated that a single 25-mg dose of COMP360 significantly reduced depression scores for up to 12 weeks when given along with psychological support, although a later analysis suggested the effect subsequently dropped off.
The vast majority of the patients in the trial were naive to psychedelics, and so, Goodwin explained, they undergo a preparation phase during which they receive psychoeducation and have at least two visits with a therapist, who then stays with them during administration of the drug to offer support if they experience psychological distress.
Following the psilocybin session, participants go through a process known as integration, which involves two sessions with a therapist within 2 weeks.
Understood. It’s all good except those who do intentionally misinform
They know who they are
The PR from last night does shed light on the current conundrum MF had gotten himself into. Hopefully he resolves for all shareholders
no one here is an expert - just folks posting their views / opinions.
The FDA is in bed with big pharma and want to control everything.
According to experts here like ric this will never get approved because fda is corrupt
It’s was a pump and dump all along
If the drug has value then the only path forward is with a partnership.
Hey CW, I'm still kicking. I'm like an eagle flying above just circling this skies ever watching. Hope you are well, along with all the longtimers!
I'm thinking even IF the data shows BUC works for hospitalizations, Revive will still have difficulty getting approval based on that since it's not as pertinent as it was at the time the data was taken IF it is effective, the data should have been unblinded a year or so ago and submitted at that time. MF is now stuck between a rock and a hard place.
Boys- There is one thing that I can't get straight in my head. Well, lots of things but that is a story for another day. I get that continuing the trial is going to be tough with the current endpoints..... but.... The 710 were done with primarily the Delta Variant upon which hospitalizations were quite high and the last 500 were done with higher doses of Buccy. Even with many getting the placebo and a third getting the dosage the same as the 210, that should tell is something definitive. I guess the argument is that a few patients can swing the vote one way or another and more data would need to be collected. Any thoughts?
ps. Let's go dmsb. Ship this thing through quickly.
These PRs sound like a broken record at this point.
Probably the only way he could respond. If he sends any type of material info in a letter to just some folks and it is acted on, it's sort of insider trading. He probably tried to hit on the questions while at the same time saying he's not going to respond to individual letters / emails with anything he feels is material. True that it gave the impression of thumbing his nose at the letter, but the response had to be expected by BMT if he knows about how this stuff works.
The company don't give up easy I'll give them that
Hey, Blue. Good day in Frankfort. Come on, we have to get excited about something. It's a funny way to respond to a letter, agreed, but I think we are finally on the right track.
I firmly believe in Bucillamine’s wider usage but candidly, I now believe little in Michael Frank as a leader to make Revive a success. I seriously hope I am proved wrong and challenge him to ensure I am and others are.
The company intends to follow the same path that was laid out since Sep/Oct 2022!?!?!.....what an absolute shock!!!
Bunch of screeching planks................
Bit of a word salad with multiple directions. Lets just hope they can deliver on SOMETHING
Thought the same. Utilized a PR to throw shade at BMT’s letter and request. Truly incredible
This Vitamin Supplement Linked To 40% Lower Dementia Risk
{take a guess}
It is thought that the vitamin helps clear the brain of the characteristic tangles of proteins that form in dementia.
Taking vitamin D supplement could decrease dementia risk, a large study suggests.
People who took vitamin D supplements lived for longer without developing dementia and overall had a 40 percent lower risk of developing the disease.
Adequate vitamin D levels have been repeatedly linked to lower dementia risk by research ( 1, 2, 3, 4).
One study has even suggested that adequate levels of vitamin D could prevent almost one-in-five cases of dementia ( Navale et al., 2022).
However, the link remains somewhat controversial, with other studies finding no connection (also: Owusu et al., 2018).
Professor Zahinoor Ismail, the study’s first author, acknowledged the contradictory findings from past studies:
“We know that vitamin D has some effects in the brain that could have implications for reducing dementia, however so far, research has yielded conflicting results.
Our findings give key insights into groups who might be specifically targeted for vitamin D supplementation.
Overall, we found evidence to suggest that earlier supplementation might be particularly beneficial, before the onset of cognitive decline.”
Vitamin D and dementiaFor this study, data from over 12,000 participants in the US National Alzheimer’s Coordinating Center was analysed.
Just over one-third were taking vitamin D supplements.
The results showed that vitamin D supplementation was associated with a reduced dementia risk in all groups.
However, the connection was stronger in women and people who had no pre-existing cognitive deficits, such as mild cognitive impairment.
Similarly, carriers of the APOEe4 gene appeared to benefit more from vitamin D supplementation.
The APOEe4 gene significantly increases the risk of developing dementia.
It is thought that vitamin D helps to clear the brain of the characteristic tangles of proteins that form, known as amyloid and tau.
Dr Byron Creese, study co-author, said:
“Preventing dementia or even delaying its onset is vitally important given the growing numbers of people affected.
The link with vitamin D in this study suggests that taking vitamin D supplements may be beneficial in preventing or delaying dementia, but we now need clinical trials to confirm whether this is really the case.
The ongoing VitaMIN D study at the University of Exeter is exploring this issue further by randomly assigning participants to either take vitamin D or placebo and examining changes in memory and thinking tests over time.”
I dig the PR and it is clear MF received the said letter. I hear unblinding and partnership, and I am getting optimistic again.
ps. Let's see.
Yeah, that sounds like a direct shot across the bow to let the "rogue faction" know that Revive is not going to comply with their "demands for answers".
I guess if there is a question that I would want answered from them at this point is if they fully intend to keep their IP and only pursue partnerships, rather than potentially selling it to BP?
But it also sounds like they were trying to be a bit more complete with their information in this last PR.
"At this time, the Company will only provide regular updates via press releases as information becomes available."
This is the first time i've seen this statement in one of Revive's PR. When Biomedical Trader (BMT) sent Revive the letter of questions approximately 5 days ago he stated that he wanted Revive to respond to the questions by the end of business Friday, April 21, 2023.
Because of this latest PR and specifically the "At this time" language in it i have a feeling that Revive (Michael Frank) will forgo providing a non PR response to the letter/questions.
A reminder of the letter...https://www.reddit.com/r/RVVTF/comments/12kpawg/letter_sent_to_the_bod/
Revive Therapeutics Provides Update of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19
April 18, 2023 18:44 ET
https://www.globenewswire.com/news-release/2023/04/18/2649628/0/en/Revive-Therapeutics-Provides-Update-of-Phase-3-Clinical-Study-for-Bucillamine-in-the-Treatment-of-COVID-19.html
Informal shareholder meeting
https://www.reddit.com/r/RVVTF/comments/12qmj8o/informal_shareholder_meeting/?sort=controversial
Good move CW :)
I remember Fress selling his 1 million RVVTF shares at around 70 cents in December '21 and then disappearing. Smart man! That's not to say we won't ever hit that (and more) again, but how many shares would $700k buy at today's prices?!!!
Lol. You have an excellent memory, Rubber. She does not really understand the concept of owning stocks. She is still holding it and doesn't quite understand what she owns, but I slipped her $100, so that in case of Armageddon, I still remain her favorite uncle
ps. I saw that Merck bought out a company today for, I believe, 11 billion or some crazy number and I peeked, hoping it to be Revive, but until will unblind, nobody knows the extent that Bucillamine works. Yes, there are lots of studies, but big pharm needs clinical studies.
pps. Release the Beast. #Bucy.
CW. How's that niece of yours who you gifted the RVVTF shares to? I hope she knows not to disown her favorite uncle just yet. There could be a twist to this tale.
There seems to be a lot of empirical evidence of this, since Covid19...And the Need for FDA approval of $RVVTF Bucillamine gets more obvious everyday,
This explains much.
https://scitechdaily.com/covid-19-strikes-again-accelerating-dementia-in-the-most-vulnerable/
Down with the CEO I have 5 million shares. Let's vote! That lying f* dolt. And his dog eo
Hotel
Keep it simple. Communism by any other name.Vast Majority of the population too ignorant to realize their fate. Im buying an island. F them all! Lol
Take care and God bless america!
Everyone has a need to be correct, but it's important to hear both sides to the story so you can make your own decisions based on your own research. Too many people today try to shut down opposing views which really isn't democracy but socialism or marxism. I like hearing from all of you.
Thanks Gator
I hope all is well
Thanks Gator
I hope all is well
I just wonder sometimes how much the company could do with the Psychedelic side if Bucillamine is finally fda approved, if it works as Bmt think and I trust his expert knowledge of how it should work on covid. If they happen to get 300 m or 1b or a little more...
would be a good time for Bucilllamine to help with this Chit :0
https://twitter.com/MLS_Dave/status/1646911946304675847
#Packers QB Aaron Rodgers will be a featured guest in a psychedelic science conference in June called "Psychedelic Science 2023"
— Dov Kleiman (@NFL_DovKleiman) March 9, 2023
It is dubbed "the largest psychedelic gathering in history.", via @TMZ https://t.co/dwFGfbJLDu pic.twitter.com/TlCNqHng7y
Ear plugs work just as well against the noise of glorified pumpers and those who continuously state that it's "time to load" up.
Am I the only one that has noticed that some want to pour gasoline on a claimed to be fire ($RVVTF) and claim they are not with the Government and are here to help?
LMAO
The only thing I see that sticks out like a sore thumb regarding $RVVTF , is loud, obnoxious, worthless claims to be shareholders that want volume to flip shares.
Ear plugs are sound (LOL) science based devices just like $RVVTF Bucillamine.
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Scientific Rationale of Bucillamine
Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to restore antioxidant and to reduce the activity of cellular glutathione 2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via restoration of glutathione activity and other anti-inflammatory activity, to lessen the negative consequences of SARS-CoV2 infection in the lungs.
| Psilocin Pharma Corp. has developed production solutions for the active compound Psilocybin. Our process encompassed with our intellectual property cover methods of production of Psilocybin based formulations. Psilocin Pharma Corp’s range of products have been engineered to work synergistically with the body's own natural pathways of absorption while offering a contemporary approach to consumption. Psilocin Pharma also has strong relationships with specific lab partners in certain areas like Brazil, where these formulations are legally approved and plan to sell products in these jurisdictions. | |
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