Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Response received for presentation request
https://www.reddit.com/r/RVVTF/comments/12bnva8/response_received_for_presentation_request/
What happened with the letter to CEO? Did he reply back ?
And the ceo was supposed to do what exactly counter top?.....go out and recruit patients for PharmO himself, or maybe fire them and start over fresh a yr+ into the trial?
Phase 3 trials usually took several yrs to complete and since the covid urgency has now greatly abated the fda seems to be reverting back to the old system, except when BP comes calling of course.
The path of the pandemic was constantly changing and as such getting the trial done after this latest shenanigan from the fda entirely moots your suggestion.
The sole issue at this point is the fda playing games with the requirements and as such this is what needs to be directly addressed.....nothing more!!!
2 babies born with brain damage after moms tested positive for COVID-19 during pregnancy, study reveals
By Patrick Reilly
April 7, 2023 9:21pm Updated
Loving mother looking at her newborn in an incubator
Both babies suffered seizures after being born and later suffered significant developmental delays. One died at 13 months while the other was placed in hospice care.
The first confirmed cases of babies born with brain damage as a result of the COVID-19 virus crossing into their mothers’ placenta were revealed in a new study this week.
Both babies were born to young mothers who had tested positive for the virus in their second trimester during the peak spread of the Delta variant in 2021 — before vaccines were available, according to the University of Miami study that was published in the journal Pediatrics.
On the day they were born, both babies suffered seizures and later suffered significant developmental delays. One child died at 13 months while the other was placed in hospice care, researchers said.
The babies did not test positive for the virus themselves, but had high levels of COVID antibodies in their blood, said Dr. Merline Benny, a neonatologist and assistant professor of pediatrics at the university, according to NBC News.
She said this indicates the virus likely transferred from mother to placenta and then to the baby.
The research team located evidence of the virus in both mothers’ placentas, according to Benny. An autopsy showed traces of COVID-19 in the baby’s brain, suggesting direct infection caused the injuries, she said.
Both mothers tested positive for the virus. One had only mild symptoms and carried the baby to full-term, while the other mother was so severely sick that doctors had to deliver her baby at 32 weeks.
Both babies suffered seizures the day they were born and suffered severe developmental disabilities, researchers said.
Doctors had suggested this is possible, but this study is the first direct evidence of the virus in a mother’s placenta or an infant’s brain, researchers said.
Other viruses have been known to cause brain damage to a fetus, including Cytomegalovirus, Rubella, HIV and Zika, according to NBC.
“This is the first time that we’ve been able to demonstrate the virus in a fetal organ with transplacental passage,” said Dr. Michael Paidas, chair of obstetrics and gynecology at the University of Miami. “That’s why we think this is so important.”
While cases like this are suspected to be rare, Dr. Shahnaz Duara, an obstetrician and gynecologist at the university, told NBC News that women who were infected with COVID-19 during their pregnancies should contact their child’s pediatrician to look out for developmental delays, which could take years to manifest.
“We know that things can be fairly subtle up to 7 or 8 years of age until kids go to school,” she added.
He went on vacation after he got investor’s to pony up 4.3mil at .15 a share
So the ceo just goes on vacation after getting pharm olam? Is still his job to stay on top of this and get the trial done. It’s his job as the head of the company to make sure things are getting done which he did not do. Time for him to leave. Those who voted to keep him in at the last meeting are getting what they deserve.
Comparing an FDA Phase III drug trial in a pandemic, hired contractor to set up and manage the Phase III trial, to a Plumbing contractor on a house is the dumbest thing I have read yet.
Go RVTTF go
This is a Double Blinded Placebo Controlled Trial, ie the GOLD STANDARD of clinical trials, so anyone who thinks that the ceo of a company has a say in how the trial is designed, implemented and conducted is a dullard.
The very purpose of the stringent protocols is to ensure that the entire process is isolated and free of biased outside influences, especially from the ceo of the company who stands to benefit hugely if its successful.
I already stated, but apparently someone cant read, the trial was designed based on the requirements at the time, ie hospitalizations and deaths but as time progressed the virus changed and so did the protocols......WHICH VIRTUALLY NO ONE FORESAW!!!
The fda has its agenda (serving BP) because they apply their requirements conveniently as i previously mentioned re the "8 mice trial" so how anyone is expected to take those clowns seriously is beyond me.
Now do continue shilling for whomever and making a complete arse of yourself as ye continue to post this ignorant drivel thats devoid of the most basic facts.
@Pennyworld...................
Pharm Olam as I see is no fly by night outfit since theyve been in operation for 20+ years, so even though they may not be a large Top Tier outfit such as those used by BP, they arent the worst either.
That said this IMO has less to do with Pharm Olam and more to do with the fda having rwo sets of rules, ie, one for BP where they can literally lie, fudge their data and still have their crap drugs rubber stamped for universal use, AND, another set for everyone else that gets scrutinized top down, which usually means a longer, tougher and delayed path to approval.
He runs the company and hired these people. It’s his job to stay on them to get the trial done. If you are a contractor building a house and the plumber is taking a year to finish the bathroom what do you do? Just say “oh well not my fault”? No, you ask him what is going on and tell him to get the job done now or screw off. Frank hires these people so it’s on him if things don’t work. So making excuses for his screwups.
Rick.. one could argue that Mike may have hired the wrong outfit to conduct the trial. He may have been trying to safe $$. This is exactly what RLFTF did. They hired an outfit that bungled everything up on the end-points.
Only an idiot with no experience tries to run a phase 3 trial. He could have hired someone but instead was too arrogant thinking he could do it.
Mike didnt "RUN" anything jester......it was Pharn Olam that was hired to conduct and oversee all aspects of the trial.
This info is so basic and yet ye still got it all wrong, therefore the only complete idiot was the joker that posted this garbage, and that would be...........................................
My previous post were questions posed to demonstrate how silly the complaining about mike thats being done here is but ye obviously missed the context, as usual!
I don't consider myself a "talking head", but I will own what I say and what I believe.
With regards to the FDA being corrupt, they are a government run entity. They have already had to admit to taking short cuts, and/or plain and simply not doing their jobs what was one of the most significant things to come through their office in the past 3 years.
With that, I have not said they are "never" going to give RVV the approval. But, I did say that they are going to look out for Big Pharm. You know...the ones who can grease their pockets the most?! If that means moving the goal line, changing the game, etc...
When BP went to them and said, "we have this...", they jumped and said, "Okay! Go ahead and give it out". There was no thorough testing, etc...
But when RVV went to them and said, "We have this...30+ year old remedy" the FDA said, "Wait! Did you test this condition? Did you shake the tree just the way we told you?" When Revive said, "Yes! Here is the proof." They said, "Okay! Let's set up a meeting 3-4 months from now to review." When the 3-4 months passed (2 or 3 times), they said "Oh! The virus has changed, and we're looking for your stuff to do ZYX, not the XYZ that you wanted to show us. Can you show us ZYX?!"
In the meantime, I see those Paxlovid commercials LEFT AND RIGHT!
It`s far from over lets hope something can still get $RVVTF a win..............For the past several months, Omicron subvariants BA.4 and BA.5 have dominated COVID-19 cases in the U.S. But now, there’s a class of new COVID subvariants on the rise and one in particular is getting plenty of attention. It’s called XBB—or Gryphon—and there’s a chance it could overtake everything else out there.
If Bucillamine is as good as we hope maybe it can help with this too........CEO of Carolina Blood and Cancer Care Associates, Dr. Kashyap Patel, believes that the COVID-19 virus not only affected cancer treatment in recent years, but may have also affected the development of “cancer itself.”.....In recent years, Patel has treated several patients in his Rock Hill, South Carolina, clinic who suffer from a rare cancer called cholangiocarcinoma. A number of the patients began developing the cancer 20 to 30 years earlier than the standard age.
Cholangiocarcinoma normally begins forming within the human body around 65 years or older. In the past year alone, Patel’s clinic had seen seven patients diagnosed with the cancer at much younger ages.
Govprs - Did you sign the request for a presentation from Revive Therapeutics? If you have, it would be a good opportunity to address your concerns directly to MF.
But the talking heads, bmt, tix etc all state FDA is corrupt and never gonna give a tiny rvv the approval.
Most ceos would do what’s in the best interests of stockholders. I snoop and others believe MF could do more for shareholders by licensing to BP and monetize this asset. Most bag holders here many proclaimed to be here 2-3 yrs are growing tired and want to monetize the shares they hold. I don’t MF dragging this out longer for a bigger return is what investors want.
What BMTs letter to MF? Bet he ignores it or says no thank you to an investor call
All this makes it more doubtful we have a drug that works. My opinion only
More importantly does MF have a position in rvvtf? How many shares does he own? Did he participate in the offering at .15/share just 8 weeks ago?
How in the F are you trying to still compare a tiny no revenue biotech penny stock firm to the Duponts and Apples of the world?!
How does this:
This is not the place to ask that question the Canadian filings are, but one that knows how to do real DD would have done the DD in the filings not here.
Dow, DuPont, Amazon, Apple, ... none of their CEOs hold shareholders hands 365/year. So you are saying they are not professional? All people get from them is a 4 filings a year and after the fact 8-K event notices.
I too have worked for public companies, going back 48+ years, and when there is Major deal brewing with a mega billion dollar firm even the flies and blinded and silenced and the CEOs are gagged.... until the NDA and deals allow a deal/news release, and even then I have seen international law firms dag shit out so long the stock got clobbered by the silence. In one case the silence was worth it.. They were closing a world wide deal with a 14 Billion dollar firm 10 years ago. Not even light leaked out on that deal for 9 months.
It was very painful. But it was what Alstom Power (Later bought part of by GE).
LMAbsoluteFAO @ “I think we should thank the CEO for trying” !!!!!!!!
WTF……………
I think shareholders are looking for more than just a CEO trying. Thanks may be appropriate if RVVTF achieves its goals, gets FDA approvals, provides a positive ROI to shareholders, etc.
“If any thing we should be thanking the CEO for trying”
In answer to your $RVVTF question:
Interesting. How does this help RVVTF shareholders?
Please elaborate and include how shareholders may have benefited. Thank you
“What MF has pulled off so far the last 3 years, is historical in nature.”
And potentially a fraud. I still can’t figure out if the drug was so good why he wouldn’t license to a BP?
Does MF actually own shares in rvvtf?
Good to know. I'd like to see exactly what the plan is as Revive moves forward. All I know is I paid a lot of money to see the trial unblinded by now and I still wait.
There trying to get last digit pump and dump. MF was just pumping and dumping and this article came out what a joke! MF should be though in jail pumping and dumbing the stock. But SE C don't care. Wait till they start being charged with crypto. LOL
Disagree it is professional. Addressing shareholder sentiment and sharing the strategy/ action plan moving forward is not illegal. I have worked for public companies. IMO mf is an amateur.
Did you notice that the article was "received" back in August 2022? It was accepted 8 months after it was received. Even then it was published nearly 3 weeks after being accepted.
This is definitely great information. But it is either so insignificant to someone that it didn't merit being published a whole 8 months after it was written, or it was significant enough that someone didn't want it published.
Am I missing something? Feel free to correct me if my deduction is wrong.
It’s franks greed that got in the way of this company being successful. Only an idiot with no experience tries to run a phase 3 trial. He could have hired someone but instead was too arrogant thinking he could do it. The fact people still can’t see that after the last 3 years is ridiculous. Open your eyes.
.....a little knowledge is a dangerous thing. It's very naive to think you know what is going on behind closed doors in any company. It's all conjecture so do whatever research you can to make yourself comfortable with your investment. It's simple, if you aren't sell and find another company you feel safe with....good luck!
You're a poet and you didn't even know it.
Dark Chocolate is bitter
White should be sweet
RVVTF ain't over yet
Say "NO" to de feet.
So in a nutshell......its Mike's fault that through amateurish GREED, many shareholders consciously and irresponsibly decided to go all in for the huge score, as opposed to simply trading the continuous swings for 2+ years which would have resulted in them recouping their total $$ investment, in addition to amassing a huge cache of "free" shares???
That Mike designed a trial that chose parameters which were practicable back in 2020-21, back when literally NO ONE, even the so called pandemic experts, had foreseen the direction the pandemic would take that made the current trial ep's moot yrs later???
That Mike is responsible for not being able to meet the ever evolving requirements set by the clowns at the fda.....the very same fda clowns who literally approved a covid booster for mass public use that was ""thoroughly"" tested on 8 mice???
Im by no means whatsoever a sycophant of MF and several of my previous posts clearly attest to that fact but the level of projection and entitlement on display here is simply amazing.
Watch and learn grasshopper.
$RVVTF has many options.
Those companies share prices are a little higher than $0.05 no? Are you putting the blame on those CEO’s? If so, you better realize it is mf’s fault for where this company is now. You realize he is going to keep this trial blinded as his job security and not for shareholder value? He knows he isn’t finishing the trial so why keep it blinded?
BS, DuPont and 3M are being sued for trillions of dollars now for lying about and selling fire fighting chemistry that is now causing sterility in Humans and Salmon and so on.
$RVVTF ? no lawsuits
Exxon lied about climate change it knew it was causing and knew was real 40 years ago. Cost? Trillions, also in courts
Dow and GE lied about agent orange, PCBs, dioxins and has lost 100s of Billions of dollars that will cost them trillions in today's dollars for next 100 years
That may be one thing MF has been waiting for:
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
These results propose that BUC can be a potential drug candidate against the COVID-19 disease progression.
$RVVTF BOOM up 10% today
Published ( online ) for the first time 3 days ago , not yet in paper print
More on the super highly contagious new strain in India
https://kathmandupost.com/health/2023/04/03/nepal-confirms-spread-of-omicron-s-xbb-1-16-sub-variant
Proof +ve of sheer ignorance of the easily verifiable fact that the trial has an extremely rigid health inclusion/exclusion criteria as opposed to having random patients simply agreeing to participate, ie, recruitment was designed to only source patients that fit the required criteria.
A simple perusing of the rvv trial on the clinical.gov site would have alerted one to this fact and as such one wouldnt make an utter fool of themselves for the world to marvel at. lololsss
Inclusion Criteria:
-- Is within 72 hours from onset of symptoms consistent with COVID 19 at time of study enrollment
-- Has at least 2 of the following: fever (oral temperature =38°C), cough, shortness of breath, chest x ray changes consistent with COVID-19 at time of screening
-- Has peripheral capillary oxygen saturation (SpO2) =94 by pulse oximetry at time of screening
-- Has either a laboratory-confirmed SARS-CoV-2 infection as determined by FDA-approved rapid diagnostic (e.g., PCR) assay
-- Has a score of = 2 on the 8-category NIAID ordinal scale at time of screening
-- Agrees to the collection of blood and urine samples, nasopharyngeal (NP) swabs, and non-invasive oxygen monitoring (via pulse oximeter) per protocol
-- Patient (or their legally authorized representative) is willing and able to provide written informed consent prior to performing study procedures
-- Understands and agrees to comply with planned study procedures
-- Women of childbearing potential must agree to either abstinence or use at least 1 primary form of contraception not including hormonal contraception from the time of screening through -- Day 29 following randomization. All subjects of childbearing potential, including males with partners of childbearing potential, must use highly effective methods of birth control defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1 percent per year) when used consistently and correctly. Abstinence is NOT an acceptable method of contraception UNLESS it is the subject's normal practice.
Exclusion Criteria:
-- Prior history of, or considered to be at risk for, agranulocytosis, nephropathy, liver disease, or interstitial pneumonia
-- Serious hepatic disorder (Child-Pugh scores B or C) or alanine transaminase (ALT) or aspartate transaminase (AST) > 5 times the upper limit of normal (ULN) at screening
-- Chronic kidney disease (CKD) National Kidney Foundation (NKF) stages 3B - 5 chronic renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min/1.73m2 according to -- ------- Cockcroft Gault formula)
-- Proteinuria = 1+ or = 30 mg on dipstick urinalysis that is confirmed on repeat assessment within 24 hours
-- Serum BUN = 2 × ULN or Cr = 2 × ULN
-- Leukopenia with absolute granulocyte count < 1500/µL
-- History of positive Human Immunodeficiency virus (HIV) test or organ transplant
-- Receipt of cancer chemotherapy or immunomodulatory drugs including (but not limited to) biologics such as anti-CD20, anti-TNF, anti-IL6; alkylating agents (e.g., cyclophosphamide); antimetabolites (e.g., azathioprine); or chronic corticosteroid use equivalent to prednisone >10 gm/day, during preceding 2 months
-- Confirmed positive for influenza at screening
-- Confirmed positive for respiratory syncytial virus (RSV) at screening
-- Pregnant or breastfeeding
-- Current use of, or known allergy to bucillamine or penicillamine (e.g., for Wilson's disease, rheumatoid arthritis)
-- Current participation in any other clinical trial of an experimental treatment
-- Receipt of any experimental treatment for COVID-19 (herbal/homeopathic, off-label, compassionate use, or trial related) within the 30 days prior to screening
Now back to my drink...............................
Two things:
1) let’s not compare revives ceo to Dow or DuPont or Exxon. Those ceos know how to run a company and what they don’t know they hire the right people to do.
2) the only thing historic in nature was the historic failure of being fast tracked to a phase 3 and still only getting to 710 patients in the worst pandemic in 100 years with literally over a million cases a day.
Actually it is very professional, not armature.
We have been told what the lawyers let him say, that is how real pubic stock disclosure works with CEO's that are not Pump-it scum bags.
They a rare bread, and attract a lot of flack and haters.
Check out how much bank stocks, Exxon, GE, Dow, DuPont tell shareholders. It is 99.9% said in 4 time a year fillings.
It is what it is.
What MF has pulled off so far the last 3 years, is historical in nature.
I blame retail more that CEO, and MM/hedge fund short profiteer pirates. That too, is what it is.
I'd rather have a company that is diversified than one that has all their eggs in one basket. I'm happy for this development.
Investigation of Bucillamine as anti-COVID-19 drug: DFT study, molecular docking, molecular dynamic simulation and ADMET analysis
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2192791?journalCode=tbsd20
True.
ps. I got nothing these days.
pps. Saw the MF letter. He likely will tell shareholders to read the PR again.
ppps. Does the study continue for hospitalization or can Revive go back and contact the patients and use that as part of a long hauler study?
Followers
|
337
|
Posters
|
|
Posts (Today)
|
0
|
Posts (Total)
|
36642
|
Created
|
02/23/17
|
Type
|
Free
|
Moderators Classic Warrior |
Scientific Rationale of Bucillamine
Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to restore antioxidant and to reduce the activity of cellular glutathione 2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via restoration of glutathione activity and other anti-inflammatory activity, to lessen the negative consequences of SARS-CoV2 infection in the lungs.
| Psilocin Pharma Corp. has developed production solutions for the active compound Psilocybin. Our process encompassed with our intellectual property cover methods of production of Psilocybin based formulations. Psilocin Pharma Corp’s range of products have been engineered to work synergistically with the body's own natural pathways of absorption while offering a contemporary approach to consumption. Psilocin Pharma also has strong relationships with specific lab partners in certain areas like Brazil, where these formulations are legally approved and plan to sell products in these jurisdictions. | |
| |
Mental Health (Depression, PTSD & Anxiety)
|
Supplements for Brain Health & Cognitive Enhancement
|
Volume | |
Day Range: | |
Bid Price | |
Ask Price | |
Last Trade Time: |