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Precipio Inc. (PRPO)

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Last Post: 5/24/2019 4:03:54 PM - Followers: 103 - Board type: Free - Posts Today: 7


Link to coporate website:

Share Structure
Market Value1 $40,142,705 a/o May 10, 2013
Shares Outstanding 88,225,725 a/o Mar 13, 2013
Float Not Available
Authorized Shares 100,000,000 a/o Aug 02, 2011
Par Value 0.01

Wells Fargo Bank Minnesota, N.A.
Shareowner Services
P.O. Box 64854
St. Paul, MN 55164-0854
Phone: 877-602-7611

Transgenomic is a global biotechnology company that provides unique products and services for automated high sensitivity genetic variation and mutation analysis. Our offerings include systems, products, discovery and laboratory testing services to the academic and medical research, clinical laboratory and pharmaceutical markets in the fields of pharmacogenomics and personalized medicine.

Transgenomic offers its WAVE® DHPLC Systems and associated consumables. These systems are specifically designed for use in genetic variation detection and single- and double-strand DNA/RNA analysis and purification and have broad applicability to genetic research. To date there have been over 1600 systems shipped to more than 30 countries.

Transgenomic's SURVEYOR® Mutation Detection Kits and the SURVEYOR Check-It Kit provide reagents and protocols for the detection of mutations in DNA.

Transgenomic's Cytogenetics offering includes HANABI automated chromosome harvesting systems that improve laboratory productivity with consistent quality compared to manual methods.

Transgenomic Clinical Reference Laboratory provides reference laboratory services specializing in molecular diagnostics including Mitochondrial Disorders, Oncology and Hematology, Molecular Pathology and Inherited Diseases.

Transgenomic Genomic Research Services is a CRO for pharmacogenomic, translational research and clinical trials.

Colorectal Cancer Testing

Very important AMGEN signs collaberation deal with Mgmt:

"Another potential meaningful near-term contributor to the Lab Services segment (as well as to the Diagnostic Tools segment) relates to the recently consummated agreement with Amgen (NasdaqGS:AMGN) whereby the two companies are collaborating on a KRAS an NRAS gene mutation assay kit to screen patients for colorectal cancer.  The RAScan test is currently available for research use only (RUO) in the U.S. (which will run through Lab Svcs) and for clinical use in Europe - which could help accelerate instrument placements (through Menarini) as well as increase consumables sales"

CRC RAScan™ is a new mutation detection test designed to screen for selected KRAS and NRAS mutations (collectively referred to as “RAS mutations”), in patients with metastatic colorectal cancer (mCRC).The identification of these RAS mutations can give physicians important clinical information to help them make better treatment decisions for their mCRC patients.

KRAS and NRAS are part of the RAS family of genes which encode proteins involved in transmitting signals within cells. When Ras proteins are “switched on” by incoming signals, other genes involved in cell growth, differentiation, and survival are activated. Mutations in KRAS, NRAS and other related genes can lead to Ras proteins becoming permanently activated, causing overactive signaling even in the absence of incoming signals, and can lead to the uncontrolled cell growth that characterizes cancer. Mutations that permanently activate Ras proteins are found in ~25% of human tumors and up to 90% of certain cancers. About 40% of colorectal tumors carry KRAS gene mutations and these mutations have been associated with poor response to EGFR antagonists such as cetuximab and panitumumab. Therefore KRAS mutation status can be used to determine whether or not a patient with colorectal cancer will respond to anti-EGFR therapy.

The CRC RAScan test can identify mCRC patients who have RAS mutations at levels that cannot be detected using traditional Sanger Sequencing methods.

CRC RAScan™ for Colorectal Cancer Tumor Testing is available immediately from Transgenomic’s CLIA-certified laboratory in the United States. For more information on this test, click here.

CRC RAScan Mutation Detection Kits will soon be available in the U.S for research use only. CRC RAScan Mutation Detection Kits include the following kits based on Transgenomic's proprietary SURVEYOR® Nuclease technology:

  • KRAS Exon 2
  • KRAS Exons 3 & 4
  • NRAS Exons 2, 3 & 4

Zacks analyst ~ OUR 2013 OUTLOOK~

We've again made some updates to our model.  We now model 2013 revenue of $32.4 million, implying growth of 3% from 2012.  We look for Laboratory Services and Instruments to generate revenue of $20.0 million (+4%) and $12.4 million (+2%), respectively.  We think net income and EPS come in at ($12.7) million and ($0.14).



New Analyses Identify Predictive Biomarkers For Vectibix® (Panitumumab) In Patients With Metastatic Colorectal Cancer

Biomarker Analysis From Phase 3 PRIME ('203) Study and Phase 2 PEAK ('509) Study Link Additional RAS Gene Mutations to Vectibix Clinical Response

THOUSAND OAKS, Calif., May 15, 2013 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced results from three analyses of Vectibix® (panitumumab) in combination with FOLFOX, an oxaliplatin-based chemotherapy regimen, as a first-line treatment for metastatic colorectal cancer (mCRC). These analyses include the description of new predictive biomarkers of clinical response to Vectibix, activating mutations in KRAS (beyond exon 2) and mutations in NRAS, collectively referred to as RAS.

"Amgen helped establish KRAS gene mutation as a biomarker for lack of response to anti-EGFR treatment," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. "The identification of new biomarkers may further help to identify appropriate patients with this incurable disease for such treatment."


Contact Information:
Phone: (402) 452-5437
E-mail: investorrelations@transgenomic.com

SEC Filings:

Press Releases:

Current Price
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PlusOneCoin Top Posts
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#2860   CLOWN SHOW!!!! Nickwvt 05/24/19 04:03:54 PM
#2859   I knew it! RealLovePipes 05/24/19 03:05:14 PM
#2858   Here it cooooooomes! RealLovePipes 05/24/19 02:30:05 PM
#2857   Yep! Happy Holidays to us! RealLovePipes 05/24/19 12:59:40 PM
#2856   Late day short covering with no float will RealLovePipes 05/24/19 12:22:18 PM
#2855   BREAKING NEWS: I’m calling for a $6+ close RealLovePipes 05/24/19 11:47:05 AM
#2854   Sneaky pre holiday Friday buying spree about to RealLovePipes 05/24/19 11:10:31 AM
#2853   Those should go good with all those you Dennisb68 05/23/19 09:29:38 PM
#2852   He's probably a junior high school kid sitting Nickwvt 05/23/19 02:06:28 PM
#2851   Bought 5k more at $5.88 and $5.90. This iDeVos 05/23/19 01:45:49 PM
#2850   And after a bit of a delay: on RealLovePipes 05/23/19 12:42:05 PM
#2849   I’m not here to be a bitter nasty RealLovePipes 05/23/19 12:06:37 PM
#2848   And I'm sure it's all with Monopoly money.... Nickwvt 05/23/19 12:05:30 PM
#2847   I’m buying all morning I assure you that. RealLovePipes 05/23/19 11:57:38 AM
#2846   Why don't you take today off Nickwvt 05/23/19 11:53:50 AM
#2845   SO OBVIOUS! thank you lord Jesus RealLovePipes 05/23/19 11:46:27 AM
#2844   Watch: about to take off. This has all RealLovePipes 05/23/19 11:18:12 AM
#2843   Just bought more at $5.72 and $5.75. If RealLovePipes 05/23/19 10:58:56 AM
#2842   And do just the opposite of what you Nickwvt 05/23/19 10:53:23 AM
#2841   Watch me. RealLovePipes 05/23/19 10:52:02 AM
#2840   You haven't shown any ability at that Nickwvt 05/23/19 10:51:54 AM
#2839   I love to make money$$ RealLovePipes 05/23/19 10:49:49 AM
#2838   What is wrong with you???? Nickwvt 05/23/19 10:49:23 AM
#2837   Bought 5k more at $5.88 and $5.90. Yes RealLovePipes 05/23/19 10:28:42 AM
#2836   BOOM!! RealLovePipes 05/23/19 10:10:13 AM
#2835   Imagine the regular buying of low float? This RealLovePipes 05/23/19 10:06:56 AM
#2834   HUGE NEWS: PR just out CEO buying shares RealLovePipes 05/23/19 10:05:29 AM
#2833   YEP! I nailed it by a minute! RealLovePipes 05/23/19 09:55:45 AM
#2832   Dow down 400 and this holding!!! BUY ALERT!! RealLovePipes 05/23/19 09:55:11 AM
#2831   Closed down over 6% today. And some thought Dennisb68 05/22/19 06:09:05 PM
#2830   Down another 6 percent today with no end Dennisb68 05/22/19 12:02:58 PM
#2829   Wow, for the first time in nearly a Dennisb68 05/21/19 04:02:55 PM
#2828   PRPO is actually up a few cents which Dennisb68 05/21/19 12:40:56 PM
#2827   Lol lol RealLovePipes 05/21/19 12:16:23 PM
#2826   Lol RealLovePipes 05/21/19 11:11:25 AM
#2825   You are correct. It has a lot FURTHER Dennisb68 05/21/19 10:42:48 AM
#2824   It has been marked, and we shall see laser777 05/21/19 10:24:49 AM
#2823   It’s “further” and you’re obviously incorrect as this RealLovePipes 05/21/19 10:13:41 AM
#2822   Sell volume running twice that of the buy Dennisb68 05/21/19 10:10:09 AM
#2821   It's been 20 minutes and the stock is Dennisb68 05/21/19 10:02:27 AM
#2820   Watch the move above $6 within minutes. This RealLovePipes 05/21/19 09:37:06 AM
#2819   And more at $5.69. Easiest $$ ever made. RealLovePipes 05/21/19 09:31:20 AM
#2818   Got more at $5.68. Good luck today fam! RealLovePipes 05/21/19 09:24:43 AM
#2817   I’ll be dollar or below by end of akamaii 05/21/19 08:26:30 AM
#2816   Traded as low as $5.90 in AH trading. Dennisb68 05/20/19 08:13:10 PM
#2815   Agreed. The only thing I can say UFO 05/20/19 04:08:15 PM
#2814   A close of $6.02 does not look good Dennisb68 05/20/19 04:02:30 PM
#2813   I see this going into the 5's this Dennisb68 05/20/19 02:52:55 PM
#2812   $6.11 was the support level (low on 5/13 UFO 05/20/19 01:05:04 PM
#2811   I agree, the stock should be much lower. Dennisb68 05/20/19 12:00:06 PM