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I read that board as well & follow RobCos recommendations. I'm also on stocktwits-m22
If you are invested in XON or ZIOP then I beleive IV is the place to be.
Not that I am recommending you do your DD through a message board but its a bigger community for both of these tickers there. IMO
If you are invested in XON or ZIOP then I beleive IV is the place to be.
Not that I am recommending you do your DD through a message board but its a bigger community for both of these tickers there. IMO
Exclusive Licensing Agreement for CAR T Cell, TCR, NK Cell Programs and Associated Technologies for the Development of Non-Viral Adoptive Cellular Therapies
Combined Technologies to Leapfrog Clinical Pipeline of Next Generation Therapies Using Synthetic and Personalized Immunology
GERMANTOWN, Md., BOSTON, and HOUSTON, Jan. 13, 2015 /PRNewswire/ -- Intrexon Corporation (NYSE: XON), a leader in synthetic biology and its oncology partner, ZIOPHARM Oncology (NASDAQ: ZIOP), today announced a broad exclusive licensing agreement with The University of Texas MD Anderson Cancer Center, including an exclusive sublicensing agreement through MD Anderson for intellectual property developed at the University of Minnesota for the development of non-viral adoptive cellular cancer immunotherapies.
The licensed technologies arise from the laboratory of Laurence Cooper, M.D., Ph.D., professor of pediatrics at MD Anderson and Perry Hackett, Ph.D., professor within the College of Biological Sciences at Minnesota.  The Cooper and Hackett laboratories have pioneered the design and clinical investigation of novel chimeric antigen receptor (CAR) T cell therapies using non-viral gene integration platforms. MD Anderson has built on this technology to deliver patient-derived T cells, as well as innovative approaches to generating products for universal off-the-shelf applications.  When combined with Intrexon's technology suite and ZIOPHARM's clinically tested RheoSwitch Therapeutic System® interleukin-12 modules, the resulting proprietary methods and technologies may help realize the promise of genetically modified CAR T cells by tightly controlling cell expansion and activation in the body, minimizing off-target effects and toxicity while maximizing therapeutic efficacy.
"Genetically engineering our patients' immune-system T cells to efficiently attack and destroy cancer cells represents one of the most exciting approaches with curative potential in oncology today," MD Anderson President Ron DePinho, M.D., said. "We believe coupling MD Anderson's unique CAR T cell approach with the powerful technologies of ZIOPHARM and Intrexon will allow us to build T cells that hit cancer harder, with greater precision, under tighter control and with potentially fewer side effects for patients. This agreement ranks as one of MD Anderson's most substantial collaborations and will provide significant resources to fuel its mission of Making Cancer History®."
"We are proud to see Perry Hackett's discovery and development work on Sleeping Beauty, a non-viral DNA plasmid-based gene transfer system, in conjunction with Dr. Cooper's expertise in immunotherapies, provide this breakthrough in oncology" said Brian Hermann, Vice President of Research at the University of Minnesota.
Employing novel cell engineering techniques and multigenic gene programs, the collaboration will implement next-generation non-viral adoptive cellular therapies based on designer cytokines and CARs under control of RheoSwitch® technology targeting both hematologic and solid tumor malignancies. The synergy between the platforms will be leveraged to accelerate a promising synthetic immunology pipeline, with up to five CARs expected to enter the clinic in 2015 and off-the-shelf programs initiating in 2016.
"It is a shared vision to maximize the speed and breadth of multigenic innovation for patients through the use of nimble, non-viral DNA cell manufacturing strategies that can further overcome viral packaging constraints and economic limitations," stated Gregory Frost, Ph.D., Senior Vice President and Head of Intrexon's Health Sector. Â "Collectively, this will assemble the most advanced set of technologies to empower the strongest adoptive cell therapy pipeline that can drive innovation through multiple horizons and patient populations."
Cooper, Hackett and colleagues developed a non-viral DNA plasmid-based gene transfer system to modify T cells by creating a CAR that recognizes and binds to a specific cell surface protein on targeted malignant cells. The testing of this system at MD Anderson in humans paves the way for the rapid design and implementation of modified T cells that can be infused into patients with many types of malignancies.
Work continues in conjunction with MD Anderson's Moon Shots Program, an ambitious initiative to accelerate the conversion of scientific discoveries into clinical advances and significantly reduce cancer deaths, first targeting eight types of cancer. Cooper leads the Applied Cellular Therapeutics platform for the moon shots, providing expertise and new cellular therapy capabilities for both blood and solid tumor cancers. Clinical trials using non-viral adoptive cellular therapies are either under way or planned for specific moon shot cancers.
The shared infrastructure between MD Anderson, Intrexon and ZIOPHARM enables two approaches to deliver these commercially viable T cells to the bedside.  The first develops a point-of-care approach with rapid assembly and infusion of autologous T cells.  The second arises from the universal donor platform to infuse off-the-shelf T cells using innovative activation and targeting gene programs that precisely recognize and systemically combat malignancies. The collaboration will advance these platforms in parallel with the most effective CAR-T products tested at MD Anderson graduating to multicenter trials.
"The promise of controlled, cell-based immuno-oncology therapy is that we can achieve dramatic, long duration anti-cancer results while keeping patients out of intensive care during treatment. As importantly, we can reproduce these results in a globally scalable and economically viable way," remarked Jonathan Lewis, M.D., Ph.D., Chief Executive Officer of ZIOPHARM Oncology. "The MD Anderson Cancer Center has long been a leader in cancer therapy, in terms of innovation, patient care, and the highest quality research. As part of our commitment to this important partnership and the acceleration of translational medicine, ZIOPHARM will build a base of operations in Houston to join and collaborate with the academic and medical community around this world-class institution."
"The human application of T cell therapies provides cancer patients with new hope, and the alignment of MD Anderson's immunotherapy and translational programs with Intrexon and ZIOPHARM will help make that hope a reality," Cooper said. "These two interconnected companies have first-in-class genetic tools and systems to reprogram cells and the management and regulatory expertise to undertake development of potent and focused cell-based immunotherapies."
Under the terms of the agreement, MD Anderson shall receive consideration of $100 million; $50 million from each Intrexon and ZIOPHARM, payable in shares of their respective common stock, as well as a commitment of $15 to $20 million annually over three years for researching and developing the technologies.  The parties will enter into additional collaboration and technology transfer agreements to accelerate technology and clinical development. Further details on the terms of the transaction will be available within the current reports on Form 8-K filed today by Intrexon and ZIOPHARM.
About Intrexon Corporation
Intrexon Corporation (NYSE: XON) is a leader in synthetic biology focused on collaborating with companies in Health, Food, Energy, Environment, and Consumer Sectors to create biologically-based products that improve the quality of life and the health of the planet. Through the company's proprietary UltraVector® platform and suite of technologies, Intrexon provides its partners with industrial-scale design and development of complex biological systems. The UltraVector® platform delivers unprecedented control over the quality, function, and performance of living cells. We call our synthetic biology approach and integrated technologies Better DNA®, and we invite you to discover more at www.dna.com.
About ZIOPHARM Oncology, Inc.
ZIOPHARM Oncology is a Boston, Massachusetts-based biotechnology company employing novel gene expression and control technology to deliver DNA for the treatment of cancer. ZIOPHARM's technology platform employs Intrexon Corporation's RheoSwitch Therapeutic System^® technology to turn on and off, and precisely modulate, gene expression at the cancer site in order to improve the therapeutic index. This technology is currently being evaluated in Phase 2 clinical studies of the immune system cytokine interleukin-12 for the treatment of breast cancer and advanced melanoma. The Company's synthetic immuno-oncology programs in collaboration with Intrexon also include chimeric antigen receptor T cell (CAR-T) approaches.
About MD Anderson
The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. It is one of only 41 comprehensive cancer centers designated by the National Cancer Institute (NCI). For the past 25 years, MD Anderson has ranked as one of the nation's top two cancer centers in U.S. News & World Report's annual "Best Hospitals" survey. It receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).
Trademarks
Intrexon, UltraVector, RheoSwitch Therapeutic System, RheoSwitch, RTS, and Better DNA are trademarks of Intrexon and/or its affiliates. Other names may be trademarks of their respective owners.
Forward-Looking Safe Harbor Statement:
This press release contains certain forward-looking information about ZIOPHARM Oncology, Inc. and Intrexon Corporation that is intended to be covered by the safe harbor for "forward-looking statements" provided by the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. Words such as "expect(s)," "feel(s)," "believe(s)," "will," "may," "anticipate(s)" and similar expressions are intended to identify forward-looking statements. These statements include, but are not limited to, statements regarding our ability to successfully develop and commercialize our therapeutic products; our ability to expand our long-term business opportunities; our future presentations at industry meetings; financial projections and estimates and their underlying assumptions; and future performance. All of such statements include certain risks and uncertainties, many of which are difficult to predict and generally beyond the control of the company, that could cause actual results to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include, but are not limited to: whether   any of our other therapeutic discovery and development efforts will advance further in  pre-clinical research or in the clinical trials process and whether and when, if at all, they will receive final approval from the U.S. Food and Drug Administration or equivalent foreign regulatory agencies and for which indications; whether any other therapeutic products we develop will be successfully marketed if approved; our ability to achieve the results contemplated by our collaboration agreements; the strength and enforceability of our intellectual property rights; competition from other pharmaceutical and biotechnology companies; the development of, and our ability to take advantage of, the market for our therapeutic products; our ability to raise additional capital to fund our operations on terms acceptable to us; general economic conditions; and the other risk factors contained in our periodic and interim SEC reports filed from time to time with the Securities and Exchange Commission, including but not limited to, our Annual Reports on Form 10-K for the fiscal year ended December 31, 2013 and our Quarterly Reports on Form 10-Q for the quarter ended September 30, 2014. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof, and we do not undertake any obligation to revise and disseminate forward-looking statements to reflect events or circumstances after the date hereof, or to reflect the occurrence of or non-occurrence of any events.
whoops last post off topic wrong forum... anyway i think squawk on the strreet was very wary of xon$... im out
Thanks Mike...I still do not know enough about this stock....I too am in a bio stock that disappoints but, I love the science......
Sorry, wrong link. Here's the link for XON
http://www.investorvillage.com/smbd.asp?mb=17828
I've been following them for a while. I invested in a company called Ziopharm that Intrexon is a major investor in. I followed XON when they went public and bought into them about a year ago. It's been a bumpy ride but the future looks bright.
Earnings for XON is tomorrow after the market closes. The link below is a great board for XON
http://www.investorvillage.com/smbd.asp?mb=16353
I don't post there as you have to join to post but there are great people there that share a great deal of information. One poster in particular worth reading is RobCos.
Mike...just saw the video about this Company...may I ask, have you been in this for a long time...
Herb Greenberg bullish on XON!!!
http://finance.yahoo.com/video/herb-39-seeing-green-xon-173000000.html
$XON Griffin Securities Maintains Buy On Intrexon; Sees 99% Potential Upside http://www.smarteranalyst.com/2014/08/25/griffin-securities-maintains-buy-on-intrexon-sees-potential-105-upside/
This is a volatile son of a snitch. When is this hitting $30?
People that sold today must be kicking themselves , great earnings release.
Earnings released, looks like a good report. +.04 a share compared to an expected loss of -.06 to -.09
http://secfilings.nasdaq.com/filingFrameset.asp?FileName=0001193125%2D14%2D187697%2Etxt&FilePath=%5C2014%5C05%5C07%5C&CoName=INTREXON+CORP&FormType=8%2DK&RcvdDate=5%2F7%2F2014&pdf=
Motley fool article downing DNA Salmon , but the fisheries in enclosed areas are taking off and major profits are being made , so I think Intrexon is the future and we should expect road bumps along the way.
No end in sight to the selling. $16.85 today, where is the management team?
Seems like the whole sector bounced up today.
Bought in today. With all the insider buying lately this will go up.. at some point, just not sure when.
Ernst & young CEO James S.Turley
http://www.sheknows.com/living/articles/1006947/10-ceos-youd-love-to-work-for
There was some good support in the mid to low $20's last year, this sell off should find support here, but no telling if this downtrend is done.
Turning low cost natural gas into a liquid using a bio process is a winning idea for Intrexon
http://investors.dna.com/phoenix.zhtml?c=249599&p=irol-newsArticle&ID=1912920&highlight=
Is XON developing an app for cancer like VNTH.Vantage health inc, VNTH, got the licence from NASA to develop a breath detection cancer smartphone app, and this small company could be worth more than XON in a year, low float ,NASA won the 2012 invention of the year award for this technology ,that VNTH has a 5 year contract with NASA, big names involved ,way under the radar , staggering health market for these apps , look at their web site
I don't know if this has changed but work environment is bad at intrexon.
http://www.glassdoor.com/Reviews/Intrexon-Reviews-E275054.htm
The stock was shorted about 6 million shares ,first shorting a stock should be illegal , these shorts seem to have a lot of influence with the market makers if not the same people , they want it to go down so they can cover what they sold, that is having an effect on the down turn ,second ,XON is just starting out I suspect a lot of debt and little profits , a few good PRs in January and uncontrolled exuberance occurred , now a sober look at XON and the price dropped to reflect all these forces at work, I suspect a one up day per 2 down days to happen in the next few months with a few Press releases to try to reverse the down trend, looking for a low in the 17 dollar range before and up turn this will be a great stock in two years ,if you are looking for cheap shares to buy ,I would wait till the dust settles first ,just my opinion don't buy or sell on the knowledge of this poster.
How far down ya'll think this will go?
Nearing bottom?
Lots of downward pressure lots of people are getting out . Financials probably are bad.
You may be correct but all I see is a lot of downward pressure plus 3 minutes after the bell 3292 shares sold someone wanted out with profit , it looks like a major adjustment is coming and I think 20 dollars will be revisited.
Smart people are buying MEDS to get XON stock at a discount , think about it you buy MEDS at 1.35 or less you get shares of XON at a 20 day average plus you get back .27 cents in cash , you can't go wrong if you want XON shares at a 20% dicount , that is what is happening now. JMHO
This starting to get into buy range again..
If you buy Medistem MEDS you will receive Cash and XON stock at a 20 day average way less than XON is trading at now.
If Medistem deal falls thru , XON will have a sell off and the PPS will fall to pre Medistem deal 20 bucks , they got a super deal buying out Medistem and if they drop the ball XON shares will tank.
The rumor with VNTH was that, just a rumor, I don't think anything will happen now , also why is XON being pumped up so much with no income producing products looks like it may tumble back to the 24 dollar range.
Rumor has it that XON is looking to get into the health app business and VNTH has just got a 5 year contract with NASA for the breath analysing sensor APP a billion dollar industry.
Congratulations for the ones who sold, big dump coming in 10 days, thats when the insiders of Medistem will get XON shares and will sell it and it will drop hard.
Why is it going up on this news?Agilis Biotherapeutics and Intrexon to Pursue Transformative Therapies for Rare Genetic Disease, they will not make any money here, because there is not enough people with this disease (a rare genetic neurodegenerative disease) This is fluff PR but people with money to buy just don't understand.
Big sec investigation , either they renegotiate the Medistem deal for a better price, or they get sued and sec gets involved , XON necks is on the line. State laws have been broken.
JP Morgan today $30.00 target XON
his is the first post WELCOME !! XON is a great new Kirk Public Company !! JMHO
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