Home > Boards > US OTC > Biotechs >

OncoSec Medical Inc. (ONCS)

Add ONCS Price Alert      Hide Sticky   Hide Intro
Moderator: trading.jeff, NGIN, chickpea598, akhsv777
Search This Board: 
Last Post: 1/24/2020 8:45:18 AM - Followers: 456 - Board type: Free - Posts Today: 0


                   OncoSec Medical Incorporated

                                 NASDAQ: ONCS

The following is taken from OncoSec's website. Only certain portions are included here.  For a complete description of OncoSec, please visit   http://www.oncosec.com/
Do not base your trading decisions solely on the information presented here. Do your own DD.  We are not licensed financial advisers. Nothing presented here should be construed
as buy/sell recommendations.



Who We Are

Cancer is a debilitating and swift-moving disease. To reach those affected by it, we need to move just as swiftly, with innovative treatments that extend lives and respect the need for quality of life.

Our mission at OncoSec is to pioneer and refine new electroporation technologies that save lives and enhance quality of life for those whose
skin cancers cannot be treated effectively with conventional treatment approaches.

Built on the foundation of a fast-paced, challenging, and entrepreneurial environment, OncoSec is committed to bringing proven treatments to the market quickly so those suffering today can have hope
for tomorrow. We will accomplish our mission through our entrepreneurial, results-driven culture, our proprietary technologies, our superior manufacturing and operational excellence, and strong
commercial leadership that identifies and expands the markets for our products.

At every step, we will fulfill our responsibilities to our stakeholders: the patients, physicians, healthcare workers, shareholders and employees who depend on-and are an integral part of-OncoSec's
continued success.

General information about OncoSec Medical, Incorporated: http://www.otcmarkets.com/stock/ONCS/company-info

SEC filings for OncoSec Medical, Incorporated: http://www.otcmarkets.com/stock/ONCS/filings

Twitter feeds
OncoSec Medical: https://twitter.com/Oncosec
Punit Dhillon, CEO: https://twitter.com/PunitDhillon

Excellent video which includes an interview with a melanoma survivor and OncoSec's CEO Punit Dhillon: http://globalnews.ca/video/539117/melanoma-monday

Investor Presentation: http://oncosec.com/QR-Downloads/ONCS-Investor-Presentation.pdf

OncoSec Corporate Profile: http://oncosec.com/QR-Downloads/ONCS-Corporate-Profile.pdf

An informative and comprehensive description of what OncoSec does: http://content.stockpr.com/oncosec/media/3edbc526ab7184e1257fcbcac727954e.pdf

A Selection of Significant Press Releases (PRs)
All news items about OncoSec Medical, Inc., can be found here: http://www.otcmarkets.com/stock/ONCS/news and here: http://ir.oncosec.com/company-news

OncoSec Announces Positive Results from Phase II Trial of ImmunoPulse™ IL-12 in Merkel Cell Carcinoma (September 27, 2015)

OncoSec Announces First Patient Enrolled in Phase II Clinical Trial Evaluating Combination of ImmunoPulse™ IL-12 and Anti-PD-1 Treatment (August 18, 2015)

OncoSec Medical Issues Annual Letter To Shareholders (June 17, 2015)


OncoSec Medical Enrolls First Patient in Squamous Cell Carcinoma of the Head and Neck Phase II Clinical Trial (June 16, 2015)

OncoSec Medical Set to Join Russell Microcap Index (June 15, 2015)

OncoSec Medical Announces Uplisting to The NASDAQ Stock Market LLC (May 27, 2015)

OncoSec Medical and Massachusetts General Hospital to Evaluate Efficacy of Intratumoral Delivery of DNA-Based Interleukin-12 (May 18, 2015)

OncoSec Medical Announces FINRA Approval of Reverse Stock Split (May 15, 2015)

OncoSec Medical Inc. and Heat Biologics, Inc. Announce Collaboration to Evaluate Combination of Immunotherapy Platforms (February 18, 2015)

OncoSec Medical Announces New Phase II Trial in Head and Neck Cancer Using ImmunoPulse (December 9, 2014)


UC San Francisco and OncoSec Medical Collaborate to Evaluate Investigational Combination of ImmunoPulse and Anti-PD-1 Treatment (November 25, 2014)





Click this link to view ONCS chart:  http://stockcharts.com/h-sc/ui?s=ONCS&p=D&yr=0&mn=3&dy=0&id=p75914482749


Patient Information

1 in 5 Americans will be diagnosed with skin cancer in their lifetime.
Each Year 125,000 new cases of melanoma, 3,000 new cases of CTCL, and 1,500 new cases of Merkel-cell carcinoma are diagnosed.
25-29 In women age 25-29, melanoma is the most common form of cancer.




Fighting Cancer with the Body's Immune System

IMMUNOPULSE uses the body's immune system to target and destroy both local and metastasized cancer cells.

Using the OMS system, DNA IL-12 (a plasmid DNA construct with instructions to produce the IL-12 protein) is delivered into the electroporated cells. Upon entry, the gene triggers each cell to produce and
secrete the IL-12 protein, which in turn identifies and eliminates cancerous cells as part of a natural immune response.


Introducing pro-inflammatory cytokine proteins into the body as a potential anti-cancer therapy has produced encouraging data. For example, interleukin-12 (IL-12) cytokine is a naturally occurring protein
that activates and increases the levels of circulating macrophages and cytotoxic T-cells. In turn, this activity eliminates both foreign organisms and emerging cancerous cells.

In the past, cytokines were not considered a viable anti-cancer therapy because toxic levels were required to achieve an effective dose. However, when cytokines are delivered using DNA and the
OMS system, effective results can be achieved with a significantly reduced dosage, making this a viable treatment for both local and metastatic melanoma.

Initial evidence suggests that this gene therapy has the potential to not only treat cancer cells in the target area, but to also trigger immune responses affecting remote cancer cells outside the direct
treatment area including distant lesions.


View the following video for a brief explanation of how OncoSec's methods work:




ImmunoPulse has demonstrated both safety and efficacy in a Phase 1 clinical trial for metastatic melanoma. It is currently being advanced in a Phase 2 confirmatory study enrolling at six centers 
throughout the US.





Targeting Cancer Cells with Greater Accuracy

NeoPulse boosts the effectiveness of an anti-cancer drug to kill cancer cells while minimizing toxic side effects.

NeoPulse uses the OMS system to destroy cancer cells using less harmful doses of bleomycin, a highly effective but also highly toxic anti-cancer drug.

Traditionally, bleomycin must be administered by intravenous infusion. Because this method targets cancer cells inefficiently, high doses must be used and significant side effects are common.

Using NeoPulse to electroporate and directly target cancerous cells with bleomycin, an effective result can be achieved with 1/20th of a traditional chemotherapy dose. In fact, by opening the cell membrane, we can enhance the
drug's ability to kill tumor cells by a factor of as much as 4,000.

Intensifying an already powerful drug

Bleomycin is proven to destroy cancer cells by attacking their DNA via an apoptotic or "suicidal" mechanism. When administered to cancer cells directly through electroporation, the efficacy of bleomycin 
is increased exponentially. Even more advantageous, the pores of treated cells close shortly after introduction of the drug, trapping it within. Tests show that electroporated cells retain more of the drug, and retain it for a
longer period, thereby increasing the effectiveness of the treatment.


Proven results

Extensive pre-clinical and clinical data from Phase 1 through 4 clinical trials demonstrate NeoPulse is safe and highly effective in eradicating solid tumors, including melanoma, basal cell
squamous cell carcinoma, and liver and pancreatic cancers, with observable cancer cell destruction, better quality of life benefits, and swift healing of the wound site.








OMS-I100 - Phase II Metastatic Melanoma Clinical Trial

Approximately 70,000 new cases of melanoma will be diagnosed every year, and this number is increasing. Despite this cancer being the deadliest form of all skin cancers, there still
remain few  treatment options for patients with advanced-stage disease.

Previous data from a Phase I study demonstrated that using ImmunoPulse in melanoma patients is safe and well tolerated. In addition, promising therapeutic outcomes were observed
in 53% of patients with metastaticdisease, demonstrating an objective response to this therapy.

A Phase II safety and efficacy trial using OMS electroporation to deliver DNA IL-12 in patients with late-stage metastatic melanoma (OMS-I100) is being conducted in collaboration with the University of
California San Francisco. This open-label, multi-center Phase II trial will enroll approximately 25 patients with advanced-stage, cutaneous, in-transit malignant melanoma. Trials are currently being
conducted at three centers across the United States.

Further information: http://clinicaltrials.gov/ct2/show/NCT01502293?term=clinical+trials+adil+daud&rank=2


OMS-I110 - Phase II Merkel Cell Carcinoma Clinical Trial

Merkel cell carcinoma is a rare and deadly disease. Despite a mortality rate of 40%, treatment options for these patients are scarce. Because 80% of Merkel cell carcinomas are caused by an associated
viral infection (Merkel cell polyomavirus), it is believed that an efficient and targeted immunotherapy may be a potential therapeutic approach for this disease.

A Phase II safety and efficacy trial using OMS ElectroImmunotherapy to deliver DNA IL-12 in patients with local and metastatic Merkel cell carcinoma (OMS-I110) is being conducted in collaboration with the
University of Washington. This open-label, multi-center Phase II trial will enroll approximately 15 patients with Merkel cell carcinoma. Trials are currently being conducted at two centers in the United States.

Further information: http://www.clinicaltrials.gov/ct2/show/NCT01440816?term=merkel+cell+carcinoma&rank=3


OMS-I120 - Phase II Cutaneous T-Cell Lymphoma Clinical Trial

Cutaneous t-cell lymphoma is a rare form of non-Hodgkin's lymphoma that affects T-cells of the immune system, resulting in immune dysfunction. Though not life-threatening, this disease has proven
difficult to treat, with current therapies unable to demonstrate long-term benefits.

As a disease of the immune system, cutaneous T-cell lymphoma may be responsive to immunotherapy, a treatment in which the immune system is stimulated to fight cancer and destroy infected cells.
Immunotherapy has the potential to provide safe and long-lasting treatment.

A Phase II safety and efficacy trial using ImmunoPulse to deliver DNA IL-12 (a gene that triggers cells to attack and eliminate cancerous cells) in patients with early and late stage cutaneous T-cell
lymphoma (OMS-I120) is being conducted in collaboration with the University of California San Francisco. This open-label, multi-center Phase II trial will enroll approximately 27 patients with cutaneous
T-cell lymphoma. Trials are currently being conducted at one center in the United States.

Further information: http://clinicaltrials.gov/ct2/show/NCT01579318?term=CTCL+UCSF&rank=1

7 Key Questions &  Answers

When and why was OncoSec formed?

OncoSec was formed in March 2011 and is led by a management team with 10 years of experience in developing electroporation technologies for the treatment of cancer. In total, more than $100 million
has been invested in the development of OncoSec's proprietary electroporation technology. Today, OncoSec is focused on refining this late-stage technology and developing a robust clinical pipeline focused on treating rare
skin cancers by delivering targeted chemotherapies and immunotherapies using electroporation.

Why is electroporation important?

Since the 1950s, a number of potentially useful drugs have been developed to treat cancer. However, the method for delivering these drugs has always been inadequate and problematic. Traditionally,
most drugs are delivered systemically: they are administered through an IV and directly into the bloodstream. When drugs are delivered this way, high concentrations of the drug are needed to reach the
cancer. At these concentrations, many of these drugs are highly toxic.

For the first time, there is a more efficient and targeted method of delivering cancer-fighting drugs.

Using a brief electrical pulse, electroporation temporarily opens the pores of cancer cells, allowing us to deliver drugs directly into those cells. This way, we can dramatically reduce the drug
concentration required to achieve therapeutic results.


What is the market size for OncoSec's target indications?

Today, more than two million skin cancers are diagnosed each year in the US alone. Most are non-deadly cancers called basal cell carcinomas and squamous cell carcinomas. These can be treated with
surgery, but surgical intervention can result in damaging cosmetic or functional outcomes.

Skin cancers can also be highly lethal and difficult-sometimes even impossible-to treat using conventional methods. These cancers including melanoma, Merkel cell carcinoma, and cutaneous T-cell

There are 125,000 new cases of melanoma diagnosed each year, and this number is increasing, especially among young adults ages 18-35. Treatments are toxic, debilitating, and not always effective.
There are also 3,000 new cases of cutaneous T-cell lymphoma and 1,500 new cases of Merkel-cell carcinoma diagnosed each year in the US. Instances of these cancers, too, are increasing, and there are
currently no treatments available for these patients.

OncoSec's electroporation technologies target these potentially lethal and hard-to-treat skin cancers that conventional therapies can't reach effectively.

How do OncoSec's therapies compare to current therapies for skin cancer?

Current therapies for skin cancer, such as IV-administered chemotherapy, have been shown to be toxic and not always effective for all patients. The side effects that result from these therapies can be debilitating, and may include additional post-treatment care, such as cosmetic surgery.


OncoSec's therapies have shown significant improvements in response compared to currently approved therapies. Just as important, they have been shown to trigger significantly fewer or less-intense side effects compared
to conventional treatment, thereby improving patients' quality of life as well as their longevity.

What is Combination Therapy?

Combination therapy (or polytherapy) is a broad term for the use of multiple medications or therapies, in order to fight the same condition. While it typically denotes the use of two or more drugs, it can also include immunotherapy, non-medical therapies – including psychological therapy – and other means of therapy or treatment. The practice may not be new but we have seen a very large increase in the number of approved and researched combination therapies, over the past decade. With many doctors, oncologists, and other medical professionals recommending combination therapies for a large number of diseases and conditions, it is important to know how this approach can aid in treatment and recovery. (From http://oncosec.com/index.php/what-is-combination-therapy/.)

What is the difference between ImmunoPulse  and NeoPulse?

ImmunoPulse is being developed to treat metastatic cancers-cancers that have spread beyond the tumor site and throughout the body. In these cases, treatment is particularly challenging, and surgical removal of the
cancer is not an option. This therapy stimulates the immune system to recognize the cancer and kill cancerous cells that have spread throughout the body.


NeoPulse is being developed to treat primary and recurrent cancers that have not yet spread to other parts of the body. For these types of cancers, surgery is a possible treatment, but one that can have detrimental
cosmetic and functional effects because of the healthy surrounding tissue that is often excised. As an alternative therapy, NeoPulse can target and kill cancer cells while keeping the surrounding healthy tissue intact. This results in a less-invasive treatment with improved outcomes. NeoPulse also has the potential to minimize the risk of recurrence compared to surgery, because the cancerous cells can be targeted and killed with greater precision.

How can I find out more information?

If you are an investor, a medical professional, or a potential trial participant, we invite you to contact us to learn more.

Investors: contact our investor relations team at                 1-855-662-6732         (               855.ONCOSEC        ) or  Investors@OncoSec.com
Current Price
Bid Ask Day's Range
  • 1D
  • 1M
  • 2M
  • 3M
  • 6M
  • 1Y
  • 2Y
  • 3Y
  • 5Y
ONCS News: Additional Proxy Soliciting Materials (definitive) (defa14a) 01/24/2020 05:14:27 PM
ONCS News: Additional Proxy Soliciting Materials (definitive) (defa14a) 01/21/2020 05:19:11 PM
ONCS News: Current Report Filing (8-k) 01/21/2020 04:48:47 PM
ONCS News: Additional Proxy Soliciting Materials - Non-management (definitive) (dfan14a) 01/21/2020 04:41:48 PM
ONCS News: OncoSec Announces the Appointment of Robert J. DelAversano, C.P.A, as Principal Accounting Officer and Controller 01/21/2020 04:30:00 PM
#46943  Sticky Note OncoSec Announces Collaboration For TAVO™ In Australia With runcaly 05/29/19 08:38:37 AM
#47622   So what has management done wrong here? I’m ignatiusrielly35 01/24/20 08:45:18 AM
#47621   Manipulated stock prices mean nothing. ignatiusrielly35 01/24/20 08:44:28 AM
#47620   The market doubt the results??? runcaly 01/24/20 01:30:02 AM
#47618   The trials are progressing nicely with approval results...... ytcheng 01/23/20 10:37:43 PM
#47617   So identify and describe the alleged scam. I ignatiusrielly35 01/23/20 11:03:45 AM
#47616   You are spot on about ONCS imo...like MOST NGIN 01/23/20 09:01:25 AM
#47614   You are so wrong as you have been HereToFightScams 01/22/20 11:41:16 PM
#47613   The trials are progressing nicely with approval results ignatiusrielly35 01/22/20 03:28:22 PM
#47612   Yes! they can cash it at any price. ytcheng 01/22/20 09:38:46 AM
#47611   There's absolutely NOTHING im confused about...lol Per another NGIN 01/22/20 09:08:59 AM
#47610   EAST LYME, Conn.--(BUSINESS WIRE)--Phesi, a data-driven provider of runcaly 01/22/20 07:50:18 AM
#47609   What scam has the current management team committed, ignatiusrielly35 01/22/20 12:17:57 AM
#47608   I'll weigh the risks with Alpha before EVER NGIN 01/20/20 08:52:45 PM
#47607   MY THOUGHTS ALSO 5TREE 01/17/20 04:47:27 PM
#47606   You are confused about CGP’s deal. They have ignatiusrielly35 01/17/20 04:42:24 PM
#47605   What is Alpha's alternative offer to this paragraph? trading.jeff 01/17/20 03:47:38 PM
#47604   "China Grand has no obligation whatsoever to exercise NGIN 01/17/20 03:18:54 PM
#47601   Right, when the hedgies manipulate a stock down ignatiusrielly35 01/17/20 12:16:29 PM
#47600   Again and again an apparent reaction of the runcaly 01/17/20 10:44:13 AM
#47598   Great summary!! YOU are correct about DOC...He HAS NGIN 01/17/20 09:12:41 AM
#47597   The stock tanked more under Punit's watch than trading.jeff 01/17/20 08:01:24 AM
#47596   I see that you can’t specify any specific ignatiusrielly35 01/17/20 07:17:06 AM
#47594   Trust has nothing to do with it. He ignatiusrielly35 01/16/20 07:44:19 PM
#47592   How has current management misled shareholders? And what ignatiusrielly35 01/16/20 03:14:44 PM
#47591   Sure would!! ANYBODY could run oncSUCK better..at least NGIN 01/16/20 02:58:32 PM
#47590   I haven’t seen current management do anything other ignatiusrielly35 01/16/20 02:37:47 PM
#47588   This sounds EXACTLY what current Management has been NGIN 01/16/20 02:04:28 PM
#47587   oncSUCK Management is an ILLUSION imo.... NGIN 01/16/20 02:02:57 PM
#47586   Hey 5TREE, No i wouldn't invest another PENNY NGIN 01/16/20 02:00:51 PM
#47585   $ONCS pps popping, 2.10. trading.jeff 01/16/20 10:39:00 AM
#47584   This is basically what some of us have ignatiusrielly35 01/16/20 10:19:57 AM
#47583   Here's the reason provided for the postponement: trading.jeff 01/16/20 09:20:46 AM
#47582   You nailed it. Alpha was waiting until ONCS ignatiusrielly35 01/16/20 09:06:26 AM
#47581   They dont have enough votes ... runcaly 01/16/20 08:54:34 AM
#47579   Hey, NGIN, YTCHENG, and "Scam Fighter" you fellas 5TREE 01/15/20 11:09:44 PM
#47578   Agree with you 1000%..voting against Alpha is shooting NGIN 01/15/20 10:27:12 PM
#47577   I would think that the fact we have James salmon 01/15/20 05:02:35 PM
#47576   It is very sequitur, very pointfull. They HereToFightScams 01/15/20 03:39:35 PM
#47575   correction>>Will there be more things 5TREE 01/15/20 12:02:09 PM
#47574   From the indications I've seen this thing has 5TREE 01/15/20 12:00:55 PM
#47573   Agreed. That whole aspect of Alpha’s offer—that they ignatiusrielly35 01/15/20 11:05:42 AM
#47572   Can't you just see the Dhillons being forced trading.jeff 01/15/20 10:12:18 AM
#47571   This is something they can’t achieve without many James salmon 01/15/20 10:10:44 AM
#47570   Probably. But who, exactly, is going to sell ignatiusrielly35 01/15/20 10:08:46 AM
#47569   I think they know if they went into James salmon 01/15/20 09:58:37 AM
#47568   I agree, James. I don’t really u see ignatiusrielly35 01/15/20 09:55:29 AM
#47567   Why would shareholders even want to sell their James salmon 01/15/20 09:42:27 AM
#47566   Same to you, my friend. ignatiusrielly35 01/15/20 09:15:13 AM
#47565   Different prospective! After all, it's our money, our akhsv777 01/15/20 09:13:06 AM