OSI Pharmaceuticals, Inc. engages in the discovery, development, and commercialization of pharmaceutical products for the treatment of oncology, ophthalmology, and diabetic diseases in the United States. Its product Tarceva, an oral small molecule inhibitor of the epidermal growth factor receptor. The company also offers Macugen for the treatment of neovascular age-related macular degeneration; Novantrone, an anthracenedione, which is used as intravenous chemotherapy agent, as well as for the treatment of nonlymphocytic leukemia, and the relief of pain associated with hormone refractory prostate cancer; and Gelclair, a bioadherant oral gel for the relief of pain associated with oral mucositis. In addition, the company offers OSI-930, a tyrosine kinase inhibitor, designed to target cancer cell proliferation and blood vessel growth, or angiogenesis, in selected tumors completed Phase I dose escalation studies; OSI-906, a tyrosine kinase inhibitor, that acts as a selective inhibitor and stimulates proliferation, enables oncogenic transformation and suppresses apoptosis; and PSN9301 is in Phase II clinical trials for the treatment of type 2 diabetes. In addition, OSI Pharmaceuticals, through its collaborative drug discovery program with Pfizer, develops CP-547,632, which targets vascular endothelial growth factor receptor and is in Phase II trials; and CP-868,596 that targets tumor derived angiogenesis and is in Phase I trials. Further, through its subsidiary, provides diabetes and obesity treatment in the United Kingdom. The company also has collaboration agreements with Cold Spring Harbor Laboratory; Genentech, Inc.; and Roche. OSI Pharmaceuticals was founded in 1983 and is headquartered in Melville, New York.