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Last Post: 5/25/2017 10:58:38 AM - Followers: 9 - Board type: Free - Posts Today: 0


NephroGenex Announces Positive Results for QT Study of Pyridorin



NephroGenex, Inc. (NRX), a pharmaceutical company focused on the development of therapeutics to treat kidney disease, today announced the Company has successfully completed a thorough QT/QTc (TQT) cardiac safety study on Pyridorin. This study assesses a drug’s risk of QT prolongation and its proarrhythmic potential, and is a standard component of all clinical development programs for new molecular entities.

Pyridorin showed no effect on the QT/QTc interval at the expected therapeutic dose of 300 mg and at a higher dose of 1200 mg. In previous Phase 1 and Phase 2 studies, Pyridorin has shown no effect on the QT/QTc interval in patients with diabetic nephropathy.

“These are important study results that support the use of Pyridorin in patients with diabetic nephropathy, many of whom suffer from cardiovascular disease. They are also important given the concerns over cardiac safety seen with other therapies in development for this disease,” said Chief Executive Officer Pierre Legault. “The overall excellent safety profile we are continuing to see, along with the promising efficacy shown in our Phase 2 trials, continues to suggest that Pyridorin has the potential to broadly address the unmet therapeutic needs of the more than 6 million diabetic patients with kidney disease.”

About Diabetic Nephropathy

Diabetic nephropathy is a chronic, degenerative disease of the kidney caused by diabetes. There are approximately 6 million patients with diabetic nephropathy in the United States (approximately 33% of diagnosed diabetics) and this population is expected to grow. Patients suffering from diabetic nephropathy progress to End Stage Renal Failure (and require dialysis) or death. There are currently no adequate treatments for this disease.


NASDAQTue, Dec 30, 2014 4:00 PM EST

About Pyridorin®

Pyridorin inhibits pathogenic oxidative chemistries, which are collectively elevated in diabetic patients and induce pathological changes implicated in the development of diabetic nephropathy. Pyridorin inhibits a broad range of these chemistries which we believe accounts for its effectiveness in slowing the progression of nephropathy in diabetic patients as shown in our Phase 2 studies. Our lead drug candidate was also found to be safe and well tolerated in these same studies.

About NephroGenex, Inc.

NephroGenex (NRX) is a clinical-stage pharmaceutical company focused on developing therapeutics to treat kidney diseases caused by pathogenic oxidative chemistries. Since our inception, we have collaborated with the leading scientific experts in pathogenic oxidative chemistries to build a strong portfolio of intellectual property and novel acting drug candidates. Our clinical program has been done in collaboration with world leading clinical investigators in kidney disease. Our product pipeline includes an oral formulation of Pyridorin, which is being developed as a chronic, therapeutic agent to slow the progression of diabetic nephropathy, as well as an intravenous formulation of Pyridorin to treat specific types of acute kidney injury.

Cautionary Note on Forward-Looking Statements

#165   NRXGQ: BK PLAN effective. All shares cancelled: Renee 05/25/17 10:58:38 AM
#164   Uranu$ blindjohn 03/03/17 12:10:21 AM
#163   I honestly can't say this surprises me. Lone Wolf 03/02/17 11:57:28 AM
#162   Got the Realtime 8KSpy Alert on AQNM $NRXGQ..... BOOOOM.... Zardiw 03/02/17 10:54:36 AM
#161   Gonna put this one on watch this morning. Lone Wolf 02/02/17 06:28:22 AM
#160   Wonder what today will bring?!? Lone Wolf 05/27/16 09:25:08 AM
#159   A lot of accumulation has been taking place Lone Wolf 05/26/16 10:52:07 AM
#158   from 0,08 to 0,20 is nice harmsen 05/26/16 10:09:13 AM
#157   Holy mother of Jesus. You ain't kidding!! Lone Wolf 05/26/16 09:48:04 AM
#156   Here we go!!!!!! harmsen 05/26/16 09:45:35 AM
#155   Nice!! There was a time everyone wrote Lone Wolf 05/25/16 02:28:35 PM
#154   Bid 0,13 ask 0,132 volume 255.627 harmsen 05/25/16 01:47:18 PM
#153   + 46.67% harmsen 05/25/16 01:36:19 PM
#152   IMO, buyout coming. This bad boy has Lone Wolf 05/25/16 08:57:33 AM
#151   wonder if NRXCQ .075 gets gap fill to PAC 05/23/16 02:07:23 PM
#150   Still here...adding! ;-) Lone Wolf 05/23/16 12:18:58 PM
#149   NRX changed to NRXGQ, bankruptcy. Delisted from the Renee 05/10/16 05:28:26 PM
#148   I see you out here, all by yourself, Lone Wolf 05/10/16 02:42:32 PM
#147   Can anyone tell me the difference between a Lone Wolf 05/06/16 07:50:31 AM
#146   This is like someone putting their sweat and Lone Wolf 05/05/16 01:37:45 PM
#145   Agree todboyd 05/05/16 12:48:01 PM
#144   Guess you haven't been watching the accumulation here Lone Wolf 05/05/16 12:44:57 PM
#143   No recovery! The company says to liquidate all hondaboost 05/05/16 12:08:19 PM
#142   Shame no one recognized the value here after Lone Wolf 05/05/16 11:05:25 AM
#141   NNRX, the insiders and funds are holding 80% gm99 05/05/16 09:23:03 AM
#140   Sometimes the markets can be a bit 'short Lone Wolf 05/03/16 01:49:11 PM
#139   The company is trying hard to get rid hondaboost 05/03/16 08:34:16 AM
#138   OMG, never thought it would file BK. Why gm99 05/03/16 12:28:28 AM
#137   Sorry...that got away from me. Was asking Lone Wolf 05/02/16 03:40:17 PM
#136   Doesn't this one meet the exact profile o Lone Wolf 05/02/16 03:36:05 PM
#135   Oopus! NRX filed Bankruptcy today. Didn't expect it hondaboost 05/02/16 12:52:27 PM
#134   Look like there is not going to be bullrider2 05/02/16 11:40:03 AM
#133   accumulations looks like finish. intraday bounce today. NRX l2 hunter 04/29/16 03:23:14 PM
#132   Yep, it's just trading at 50% of cash gm99 04/29/16 11:47:15 AM
#131   NRX is searching to complete a reverse merger, gm99 04/29/16 11:39:08 AM
#130   NRX, the insiders and funds are holding 80% gm99 04/28/16 09:24:10 AM
#129   WTF are you talking about? Dis you Runners123 04/28/16 08:25:29 AM
#128   NRX hold the 0.55$ support line. have add l2 hunter 04/27/16 03:25:38 PM
#127   NRX just halted its trial and fired CEO hondaboost 04/27/16 08:31:05 AM
#126   gem The Night Stalker 04/27/16 12:52:17 AM
#125   * * $NRX Video Chart 04-26-16 * * ClayTrader 04/26/16 04:58:44 PM
#124   This play couldn't find the steam to break TrendTrade2016 04/26/16 03:55:25 PM
#123   NRX looking good. nice found. l2 hunter 04/26/16 03:06:33 PM
#122   This ticker setting up for a short term TrendTrade2016 04/26/16 12:17:51 PM
#121   NRX, $0.54, moving, O/S: 13 m. IPO at gm99 04/25/16 03:49:51 PM
#120   Everybody SPEECHLESS? pberger 01/26/16 09:38:31 AM
#119   $0.81, worst trap I ever experienced on GOOD pberger 01/25/16 09:42:34 AM
#118   So, why it is now down to a pberger 01/25/16 09:40:35 AM
#117   This trading makes NO SENSE, down to 52 pberger 01/25/16 09:33:54 AM
#116   SM that really bothered you..,. as in , OB_WEALTH_INC 01/22/16 02:34:53 PM
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